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1.
Antonio G. González Antonio Gallindo Horacio Mansilla Angeles Gutiérrez 《Phytochemistry》1981,20(10):2367-2369
1-Keto-6β,7α,11β-H-selin-4(5)-en-6,12-olide, vulgarin and a new eudesmanolide, maritimin, were isolated from Artemisia maritima gallica. The structure and stereochemistry of this lactone have been determined by spectral studies and chemical transformations. 相似文献
2.
Chemical investigation of the young flower stalks of Petasites japonicus afforded some eremophilenolides, including a mixture of the two new compounds 6β-angeloyloxy-3β,8α-dihydroxyeremophil-7(11)-en-12,8β- olide and 6β-angeloyloxy-3β,8β-dihydroxyeremophil-7(11)-en-12,8α- olide. Their structures were elucidated by chemical and spectroscopic methods. The 13C NMR signals for the carbon atoms of the eremophilenolides were assigned with the help of Beierbeck's parameters. The CD spectra of the compounds are briefly discussed. 相似文献
3.
Repetition of an investigation of the petrol extracts of Rhodomyrtus tomentosa has led to the isolation of two new triterpenoids, R4 from the leaves and R5 from the stems besides R1, R2, R3 and the other known compounds already reported. R1 and R4 were proved to be 21α-hop-22(29)en-3β,30-diol and 3β-hydroxy-21α-hop-22(29)-en-30-al respectively, and R2, R3 and R5 are 3β-acetoxy-11α,12α-epoxyoleanan-28,13β-olide, 3β-acetoxy-12α-hydroxyoleanan-28, 13β-olide and 3β-acetoxy-12-oxo-oleanan-28,13β- olide respectively. The ethanol extract of the leaves contained betulinic, ursolic and aliphitolic acids and that of the stems betulonic, betulinic and oleanolic acids. 相似文献
4.
The transformation of 23,24-bisnorchol-4-en-3-one-22-ol into 6β,11α,22-trihydroxy-23,24-bisnorchol-4-en-3-one by the fungus Rhizopus arrhizus has been shown to be dependent on the composition of the culture medium, with respect to yield of the triol. The transformation of the 22-alcohol to 6β,11α-dihydroxy-pregn-4-ene-3,20-dione is also reported. 相似文献
5.
《Phytochemistry》1986,25(10):2412-2414
The aerial parts of Senecio rosmarinus afforded, in addition to the already known compounds, a new sesquiterpenic lactone, 1-oxo-10βH-eremophila-7(11)-en-8α,12 olide. The structure was established by spectral studies in which 2D-NMR spectroscopy played an essential role. 相似文献
6.
Tetsuro Fujita Yoshio Takeda Eiji Yuasa Akio Okamura Tetsuro Shingu Toshio Yokoi 《Phytochemistry》1982,21(4):903-905
From the leaves of Rabdosia inflexa a new cytotoxic diterpenoid, inflexinol was isolated, together with the known inflexin, and the structure was established as ent-kaur-16-en-15-one-1α,3α,6β,11β-tetraol 1,3-diacetate. 相似文献
7.
二萜佛司可林I、J、K、L,已从毛喉鞘蕊花分离得到。本文根据一维和二维的核磁共振谱详细描述了它们的光谱特征,二萜佛司可林K、L是首次报道。 相似文献
8.
