共查询到20条相似文献,搜索用时 15 毫秒
1.
O.M. Raspopov V.A. Dergachev J. Esper O.V. Kozyreva D. Frank M. Ogurtsov T. Kolström X. Shao 《Palaeogeography, Palaeoclimatology, Palaeoecology》2008,259(1):6-16
Long-term climatic changes related to solar forcing were examined using millennium-scale palaeoclimatic reconstructions from the Central Asian mountain region, i.e. summer temperature records for the Tien Shan mountains and precipitation records for the Tibetan Plateau. The reconstructions were based on juniper tree-ring width records, i.e. Juniperus turkestanica for the Tien Shan and Sabina przewalskii for the Tibetan Plateau. The data were processed using spectral and wavelet analysis and filtered in the frequency range related to major solar activity periodicities. The results obtained for various tree-ring chronologies indicate palaeoclimatic oscillations in the range of the de Vries (~ 210-year) solar cycles through the last millennium.The quasi-200-year variations revealed in the palaeoclimatic reconstructions correlate well (R2 = 0.58–0.94) with solar activity variations (Δ14C variations). The quasi-200-year climatic variations have also been detected in climate-linked processes in Asia, Europe, North and South America, Australia, and the Arctic and Antarctica. The results obtained point to a pronounced influence of solar activity on global climatic processes.Analysis has shown that climate response to the long-term global solar forcing has a regional character. An appreciable delay in the climate response to the solar signal can occur (up to 150 years). In addition, the sign of the climate response can differ from the solar signal sign. The climate response to long-term solar activity variations (from 10s to 1000s years) manifests itself in different climatic parameters, such as temperature, precipitation and atmospheric and oceanic circulation. The climate response to the de Vries cycle has been found to occur not only during the last millennia but also in earlier epochs, up to hundreds of millions years ago. 相似文献
2.
Abstract Long‐period (1948–1967) correlations have been statistically determined for the frequency of occurrence of solar flares associated with type IV radio bursts, negative variation of cosmic ray level, geomagnetic indices AP, lower ionospheric absorption, polar vortex activity in the circumpolar pressure field pattern and long‐term microseismic activity, expressed in statistical variations of amplitudes and periods of meteorological microseisms down to latitudes of about 35° N. All of the characteristics mentioned exhibit the same type of changes even in the time position of secondary maxima while only a rough similarity was observed with respect to the correlation of sunspot numbers and A= 10.7 cm solar radio flux. As a whole this represents a wide scale of interactions between the space‐solar phenomena and physical fields of the earth. 相似文献
3.
Karnaukhova NA Sergievich LA Kuzhevskiĭ BM Sigaeva EA Nechaev OIu Karnaukhov VA Karnaukhov VN 《Biofizika》2007,52(4):699-704
A correlation between the functional activity of the synthesis apparatus of blood lymphocytes in different animals and the variations in the neutron count rate near the Earth surface has been studied. From 1999 to 2002 for rats and from 2002 to 2003 for ground squirrels, a reliable positive correlation between the synthetic activity of animal blood lymphocytes and the neutron count rate was found. The correlation was observed for both the neutron flux directed towards the Earth and the total neutron flux (the neutron field of the Earth). There was no a correlation for the neutron flux directed away from the Earth in this period. In 2005-2006, which is characterized by a minor variations in the neutron count rate, no correlation was observed. Thus, the biotropic effect of thermal neutrons makes its self-evident as changes in the functional activity of blood lymphocytes in periods of significant variations of neutron fluxes. 相似文献
4.
Circadian variations in the proliferative activity of squamous epithelia are well known. However, circadian variations in the duration of the various cell cycle phases (S, G2 and mitosis) have been disputed. The percent labelled mitoses method, which is traditionally used to obtain duration of cell cycle phases, is poorly suited for identification of circadian variations. Therefore methods combining changes in compartment size (cell cycle phase) and cellular flux through the compartments have been used. Three different methods using such data are presented. These incorporate various simplifying assumptions that cause methodological errors. Limits for use of the different methods are indicated. The use of all three methods gives comparable and pronounced circadian variations in the duration of S and G2 phase. These results are also compatible with circadian variations in the mitotic duration, but they may also represent artefacts due to sensitivity to model errors. 相似文献
5.
