共查询到20条相似文献,搜索用时 15 毫秒
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Wang QH Nishiyama C Nakano N Shimokawa N Hara M Kanada S Ogawa H Okumura K 《Immunogenetics》2008,60(10):557-563
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C Nishiyama T Yokota K Okumura C Ra 《Journal of immunology (Baltimore, Md. : 1950)》1999,163(2):623-630
Key regulatory regions necessary for the expression of the gene encoding FcepsilonRI alpha-chain, a component of the high-affinity IgE receptor primarily responsible for IgE-dependent allergic response, were investigated. Two regions, -74/-69 and -55/-47, which contained binding motifs for proteins belonging to the Ets family and the GATA family, respectively, were shown to be necessary for the activation of the alpha-chain promoter. Both the regulatory elements enhanced the promoter activity only in alpha-chain-producing cells PT18 and RBL-2H3 (mast cell lines), indicating that the elements required specific trans-acting proteins present in the alpha-chain-producing cells. EMSA using nuclear extracts and in vitro-translated proteins revealed that Elf-1 and GATA-1 bound to the enhancer elements. This is the first report describing the regulation in the expression of the FcepsilonRI alpha-chain. 相似文献
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