Effect of repeated alcohol administration on urine secretion and antidiuretic hormone in rats]

The administration of ehtanol by gavage immediately produced a maintened hyperdiuresis, a transient decrease of urinary osmolality and antidiuretic hormone secretion, followed by increased plasmatic and urinary antidiuretic hormone concentrations. Chronic intoxication enhanced these effects probably due to central disturbance.     

Effects of some chemopreparations on the causative agents of glanders and melioidosis]

The authors present the results of in vitro determination of the sensitivity of the causative agent of glanders and melioidosis to 8 preparations-5-nitrofuran derivatives, and also to negram and PASK. The most active against M. mallei and Ps. pseudomallei were furazonal and furacrillin; negram was less active. No naturally resistanct strains to furacrylin and furazonal were revealed among the M. mallei and Ps. pseudomallei strains studied.     

Effect of non-steroidal anti-inflammatory agents on interferon induction]

Nonsteroid antiinflammatory agents (NAIA) such as antipyrine, butadion, acetylsalicylic acid, sodium salicylate, stampyrine and 4-iodantipyrine are not interferonogenic. Still, they stimulated interferonogenic action of poly(G).poly(C) in studies on animals. Relation between the interferon-stimulating action of the NAIA and their effect on activity of prostaglandin and the influence on the immune system was suggested.     

Cardiac and vascular reactions provoked by 5-HT in rats]

In normal rat, anaesthetized with pentobarbital, 5-HT, injected or perfused by intravenous route, provokes different types of cardiovascular responses. These variations are due to the activation of three classes of receptors. The first ones explain the fall of the arterial blood pressure: they are located on arterioles which are dilatated. The second one are para- or perivascular nervous receptors: when stimulated, they induce vago-vagal reflexes (Bezold-Jarisch reflexes) suppressed by vagotomy. The third ones are vasoconstrictor and located on arterioles.