The principle of agency

The Principle of Agency says that if it would be good for a state of affairs to occur "naturally", then it is permissible to take action to bring it about. This contradicts the views of some bioethicists, who object to euthanasia, in vitro fertilization, and cloning, even though they acknowledge that the states of affairs produced are good. But the principle, or some form of it, seems inescapable. The opposite view — that we may not, by our action, reproduce "natural" goods — may owe its appeal to an implicitly religious view of nature.     

The reconstruction principle

The theory of epigenesis is the undisputed paradigm of embryology, and it is still based on the classical concept proposed by Aristotle: the idea that embryonic development is a generation of structures which takes place according to a design--today we say a set of instructions--already present in the fertilized egg. This is a doctrine which can be referred to as 'pre-information', since it claims the preexistence of information exactly as the old theory of preformation claimed the preexistence of form. Here, however, it is shown that a more general version of epigenesis can be held, because of a new principle which states that it is mathematically possible to obtain not only a convergent generation of form, or structure, but also a convergent generation of information.     

Optimal principle of bone structure

Bone modeling and remodeling is an optimization process where no agreement has been reached regarding a unified theory or model. We measured 384 pieces of bone in vivo by 64-slice CT and discovered that the bone's center of mass approximately superposes its centroid of shape. This phenomenon indicates that the optimization process of non-homogeneous materials such as bone follows the same law of superposition of center of mass and centroid of shape as that of homogeneous materials. Based upon this principle, an index revealing the relationship between the center of mass and centroid of shape of the compact bone is proposed. Another index revealing the relationship between tissue density and distribution radius is followed. Applying these indexes to evaluate the strength of bone, we have some new findings.     

Mathematical principle of planar Z-plasty

To extend the work of precursors attempting to use Z-plasties with angles that have arbitrary degrees and may or may not be equal in size, a comprehensive study was done to clarify and simplify the correlation among the angles, limbs, and diagonals of the geometrical construction of Z-plasties. In geometry, the truth of a proposition must be proved; it is a question to which the answer must be found. By law and formula, a ternary trigonometric equation was derived from a simplified geometric diagram by a trigonometric approach. A procedure declaration accompanies this formula; neither was previously mentioned in the literature.     

Bateman's principle and immunity

The immunocompetence handicap hypothesis (ICHH) of Folstad and Karter has inspired a large number of studies that have tried to understand the causal basis of parasite-mediated sexual selection. Even though this hypothesis is based on the double function of testosterone, a hormone restricted to vertebrates, studies of invertebrates have tended to provide central support for specific predictions of the ICHH. I propose an alternative hypothesis that explains many of the findings without relying on testosterone or other biochemical feedback loops. This alternative is based on Bateman's principle, that males gain fitness by increasing their mating success whilst females increase fitness through longevity because their reproductive effort is much higher. Consequently, I predict that females should invest more in immunity than males. The extent of this dimorphism is determined by the mating system and the genetic correlation between males and females in immune traits. In support of my arguments, I mainly use studies on insects that share innate immunity with vertebrates and have the advantage that they are easier to study.     

Chiral symmetry conservation principle

We show a chiral symmetry conservation principle based on chemical kinetics using stochastic results. Suppose the chiral symmetry conservation is evoked, and our universe can be considered globally asymmetric. In that case, there are at least two mirrored asymmetric universes if all the chiral properties are strongly correlated. However, if the chiral correlations are weak or nonexistent, there are possibly Many-(Chiral-Symmetry)-Worlds. Alternatively, if our universe is only locally asymmetric, there could be a single universe with segregated chiral regions. The possible mechanisms of the primordial chiral symmetry breaking can only be found if the chiral symmetry is not truly conserved by assuming the initial racemic conditions. In that case, our universe is asymmetric and could be alone. On the other hand, if the chiral symmetry is conserved, there is no chance of finding the primordial chiral symmetry breaking. Based on this conservation (or not), it is possible to infer two opposite hypotheses, where two general scenarios about the chiral universes are possible.     

The average enzyme principle

The Michaelis–Menten equation for an irreversible enzymatic reaction depends linearly on the enzyme concentration. Even if the enzyme concentration changes in time, this linearity implies that the amount of substrate depleted during a given time interval depends only on the average enzyme concentration. Here, we use a time re-scaling approach to generalize this result to a broad category of multi-reaction systems, whose constituent enzymes have the same dependence on time, e.g. they belong to the same regulon. This “average enzyme principle” provides a natural methodology for jointly studying metabolism and its regulation.     

On the Volterra-Lotka principle

The supplantation of one of two closely similar competing species by the other (Volterra-Lotka principle) is studied as an example, according to Volterra's general theory of population dynamics, of the decay of a biological association of an odd number 2n+1 of species into one with an even number 2n. The three-species association (n=1) is worked out in detail, with a demonstration of how a Volterra predator-prey cycle gets gradually deformed—when a slightly superior predator is introduced—into another new-predator-prey cycle, spelling a steady eclipse of the original predator. Whenn is made large, the close competitors being embedded in an association of many other species, a statistical treatment of the supplantation process can be given through the author's statistical-mechanical theory of Volterra's dynamics. The result is a probability law, changing systematically as time goes on, for the chance that the successful competitor's population has any given amplitude; explicitly time-dependent measures of mean amplitude and mean frequency of oscillation of all populations can then be worked out. Throughout, the simplifying assumption is made that the competitors differ only as regards intrinsic rate of self-growth. Two things are accomplished by viewing the competition as a decay of 2n+1 into 2n: the competitors are not abstracted from the rest of the biological world, and their population variations are always oscillatory (with long-term rises and falls of amplitude); this is in contrast to the original Volterra-Lotka analysis in which purely static, and therefore ecologically unrealistic, population levels of but two species eventuate.     

An evolutionary optimization principle

Characteristics of evolutionarily stable strategies, or ESS's, are investigated for a general class of evolutionary models. Both differential equation and difference equation models are considered. At an ESS, species that exhibit negative density dependence maximize population size; those that show positive density dependence minimize population size.     

A possible principle of kinesthetic compensation

The movement of the cat forelimb was studied under the conditions of complete transection of the classical somatosensory pathways from the limb to the cortex of the contralateral hemisphere. It was demonstrated that in animals with the intact system of the somatosensory (kinesthetic) feedback, the parameters of the same memorized movement varied widely from response to response whereas the exclusion of lemniscus projections from the control system led to the poor movement pattern and to the appearance of motor stereotypy. The hypothesis is advanced that deficit of kinesthetic information in this case is compensated for not only by the other intact connections of the kinesthetic analyzer but also due to the conversion of the nervous system to the central-programmed level control which itself demands less participation of the somatosensory feedback. The non-crossed projections of the kinesthetic analyzer are capable of forming and correcting this program and of ensuring the effect afferentation as well. The same principle of the functioning may take place in any compensatory reconstructions in the CNS.