共查询到20条相似文献,搜索用时 125 毫秒
1.
Background
Pseudomonas aeruginosa is the major pathogen associated with chronic and ultimately fatal lung infections in patients with cystic fibrosis (CF). To investigate how P. aeruginosa-derived vesicles may contribute to lung disease, we explored their ability to associate with human lung cells. 相似文献2.
Carolina C Otoni Sheila C Rahal Luiz C Vulcano Sérgio M Ribeiro Khadije Hette Tatiana Giordano Danuta P Doiche Renée L Amorim 《Acta veterinaria Scandinavica》2010,52(1):20
Background
Accurate early diagnosis of lung metastases is important for establishing therapeutic measures. Therefore, the present study aimed to compare survey thoracic radiographs and computerized tomography (CT) scans to specifically identify lung metastases in female dogs with mammary tumors. 相似文献3.
Tzyy-Bin Tsay Ming-Chieh Yang Pei-Hsuan Chen Ching-Mei Hsu Lee-Wei Chen 《Journal of biomedical science》2011,18(1):68
Background
The influence of the gut flora on lung inflammatory reaction against bacterial challenge remains undefined. This study was designed to investigate whether gut flora enhances lung defense against E.coli pneumonia through TLR4 signaling. 相似文献4.
Balagopal P Pandey M Chandramohan K Somanathan T Kumar A 《World journal of surgical oncology》2003,1(1):4
Background
Choriocarcinoma is an aggressive neoplasm arising in the body of the uterus. The disease normally spreads to lung and brain. 相似文献5.
Eva Bresson Tommy Seaborn Mélissa Côté Geneviève Cormier Pierre R Provost Bruno Piedboeuf Yves Tremblay 《Reproductive biology and endocrinology : RB&E》2010,8(1):2
Background
Accumulating evidences suggest that sex affects lung development. Indeed, a higher incidence of respiratory distress syndrome is observed in male compared to female preterm neonates at comparable developmental stage and experimental studies demonstrated an androgen-related delay in male lung maturation. However, the precise mechanisms underlying these deleterious effects of androgens in lung maturation are only partially understood. 相似文献6.
J Craig Cohen Janet E Larson Erin Killeen Damon Love Ken-Ichi Takemaru 《BMC developmental biology》2008,8(1):70
Background
Cystic fibrosis transmembrane conductance regulator (CFTR) was shown previously to modify stretch induced differentiation in the lung. The mechanism for CFTR modulation of lung development was examined by in utero gene transfer of either a sense or antisense construct to alter CFTR expression levels. 相似文献7.
Turgut Isitmangil Gulbu Isitmangil Yasemin Budak Recep Aydilek Mehmet Kutlu Celenk 《BMC pulmonary medicine》2001,1(1):4-5
Background
It is known that tissue and serum sialic acid levels may be altered by malignant transformation. In this study, sialic acid levels were determined in bronchoalveolar lavage fluid (BAL) and serum in two groups of patients with lung cancer and non-malignant diseases of the lung. 相似文献8.
Background
Cystic Fibrosis is a pleiotropic disease in humans with primary morbidity and mortality associated with a lung disease phenotype. However, knockout in the mouse of cftr, the gene whose mutant alleles are responsible for cystic fibrosis, has previously failed to produce a readily, quantifiable lung phenotype. 相似文献9.
Thais Graziela Donegá França Larissa Lumi Watanabe Ishikawa Sofia Fernanda Gonçalves Zorzella-Pezavento Fernanda Chiuso-Minicucci Clara Pires Fujiara Guerino de Lourdes Ribeiro de Souza Maria da Cunha Alexandrina Sartori 《BMC microbiology》2009,9(1):240-7
Background
Staphylococcus aureus methicillin-resistant (MRSA) has been frequently isolated from endotracheal and lung puncture aspirates in malnourished children with pneumonia. In this work we evaluated the susceptibility of undernourished BALB/c mice and its ability to mount a protective immunity against MRSA with emphasis on the lung involvement. 相似文献10.
