The FRAME Research Programme under the direction of Dr Richard Clothier

The work of Dr Richard Clothier (Reader in Cellular Toxicology and Director of the FRAME Alternatives Laboratory in the University of Nottingham Medical School) in relation to the FRAME Research Programme, is reviewed. He made a very substantial contribution to FRAME's laboratory research work over the last 20 years, by publishing many research papers, mainly with respect to method development and the application of new replacement toxicity test methods, particularly those involving the use of human cells in tissue culture. In addition, he participated in a number of international validation studies that have facilitated the regulatory acceptance of certain new methods. Lastly, he has been closely involved in the logistical aspects of obtaining and maintaining external research funding for FRAME from industrial sponsors.     

Richard H. Osborne: Richard H. Osborne,retiring editor: An appreciation, 1977

Secrets of the Savanna: Twenty‐Three Years in the African Wilderness Unraveling the Mysteries of Elephants and People. Mark and Delia Owens. Houghton Mifflin Company, 2006     

Laurence Irving: an appreciation

Laurence Irving (1895-1979) contributed significantly over five decades to the development of environmentally oriented physiological studies. He is best known for his investigations of the physiology of diving mammals, the respiratory properties of fish blood, and cold adaptation and acclimatization in poikilotherms and homeotherms, including man. Beyond his own research contributions, Irving benefited American comparative physiology through his key roles in the immigration of Per F. Scholander and Knut and Bodil Schmidt-Nielsen to the United States. The Irving-Scholander research collaboration provides a substantial legacy for comparative physiology. Laurence Irving's administrative contributions include service as the first scientific director of the Arctic Research Laboratory at Barrow, Alaska, and as the founding director of the Institute of Arctic Biology at the University of Alaska, Fairbanks. These units have assured the implementation of his philosophy of combining laboratory and field studies in the investigation of environmentally oriented physiological problems. Laurence Irving was an ardent advocate for Alaskan research, and his efforts were an important help in the advancement of science in the state.     

William R. Harvey: an appreciation

Bill Harvey in Temple University days, circa 1983. From the left, Julian Dow, Michael Wolfersberger, Bill Harvey, Moira Cioffi and Dan Spaeth.

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Highlights? Bill Harvey is a clever guy. ? He is over 80, and still publishing. ? This article summarizes his career and achievements, in a nice way, without being too sycophantic.