The potential for biotransformation of the substrate 17β-hydroxyandrost-4-en-3-one (testosterone) by six filamentous fungi, namely, Rhizopus oryzae ATCC 11145, Mucor plumbeus ATCC 4740, Cunninghamella echinulata var. elegans ATCC 8688a, Aspergillus niger ATCC 9142, Phanerochaete chrysosporium ATCC 24725 and Whetzelinia sclerotiorum ATCC 18687, was investigated. In this study both free cells and macerated mycelia immobilised in calcium alginate were utilised and the results (products, % yields, % transformation) were compared. In general the encapsulated cells of the microorganisms effectively generated products similar to those found using free cells. However, with immobilised macerated mycelia, isolation of the transformation products was expedited by the simple work up procedure, and their purification was facilitated by the absence of fungal secondary metabolites. Twenty seven analogues of testosterone were generated, wherein the androstane skeleton was functionalised at C-1β, -2β, -6β, -7α, -11α, -14, -15α, -15β and -16β by the moulds. Redox chemistry was also observed. Seven of the analogues, 6β,11α,17β-trihydroxyandrost-4-en-3-one, 6β,14α,17β-trihydroxyandrost-4-en-3-one, 2,6β-dihydroxyandrosta-1,4-diene-3,17-dione, 2β,16β-dihydroxyandrost-4-ene-3,17-dione, 2β,6β-dihydroxyandrost-4-ene-3,17-dione, 2β,15β,17β-trihydroxyandrost-4-en-3-one and 2β,3α,17β-trihydroxyandrost-4-ene, were novel compounds. Five others, namely, 7α,17β-dihydroxyandrost-4-en-3-one, 6β,14α-dihydroxyandrost-4-ene-3,17-dione, 15α,17β-dihydroxyandrost-4-en-3-one, 16β,17α-dihydroxyandrost-4-en-3-one and 2β,16β,17β-trihydroxyandrost-4-en-3-one, were fully characterised for the first time. 相似文献
9.
From the extract of the fruits of Solanum xanthocarpum (Solanaceae), five new steroidal compounds were isolated and characterized: 4α-methyl-24ξ-ethyl-5α-cholest-7-en-3β,22ξ-diol (1), 3β,22ξ-dihydroxy-4α-methyl-24ξ-ethyl-5α-cholest-7-en-6-one (2), 3β-benzoxy-14β,22ξ-dihydroxy-4α-methyl-24ξ-ethyl-5α-cholest-7-en-6-one (3), 3β-benzoxy-14α,22ξ-dihydroxy-4α-methyl-24ξ-ethyl-5α-cholest-7-en-6-one (4) and 3β-(p-hydroxy)-benzoxy-22ξ-hydroxy-4α-methyl-24ξ-ethyl-5α-cholest-7-en-6-one (5). 相似文献
10.
Chao Zhang Shao-Hua Xu Bai-Ling Ma Wei-wei Wang Bo-Yang Yu Jian Zhang 《Bioorganic & medicinal chemistry letters》2017,27(11):2575-2578
Microbial transformation of ursolic acid (1) by Bacillus megaterium CGMCC 1.1741 was investigated and yielded five metabolites identified as 3-oxo-urs-12-en-28-oic acid (2); 1β,11α-dihydroxy-3-oxo-urs-12-en-28-oic acid (3); 1β-hydroxy-3-oxo-urs-12-en-28, 13-lactoe (4); 1β,3β, 11α-trihydroxyurs-12-en-28-oic acid (5) and 1β,11α-dihydroxy-3-oxo-urs-12-en-28-O-β-d-glucopyranoside (6). Metabolites 3, 4, 5 and 6 were new natural products. Their nitric oxide (NO) production inhibitory activity was assessed in lipopolysaccharide (LPS) – stimulated RAW 264.7 cells. Compounds 3 and 4 exhibited significant activities with the IC50 values of 1.243 and 1.711 μM, respectively. A primary structure-activity relationship was also discussed. 相似文献
11.
Walter Vichnewski Palaniappan Kulanthaivel Virgil L. Goedken Werner Herz 《Phytochemistry》1985,24(2):291-296
The structures and stereochemistries of two sesquiterpene lactones from Trichogonia gardneri were established as (6R,7S,8S,9S,IOR)-4E-9,10-dihydroxy-8-tigloxygermacr-4-en-6,12-olide) and (5R*,6R*,7S*,8S*,9R*)-14-acetoxy-3-chloro-9-hydroxy-2-oxo-8-tigloxyguia-1(10),3-dien-6,12-of olide by a combination of NMR spectrometry and X-ray diffraction. The results show that the structures of several sesquiterpene lactones which were isolated previously from related species require revision. 相似文献
12.
