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1.
Ersan Kara Mehmet Gunay İbrahim Cicioglu Mehmet Ozal Mehmet Kilic Rasim Mogulkoc Abdulkerim Kasim Baltaci 《Biological trace element research》2010,134(1):55-63
This study aims to examine the effect of zinc supplementation on free-radical formation and antioxidant system in individuals
who are actively engaged in wrestling as a sport. The study registered a total of 40 male subjects, of whom 20 were wrestlers
and 20 were sedentary individuals. The subjects were equally allocated to four groups: group 1, zinc-supplemented sportsmen
group; group 2, sportsmen group without supplementation; group 3, zinc-supplemented sedentary group; group 4, sedentary group
without supplementation. Blood samples were collected from all subjects twice, once at the beginning of the study and once
again at the end of 8-week procedures. The blood samples collected were analyzed to determine the levels of malondialdehyde
(MDA), serum glutathione (GSH), serum glutathione peroxidase (GPx) activity, serum superoxide dismutase (SOD) activity (ELISA
colorimetric method) and zinc (colorimetric method). No difference was found between MDA levels of the study groups in the
beginning of the study. The highest MDA value at the end of the study was obtained in group 4 (p < 0.01). MDA levels in group 2 were established to be significantly higher than those in groups 1 and 3 (p < 0.01). GSH level, GPx, and SOD activities and zinc level measured in the beginning of the study were not different between
groups. Measurements performed at the end of the study showed that groups 1 and 3 (zinc-supplemented groups) had the highest
GSH level, GPx, and SOD activities and zinc level (p < 0.01). These parameters were not different in the groups without supplementation (groups 2 and 4). Results obtained at
the end of the study indicate that zinc supplementation prevents production of free radicals by activating the antioxidant
system. In conclusion, physiologic doses of zinc supplementation to athletes may beneficially contribute to their health and
performance. 相似文献
2.
Vedat Cinar Rasim Mogulkoc Abdulkerim Kasim Baltaci 《Biological trace element research》2010,134(2):130-135
In the present study, experiments were designed to investigate if supplementation with calcium during 4 weeks had an effect
on blood parameters in sedentary male athletes at rest and exhaustion. Thirty healthy subjects of ages ranging from 18 to
22 years were included in the study. The subjects were separated into three groups, as follows: Group 1 consisted sedentary
athletes receiving 35 mg/kg/day calcium gluconate. Group 2 included subjects equally supplemented with calcium training 90 min/day
for 5 days/week. Group 3 were subject to the same exercise regime but did not receive calcium supplements. Blood parameters
were determined in the experimental subjects at rest and after exhaustion. The leukocyte count (WBC) of athletes in groups
2 and 3 were significantly higher at exhaustion (p < 0.05). There were no significant differences in the WBC of the two supplemented groups. The erythrocyte count (RBC) was
increased in the supplemented athletes after training (p < 0.05), but hemoglobin, hematocrit, and trombocyte levels remained unchanged. The mean corpuscular volume increased in the
calcium-supplemented group at rest (p < 0.05). These results suggest that calcium supplementation only causes increases in white and red blood cell counts in athletes
after exhaustion while other hematological parameters remain unchanged. 相似文献
3.
Kara E Ozal M Gunay M Kilic M Baltaci AK Mogulkoc R 《Biological trace element research》2011,143(3):1435-1440
The present study aims to examine the effect of zinc supplementation on the release of some cytokines in young wrestlers actively
involved in wrestling. A total of 40 male subjects of the same age group were included in the study: half were wrestlers and
the other half were not involved in sports. The subjects were equally divided into four groups and treated during an 8-week
period as follows: group 1, zinc-supplemented athletes; group 2, non-supplemented athletes; group 3, zinc-supplemented sedentary
subjects, and group 4, non-supplemented sedentary group. Blood samples were taken from each subject at the beginning and at
the end of the study period. The serum tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), and interpheron-γ levels (IFN-γ)
were determined using the enzyme-linked immunosorbent assay method. At the beginning of the study, there were no significant
differences of the measured parameters between the four study groups. At the end of the study, the levels of TNF-α, IL-2,
and IFN-γ were significantly higher in the two zinc-supplemented groups compared to those that did not receive supplementation,
regardless of the activity status (p < 0.01). 相似文献
4.
