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1.
Krishan K. Kohli Richard M. Philpot Phillip W. Albro James D. McKinney 《Life sciences》1980,26(12):945-952
The effects of coplanar+ 3,4,5,3′,4′,5′-hexachlorobiphenyl (HCB) and noncoplanar 2,4,5,2′,4′,5′-HCB, 2,3,5,2′,3′,5′-HCB, phenobarbitone (PB) and 3-methylcholanthrene (3-MC) on drug metabolizing enzymes have been studied 72 hr after dosing in male rat liver. 3-MC and 3,4,5,3′,4′,5′-HCB induced the activity of ethoxyresorufin deethylase dramatically. NADPH cytochrome P-450 reductase and benzphetamine -demethylase were induced by PB and noncoplanar isomers and not by 3-MC or 3,4,5,3′,4′,5′-HCB. Sodium dodecyl sulfate polyacrylamide gel electrophoresis of the microsomes obtained from various groups showed that 3-MC and 3,4,5,3′,4′,5′-HCB induced the synthesis of a polypeptide of approximate 54,500 daltons which was absent in the microsomes obtained from control, PB or noncoplanar isomer treated animals. Noncoplanar isomers and PB induced the synthesis of a polypeptide of approximate 51,000 daltons. These results, along with the reduced, CO difference spectra, demonstrate that 3,4,5,3′,4′,5′-HCB induces the synthesis of cytochrome P-448 and resembled 3-MC in its mechanism of action, while noncoplanar isomers induced the synthesis of cytochrome P-450 and resembled PB in its mechanism of action. Further administration of various doses of 3,4,5,3′,4′,5′-HCB to genetically responsive mice (C57BL/6J), induced cytochrome P-450, caused one nm shift in the difference spectrum of reduced microsomes and induced the activity of ethoxyresorufin deethylase, whereas it did not induce the activity of ethoxyresorufin deethylase in non-responsive mice (DBA/2J) even at the highest dose studied. These studies indicate the fact that coplanar and noncoplanar isomers have differential interaction with . 相似文献
2.
Nineteen flavonoids were isolated from Artemisia ludoviciana var. ludoviciana, including a new 2′- hydroxy- 6-methoxyflavone, 5,7,2′,4′-tetrahydroxy-6,5′-dimethoxyflavone. The known compounds include quercetagetin 3,6,3′,4′-tetramethyl ether, eupatilin, 5,7-dihydroxy-3,6,8,4′-tetramethoxyflavone, luteolin 3′,4′-dimethyl ether, jaceosidin, 5,7,4′-trihydroxy-3,6-dimethoxyflavone, tricin, hispidulin, chrysoeriol, kaempferol 3-methyl ether, apigenin, axillarin, eupafolin, selagin and luteolin together with three flavones which were previously isolated for the first time from Artemisia frigida: 5,7,4′-trihydroxy-6, 3′,5′-trimethoxyflavone, 5,7,3′-trihydroxy-6,4′,5′-trimethoxyflavone and 5,7,3′,4′-tetrahydroxy-6,5′- dimethoxyflavone. 相似文献
3.
Thirteen flavonoids, including three new compounds, were isolated from Gutierrezia grandis. The structures of the new compounds were 3,5,7,3′,4′-pentahydroxy-6,8-dimethoxyflavone, 5,7,3′-trihydroxy-3,6,8,4′,5′-pentamethoxyflavone and 5,7,3′,5′-tetrahydroxy-3,6,8,4′-tetramethoxyflavone 3′-O-glucoside. 相似文献
4.
Putul Baruah Nabin C. Barua Ram P. Sharma Jogendra N. Baruah Palaniappan Kulanthaivel Werner Herz 《Phytochemistry》1984,23(2):443-447
Chemical examination of Millettia pulchra yielded (?)-maackiain, (?)-pterocarpin, (?)-sophoranone and the new compounds (6S, 6aS, 11aR)-6α-methoxypterocarpin, (6S, 6aS,11aR)-6α-methoxyhomopterocarpin, (2S)5,7,4′-trihydroxy-8,3′,5′-triprenylflavanone, (2R,3R)7,4′-dihydroxy-8,3′,5′-triprenyldihydroflavanol, 5,7,2′,4′-tetrahydroxy-6,3′-diprenylisoflavone and 5,7,4′-trihydroxy-2′-methoxy-6,3′-diprenylisoflavone. 相似文献
5.