Erik Thorud† Erik Aarnæs‡ Ole Petter F. Clausen Rolf Bjerknes§ Peder Anker§ 《Cell proliferation》1985,18(3):279-295
Circadian variations in the proliferative activity of squamous epithelia are well known. However, circadian variations in the duration of the various cell cycle phases (S, G2 and mitosis) have been disputed. the percent labelled mitoses method, which is traditionally used to obtain duration of cell cycle phases, is poorly suited for identification of circadian variations. Therefore methods combining changes in compartment size (cell cycle phase) and cellular flux through the compartments have been used. Three different methods using such data are presented. These incorporate various simplifying assumptions that cause methodological errors. Limits for use of the different methods are indicated. the use of all three methods gives comparable and pronounced circadian variations in the duration of S and G2 phase. These results are also compatible with circadian variations in the mitotic duration, but they may also represent artefacts due to sensitivity to model errors. 相似文献
6.
Karnaukhova NA Sergievich LA Karnaukhov VA Karnaukhov AV Rodionov AV Karnaukhov VN 《Biofizika》2004,49(3):539-544
A correlation between the functional (synthetic) activity of animal blood lymphocytes and the intensity of radiation of the Sun at a frequency of 2800 MHz in 2000 and 2002 was studied. The results were compared with the data obtained in 1993 and 1994. These data suggest that there are seasonal regularities in the interrelationship of the processes studied. A change in the sign of the correlation coefficients at the maximum of the 23rd solar cycle was shown. Possible mechanisms of the phenomena are discussed. 相似文献
7.
Metabolic Flux Ratio Analysis of Genetic and Environmental Modulations of Escherichia coli Central Carbon Metabolism
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Uwe Sauer Daniel R. Lasko Jocelyne Fiaux Michel Hochuli Ralf Glaser Thomas Szyperski Kurt Wüthrich James E. Bailey 《Journal of bacteriology》1999,181(21):6679-6688
The response of Escherichia coli central carbon metabolism to genetic and environmental manipulation has been studied by use of a recently developed methodology for metabolic flux ratio (METAFoR) analysis; this methodology can also directly reveal active metabolic pathways. Generation of fluxome data arrays by use of the METAFoR approach is based on two-dimensional (13)C-(1)H correlation nuclear magnetic resonance spectroscopy with fractionally labeled biomass and, in contrast to metabolic flux analysis, does not require measurements of extracellular substrate and metabolite concentrations. METAFoR analyses of E. coli strains that moderately overexpress phosphofructokinase, pyruvate kinase, pyruvate decarboxylase, or alcohol dehydrogenase revealed that only a few flux ratios change in concert with the overexpression of these enzymes. Disruption of both pyruvate kinase isoenzymes resulted in altered flux ratios for reactions connecting the phosphoenolpyruvate (PEP) and pyruvate pools but did not significantly alter central metabolism. These data indicate remarkable robustness and rigidity in central carbon metabolism in the presence of genetic variation. More significant physiological changes and flux ratio differences were seen in response to altered environmental conditions. For example, in ammonia-limited chemostat cultures, compared to glucose-limited chemostat cultures, a reduced fraction of PEP molecules was derived through at least one transketolase reaction, and there was a higher relative contribution of anaplerotic PEP carboxylation than of the tricarboxylic acid (TCA) cycle for oxaloacetate synthesis. These two parameters also showed significant variation between aerobic and anaerobic batch cultures. Finally, two reactions catalyzed by PEP carboxykinase and malic enzyme were identified by METAFoR analysis; these had previously been considered absent in E. coli cells grown in glucose-containing media. Backward flux from the TCA cycle to glycolysis, as indicated by significant activity of PEP carboxykinase, was found only in glucose-limited chemostat culture, demonstrating that control of this futile cycle activity is relaxed under severe glucose limitation. 相似文献
8.
