共查询到20条相似文献,搜索用时 31 毫秒
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Zlobin I. E. Kholodova V. P. Rakhmankulova Z. F. Kuznetsov Vl. V. 《Photosynthesis research》2015,125(1-2):141-150
Photosynthesis Research - In the present study, the influence of 50 and 100 µM CuSO4 was investigated starting from 3 h till 72 h treatment of 4-weeks Brassica napus... 相似文献
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Susanne Löfgren Stina Ekman Ylva Terelius Ronny Fransson-Steen 《Acta veterinaria Scandinavica》2008,50(1):47
Background
This study was performed to characterize a gene-addition transgenic mouse containing a BAC (bacterial artificial chromosome) clone spanning the human CYP2C18&19 genes (tg-CYP2C18&19). 相似文献4.
He Jun Bouwmeester Harro J. Dicke Marcel Kappers Iris F. 《Plant molecular biology》2020,103(4-5):507-509
Plant Molecular Biology - In the above mentioned publication, part of Fig. 1b was distorted (48 h after TSSM Infestation). The original article has been corrected and the proper... 相似文献
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Salma Firdaus Nazia Hassan Mohd. Aamir Mirza Tabasum Ara Hamed A. El-Serehy Fahad A. Al-Misned Zeenat Iqbal 《Saudi Journal of Biological Sciences》2021,28(1):317-326
Candidal vulvovaginitis (CVV), is the second most leading vaginal infection (global prevalence > 75%), caused due to excessive growth of Candida spp., predominantly Candida albicans (>95% cases). The current treatment regimens for CVV are marred with the challenges of fungal resistance & infection recurrence, subsequently leading to the compromised therapeutic efficacy of anti-fungal drugs, prolonged treatment and low patient compliance. The core of the present research was the fabrication & investigation of 2 T-SLN (solid lipid nanoparticles) gel carrying luliconazole for the amelioration of CVV. ‘2T’ symbolizes transvaginal & thermosensitive attributes of the present formulation. SLNs were prepared by a modified melt emulsification-ultra sonication method using a combination of solid lipids (Gelucire 50/13 & Precirol ATO 5), surfactant (Tween 80) and co-surfactant (Kolliphor). Formulation by design (FbD) approach was adopted to obtain appropriately screened and tailored SLNs. The optimized SLNs yielded a particle size, polydispersity index & entrapment efficiency of 62.18 nm, 0.263 & 81.5% respectively. To formulate the 2 T-gel, the final SLNs were loaded into Carbopol 971P-NF and Triethanolamine based gel. The 2 T-SLN gel was found to be easily spreadable and homogenous with mean extrudability (15 ± 0.4 g/cm2), viscosity (696.42 ± 2.34 Pa·s) and %drug content (93.24 ± 0.73%) values.. The pH of the prepared 2 T-SLN gel (4.5 ± 0.5) was in concordance with the vaginal pH (normal conditions). For in-vitro characterization of an optimized 2 T-SLN gel the release kinetics & anticandidal activity were assessed which offers a %cumulative drug release of 62 ± 0.5% in 72 h and 37.3 ± 1.5 mm zone of inhibition in 48 h. The visual appearance & dimensions were determined using fluorescent microscopy (spherical shape) & transmission electron microscopy (90–120 nm) respectively. The optimized 2 T-SLN gel showcases a skin-friendly profile with no significant signs of erythema and oedema and was found to be stable at room temperature for 2 months without any visual non-uniformity/cracking/breaking. In conclusion, the current research serves a new therapeutic perspective in assessing the activity of luliconazole for vaginal drug delivery using a 2 T-SLN gel system. 相似文献
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Gruzdev G. A. Karpukhina O. V. Inozemtsev A. N. Kamensky A. A. 《Doklady. Biochemistry and biophysics》2022,502(1):36-39
Doklady Biochemistry and Biophysics - The effect of adrenaline in various concentrations and dopamine at... 相似文献
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Biotechnology Letters - In the wake of SARS-CoV-2’s global spread, human activities from health to social... 相似文献
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Kiesewetter S Köpsel A Mai K Stroux A Bobbert T Spranger J Köpp W Deter HC Kallenbach-Dermutz B 《BioPsychoSocial medicine》2012,6(1):3
Background & Aims
The long-term success of life-style interventions in the treatment of obesity is limited. Although psychological factors have been suggested to modify therapeutic effects, specifically the implications of attachment styles and the patient-therapist relationship have not been examined in detail yet. 相似文献11.
