大剂量东菱克栓酶治疗急性梗死疗效观察

目的 研究和探讨大剂量东菱克栓酶与常规剂量的治疗效果。方法大剂量组２０ＩＵ、１０ＩＵ、１０ＩＵ连用３天，常规剂量１０ＩＵ、５ＩＵ、５ＩＵ隔日１次。结果 大剂量组显效治疗脑梗死优于常规剂量，可缩现程。     

降纤酶治疗急性脑梗死的临床研究

目的　评估降纤酶对急性脑梗死的疗效及安全性。　方法　采用前瞻性、随机、对照试验 ,以东菱精纯克栓酶 ( DF-52 1 )和低分子右旋糖酐为对照组 ,从 1 996年 1月至 1 998年 1 0月共观察 4 81例 ,其中降纤酶组 2 89例 ,东菱组 92例 ,低右组 1 0 0例 ,共完成试验者 30 1例 ,各组份别为 1 4 9例、 70例和 82例 ,于治疗前及治疗后第 1天 ,第 3天 ,第 7天 ,第 1 4天查血浆纤维蛋白原、凝血酶原时间及血小板计数、肝肾功能等。并于治疗前及治疗后 1 ,7,1 4天评估神经功能恢复情况。　结果　降纤酶对急性脑梗死疗效显著 ,明显优于低分子右旋糖酐 ,在治疗后 1天已表现出明显效果 ,与日本生产的东菱精纯克栓酶比较疗效相似 ,发病 1 4天治疗总有效率分别为 84 .4 5%和 80 .0 0 %。同时降纤酶组与东菱组治疗后纤维蛋白原下降明显 ,于 7～ 1 4天有回升趋势 ;低右组则无明显变化。　结论　降纤酶具有与东菱精纯克栓酶相似的疗效、副作用小 ,价格明显低于东菱精纯克栓酶。认为国产降纤酶可以取代东菱精纯克栓酶 ,其在脑梗死急性期治疗上具有广泛的前景     

蕲蛇酶注射液能有效治疗基底节区的脑出血患者

为了分析蕲蛇酶注射液对基底节区脑出血患者血清髓鞘碱性蛋白及凝血酶的影响,本研究选取2014年5月至2016年5月我院收治的基底节区脑出血患者80例作为研究对象,依据随机数字表法将这些患者分为蕲蛇酶组(n=40)和东菱克栓酶组(n=40)两组,蕲蛇酶组患者接受蕲蛇酶注射液治疗,给予患者静脉滴注0.75 U蕲蛇酶注射液+500 m L生理盐水,每天1次,2周为1个疗程;东菱克栓酶组患者接受东菱克栓酶注射液治疗,给予患者静脉滴注10 BU东菱克栓酶注射液+150 m L生理盐水,至少1 h滴注完,每2天1次,共治疗5次。对两组患者的NIHSS评分、ADL评分及GCS评分、临床疗效、血清MBP、凝血酶水平进行统计分析。结果表明,蕲蛇酶组患者的NIHSS评分显著低于东菱克栓酶组(p0.05),ADL评分及GCS评分均显著高于东菱克栓酶组(p0.05),治疗的总有效率为95.0%(38/40)显著高于东菱克栓酶组80.0%(32/40)(p0.05),血清MBP、凝血酶水平均显著低于东菱克栓酶组(p0.05),两组患者均没有发生严重不良反应。本研究结果表明蕲蛇酶注射液较东菱克栓酶更能促进基底节区脑出血患者的血清髓鞘碱性蛋白及凝血酶的有效降低,并对患者的神经功能缺损情况、日常生活能力及预后进行改善,临床疗效更为显著,值得临床应用推广。     

东菱精纯克栓酶对高粘血症患者血流变的影响

目的观察东菱精纯克栓酶对高粘血症患者血液流变学的影响,并探讨其影响机制。方法用东菱精纯克栓酶治疗２８例高粘血症患者。结果东菱精纯克栓酶能明显地降低血粘度,表现为全血粘度、血浆比粘度、全血还原粘度及纤维蛋白原水平降低。结论东菱精纯克栓酶通过降低高粘血症患者血粘度而起治疗作用。     