Throughout Earth's history there have been temporal and spatial variations in the amount of visible and ultraviolet radiation received by ecosystems. This paper examines if temporal changes in these forms of energy receipt could have influenced the tempo and mode of plant diversity and speciation, focusing in particular upon Cenozoic time-scales. Evidence for changing patterns of plant diversity and speciation apparent in various fossil records and molecular phylogenies are considered alongside calculated changes in thermal and solar ultraviolet energy (specifically UV-B) over the past 50 Myr. We suggest that changes in thermal energy influx (amount and variability) affected the tempo of evolution through its influence upon community dynamics (e.g. population size, diversity, turnover, extinctions). It was not only the amount of thermal energy but also variability in its flux that may have influenced these processes, and ultimately the rate of diversification. We suggest that variations in UV-B would have influenced the mode and tempo of speciation through changes to genome stability during intervals of elevated UV-B. We argue, therefore, that although variability in thermal energy and UV-B fluxes through time may lead to the same end-point (changing the rate of diversification), the processes responsible are very different and both need to be considered when linking evolutionary processes to energy flux. 相似文献
9.
A correlation between variations in the medical parameters and the heliogeophysical indices describing physical processes during solar storms was established. It was proposed that one of the reasons for the biotropic effects observed is rheological shifts of human blood during enhancement of solar activity. The influence of heliogeophysical disturbances on the rheological properties of blood was investigated. 相似文献
10.
The effect of audiogenic seizures on regional CNS energy reserves, glycolysis and citric acid cycle flux 总被引:3,自引:2,他引:1
Selected energy reserves, glycolytic intermediates and citric acid cycle intermediates were measured in the cerebral cortex, thalamus, brain stem, cerebellum and spinal cord of susceptible mice during audiogenic seizures. Changes in energy reserves (ATP, phosphocreatine and glucose) differed strikingly in extent and temporal pattern from region to region. The audiogenic seizure produced a transient, large decrease in thalamic energy reserves during the early, pretonic phase of the seizure. Less extensive decreases were observed in brain stem and spinal cord; but in these latter regions the changes persisted throughout the pretonic and tonic phases of the seizures. In cerebellum there was a biphasic decrease in energy reserves; a small decrease was observed immediately after the sound stimulus and a second much greater decrease was observed during the tonic phase of the seizure. No change in energy reserves was observed in cerebral cortex. Changes in glycolytic intermediates (glucose 6-phosphate, fructose diphosphate, pyruvate and lactate) also varied from region to region in response to the decreases in energy reserves. In contrast, changes in the two citric acid cycle intermediates, α-oxoglutarate and malate, were essentially the same in all regions studied. α-Oxoglutarate decreased during the tonic phase of the seizure and rose during recovery. Malate remained at control levels throughout the seizure and then slowly increased. These findings are interpreted as indicating regional variations in nueronal activity during audiogenic seizures. During the period when clinical seizure activity is apparent neuronal activity increases in the subcortical regions. This is reflected by an increase in energy utilization and an increase in glycolytic flux in these areas. However, a concomitant increase in citric acid cycle flux does not seem to occur during this period. Citric acid cycle flux does appear to increase after the seizure is over. 相似文献
11.