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Neverov Konstantin V. Krasnovsky Alexander A. Zabelin Alexey A. Shuvalov Vladimir A. Shkuropatov Anatoly Ya. 《Photosynthesis research》2015,125(1-2):43-49
Photosynthesis Research - Phosphorescence characterized by the main emission band at 952 ± 1 nm (1.30 eV), the lifetime of... 相似文献
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Roemmich James N.; Clark Pamela A.; Weltman Arthur; Rogol Alan D. 《Journal of applied physiology》1997,83(3):927-935
Roemmich, James N., Pamela A. Clark, Arthur Weltman, andAlan D. Rogol. Alterations in growth and body composition duringpuberty. I. Comparing multicompartment body composition models.J. Appl. Physiol. 83(3): 927-935, 1997.A four-compartment (4C) model of body composition was used as acriterion to determine the accuracy of three-compartment (3C) andtwo-compartment (2C) models to estimate percent body fat (%BF) inprepubertal and pubertal boys (genital I & II,n = 17; genital III & IV,n = 7) and girls (breast I & II, n = 8; breast III & IV,n = 15). The 3C water-density (3C-H2O) and 3C mineral-densitymodels, dual-energy X-ray absorptiometry, the Lohman age-adjustedequations, the Slaughter et al. skinfold equations, and the Houtkooperet al. and Boileau bioelectrical impedance equations wereevaluated. Agreement with the 4C model increased with thenumber of compartments (i.e., body water, bone mineral) measured.Except for the 3C-H2O model, thelimits of agreement were large and did not perform well forindividuals. The mean %BF by dual-energy X-ray absorptiometry (23.6%)was greater than that of the criterion 4C method (21.7%).For the field methods, the Slaughter et al. skinfold equationsperformed better than did the Houtkooper et al. and Boileaubioimpedance equations. The hydration of the fat-free mass decreased(genital I & II = 75.7%, genital III & IV = 74.8%, breast I & II = 75.5%, breast III & IV = 74.4%) and the mineral content increased(genital I & II = 4.9%, genital III & IV = 5.0%, breast I & II = 5.1%, breast III & IV = 5.7%) with maturation. The densityof the fat-free mass also increased (genital I & II = 1.084 g/ml,genital III & IV = 1.087 g/ml, breast I & II = 1.086 g/ml, breast III & IV = 1.091 g/ml) with maturation. All of the models reduced the %BF overprediction of the Siri 2C model, but only the 4C and3C-H2O models should be used ascriterion methods for body composition validation in children andadolescents. 相似文献
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Journal of Ichthyology - Three species of the genus Tribolodon (T. hakonensis, T. brandtii, and T. sachalinensis) and hybrids between T. hakonensis and... 相似文献
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Soltani Mehdi Pakzad Komael Taheri-Mirghaed Ali Mirzargar Saeed Shekarabi Seyed Pezhman Hosseini Yosefi Parasto Soleymani Narges 《Probiotics and antimicrobial proteins》2019,11(1):207-219
Probiotics and Antimicrobial Proteins - This study was aimed to assess the effect of oral application of Lactobacillus plantarum (2 × 107 CFU g−1... 相似文献
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Background
This paper presents a simple method to increase the sensitivity of protein family comparisons by incorporating secondary structure (SS) information. We build upon the effective information theory approach towards profile-profile comparison described in [Yona & Levitt 2002]. Our method augments profile columns using PSIPRED secondary structure predictions and assesses statistical similarity using information theoretical principles. 相似文献17.
Farris James W.; Hinchcliff Kenneth W.; McKeever Kenneth H.; Lamb David R.; Thompson Donald L. 《Journal of applied physiology》1998,85(3):807-816
We hypothesized that central fatigue may have a role in limitingthe endurance capacity of horses. Therefore, we tested the effect ofinfusing tryptophan and/or glucose on endurance time and plasmaconcentrations of free tryptophan and other substrates thought toaffect tryptophan uptake into the brain of seven mares (3-4 yr ofage, 353-435 kg) that ran on a treadmill at 50% of maximalO2 consumption to fatigue. Withuse of a counterbalanced crossover design, the horses were infused withtryptophan (100 mg/kg in saline solution) or a similar volume of salinesolution (placebo) before exercise. During exercise, horses receivedinfusions of glucose (2 g/min, 50% wt/vol) or a similar volume ofsaline. Thus the treatments were 1)tryptophan and glucose (T & G), 2) tryptophan and placebo (T & P), 3)placebo and glucose (P & G), and 4)placebo and placebo (P & P). Mean heart rate, hematocrit, andconcentration of plasma total solids before and during exercise weresimilar for all trials. Mean time to exhaustion was reduced (P < 0.05) for T & P and T & Gcompared with P & P [86.1 ± 6.9 and 87.1 ± 6.8 vs. 102.3 ± 10.3 (SE) min], whereas endurance for P & G(122.4 ± 11.9 min) was greater than for all other trials (P < 0.05). Compared withnontryptophan trials, during the tryptophan trials plasma prolactinincreased (P < 0.05) nearlythreefold before exercise and almost twofold early in exercise. Muscleglycogen concentrations were reduced(P < 0.05) below preexercise values in the P & G and P & P trials only. However, glucose infusions (P & G)did not affect (P > 0.05)concentrations of plasma free fatty acids or ratios of branched-chainamino acids to free tryptophan. In conclusion, tryptophan infusionreduced endurance time, which was consistent with the central fatiguehypothesis. The failure of glucose infusion to alleviate the effects oftryptophan and the absence of significant muscle glycogen reduction inthe tryptophan trials suggest that the early onset of fatigue in thetryptophan trials is not due to a lack of readily available substrate. 相似文献
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Background
Thermostable enzymes from thermophilic microorganisms are playing more and more important roles in molecular biology R&D and industrial applications. However, over-production of recombinant soluble proteins from thermophilic microorganisms in mesophilic hosts (e.g. E. coli) remains challenging sometimes. 相似文献20.
Dong Pengjuan Wang Yaping Liu Yutong Zhu Chunting Lin Jiaxin Qian Ruizhe Hua Luchun Lu Chao 《Molecular biology reports》2022,49(1):373-384
Molecular Biology Reports - To adapt to daily changes in the external environment, organisms have developed circadian rhythm systems with a period of approximately 24 h. Many studies have... 相似文献