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The transcription factors SOX9 and SOX10 are vitiligo autoantigens in autoimmune polyendocrine syndrome type I. 总被引:4,自引:0,他引:4
H Hedstrand O Ekwall M J Olsson E Landgren E H Kemp A P Weetman J Perheentupa E Husebye J Gustafsson C Betterle O K?mpe F Rorsman 《The Journal of biological chemistry》2001,276(38):35390-35395
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Ala-Eddin Al Moustafa 《Cell Adhesion & Migration》2015,9(5):392-393
It is estimated that 10–20% of human carcinogenesis is linked to virus infection including papillomaviruses (HPVs). Moreover, since metastatic cancer disease is a major cause of morbidity and mortality in cancer patients, the role of onco-viruses in cancer progression to a metastatic form is of particular interest. Recent studies reported that E5 and E6/E7 onco-proteins of high-risk HPVs could enhance cancer progression via the initiation of the epithelial–mesenchymal transition (EMT) event. Herein, we discuss the association between E5 as well as E6/E7 of high-risk HPV and cancer progression. 相似文献
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Sunadome K Yamamoto T Ebisuya M Kondoh K Sehara-Fujisawa A Nishida E 《Developmental cell》2011,20(2):192-205
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Wilhelm D Hiramatsu R Mizusaki H Widjaja L Combes AN Kanai Y Koopman P 《The Journal of biological chemistry》2007,282(14):10553-10560
In mammals, male sex is determined by the Y-chromosomal gene Sry (sex-determining region of Y chromosome). The expression of Sry and subsequently Sox9 (SRY box containing gene 9) in precursors of the supporting cell lineage results in the differentiation of these cells into Sertoli cells. Sertoli cells in turn orchestrate the development of all other male-specific cell types. To ensure that Sertoli cells differentiate in sufficient numbers to induce normal testis development, the early testis produces prostaglandin D(2) (PGD(2)), which recruits cells of the supporting cell lineage to a Sertoli cell fate. Here we show that the gene encoding prostaglandin D synthase (Pgds), the enzyme that produces PGD(2), is expressed in Sertoli cells immediately after the onset of Sox9 expression. Promoter analysis in silico and in vitro identified a paired SOX/SRY binding site. Interestingly, only SOX9, and not SRY, was able to bind as a dimer to this site and transactivate the Pgds promoter. In line with this, a transgenic mouse model showed that Pgds expression is not affected by ectopic Sry expression. Finally, chromatin immunoprecipitation proved that SOX9 but not SRY binds to the Pgds promoter in vivo. 相似文献
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P Smits P Li J Mandel Z Zhang J M Deng R R Behringer B de Crombrugghe V Lefebvre 《Developmental cell》2001,1(2):277-290
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The DNA-binding specificity of SOX9 and other SOX proteins. 总被引:14,自引:0,他引:14