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1.
The neurons of the dorsal periaqueductal nucleus of the mesencephalon and their synaptic contacts were observed under a transmission electron microscope. We found various types of synapses which constituted an exception to Cajal's neuron theory (law of neuron independence). Some of these synapses had an open communicating or continuity 'passage' between the presynaptic bouton of a neuron (first neuron) and the postsynaptic portion of another neuron (second neuron). The 'communicating' passage (located in the synaptosome) is formed by the continuity of the presynaptic and postsynaptic membrane, and its limits or rims are the reflexion points of the membranes. When only two neurons intervene they could be termed 'simple communicating synapses'. We found three types: I = communicating axosomatic synapses; II = communicating axodendritic synapses, and III = communicating axoaxonic synapses'. When three neurons intervene in the synaptic contact, they could be termed 'complex communicating synapses'. In these, the first and second neurons form a normal synapse, but the lateral portion of the presynaptic bouton of the first neuron also enters into contact with a third neuron, with which it establishes an open communicating or continuity passage. The points of these passages are collateral to the synapse, and may be in the presynaptic or pre-postsynaptic portions simultaneously, communicating collaterally with the third neuron. We found a further three types: IV = complex communicating axosomatic and dendritic synapses; V = complex communicating axoaxonic and somatic synapses, and VI = complex communicating axodendritic and double-somatic synapses. It is suggested that communicating synapses may constitute an exception to Cajal's neuron theory, representing functional states for the acceleration, retardation or modulation of the synaptic function. The neurotransmitters would pass en masse through the communicating passage and the depolarization wave would pass through the rims without being retarded. In the simple communicating synapses, their action would be intensifying. In the complex communicating synapses, their action would be modulating or retarding, since the collateral communicating passage would function as an 'escape valve' through which part of the impulse reaching the presynaptic bouton would escape.  相似文献   

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The self-tuning neuron: synaptic scaling of excitatory synapses   总被引:1,自引:0,他引:1  
Turrigiano GG 《Cell》2008,135(3):422-435
Homeostatic synaptic scaling is a form of synaptic plasticity that adjusts the strength of all of a neuron's excitatory synapses up or down to stabilize firing. Current evidence suggests that neurons detect changes in their own firing rates through a set of calcium-dependent sensors that then regulate receptor trafficking to increase or decrease the accumulation of glutamate receptors at synaptic sites. Additional mechanisms may allow local or network-wide changes in activity to be sensed through parallel pathways, generating a nested set of homeostatic mechanisms that operate over different temporal and spatial scales.  相似文献   

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 An intracellular recording made from the retinal luminosity horizontal cell (LHC) demonstrated that repetitive red flashes enhanced the cell's responsiveness to red stimulus and depressed its responsiveness to green stimulus and that repetitive green flashes suppressed the cell's red response but produced little change in its green response. Based on the idea that the spectral plasticity of LHCs may reflect some synaptic efficacy changes between the LHC and various cones, a self-organizing system is proposed to investigate the possible manner of information processing and storage within the synapses. The results of model analysis suggest that the stimulus-pattern-related spectral plasticity is attributable to the excitatory interaction within the same kinds of synapses and the inhibitory interaction between different kinds of synapses. This system is able to encode and store the history of signal transmission in a graded and cumulative fashion. Received: 7 December 2001 / Accepted: 26 November 2002 / Published online: 28 March 2003 Correspondence to: Pei-Ji Liang (email: pjliang@sjtu.edu.cn, Tel./Fax: (86) 2164070495) Acknowledgements. This research was supported by the National Basic Research Program (G1999054000) of China and the National Foundation of Natural Science of China (No. 30170263).  相似文献   

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微波在Cajal染色中的应用   总被引:3,自引:0,他引:3  
在Cajal氨酒精去神经组织块镀银染色过程中,对固定、浸银、还原等过程进行微波辐射处理,结果表明微波辐射能明显促进固定、浸银、还原作用,使组织块镀银染色时程大大缩短。  相似文献   

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Lammel S  Ion DI  Roeper J  Malenka RC 《Neuron》2011,70(5):855-862
Midbrain dopamine (DA) neurons are not homogeneous but differ in their molecular properties and responses to external stimuli. We examined whether the modulation of excitatory synapses on DA neurons by rewarding or aversive stimuli depends on the brain area to which these DA neurons project. We identified DA neuron subpopulations in slices after injection of "Retrobeads" into single target areas of adult mice and found differences in basal synaptic properties. Administration of cocaine selectively modified excitatory synapses on DA cells projecting to nucleus accumbens (NAc) medial shell while an aversive stimulus selectively modified synapses on DA cells projecting to medial prefrontal cortex. In contrast, synapses on DA neurons projecting to NAc lateral shell were modified by both rewarding and aversive stimuli, which presumably reflects saliency. These results suggest that the mesocorticolimbic DA system may be comprised of three anatomically distinct circuits, each modified by distinct aspects of motivationally relevant stimuli.  相似文献   