(±)-(2Z,4E)-5-(1′,2′-epoxy-2′,6′,6′-trimethylcyclohexyl)-3-methyl-2,4-pentadienoic acid was metabolized by Cercospora cruenta, which has the ability to produce (+)-abscisic acid (ABA), to give (±)-(2Z,4E)-xanthoxin acid, (±)-(2Z,4E)-5′-hydroxy-1′,2′-epoxy-1′,2′-dihydro-β-ionylideneacetic acid, (±)-1′,2′-epoxy-1′,2′-dihydro-β-ionone and trace amounts of ABA. 相似文献
6.
Besides coumarin, nobiletin, lucidin dimethyl ether and 5,6,7,3′,4′-pentamethoxyflavone, two new highly oxygenated flavones were isolated from Eupatorium coelestinum. Their structures were determined by spectroscopic methods and alkaline degradations as 5,6,7,8,3′,4′,5′ -heptamethoxyflavone and 5,6,7,8,5′-pentamethoxy-3′,4′-methylenedioxyflavone. 相似文献
7.
《Phytochemistry》2012
Three benzophenones, 2,6,3′,5′-tetrahydroxybenzophenone (1), 3,4,5,3′,5′-pentahydroxybenzophenone (3) and 3,5,3′,5′-tetrahydroxy-4-methoxybenzophenone (4), as well as a xanthone, 1,3,6-trihydroxy-5-methoxy-7-(3′-methyl-2′-oxo-but-3′-enyl)xanthone (9), were isolated from the twigs of Garcinia cantleyana var. cantleyana. Eight known compounds, 3,4,5,3′-tetrahydroxy benzophenone (2), 1,3,5-trihydroxyxanthone (5), 1,3,8-trihydroxyxanthone (6), 2,4,7-trihydroxyxanthone (7), 1,3,5,7-tetrahydroxyxanthone (8), quercetin, glutin-5-en-3β-ol and friedelin were also isolated. The structures of the compounds were elucidated by spectroscopic methods. The compounds were investigated for their ability to inhibit low-density lipoprotein (LDL) oxidation and platelet aggregation in human whole blood in vitro. Most of the compounds showed strong antioxidant activity with compound 8 showing the highest inhibition with an IC50 value of 0.5 μM, comparable to that of probucol. Among the compounds tested, only compound 4 exhibited strong inhibitory activity against platelet aggregation induced by arachidonic acid (AA), adenosine diphosphate (ADP) and collagen. Compounds 3, 5 and 8 showed selective inhibitory activity on platelet aggregation induced by ADP. 相似文献
8.
John L. Ingham 《Phytochemistry》1977,16(8):1279-1282
Two previously unreported phytoalexins, 7,4′dihydroxy-2′-methoxy- and 7,2′,4′-trihydroxyisoflavan, have been isolated from the fungus-inoculated leaves of Anthyllis vulneraria and 5 Tetragonolobus species. Examination of Lotus corniculatus revealed the co-occurrence of the latter with the known isoflavans, vestitol and sativan. Only 7,2′4′-trihydroxyisoflavan and vestitol were produced by the closely related L. uliginosus. 相似文献
9.
The monohydroxycarotenoids formed by diphenylamine-inhibited cultures of Rhodospirillum rubrum have been investigated. Nine have been isolated and identified as 1-hydroxy-1,2-dihydrophytofluene (1), 1-Hydroxy-1,2,7′,8′,11′,12′-hexahydrolycopene (2), chloroxanthin (3), 1-methoxy-1′-hydroxy-1,2,1′,2′-tetrahydrophytofluene (4a), 1′-hydroxy-3,4,1′,2′,11′,12′-hexahydrospheroidene (5, 1′-hydroxy-3,4,1′,2′-tetrahydrospheroidene (6, 1′-hydroxy 1′,2′-dihydrospheroidene (7), rhodovibrin (8a) and monodeme thylated spirilloxanthin (9). 4a, 5 and 6 are novel carotenoids, and a definite structure has been assigned to 2 for the first time; the structure of 1 has been amended. The possible role of these carotenoids in spirilloxanthin biosynthesis is discussed. 相似文献
10.
Four neolignans, dehydrodieugenol, its monomethylether, carinatone and carinatin have been isolated from the hexane fraction of the bark of Virola carinata. Three new neolignans were separated from the chloroform fraction and examined by spectroscopy and chemical reactions. Their structures were determined as (2S, 3S)-5-allyl- 7-methoxy-3-hydroxymethyl-2-(3′,4′-dimethoxyphenyl)-2,3-dihydrobenzofuran, (2S)- 1-(3′,4′-dimethoxyphenyl)-2-(3″-allyl-5″-methoxy-6″-hydroxyphenyl)propanone(1) ol(3), (1S,2S)-1-(3′,4′-dimethoxyphenyl)-2-(3″-allyl-5″-methoxy-6″-hydroxyphenyl) propanol(1) and called dihydrocarinatinol, carinatonol and carinatol, respectively. 相似文献
11.
