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The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2 总被引:4,自引:0,他引:4
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Decary S Decesse JT Ogryzko V Reed JC Naguibneva I Harel-Bellan A Cremisi CE 《Molecular and cellular biology》2002,22(22):7877-7888
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Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. 总被引:84,自引:0,他引:84
We have examined E2F binding activity in extracts of synchronized NIH 3T3 cells. During the G0 to G1 transition, there is a marked increase in the level of active E2F. Subsequently, there are changes in the nature of E2F-containing complexes. A G1-specific complex increases in abundance, disappears, and is then replaced by another complex as S phase begins. Analysis of extracts of thymidine-blocked cells confirms that the complexes are cell cycle regulated. We also show that the cyclin A protein is a component of the S phase complex. Each complex can be dissociated by the adenovirus E1A 12S product, releasing free E2F. The release of E2F from the cyclin A complex coincides with the stimulation of an E2F-dependent promoter. We suggest that these interactions control the activity of E2F and that disruption of the complexes by E1A contributes to a loss of cellular proliferation control. 相似文献
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Saito H Yasumoto K Takeda K Takahashi K Fukuzaki A Orikasa S Shibahara S 《The Journal of biological chemistry》2002,277(32):28787-28794
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