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The TRANSFAC system on gene expression regulation 总被引:35,自引:2,他引:33
Wingender E Chen X Fricke E Geffers R Hehl R Liebich I Krull M Matys V Michael H Ohnhäuser R Prüss M Schacherer F Thiele S Urbach S 《Nucleic acids research》2001,29(1):281-283
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Wingender E Chen X Hehl R Karas H Liebich I Matys V Meinhardt T Prüss M Reuter I Schacherer F 《Nucleic acids research》2000,28(1):316-319
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CYTOMER is a relational database of organs/tissues, cell types, physiological systems and developmental stages that currently focuses on the human system. From this database, we have derived an ontology for anatomical and morphological structures for the human organism which includes all embryonal stages and the cell types constituting these structures. The ontology has been transferred to the OWL format and is freely available for download at http://cytomer/bioinf.med.uni-goettingen.de. 相似文献
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With so many databases available for research in the Human Genome Project, it is crucial to efficiently relate information from different resources. For that purpose, we maintain Virgil, a database of rich links for data browsing, data analysis and database interconnection. Virgil current version contains more than 40 000 rich links from five major databases: SWISS-PROT, GenBank, PDB, GDB and OMIM. Materials described in this paper are available from http://www.infobiogen.fr/services/virgil/ 相似文献
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Münch R Hiller K Barg H Heldt D Linz S Wingender E Jahn D 《Nucleic acids research》2003,31(1):266-269
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Marchler-Bauer A Anderson JB DeWeese-Scott C Fedorova ND Geer LY He S Hurwitz DI Jackson JD Jacobs AR Lanczycki CJ Liebert CA Liu C Madej T Marchler GH Mazumder R Nikolskaya AN Panchenko AR Rao BS Shoemaker BA Simonyan V Song JS Thiessen PA Vasudevan S Wang Y Yamashita RA Yin JJ Bryant SH 《Nucleic acids research》2003,31(1):383-387
The Conserved Domain Database (CDD) is now indexed as a separate database within the Entrez system and linked to other Entrez databases such as MEDLINE(R). This allows users to search for domain types by name, for example, or to view the domain architecture of any protein in Entrez's sequence database. CDD can be accessed on the WorldWideWeb at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=cdd. Users may also employ the CD-Search service to identify conserved domains in new sequences, at http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi. CD-Search results, and pre-computed links from Entrez's protein database, are calculated using the RPS-BLAST algorithm and Position Specific Score Matrices (PSSMs) derived from CDD alignments. CD-Searches are also run by default for protein-protein queries submitted to BLAST(R) at http://www.ncbi.nlm.nih.gov/BLAST. CDD mirrors the publicly available domain alignment collections SMART and PFAM, and now also contains alignment models curated at NCBI. Structure information is used to identify the core substructure likely to be present in all family members, and to produce sequence alignments consistent with structure conservation. This alignment model allows NCBI curators to annotate 'columns' corresponding to functional sites conserved among family members. 相似文献
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Estimating transcription factor bindability on DNA. 总被引:4,自引:0,他引:4