Gautam D Badhwar 《Radiation research》2002,157(1):69-75
The International Space Station (ISS) is now a reality with the start of a permanent human presence on board. Radiation presents a serious risk to the health and safety of the astronauts, and there is a clear requirement for estimating their exposures prior to and after flights. Predictions of the dose rate at times other than solar minimum or solar maximum have not been possible, because there has been no method to calculate the trapped-particle spectrum at intermediate times. Over the last few years, a tissue-equivalent proportional counter (TEPC) has been flown at a fixed mid-deck location on board the Space Shuttle in 51.65 degrees inclination flights. These flights have provided data that cover the expected changes in the dose rates due to changes in altitude and changes in solar activity from the solar minimum to the solar maximum of the current 23rd solar cycle. Based on these data, a simple function of the solar deceleration potential has been derived that can be used to predict the galactic cosmic radiation (GCR) dose rates to within +/-10%. For altitudes to be covered by the ISS, the dose rate due to the trapped particles is found to be a power-law function, rho(-2/3), of the atmospheric density, rho. This relationship can be used to predict trapped dose rates inside these spacecraft to +/-10% throughout the solar cycle. Thus, given the shielding distribution for a location inside the Space Shuttle or inside an ISS module, this approach can be used to predict the combined GCR + trapped dose rate to better than +/-15% for quiet solar conditions. 相似文献
12.
Experimental studies of enzyme kinetics in vitro and metabolic fluxes in vivo have been used by Wright and her colleagues to develop a detailed kinetic model of the tricarboxylic acid cycle in Dictyostelium discoideum. This model has recently been been analyzed by two different methods (Albe, K. R., and Wright, B. E. (1992) J. Biol. Chem. 267, 3106-3114; Shiraishi, F., and Savageau, M. A. (1992) J. Biol. Chem. 267, 22926-22933 in an effort to determine the response of individual fluxes and metabolite concentrations to changes in levels of the enzymes that constitute the system. Individual responses were found to differ significantly in magnitude as well as in sign. Perhaps the most glaring difference concerns the influence of the enzyme succinate dehydrogenase on the flux through the cycle; in one study, it has the maximum influence, whereas, in the other, it has absolutely no influence. In this paper, we provide a resolution of these discrepancies. We have reconstructed the methodology of Albe and Wright and have been able to reproduce their results in detail. We show that their methodology does not yield a valid steady state analysis, and, consequently, that the conclusions drawn from their analysis must be called into question. First, they concluded that their model is realistic and predictive. It is now clear that their model is ill-determined and has a steady state only for unrealistically narrow conditions. Second, they concluded that their analysis is valid for variations of less than 2% in the levels of the enzymes because they could satisfy summation relationships considered to be mathematically inevitable. It is now clear that these relationships are neither necessary nor sufficient for establishing the validity of an analysis or the appropriateness of a biochemical model. Third, they concluded on the basis of their empirical methodology that certain enzymes are most important in influencing flux through the cycle. It is now clear that these results are inaccurate because of deficiencies in their methodology. Finally, they concluded that steady state analyses cannot be carried out experimentally because of the small variations required in enzyme levels. It is now clear that the requirement for such small variations reflects the ill-determined character of the underlying model and is not a necessary property of the real system. 相似文献
13.
Bertolucci C Pinotti M Colognesi I Foà A Bernardi F Portaluppi F 《Journal of biological rhythms》2005,20(3):219-224
The circadian clock, influencing many biological processes, has been demonstrated to modulate levels of specific coagulation factors, but its impact on the coagulation efficiency is unknown. In a mouse model, the authors evaluated the temporal variations in the initial rate of activated factor X (FXa) and thrombin generation. Upon coagulation activation through the FVIIa-TF pathway (extrinsic activation), both parameters showed rhythmic variations with a significant peak at ZT 12, the light-to-dark transition. In mice subjected to a 6-h delayed light-dark cycle, the peak was shifted as expected. These cyclic oscillations were also observed in constant darkness, thus demonstrating, for the first time, the existence of strong circadian rhythms of the initial rate of either FXa or thrombin generation activity levels. These circadian variations overlapped with those that have been recently described in factor VII (FVII) activity. The peak of FXa generation activity was simulated by the addition of purified human FVII, thus indicating that circadian variations in FVII activity are important determinants of the circadian rhythm of the procoagulant cascade efficiency. These findings help to elucidate the complex control on the coagulation process and might contribute in explaining the temporal variations in the frequency of cardiovascular events observed in humans. 相似文献
14.