The effects of magnesium supplementation on blood parameters were studied during a period of 4 wk in adult tae-kwon-do athletes
at rest and exhaustion. Thirty healthy subjects of ages ranging in age from 18 to 22 yr were included in the study. The subjects
were separated into three groups, as follows: Group 1 consisted of subjects who did not train receiving 10 mg/kg/d magnesium.
Group 2 included subjects equally supplemented with magnesium and exercising 90–120 min/d for 5 d/wk. Group 3 were subject
to the same exercise regime but did not receive magnesium supplements. The leukocyte count (WBC) was significantly higher
in groups 1 and 2 than in the subjects who did not receive any supplements (p < 0.05). There were no significant differences in the WBC of the two groups under magnesium supplementation. The erythrocyte,
hemoglobin, and trombocyte levels were significantly increased in all groups (p < 0.05), but the hematocrit levels did not show any differences between the groups although they were increased after supplementation
and exercise. These results suggest that magnesium supplementation positively influences the performance of training athletes
by increasing erythrocyte and hemoglobin levels. 相似文献
5.
Vedat Cinar Yahya Polat Abdulkerim Kasim Baltaci Rasim Mogulkoc 《Biological trace element research》2011,140(1):18-23
This study was performed to assess how 4 weeks of magnesium supplementation and exercise affect the free and total plasma
testosterone levels of sportsmen practicing tae kwon do and sedentary controls at rest and after exhaustion. The testosterone
levels were determined at four different periods: resting before supplementation, exhaustion before supplementation, resting
after supplementation, and exhaustion after supplementation in three study groups, which are as follows: Group 1—sedentary
controls supplemented with 10 mg magnesium per kilogram body weight. Group 2—tae kwon do athletes practicing 90–120 min/day
supplemented with 10 mg magnesium per kilogram body weight. Group 3—tae kwon do athletes practicing 90–120 min/day receiving
no magnesium supplements. The free plasma testosterone levels increased at exhaustion before and after supplementation compared
to resting levels. Exercise also increased testosterone levels relative to sedentary subjects. Similar increases were observed
for total testosterone. Our results show that supplementation with magnesium increases free and total testosterone values
in sedentary and in athletes. The increases are higher in those who exercise than in sedentary individuals. 相似文献
6.
Vedat Cinar Rasim Mogulkoc Abdulkerim Kasim Baltaci Ozgur Bostanci 《Biological trace element research》2010,133(1):29-33
This study was performed to determine how the calcium supplementation for a 4-week period affects the glucose and insulin
levels at rest and at exhaustion in athletes. This is a 4-week study performed on 30 healthy subjects varying between 18 and
22 ages. Subjects were separated into three groups: first group (group supplemented with calcium, sedentary group), second
group (calcium supplementations + exercise group), and third group (training group). Glucose and insulin parameters of the
groups were measured four times, at rest and exhaustion in the beginning of the research and at rest and exhaustion after
the end of 4 weeks application period. Exhaustion measurements both before and after the supplementations significantly decreased
in compared to rest measurements in terms of insulin (p < 0.05). Significant difference was not determined in the glucose values of groups. In terms of glucose, values increased
in all of the three groups occurred with exercise both before and after the supplementation by exercise and exhaustion (p < 0.05). The results of our study indicate that calcium gluconate supplementations for 4 weeks in sedentary subjects and
athletes did not significantly affect plasma insulin levels at rest and exhaustion. However, glucose levels were affected
by calcium supplementation and exhausting exercise in athletes. 相似文献
7.
