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The Publisher 《Population Ecology》2012,54(2):367-367
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In W303-derived strains, disruption of FIG2 increased agglutinability of α cells, but not a cells, and did not alter expression of α-agglutinin, binding of 125I-labeled α-agglutinin, or mating efficiency. Fig2p overexpression led to α-cell-specific suppression of agglutinability. These results imply that Fig2p is an indirect masker of the active sites in α-agglutinin. 相似文献
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Fungal adhesins represent a large family of serine/threonine-rich secreted glycoproteins. Adhesins have been shown to play roles in heterotypic and homotypic cell-cell adhesion processes, morphogenetic pathways and invasive/pseudohyphal growth, frequently in response to differentiation cues. Here we address the role of the Saccharomyces cerevisiae mating-specific adhesin Fig2p. Cells lacking FIG2 possess a variety of mating defects that relate to processes involving the cell wall, including morphogenetic defects, cell fusion defects, and alterations in agglutination activities. We found that mating-specific morphogenetic defects caused by the absence of FIG2 are suppressible by increased external osmolarity and that, during mating, fig2Δ cells display reduced viability relative to wild-type cells. These defects result from alterations in signaling activated by the mating and cell integrity pathways. Finally, we show that fig2Δ zygotes also have defects in zygotic spindle positioning that are osmoremedial, whereas the requirements for FIG2 in normal cell-cell agglutination and cell fusion during mating are insensitive to changes in the extracellular osmotic environment. We conclude that FIG2 performs distinct functions in the mating cell wall that are separable with respect to their ability to be suppressed by changes in external osmolarity and that a fundamental role of FIG2 in mating cells is the maintenance of cell integrity. 相似文献
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Hwang JH Yuk SH Lee JH Lyoo WS Ghil SH Lee SS Khang IG Paik SY Lee JY 《Molecules and cells》2004,17(2):381
Due to a mis-communication between the authors and the editorial office, the title of this paper was incorrectly printed. The correct title should read as: Isolation of Muscle Derived Stem Cells from Rat and its Smooth Muscle Differentiation. The correct format of the title section is presented below. Citations to the article should use the original volume, issue, and page numbers. 相似文献