Fulin Yang Rafat Qubaja Fyodor Tatarinov Eyal Rotenberg Dan Yakir 《Global Change Biology》2018,24(8):3486-3498
Carbonyl sulfide (COS) is a tracer of ecosystem photosynthesis that can advance carbon cycle research from leaf to global scales; however, a range of newly reported caveats related to sink/source strength of various ecosystem components hinder its application. Using comprehensive eddy‐covariance and chamber measurements, we systematically measure ecosystem contributions from leaf, stem, soil, and litter and were able to close the ecosystem COS budget. The relative contributions of nonphotosynthetic components to the overall canopy‐scale flux are relatively small (~4% during peak activity season) and can be independently estimated based on their responses to temperature and humidity. Converting COS to photosynthetic CO2 fluxes based on the leaf relative uptake of COS/CO2, faces challenges due to observed daily and seasonal changes. Yet, this ratio converges around a constant value (~1.6), and the variations, dominated by light intensity, were found unimportant on a flux‐weighted daily time‐scale, indicating a mean ratio of daytime gross‐to‐net primary productivity of ~2 in our ecosystem. The seasonal changes in the leaf relative uptake ratio may indicate a reduction in mesophyll conductance in winter, and COS‐derived canopy conductance permitted canopy temperature estimate consistent with radiative skin temperature. These results support the feasibility of using COS as a powerful and much‐needed means of assessing ecosystem function and its response to change. 相似文献
15.
Abstract The endogenous activity cycle of the nocturnal bannertail kangaroo rat was investigated. Although bannertail activity is a function of the lunar day as well as the solar day, all ten subjects exhibited free‐running activity periods of solar‐day length; there was no evidence of an endogenous lunar‐day cycle. Animals were provided with a burrow system and a small pseudo‐desert, a laboratory facility in which animal activity data closely resembled measurements taken in the field. Several analytical techniques for quantifying the data were utilized, and one, the mean interval of activity, is recommended to other investigators. 相似文献
16.
N. A. Karnaukhova L. A. Sergievich B. M. Kuzhevskij E. A. Sigaeva O. Yu. Nechaev V. A. Karnaukhov V. N. Karnaukhov 《Biophysics》2007,52(4):414-417
The synthetic activity of lymphocytes from rat and ground squirrel was assessed for correlation with the rate of neutron radiation about the Earth surface. In the periods 1999–2002 for rats and 2002–2003 for ground squirrels, significant positive correlation was obtained with the neutron flux incident on Earth and the overall “terrestrial neutron field” but not with the neutron efflux from Earth. No correlation was observed in 2005–2006 when the solar activity and the variation in neutron count were minimal. It is concluded that low-energy neutrons may be bioeffective in periods of substantial variation in flux intensity. 相似文献
17.
Comte B Vincent G Bouchard B Benderdour M Des Rosiers C 《American journal of physiology. Heart and circulatory physiology》2002,283(4):H1505-H1514
Little is known about the role of mitochondrial NADP(+)-isocitrate dehydrogenase (NADP(+)-ICDH) in the heart, where this enzyme shows its highest expression and activity. We tested the hypothesis that in the heart, NADP(+)-ICDH operates in the reverse direction of the citric acid cycle (CAC) and thereby may contribute to the fine regulation of CAC activity (Sazanov and Jackson, FEBS Lett 344: 109-116, 1994). We documented a reverse flux through this enzyme in rat hearts perfused with the medium-chain fatty acid octanoate using [U-(13)C(5)]glutamate and mass isotopomer analysis of tissue citrate (Comte et al., J Biol Chem 272: 26117-26124, 1997). In this study, we assessed the significance of our previous finding by perfusing hearts with long-chain fatty acids and tested the effects of changes in O(2) supply. We showed that under all of these conditions citrate was enriched in an isotopomer containing five (13)C atoms. This isotopomer can only be explained by substrate flux through reversal of the NADP(+)-ICDH reaction, which is evaluated at 3-7% of flux through citrate synthase. Small variations in reversal fluxes induced by low-flow ischemia that mimicked hibernation occurred despite major changes in contractile function and O(2) consumption of the heart as well as citrate and succinate release rates and tissue levels. Our data show a reverse flux through NADP(+)-ICDH and support its hypothesized role in the fine regulation of CAC activity in the normoxic and O(2)-deprived heart. 相似文献
18.