Suleyman Patlar Ekrem Boyali Abdulkerim Kasim Baltaci Rasim Mogulkoc Mehmet Gunay 《Biological trace element research》2011,139(2):119-125
Many researchers have emphasized the relation between nutrition and development and sustaining performance. Two methods are
commonly employed to identify the interaction between physical activity and nutrition. The first consists of administering
food with a variety of contents to people engaged in physical activity and observing their performance responses, and the
other is concerned with determining the effects of physical activity on nutrition. Therefore, it can be said that there has
been a growing interest in the explorations into the relation between exercise and vitamins, minerals, and elements. The present
study reports the effects of 6 weeks administration of 300 mg/day vitamin E on the distribution of serum elements in elite
taekwondo athletes. Seven male athletes, mean ages 22.1 ± 0.5 years weighing on average 66.4 ± 2.4 kg were included in the
study. The athletes had been practicing taekwondo for 10–12 years. Resting blood samples were collected in duplicate before
and after supplementation for determination of serum levels of cobalt, boron, cadmium, chromium, nickel, manganese, sulfur,
copper, iron, zinc, phosphorus, sodium, potassium, and calcium. Supplementation resulted in significant increases of all elements
relative to values before supplementation (p < 0.001), with the exception of boron and sulfur, which remained without change. The results of the present study demonstrate
that vitamin E supplementation crucially influences the element and mineral metabolism in elite athletes. 相似文献
8.
The effects of a 1-month exercise program and magnesium supplementation on the adrenocorticotropic hormone and cortisol levels
were studied in young tae-kwon-do and sedentary subjects both at rest and exhaustion. The hormone levels were compared before
and after supplementation with 10 mg of magnesium (as magnesium sulfate) per kilogram of body weight. Both exercise and magnesium
supplements caused significant increases of the adrenocorticotropic hormone (p < 0.05). The cortisol levels were increased in training subjects receiving supplements (p < 0.05) but not so in subjects that either trained or received magnesium supplements in an independent manner. The cortisol
levels measured in resting individuals were higher in the supplemented and non-supplemented athletes than those in sedentary
subjects (p < 0.05). The results of this study show that exercise and/or magnesium supplementation causes a rise of the adrenocorticotropic
hormone, whereas cortisol is increased only as a result of combined exhaustion and magnesium supplements. 相似文献
9.
Lucianna Fernandes J. C. Marques Carmen Marino Donangelo Juliana Gastao Franco Luciane Pires Aderval Severino Luna Gustavo Casimiro-Lopes Patricia Cristina Lisboa Josely Correa Koury 《Biological trace element research》2011,142(3):415-423
Intense physical activity is associated with biological adaptations involving hormones and trace elements. Zinc supplementation
may affect plasma copper concentration, thyroid-stimulating hormone (TSH), thyroid hormones, insulin, and glucose homeostasis,
but data in athletes are scarce. The aim of this study was to evaluate in competitive athletes (cyclists, n = 7, 32 ± 8 years) the effect of zinc supplementation (22 mg/day as zinc gluconate) during 30 days, and discontinuation using
placebo (maltodextrin) during the following 30 days, on plasma zinc and copper concentrations, serum thyroid hormones, insulin
and glucose levels, and HOMA2-IR. Compared to baseline, plasma zinc and Zn:Cu plasma ratio increased, but plasma copper decreased
after zinc supplementation (day 30) and discontinuation (day 60) (p < 0.05). Zn supplementation and discontinuation had no effect on TSH, T3, and T4. Fasting serum insulin and HOMA2-IR increased
(27% and 47%, respectively) on day 60 compared to baseline (p = 0.03), suggesting a delayed effect of zinc supplementation. Moreover, plasma zinc was positively associated with serum
insulin (r = 0.87, p = 0.009) and HOMA2-IR (r = 0.81, p = 0.03) after zinc supplementation (day 30), indicating that supplemental zinc may impair glucose utilization in cyclists. 相似文献
10.
Morgan SL Strong DC Kitchin EM Johnston KE Disilvestro RA Tamura T 《Biological trace element research》2006,110(3):211-222
We evaluated whether a daily high-dose calcium supplement perturbs the zinc status in 23 postmenopausal women (mean age: 63yr)
with low bone mineral density. Plasma and erythrocyte zinc concentrations, plasma bone-specific alkaline phosphatase (BSAP)
and 5′-nucleotidase activities, and urinary zinc and calcium excretion were determined first at the end of 4 wk of daily oral
calcium (1200 mg) and were measured again at the end of the subsequent 4 wk of daily cosupplementation with calcium (1200
mg) and zinc (30 mg). Mean plasma and erythrocyte zinc concentrations after 4 wk of calcium alone were not significantly different
from concentrations after cosupplementation of calcium and zinc. Mean plasma BSAP activities before cosupplementation with
zinc was significantly higher than that after zinc (p<0.02), whereas plasma 5′-nucleotidase activities were not affected by zinc supplementation. Urinary zinc excretion slightly,
but significantly, increased after the supplementation of zinc (p<0.05), whereas calcium excretion remained similar. Our data indicate that a 4-wk zinc supplementation did not significantly
improve zinc status. Although limited by the small sample size and short study duration, our data suggest that a daily calcium
dose of 1200 mg had no effect on the zinc status of our subjects. 相似文献
11.