Shosuke Kawanishi Tamio Mizutani Seiyo Sano 《Biochimica et Biophysica Acta (BBA)/General Subjects》1978,540(1):83-92
The effects of a series of synthetic di-tetra- and hexachlorobiphenyl isomers and commercial polychlorinated biphenyls on the porphyrin biosynthesis in chick embryo liver cells in culture were examined.It was found that 3,4,3′,4′-tetra- and 3,4,5,3′,4′,5′-hexachlorobiphenyl isomers were the most active inducers, which were approximately 20 times as active as 1,4-dihydro-3,5-dicarbethoxy-2,4,6-trimethylpyridine (DDC) in porphyrin production. 3,5,3′,5′-Tetra- and 2,3,4,2′,3′,4′-hexachlorobiphenyl isomers were moderate inducers, which were approximately 2.0 to 2.5 times as active as DDC. 2,4,6,2′,4′,6′-Hexachlorobiphenyl showed the same activity as DCC. Compounds such as 4,4′-di-, 2,3,2′,3′-, 2,4,2′,4′- and 2,6,2′,6′-tetrachlorobiphenyl were weak inducers and 2,5,2′,5′-tetrachloro- and decachlorobiphenyl isomers were found to be inactive. Kanechlor-400 was the strongest inducer among the commercial polychlorinated biphenyls investigated.The structural requirements for potent porphyrin-inducing activity of chlorobiphenyl isomers were found to be the para and meta substituted structure causing a more highly conjugated and nearly coplanar conformation. It was found that induction caused by some chlorobiphenyls was subject to feed-back repression by end-product heme. In addition, the metabolism of chlorobiphenyls in mice was influenced by the unsubstituted pairs of carbon atoms in the molecule. These results lead us to postulate the following hypothesis, namely, that strong inducers may displace heme directly and incorporate into a hydrophobic pocket of the apo-represor protein, thus causing an induction of δ-aminolevulinic acid synthetase. 相似文献
12.
J A Goldstein P Hickman H Bergman J D McKinney M P Walker 《Chemico-biological interactions》1977,17(1):69-87
A number of isomerically pure polychlorinated biphenyls (PCBs) were tested as inducers of hepatic drug-metabolizing enzymes in the rat. The chlorinated biphenyl isomers can be categorized into two distinct groups of inducers, while commercial PCB mixtures have characteristics of both groups. Biphenyls chlorinated symmetrically in both the meta and para positions (3,4,3′,4′- and 3,4,5,3′,4′,5′-) increase the formation of cytochrome P-448, the ratio of the 455 to 430 peaks of the ethyl isocyanide difference spectrum, and aryl hydrocarbon hydroxylase and glucuronyl transferase activities, but decrease aminopyrine N-demethylase activity. These isomers are also the most toxic, as measured by weight loss. Biphenyl isomers chlorinated in both the para and ortho positions induce the formation of cytochrome P-450 rather than P-448, regardless of the chlorination of the meta position. These isomers, which include 2,4,2′,4′-tetra- and 2,4,5,2′,4′,5′-, 2,3,4,2′,3′,4′- and 2,4,6,2′,4′,6′-hexachlorobiphenyls, increase cytochrome P-450 and N-demethylase activity, but produce only a slight increase in aryl hydrocarbon hydroxylase activity, and do not alter the peak of the CO-difference spectrum or the ratio of the 455/430 peaks of the ethyl isocyanide difference spectrum. Isomers which are chlorinated in only one ring, or are chlorinated in both rings but not in the para positions, have very little activity as inducers of liver enzymes. Of the dichlorobiphenyls tested, 3,3′- and 4,4′-dichlorobiphenyls have very slight activity at extremely high doses. 相似文献
13.