《Phytochemistry》1987,26(9):2585-2587
In addition to five known sesquiterpenoids, six new compounds were isolated from Smyrnium perfoliatum. The new compounds were 1β-acetoxy-eudesma-3,7(11),8-trien-8,12-olide, 1β-acetoxyeudesma-4(15),7(11),8-trien-8,12-olide, 1β-10α;4α,5β-diepoxy-8β-isobutoxy-glechomanolide, 1β, 10α;4α,5β-diepoxy-8α-isobutoxy-glechomanolide, 1β,4α-dihydroxy-2α,3α-epoxy-eudesma-7(11),8-dien-8,12-olide, 1β,4α-dihydroxy-2α,3α-epoxy-8β-methoxy-eudesma-7(11)-en-8α,12-olide. 相似文献
13.
Jayant S. Sohoni Bhimsen A. Nagasampagi Jürgen Ziesche Rajinder K. Gupta Ferdinand Bohlmann 《Phytochemistry》1984,23(5):1181-1183
While Cyathocline lyrata only afforded known compounds, the aerial parts of C. lutea gave a new sesquiterpene lactone, 5β-hydroxy-4,9-oxidogermacr-11-en-6,12-olide. 相似文献
14.
The tuber of Humirianthera rupestris (Icacinaceae) contains the degraded diterpenoids 3β,20-epoxy-30α- hydroxy- 14-oxo-9β-podocarpan-19,6β-olide (humirianthenolide A), 3β,20-epoxy-3α,14α-dihydroxy-9β-podocarpan-19,6β- olide (humirianthenolide B), 3β,20; 16,14-diepoxy-3α-hydroxy-17-nor-15-oxo-9β-abiet-13-en-19,6β-olide (humirianthenolide C), 3β,20-epoxy-3α,14-dihydroxy-13-oxo-9β-podocarp-8(14)-en-19,6β-olide (humirianthenolide D), 3β,20-epoxy-3α-hidroxy-14-oxo-8α,9β-podocarpan-19,6β-olide (humirianthenolide E) and 3β,20-epoxy-3α,14β- dihydroxy-8α,9β-podocarpan-19,6β-olide (humirianthenolide F). 1H NMR and 13C NMR spectroscopy were efrective for the determination of the humirianthenolide structures. 相似文献
15.
- 1.1. The major aglycones produced by acid hydrolysis of the saponins from the starfish Astropecten aurantiacus are identified as 3β,6α-dihydroxy-5α-pregn-9(11)-en-20-one (1), (17 E)- and (17 Z)-3β,6α-dihydroxy-5α-cholesta-9(11),17(20)-dien-23-one (9 and 10), (17 E)- and (17 Z)-3β,6α-dihydroxy-5α-cholesta-9(11), 17(20),24-trien-23-one (11 and 12), (20 E)-3β,6α-dihydroxy-5α-cholesta-9(11),20(22)-dien-23-one (4), and 17β-methyl-3β,6α-dihydroxy-18-nor-5α-cholesta-9(11),13-dien-23-one (13).
- 2.2. A re-examination of the sapogenins from the starfish Marthasterias galcialis, in addition to the previously isolated 1, 3β,6α-dihydroxy-5α-cholesta-9(11)-en-23-one (2, dihydromarthasterone), 3β,6αdihydroxy-5α-cholesta-9(11),24-dien-23-one (3, marthasterone) and 3β,6α-dihydroxy-5α-chol-9(11)-en-23-one (14), has shown the presence of minor amounts of 9, 10, 4 and 13.
- 3.3. A [13C]NMR study of the major sapogenins, 9 and 10, from A. aurantiacus, and 1, 2 and 14 from M. glacialis is also reported.
16.