The objective of the present study is to explore the effects of acute swimming exercise on plasma levels of some elements
in rats, immediately after the exercise, and 24 and 48 h later. The study included 40 adult male rats of Spraque Dawley species,
which were equally allocated to four groups. Group 1: General Control Group; Group 2: Swimming Group, the group that was decapitated
immediately after 30-min acute swimming exercise; Group 3: Swimming Group, the group that was decapitated 24 h after 30-min
acute swimming exercise; Group 4: Swimming Group, the group that was decapitated 48 h after 30-min acute swimming exercise.
Plasma copper (Cu), iron (Fe), magnesium (Mg), phosphorus (P), selenium (Se), zinc (Zn) levels were determined according to
atomic emission method in the blood samples collected from the animals by decapitation method. Measurements conducted immediately
after acute swimming exercise (group 2) showed a significant decrease in Se and Zn levels (p < 0,01) and a significant increase in P levels (p < 0,01), when compared to group 1. Measurements carried out 24 h after the exercise (group 3) demonstrated a significant
increase in all parameters except for Mg, in comparison to groups 1 and 2 (p < 0,01). It was seen in the measurements made 48 h after the exercise (group 4) that all parameters were restored to control
values. The results of our study show that acute swimming exercise significantly changes plasma Cu, Fe, P, Se, and Zn levels. 相似文献
12.
The combined effects of vitamin E and selenium were studied in native Anatolian horses subject to strenuous exercise. The
concentrations of copper, zinc, iron, calcium, potassium, and magnesium were determined in serum by atomic absorption spectrometry
in two study groups (n = 25 each), one of which served as untreated controls. After exercising the horses by running 1,500 m in about 7 min, only
the copper level and the copper/zinc ratio significantly increased (p < 0.05), but the concentrations of calcium, potassium, iron, and magnesium remained unchanged. In horses treated with vitamin
E and selenium, the calcium and potassium levels decreased to levels lower than those of untreated controls before and after
exercise. The iron levels were not changed by exercise or treatment alone but increased when the horses had been supplemented
and exercised. The copper level and the copper/zinc ration increased as a result of exercise in both treated and untreated
horses. These changes suggest that supplementation with vitamin E and selenium had an important effect on the serum concentrations
of calcium, potassium, copper, iron, and the copper/zinc ratio. 相似文献
13.
Zinc and selenium are essential minerals and have roles for more than 300 metabolic reactions in the body. The purpose of this study was to investigate how exhaustive exercise affects testosterone levels and plasma lactate in cyclists who were supplemented with oral zinc and selenium for 4?weeks. For this reason, 32 male road cyclists were selected equally to four groups: PL group, placebo; Zn group, zinc supplement (30?mg/day); Se group, selenium supplement (200?μg/day); and Zn-Se group, zinc-selenium supplement. After treatment, free, total testosterone, and lactate levels of subjects were determined before and after exhaustive exercise. Resting total, free testosterone, and lactate levels did not differ significantly between groups, and were increased by exercise (P?>?0.05). Serum total testosterone levels in Zn group were higher than in Se group after exercise (P?0.05). Serum-free testosterone levels in the Zn group were higher than the other groups (P?0.05).There was an insignificant difference between levels of lactate in the four groups after exercise (P?>?0.05). The results showed that 4-week simultaneous and separately zinc and selenium supplementation had no significant effect on resting testosterone and lactate levels of subjects who consume a zinc and selenium sufficient diet. It might be possible that the effect of zinc supplementation on free testosterone depends on exercise. 相似文献
14.