Raed Salim Noah Zafran Zohar Nachum Gali Garmi Eliezer Shalev 《Reproductive biology and endocrinology : RB&E》2009,7(1):112-5
Background
Amniocentesis is the accepted mode of attaining amniotic fluid to perform tests for fetal lung maturity. The purpose of this study was to validate a non-invasive fetal lung maturity test by counting lamellar bodies from a vaginal pool among women with preterm premature rupture of membranes. 相似文献11.
Wojciech Filipiak Andreas Sponring Tomas Mikoviny Clemens Ager Jochen Schubert Wolfram Miekisch Anton Amann Jakob Troppmair 《Cancer cell international》2008,8(1):17
Background
The aim of this work was to confirm the existence of volatile organic compounds (VOCs) specifically released or consumed by lung cancer cells. 相似文献12.
Background
The present study mainly aimed to investigate the direct effects of Endostar (ES) on the proliferation and radiosensitivity of human lung squamous cancer cell line H-520. 相似文献13.
Background
It has been proposed that high insulin levels may cause delayed lung development in the fetuses of diabetic mothers. A key event in lung development is the production of adequate amounts of pulmonary surfactant. Insulin inhibits the expression of surfactant protein A (SP-A), the major surfactant-associated protein, in lung epithelial cells. In the present study, we investigated the signal transduction pathways involved in insulin inhibition of SP-A gene expression. 相似文献14.
Ashraf Gad Delon L Callender Erin Killeen Joseph Hudak Malgosia A Dlugosz Janet E Larson J Craig Cohen Avinash Chander 《BMC cell biology》2009,10(1):24
Background
Mechanicosensory mechanisms regulate cell differentiation during lung organogenesis. We have previously demonstrated that cystic fibrosis transmembrane conductance regulator (CFTR) was integral to stretch-induced growth and development and that transient expression of antisense-CFTR (ASCFTR) had negative effects on lung structure and function. In this study, we examined adult alveolar type II (ATII) cell phenotype after transient knock down of CFTR by adenovirus-directed in utero expression of ASCFTR in the fetal lung. 相似文献15.
Background
The aim of this study was to analyze the cell-specific expression of E- and N-cadherin and β-catenin in developing human lung tissues from 12 to 40 weeks of gestation. 相似文献16.
Fujii Y Tomita K Sano H Yamasaki A Hitsuda Y Adcock IM Shimizu E 《Cancer cell international》2002,2(1):16-11
Background
Since lung epithelial cells are constantly being exposed to reactive oxygen intermediates (ROIs), the alveolar surface is a major site of oxidative stress, and each cell type may respond differently to oxidative stress. We compared the extent of oxidative DNA damage with that of mitochondrial injury in lung epithelial cells at the single cell level. 相似文献17.
Pengcheng Wang Narendranath Reddy Chintagari Jeyaparthasarathy Narayanaperumal Sahlu Ayalew Steven Hartson Lin Liu 《BMC cell biology》2008,9(1):34
Background
Lamellar bodies are lysosome-related secretory granules and store lung surfactant in alveolar type II cells. To better understand the mechanisms of surfactant secretion, we carried out proteomic analyses of lamellar bodies isolated from rat lungs. 相似文献18.
Malgorzata Krajnik Iwona Damps-Konstanska Lucyna Gorska Ewa Jassem 《Biomedical engineering online》2010,9(1):17
Background
Cough is one of the main symptoms of advanced lung disease. However, the efficacy of currently available treatment remains unsatisfactory. Research into the new antitussives requires an objective assessment of cough. 相似文献19.
Pierre-Paul Lizotte Lana E Hanford Jan J Enghild Eva Nozik-Grayck Brenda-Louise Giles Tim D Oury 《BMC developmental biology》2007,7(1):15
Background
The receptor for advanced glycation end products (mRAGE) is associated with pathology in most tissues, while its soluble form (sRAGE) acts as a decoy receptor. The adult lung is unique in that it expresses high amounts of RAGE under normal conditions while other tissues express low amounts normally and up-regulate RAGE during pathologic processes. We sought to determine the regulation of the soluble and membrane isoforms of RAGE in the developing lung, and its expression under hyperoxic conditions in the neonatal lung. 相似文献20.
Johannes Voortman Thang V Pham Jaco C Knol Giuseppe Giaccone Connie R Jimenez 《Proteome science》2009,7(1):34-14