Braulio M. Fraga Pedro Gonzalez Victoria Gonzalez-Vallejo Ricardo Guillermo Luz N. Diaz 《Phytochemistry》2010,71(11-12):1313-1321
The microbiological transformation of 7α,19-dihydroxy-ent-atis-16-ene by the fungus Gibberella fujikuroi gave 19-hydroxy-7-oxo-ent-atis-16-ene, 13(R),19-dihydroxy-7-oxo-ent-atis-16-ene, 7α,11β,19-trihydroxy-ent-atis-16-ene and 7α,16β,19-trihydroxy-ent-atis-16-ene, while the incubation of 19-hydroxy-7-oxo-ent-atis-16-ene afforded 13(R),19-dihydroxy-7-oxo-ent-atis-16-ene and 16β,17-dihydroxy-7-oxo-ent-atisan-19-al. The biotransformation of 7-oxo-ent-atis-16-en-19-oic acid gave 6β-hydroxy-7-oxo-ent-atis-16-en-19-oic acid, 6β,16β,17-trihydroxy-7-oxo-19-nor-ent-atis-4(18)-ene and 3β,7α-dihydroxy-6-oxo-ent-atis-16-en-19-oic acid. 相似文献
17.
John H. Adler 《Phytochemistry》1983,22(2):607-608
The 4-desmethylsterol fraction of the liverwort Palavicinnia lyellii is composed of 36% 24β-methylcholest-5-en-3β-ol (dihydrobrassicasterol), 16% 24α-methylcholest-5-en-3β-ol (campesterol), 33% 24α-ethylcholest-5-en-3β-ol (sitosterol) and 15% 24ξ-ethylcholesta-5,22-dien-3β-ol. 相似文献
18.
Tomasz Janeczko Jadwiga Dmochowska-G?adysz Edyta Kostrzewa-Sus?ow Agata Bia?ońska 《Steroids》2009,74(8):657-1046
Biotransformations of steroid compounds: androstenedione, testosterone, progesterone, pregnenolone and DHEA using Chaetomium sp. 1 KCH 6651 strain as a biocatalyst were investigated. The microorganism proved capable of selective hydroxylation of the steroid substrates. Androstenedione was converted to 14α-hydroxyandrost-4-en-3,17-dione (in over 75% yield) and 6β-hydroxyandrost-4-en-3,17-dione (in low yield), while testosterone underwent regioselective hydroxylation at 6β position. Progesterone was transformed to a single product—6β,14α-dihydroxypregnan-4-en-3,20-dione in high yield, whereas biotransformation of DHEA resulted in the formation of 7α-hydroxy derivative, which was subsequently converted to 7α-hydroxyandrost-4-en-3,17-dione. 相似文献
19.
本文对采自海南三亚海域的疏枝刺柳珊瑚(Echinogorgia pseudossapo)化学成分进行研究,分离到11个甾醇类化合物。经波谱数据分析,分别鉴定为cholest-5-en-3β-ol(1),24-methylene-cholest-4-ene-3β,6β-diol(2),24-norcholesta-22-en-3β-ol(3),acanthovagasteroid A(4),calicoferol E(5),calicoferol F(6),6-hydroxy-cholest-4-ene-3-one(7),echinoflorasterol(8),echissaposterol(9),24-methylcholest-5-en-3β,7α-diol(10)和24-methylcholest-5,22(E)-dien-3β,7α-diol(11)。除化合物8外,其余化合物均首次从该种海洋动物中分离得到。 相似文献
20.
Carmen E. Diaz Braulio M. Fraga Antonio G. Gonzalez James R. Hanson Melchor G. Hernandez Aurelio San Martin 《Phytochemistry》1985,24(7):1489-1491
The microbiological transformation by Gibberelia fujikuroi of ent-beyer-15-ene into the beyergibberellins A9 and A13, 7β-hydroxy- and 7β,18-dihydroxybeyerenolides, and of ent-beyer-15-en-19-ol into beyergibberellins A4, A7, A9, A13 and A25,and 7β-hydroxy-and 7β,18-dihydroxybeyerenolides is described. In contrast, ent-beyer-15-en-18-ol gave ent-7α, 18,19-trihydroxybeyer-15-ene, 7β,18-dihydroxybeyerenolide and ent-7α,18-dihydroxybeyer-15-en-19-oic acid again revealing the inhibitory effect of an 18-hydroxyl group on oxidative transformations at C-6β by Gibberella fujikuroi. 相似文献