The aim of the study was to examine the effects of zinc supplementation on some hematological parameters. Sixty newborn male
broiler chicks were utilized in the study. Zinc (Zn) was added into drinking water at levels of 0, 125, 500, and 1000 mg/kg.
In the study, there was no significant difference between control and Zn-supplemented groups in erythrocyte count, hemoglobin
amount, hematocrit levels, total leukocyte count, and differential leukocyte % levels, but the α-naphthyl acetate esterase
ANAE(+) lymphocyte rate significantly (p<0.05) increased in the 125-ppm Zn-supplemented group compared with the control group. In conclusion, the data obtained may
be beneficial in demonstrating the effects of zinc on, at least, these parameters. 相似文献
15.
Abdulkerim Kasim Baltaci Hakki Gokbel Rasim Mogulkoc Nilsel Okudan Kagan Ucok Ihsan Halifeoglu 《Biological trace element research》2010,134(1):79-83
The objective of the present study was to determine the effects of exercise and zinc deficiency on some elements in rats.
Forty adult male Sprague–Dawley species male rats were allocated to four groups as follows: Group 1: control, Group 2: zinc-deficient,
Group 3: exercise in which exercise group fed with a normal diet, Group 4: zinc-deficient exercise, exercise group fed by
a zinc-deficient diet for 15 days. After the procedure ended, rats in groups 3 and 4 were exercised on the treadmill for 60 min
at a speed of 6 m/min until the exhaustion. The rats were decapitated 48 h after exercise together with their controls, and
blood samples were collected to determine copper (Cu), iron (Fe), magnesium (Mg), calcium (Ca), and phosphorus (P) levels.
The highest Cu and Fe values in the serum were obtained in group 2 (p < 0.01). The levels of these elements in group 4 were lower than those in group 2 and higher than the levels in groups 1
and 3 (p < 0.01). Serum Mg levels did not differ significantly between groups. Group 4 had the lowest serum Ca and P levels (p < 0.01). These same parameters in Group 2 were higher than those in group 4 but significantly lower than those in groups
1 and 3 (p < 0.01). There was no significant difference between Ca and P levels of groups 1 and 3. The results of the study indicate
that zinc deficiency adversely affects copper, iron, calcium, and phosphorus mechanisms and that these adverse effects much
more marked after an effort exercise. 相似文献
16.
Vedat Cinar Abdulkerim Kasim Baltaci Rasim Mogulkoc Mehmet Kilic 《Biological trace element research》2009,129(1-3):65-69
The effects of 4 weeks of calcium supplementation on free- and total testosterone levels were established in active and sedentary adult males at rest and exhaustion. Thirty healthy male athletes were equally divided into three study groups, as follows: Group 1—non-exercising subjects receiving 35 mg calcium/kg body weight; Group 2—subjects receiving 35 mg calcium/kg body weight undergoing training routines for 90 min/day, 5 days a week and Group 3—subjects undergoing training routines for 90 min/day, 5 days a week. The testosterone levels were determined before and after supplementation, at rest and following a hard training routine. The plasma free- and total testosterone levels increased at exhaustion before and after supplementation relative to resting values (p?<?0.05). This was also true when active subjects were compared to inactive subjects (p?<?0.05). Our results show that training results in increased testosterone levels in athletes and that the increase is greater if accompanied by calcium supplementation, which may be useful for increasing overall athletic performance. 相似文献
17.
Karla de Jesus Fernandes de Oliveira Carmen Marino Donangelo Astrogildo Vianna de Oliveira Jr. Carmen Lucia Porto da Silveira Josely Correa Koury 《Cell biochemistry and function》2009,27(3):162-166
Puberty associated with intense physical activity results in oxidation stress. Zinc supplementation may benefit antioxidant capacity although it may also affect iron and copper status. This study evaluated the effect of zinc supplementation on antioxidant, zinc and copper status of physically active male football players (13 years ± 0.4 years), divided in two groups and studied during 12 weeks: Zn‐supplemented (Zn‐SUP, 22 mg Zn d?1 as zinc gluconate, n = 21) and placebo (PLA, n = 26). At baseline, there was no significant difference in biochemical indices between the two groups. After treatment, plasma zinc and erythrocyte iron increased in both groups (p < 0.001); urinary zinc increased (p < 0.001) only in Zn‐SUP, and erythrocyte zinc decreased (p = 0.002) only in PLA. Plasma iron and copper decreased (p = 0.01 and p = 0.015, respectively) only in Zn‐SUP. Plasma ferric‐reducing ability and plasma conjugated dienes increased, and erythrocyte osmotic fragility decrease in both groups, although the latter two were significantly lower in Zn‐SUP compared to PLA (p < 0.01). In conclusion, our study indicates that the use of 22 mg d?1 of supplemental zinc during 12 week in adolescent athletes did not affect growth, improved markers of antioxidant status but reduced plasma iron and copper. Therefore, it appears that the use of zinc supplementation by healthy adolescent athletes benefits their antioxidant capacity but impairs copper and iron nutritional status. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
18.