The perennial American desert shrub, Gutierrezia microcephala, contains 20 flavonol methyl ethers displaying nine different oxygenation patterns. These include 11 new flavonols: 5,7-dihydroxy-3,6,8,3′,4′,5′-hexamethoxyflavone, 5,7,4′-trihydroxy-3,6,8,3′,5′-pentamethoxyflavone, 5,7,3′-trihydroxy-3,6,8,4′,5′-pentamethoxyflavone, 5,7,2′,4′-tetrahydroxy-3,6,8,5′-tetramethoxyflavone, 5,7,3′,4′-tetrahydroxy-3,6,8-trimethoxyflavone, 5,7,8,3′,4′-pentahydroxy-3,6-dimethoxyflavone, 3,5,7,3′,4′-pentahydroxy-6,8-dimethoxyflavone, 5,7,4′-trihydroxy-3,6,8-trimethoxyflavone, 5,7,8,4′-tetrahydroxy-3,3′-dimethoxyflavone, 5,7,8,3′,4′-pentahydroxy-3-methoxyflavone and 5,7,8,4′-tetrahydroxy-3-methoxyflavone. In addition, the following known flavonols were isolated: 5,7-dihydroxy-3,8,3′,4′,5′-pentamethoxyflavone, 5,7,4′-trihydroxy-3,8-dimethoxyflavone, 5,7,4′-trihydroxy-3,8,3′-trimethoxyflavone, 5,7,3′,4′-tetrahydroxy-3,8-dimethoxyflavone, 5,7,4′-trihydroxy-3,6,3′-trimethoxyflavone, 5,7,3′,4′-tetrahydroxy-3-methoxyflavone, 5,4′-dihydroxy-3,6,7,8,3′-pentamethoxyflavone, 5,7,4′-trihydroxy-3,6,8,3′-tetramethoxyflavone and 3,5,7,4′-tetrahydroxy-6,8,3′-trimethoxyflavone. 相似文献
14.
The major flavonoids of Marchantia polymorpha var. polymorpha and aquatica are the 7-O-β-d-glucuronides of apigenin and luteolin, luteolin 3′-O-β-d-glucuronide, luteolin 7,3′-di-O-β-d-glucuronide, and the 7,4′-di-O-β-d-glucuronides of apigenin and luteolin. These are accompanied by minor amounts of apigenin, luteolin, luteolin 3′,4′-di-O-β-d-glucuronide and luteolin 7,3′,4′-tri-O-β-d-glucuronide. All the luteolin di- and triglucuronides except the 3′,4′-di- substituted compound are new natural products. 相似文献
15.
A new phytoalexin isolated from the fungus-inoculated leaflets of Astragalus cicer has been identified as 7-hydroxy-2′-methoxy-4′,5′-methylenedioxyisoflavan (astraciceran). The synthesis of astraciceran and its 3′,4′-methylenedioxy analogue is described. 相似文献
16.
In addition to the previously described 7-hydroxy-8,4′-dimethoxy- and 7,3′-dihydroxy-8,4′-dimethoxy-isoflavone the heartwood of Xanthocercis zambesiaca has been shown to contain 7-hydroxy-8,3′,4′-trimethoxy-,3′,4′-dimethoxy-6,7-methylenedioxy- and 8,3′,4′-trimethoxy-6,7-methylenedioxy-isoflavone. A technique of determining isoflavone hydroxylation patterns by deuterium labelling is described. 相似文献
17.
E. Ayanoglu A. Ulubelen W.D. Clark G.K. Brown R.R. Kerr T.J. Mabry 《Phytochemistry》1981,20(7):1715-1717
Nine flavonoids including two new myricetin derivatives, myricetin 3′,4′-dimethyl ether and myricetin 3,3′, 4′-trimethyl ether, were obtained from Haplopappus integerrimus var. punctatus. The known compounds are quercetin 7,3′-dimethyl ether, querectin 3,3′-dimethyl ether, isorhamnetin, quercetin 3,7-dimethyl ether, quercetin 3-methyl ether, quercetin and quercetin 3-β-d-glucoside. 相似文献
18.
R.I. Gilbert 《Phytochemistry》1973,12(4):809-810
Three chalcones have been found in yellow flowers of A. majus, two of which have been identified as chalcononaringenin 4′-glucoside and 3,4,2′,4′,6′-pentahydroxychalcone 4′-glucoside. 相似文献
19.
Margaret F. Roberts Barbara N. Timmermann Tom J. Mabry Richard Brown Stephen A. Matlin 《Phytochemistry》1984,23(1):163-165
A new highly oxygenated flavone methyl ether has been isolated from Brickellia veronicaefolia and B. chlorolepis. It has been identified as 5,6′-dihydroxy-6,7,2′,3′,4′-pentamethoxyflavone and given the name brickellin. 相似文献
20.
Two new prenylated isoflavones were isolated from the root bark of Piscidia erythrina. The first compound was identified as 2′-deoxypiscerythrone. The second compound, the most abundant component of the extract, was identified as 3′-6′-di-Δ2-isopentenyl-5,7,2′,4′-tetrahydroxy-5′-methoxyisoflavone. 相似文献