A steady-state computer model of the tricarboxylic cycle in Dictyostelium discoideum was analyzed using metabolic control theory. The steady state had variations of less than 0.04% over the last half of the simulation for both metabolite concentrations and fluxes. Metabolite and flux control coefficients were determined by varying enzymatic activities within 2% of their initial values and simulating the responses of metabolite concentrations and fluxes to these changes. Under these conditions, summation properties were met for most metabolite and all flux control coefficients. Maximum flux control coefficients were found for succinate dehydrogenase (0.35), malic enzyme (0.24), and malate dehydrogenase (-0.18). Comparable control was found for the reaction supplying pyruvate (0.14) and for the sum of the input amino acids (0.43), which serve as an energy source for D. discoideum. The time-dependent processes by which a new steady state was established were examined after increasing malic enzyme or malate dehydrogenase activities. This provided a method for an analysis of the mechanisms by which the observed control coefficients were generated. In addition, the effects of increasing the stimuli within 5-20% of the original enzyme activity were examined. Under these conditions, more typical of experimental stimuli and measurable responses, the metabolic model failed to return to steady state, and thus summation properties were not met. Whether "true" steady states ever occur or whether metabolic control theory can be applied in vivo is discussed. 相似文献
19.
The relationships between the time series of the changes in the sizes of experimental Drosophila melanogaster populations at the preimaginal stage and three heliogeophysical indices (Wolf numbers, 10.7-cm radio flux intensity, and the K p index of geomagnetic activity) have been analyzed. The results demonstrate a significant relationship between the population dynamics and heliogeophysical factors and dependence of this relationship on the phase of the 11-year solar activity cycle. Factors related to solar activity may stimulate female fertility and egg survival. 相似文献
20.
Multiple models and experiments underscore large uncertainty in soil carbon dynamics 总被引:1,自引:0,他引:1
Benjamin N. Sulman Jessica A. M. Moore Rose Abramoff Colin Averill Stephanie Kivlin Katerina Georgiou Bhavya Sridhar Melannie D. Hartman Gangsheng Wang William R. Wieder Mark A. Bradford Yiqi Luo Melanie A. Mayes Eric Morrison William J. Riley Alejandro Salazar Joshua P. Schimel Jinyun Tang Aimée T. Classen 《Biogeochemistry》2018,141(2):109-123
Soils contain more carbon than plants or the atmosphere, and sensitivities of soil organic carbon (SOC) stocks to changing climate and plant productivity are a major uncertainty in global carbon cycle projections. Despite a consensus that microbial degradation and mineral stabilization processes control SOC cycling, no systematic synthesis of long-term warming and litter addition experiments has been used to test process-based microbe-mineral SOC models. We explored SOC responses to warming and increased carbon inputs using a synthesis of 147 field manipulation experiments and five SOC models with different representations of microbial and mineral processes. Model projections diverged but encompassed a similar range of variability as the experimental results. Experimental measurements were insufficient to eliminate or validate individual model outcomes. While all models projected that CO2 efflux would increase and SOC stocks would decline under warming, nearly one-third of experiments observed decreases in CO2 flux and nearly half of experiments observed increases in SOC stocks under warming. Long-term measurements of C inputs to soil and their changes under warming are needed to reconcile modeled and observed patterns. Measurements separating the responses of mineral-protected and unprotected SOC fractions in manipulation experiments are needed to address key uncertainties in microbial degradation and mineral stabilization mechanisms. Integrating models with experimental design will allow targeting of these uncertainties and help to reconcile divergence among models to produce more confident projections of SOC responses to global changes. 相似文献