The effects of magnesium supplementation on plasma magnesium, zinc, and copper levels were determined in young adult tae-kwon-do
athletes and sedentary controls at rest and exhaustion. After a 4-week supplementation period with 10 mg/day/kg Mg, the plasma
magnesium, copper, and zinc levels significantly increased in sedentary and training (90–120 min training 5 days a week) subjects
when compared to nonsupplemented controls (p < 0.05). 相似文献
19.
《Journal of trace elements in medicine and biology》2014,28(1):35-38
ProjectThe aim of this study was to determine the effects of zinc supplementation on serum zinc and leptin levels as well as on anthropometric status and some biochemical parameters in hemodialysis (HD) patients.ProcedureIn this randomized, double-blind, and placebo-controlled trial, sixty HD patients were randomly divided into groups to receive a daily supplement of 100 mg elemental Zn (supplemented group) or placebo (control group) for 60 days. Anthropometric measurements were taken using standard calibrated instruments. Serum zinc and leptin levels were determined by atomic absorption and ELISA method respectively before and after intervention.ResultsZinc supplementation resulted in significant increase in the mean serum zinc level in the experimental group while changes observed in the placebo group were not significant. The mean serum leptin in women part of the experimental group was decreased significantly after supplementation. After adjusting for age, BMI, body fat (%), serum zinc and dietary Zn intake, a negative and significant association was observed between serum zinc and leptin levels in all subjects (β = −0.33, P = 0.03) as a result of Zn supplementation.ConclusionsMore studies are needed to clarify the mechanisms by which serum leptin level is influenced as a result of zinc supplementation in HD patients. 相似文献
20.
Bicer M Akil M Sivrikaya A Kara E Baltaci AK Mogulkoc R 《Journal of physiology and biochemistry》2011,67(4):511-517
The present study aims to examine the effect of supplementation of zinc on the distribution of various elements in the sera
of diabetic rats subjected to an acute swimming exercise. A total of 80 Sprague–Dawley-type adult male rats were equally allocated
to one of eight groups: Group 1, general; Group 2, zinc-supplemented; Group 3, zinc-supplemented diabetic; Group 4, swimming
control; Group 5, zinc-supplemented swimming; Group 6, zinc-supplemented diabetic swimming; Group 7, diabetic swimming; and
Group 8, diabetes. The rats were injected with 40 mg/kg/day subcutaneous streptozotocin (STZ) twice, with a 24-h interval
between two injections. Zinc was supplemented at a dose of 6 mg/kg/day (ip) for 4 weeks. Blood samples were collected at the
end of the 4-week study, and serum levels of lead, cobalt, molybdenum, chrome, sulfur, magnesium, manganese, sodium, potassium,
phosphorus, copper, iron, calcium, zinc, and selenium (mg/L) were determined with atomic emission. The lowest molybdenum,
chrome, copper, iron, potassium, magnesium, sodium, phosphorus, lead, selenium, and zinc values were obtained in Group 7 and
8. These same parameters were higher in the swimming exercise group (Group 4), relative to all other groups. The values in
zinc-supplemented groups were found lower than the values in Group 4, but higher than those in Group 6 and 7. The results
obtained from the study demonstrate that acute swimming exercise and diabetes affect the distribution of various elements
in the serum, while zinc supplementation can prevent the negative conditions associated with both exercise and diabetes. 相似文献