大剂量清栓酶治疗急性心梗的疗效观察

大剂量清栓酶治疗急性心梗的疗效观察赵一民（广西永福县医院）收集我院８８年１２月至９３年５月底的急性心梗４０例临床资料,９１年２月以后的２２例采用大剂量清栓酶（抚顺市青峰制药厂生产,每支０．２５ｕ）静滴治疗急性心梗,与清栓酶的常规用量治疗急性心梗相比较...     

大剂量清栓酶静脉溶栓与颈动脉注射治疗急性脑梗塞疗效对比观察

大剂量清栓酶静脉溶栓与颈动脉注射治疗急性脑梗塞疗效对比观察河北省赵县中西医结合医院张存志赵县人民医院陈启俟我们试用大剂量清栓酶快速静脉滴注联合大剂量川芎嗪静滴治疗急性脑梗塞,并与颈动脉注射法［对照组（１）］与一般剂量清栓酶、川芎嗪静滴［对照组（２）］...     

大剂量清栓酶治疗脑梗塞引起大片紫癜1例（摘要）

大剂量清栓酶治疗脑梗塞引起大片紫癜１例（摘要）福建省泉州市人民医院相明治本文就超大剂量清栓酶每日１克治疗脑梗塞,六天后出现皮肤紫癜,即刻停止用药,用鲜马铃薯切成０．５－１ｃｍ厚,贴于病灶表面,面积稍超病灶的边缘,外层敷塑薄膜并用胶布固定,更换时要注意...     

路路通与清栓酶治疗脑梗死的血液流变学变化比较

为了研究路路通与清栓酶对血液流变学的影响。我们对 2 0例确诊为脑梗死患者分别采用路路通和清栓酶治疗 ,并观察用药前、后患者的血液流变学变化 ,现将结果报告如下。1　临床资料1 .1　一般资料　脑梗死患者均为住院患者 ,临床诊断与 CT或 MRI定位诊断相符 ,其中男 1 2例 ,女 8例 ,年龄 35～ 77岁 ,平均 5 3.5岁。路路通用药和清栓酶用药各 1 0例 ,两组病例的性别、年龄、并发症均无明显差异 ( P >0 .0 5 )。1 .2　治疗方法　路路通组 :应用 0 .9%氯化钠2 5 0 ml加路路通 2 0 ml。清栓酶组 :应用 0 .9%氯化钠 2 5 0 ml加清栓酶 0 .75 u…     

不同激素和注射方式对家猫超排效果的比较

比较了PMSG hCG和FSH hCG两种方案以及PMSG的不同剂量和注射方式对家猫的超排效果的影响。用 1 0 0IU的PMSG超排家猫所得到的排卵点数及平均每只猫获得的卵数显著低于 2 0 0IU处理组或 30 0IU处理组 (P <0 0 5 ) ,但 2 0 0IU处理组与 30 0IU处理组之间的超排效果也无显著差异 (P >0 0 5 ) ;用皮下注射 2 0 0IU的PMSG或用肌肉注射 2 0 0IU的PMSG对超排效果无差异 (P >0 0 5 ) ;用 2 0 0IUPMSG 2 0 0IUhCG和 1 5mgFSH 2 0 0IUhCG两种方案对家猫超排 ,发现不论是每只猫的排卵点数、卵子获得数 ,还是卵子的第一极体排放率都没有显著差异 (P >0 0 5 )。实验说明 ,PMSG的注射方式不影响对家猫的超排效果 ,用 2 0 0IU的PMSG超排家猫是较适合的剂量 ,FSH和PMSG都可用于家猫的超排 ,但PMSG使用更为方便。     

常规剂量与较大剂量清栓酶对中风预测及纤维蛋白原的影响各比较观察（摘要）

常规剂量与较大剂量清栓酶对中风预测及纤维蛋白原的影响各比较观察（摘要）沈后丹东干休所老年病防治院刘光,薛景兰本文报告用常规剂量与较大剂量清栓酶治疗高粘滞综合征各５０例的中风预测及纤维蛋白原结果比较观察。本文资料各方力求一致,（包括疾病病程等）。治疗方...     

Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis

It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.     

The structure, reproduction and taxonomy of Vidalia and Osmundaria (Rhodophyta, Rhodomelaceae)

Comprises species occurring mostly in subtidal habitats in tropical, subtropical and warm-temperate areas of the world. An analysis of the type species, V. spiralis (Sonder) Lamouroux ex J. Agardh, a species from Australia, establishes basic characters for distinguishing species in the genus. These characters are (1) branching patterns of thalli, (2) flat blades that may be spiralled on their axis, (3) width of the blade, (4) primary or secondary derivation of sterile and fertile branchlets and (5) position of sterile and fertile branchlets on the thalli. Application of the latter two characters provides an important basic method for separation of species into three major groups. Osmundaria , a genus known only in southern Australia, was studied in relation to Vidalia , and its separation from the Vidalia assemblage is not accepted. Species of Vidalia therefore are transferred to the older genus name, Osmundaria. Two new species, Osmundaria papenfussii and Osmundaria oliveae are described from Natal. Confusion in the usage of the epithet, Vidalia fimbriala Brown ex Turner has been clarified, and Vidalia gregaria Falkenberg, described as an epiphyte on Osmundaria pro/ifera Lamouroux, is revealed to be young branches of the host, Osmundaria prolifera.     

New or rare chromosome counts in Artemisia L. (Asteraceae, Anthemideae) and related genera from Kazakhstan

Fifteen chromosome counts of six Artemisia taxa and one species of each of the genera Brachanthemum, Hippolytia, Kaschgaria, Lepidolopsis and Turaniphytum are reported from Kazakhstan. Three of them are new reports, two are not consistent with previous counts and the remainder are confirmations of very scarce (one to four) earlier records. All the populations studied have the same basic chromosome number, x = 9, with ploidy levels ranging from 2x to 6x. Some correlations between ploidy level, morphological characters and distribution are noted.     

肝癌中HBV和HCV基因和抗原的分布及意义

采用原位分子杂交方法检测HCV RNA及HBV X基因;采用免疫组织化学方法研究HCV核心抗原,非结构区C33c抗原及HBxAg在肝细胞肝癌中的定位及分布.结果表明(1)HCV RNA、HBV X基因在肝细胞肝癌组织检出率分别为40%(55/136)和82%(112/136).HCV RNA定位于癌细胞的胞浆内,阳性细胞呈散在、灶状及弥漫分布三种形式;HBV X基因在肝癌细胞中的分布呈胞浆型、核型及核浆型,阳性细胞也呈上述三种分布形式;(2)HCV C33c抗原、核心抗原在肝细胞肝癌中的阳性率为81%(133/164)及86%(141/164).C33c抗原定位于癌细胞及肝细胞的胞浆内;核心抗原既定位于癌细胞核中,又可定位于胞浆中.C33c抗原阳性细胞以灶状分布为主;而核心抗原阳性细     

Selection with two alleles and complete dominance

For a plant selection model with frequency-independent viabilities, fertilities and selfing rates, it is shown that apart from global fixation, for certain parameter combinations a protected polymorphism and facultative fixation (either allele may become fixed according to initial frequencies) may both occur. Facultative fixation requires different selling rates for the dominant and recessive type. Protection of the polymorphism requires resource allocation for male and female function. In this connection the problem of purely genetically caused population extinction is discussed.
For general frequency dependence and regular segregation, the chances for establishment of a completely recessive gene are compared to those of a completely dominant gene. It is proven that the process of establishment of the recessive gene, despite a fitness advantage, may be considerably endangered by drift effects if random mating prevails. The recessive gene may reach the same effectivity in establishment as a dominant gene, only if the recessive homozygote mates exclusively with its own type during the period of establishment.