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D A Lednov  S A Chebkasov 《Biofizika》2001,46(6):1108-1111
On the basis of the conception of the discrete wave mechanism for the integration of heterogeneous neuron elements, a hypothesis was put forward that neuron excitation propagates as waves of changes in the conformational states of neuron membrane lipids. A mathematical model was constructed, which confirms the wave mode of excitation propagation. The model enables one to consider the integration of postsynaptic potentials as a process of wave interference. It was assumed that the training of neuron elements can be considered as a process of nonuniform distribution of lipids.  相似文献   

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The construction of a theory of activity in neuron networks of arbitrary topological structure is commenced under the linear excitation hypothesis: we consider conditions for possible steady-state equilibria, deferring a dynamical treatment to the sequel.  相似文献   

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The development of a general theory of neuron-networks is here extended to cases of non-steady state activity. Conditions for stability and neutrality of an equilibrium point are set up, and the possible functions representing the variation of excitation over time are enumerated. The inverse network problem is considered—which is, given a preassigned pattern of activity over time, to construct when possible a neuron-network having this pattern. Finally, a canonical form for neuron networks is derived, in the sense of a network of a certain special topological structure which is equivalent in activity characteristics to any given network.  相似文献   

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During late stages of neural development, synaptic circuitry is edited by neural activity. At neuromuscular synapses, the transition from multiple to single innervation is modulated by the relative pattern of activity among inputs competing for innervation of the same muscle fiber. While experimental perturbations of activity result in marked changes in the timing of neuromuscular synaptic competition, little is known about the patterns of activity present during normal development. Here, we report the temporal patterning of motor unit activity in the soleus muscle of awake, behaving neonatal mice, and that patterning is modulated by gap-junctional coupling. Our work suggests that neuromuscular synaptic competition is modulated by surprisingly low levels of activity and may be triggered by the disappearance of temporally correlated activity among inputs competing for innervation of the same muscle fiber.  相似文献   

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The ultrastructure of the presynaptic and postsynaptic components of the axo-dendritic synapses of layer V in the sensorimotor region of the rat neocortex is compared for microlonophoretic applications of 1-glutamate and norepinephrine, as well as for combined and successive administrations of these substances. A reliable increase is noted in the width of the postsynaptic density for combined electrophoresis of glutamate and norepinephrine, and a decrease in the number of synaptic vesicles at the terminals for applications of norepinephrine and combined and isolated administration of both transmitters. The results are discussed as an index of the modulating effect of norepinephrine on other neurotransmitter systems.M. V. Lomonosov State University, Moscow. Translated from Neirofiziologiya, Vol. 17, No. 4, pp. 476–481, July–August, 1985.  相似文献   

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《Biophysical journal》2020,118(10):2434-2447
Diffusion obstacles in membranes have not been directly visualized because of fast membrane dynamics and the occurrence of subresolution molecular complexes. To understand the obstacle characteristics, mobility-based methods are often used as an indirect way of assessing the membrane structure. Molecular movement in biological plasma membranes is often characterized by anomalous diffusion, but the exact underlying mechanisms are still elusive. Imaging total internal reflection fluorescence correlation spectroscopy (ITIR-FCS) is a well-established mobility-based method that provides spatially resolved diffusion coefficient maps and is combined with FCS diffusion law analysis to examine subresolution membrane organization. In recent years, although FCS diffusion law analysis has been instrumental in providing new insights into the membrane structure below the optical diffraction limit, there are certain exceptions and anomalies that require further clarification. To this end, we correlate the membrane structural features imaged by atomic force microscopy (AFM) with the dynamics measured using ITIR-FCS. We perform ITIR-FCS measurements on supported lipid bilayers (SLBs) of various lipid compositions to characterize the anomalous diffusion of lipid molecules in distinct obstacle configurations, along with the high-resolution imaging of the membrane structures with AFM. Furthermore, we validate our experimental results by performing simulations on image grids with experimentally determined obstacle configurations. This study demonstrates that FCS diffusion law analysis is a powerful tool to determine membrane heterogeneities implied from dynamics measurements. Our results corroborate the commonly accepted interpretations of imaging FCS diffusion law analysis, and we show that exceptions happen when domains reach the percolation threshold in a biphasic membrane and a network of domains behaves rather like a meshwork, resulting in hop diffusion.  相似文献   

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Although it is considered to be the most complex organ in the body, the brain can be broadly classified into two major types of cells, neuronal cells and glial cells. Glia is a general term that encompasses multiple types of non-neuronal cells that function to maintain homeostasis, form myelin, and provide support and protection for neurons. Astrocytes, a major class of glial cell, have historically been viewed as passive support cells, but recently it has been discovered that astrocytes participate in signalling activities both with the vasculature and with neurons at the synapse. These cells have been shown to release d-serine, TNF-α, glutamate, atrial natriuretic peptide (ANP) and ATP among other signalling molecules. ATP and its metabolites are well established as important signalling molecules, and astrocytes represent a major source of ATP release in the nervous system. Novel molecular and genetic tools have recently shown that astrocytic release of ATP and other signalling molecules has a major impact on synaptic transmission. Via actions at the synapse, astrocytes have now been shown to regulate complex network signalling in the whole organism with impacts on respiration and the sleep–wake cycle. In addition, new roles for astrocytes are being uncovered in psychiatric disorders, and astrocyte signalling mechanisms represents an attractive target for novel therapeutic agents.  相似文献   

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