Functional interpretation,cataloging, and analysis of 1,341 glucose-6-phosphate dehydrogenase variants

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3β-Hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males

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Integrative structure of a 10-megadalton eukaryotic pyruvate dehydrogenase complex from native cell extracts

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Gut-microbiome-expressed 3β-hydroxysteroid dehydrogenase degrades estradiol and is linked to depression in premenopausal females

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Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination

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High-resolution structural-omics of human liver enzymes

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The NADH Dehydrogenase Nde1 Executes Cell Death after Integrating Signals from Metabolism and Proteostasis on the Mitochondrial Surface

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The requirement for pyruvate dehydrogenase in leukemogenesis depends on cell lineage

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TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition

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Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation

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MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex

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A role of cytoplasmic p53 in the regulation of metabolism shown by bat-mimicking p53 NLS mutant mice

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Uncoupled glycerol-3-phosphate shuttle in kidney cancer reveals that cytosolic GPD is essential to support lipid synthesis

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Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

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An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism

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The malate-aspartate shuttle is important for de novo serine biosynthesis

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Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth

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Q-Flux: A method to assess hepatic mitochondrial succinate dehydrogenase,methylmalonyl-CoA mutase,and glutaminase fluxes in vivo

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Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation

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Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway

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