共查询到20条相似文献,搜索用时 31 毫秒
1.
Kestutis Planutis Marina Planutiene Mary Pat Moyer Anthony V Nguyen Cherlyn A Pérez Randall F Holcombe 《BMC cell biology》2007,8(1):12
Background
Norrin is a potent Wnt pathway ligand. Aberrant activation of this signaling pathway can result in colon tumors but the role of norrin-based signaling in the genesis of colon cancer, and its relationship to activation of the pathway by traditional Wnt ligands, is not defined. 相似文献2.
Alesia B Sadosky Andrew G Bushmakin Joseph C Cappelleri David R Lionberger 《Arthritis research & therapy》2010,12(4):R162
Introduction
Understanding the relationship between patient-reported osteoarthritis (OA) severity and other patient-reported outcomes in the real-world clinical setting can provide a basis for appropriate patient management. The objective of this study was to determine how patient-reported OA severity correlates with patient-reported outcomes including pain, function and productivity. 相似文献3.
Background
Experimental results are commonly fitted by determining parameter values of suitable mathematical expressions. In case a relation exists between different data sets, the accuracy of the parameters obtained can be increased by incorporating this relationship in the fitting process instead of fitting the recordings separately. 相似文献4.
April DeLaurier Nicholas Burton Michael Bennett Richard Baldock Duncan Davidson Timothy J Mohun Malcolm PO Logan 《BMC developmental biology》2008,8(1):83
Background
The developing mouse limb is widely used as a model system for studying tissue patterning. Despite this, few references are available that can be used for the correct identification of developing limb structures, such as muscles and tendons. Existing textual references consist of two-dimensional (2D) illustrations of the adult rat or mouse limb that can be difficult to apply when attempting to describe the complex three-dimensional (3D) relationship between tissues. 相似文献5.
Background
A great deal is known about the qualitative aspects of the sequence-structure relationship, for example that buried residues are usually more conserved between structurally similar homologues, but no attempts have been made to quantitate the relationship between evolutionary conservation at a sequence position and change to global tertiary structure. In this paper we demonstrate that the Spearman correlation between sequence and structural change is suitable for this purpose. 相似文献6.
Background
The identification of unique proteins at different taxonomic levels has both scientific and practical value. Strain-, species- and genus-specific proteins can provide insight into the criteria that define an organism and its relationship with close relatives. Such proteins can also serve as taxon-specific diagnostic targets. 相似文献7.
8.
David J Llewellyn Iain A Lang Jing Xie Felicia A Huppert David Melzer Kenneth M Langa 《BMC neurology》2008,8(1):12
Background
The relationship between stroke risk and cognitive function has not previously been examined in a large community living sample other than the Framingham cohort. The objective of this study was to examine the relationship between 10-year risk for incident stroke and cognitive function in a large population-based sample. 相似文献9.
Jennie Ursum Wouter H Bos Rob J van de Stadt Ben AC Dijkmans Dirkjan van Schaardenburg 《Arthritis research & therapy》2009,11(3):R75-6
Introduction
The aim of this study was to examine seroconversion and the relationship with age and inflammation of autoantibodies in a large group of patients attending an outpatient rheumatology clinic. 相似文献10.
Felix Eckstein Wolfgang Wirth Martin I Hudelmaier Susanne Maschek Wolfgang Hitzl Bradley T Wyman Michael Nevitt Marie-Pierre Hellio Le Graverand David Hunter 《Arthritis research & therapy》2009,11(3):R90-10
Introduction
The aim was to investigate the relationship of cartilage loss (change in medial femorotibial cartilage thickness measured with magnetic resonance imaging (MRI)) with compartment-specific baseline radiographic findings and MRI cartilage morphometry features, and to identify which baseline features can be used for stratification of fast progressors. 相似文献11.
Rune B Leistad Trond Sand Kristian B Nilsen Rolf H Westgaard Lars Jacob Stovner 《BMC neurology》2007,7(1):23
Background
The purpose of this study was to investigate the temporal relationship between autonomic changes and pain activation in migraine and tension-type headache induced by stress in a model relevant for everyday office-work. 相似文献12.
Courvoisier N Dougados M Cantagrel A Goupille P Meyer O Sibilia J Daures JP Combe B 《Arthritis research & therapy》2008,10(5):R106
Introduction
The objectives of this study were to determine the predictive factors of long-term radiographic outcome of rheumatoid arthritis (RA) and to describe the relationship between joint damage and disability over the course of the disease. 相似文献13.
Background
The wealth of information on protein structure has led to a variety of statistical analyses of the role played by individual amino acid types in the protein fold. In particular, the contact propensities between the various amino acids can be converted into folding energies that have proved useful in structure prediction. The present study addresses the relationship of protein folding propensities to the evolutionary relationship between residues. 相似文献14.
15.
Aims
The purpose of this study was to examine HRQOL depending on whether the participants have family members with disabilities or not. In addition, we examined the relationship between HRQOL and social networks among family caregivers in Japan. 相似文献16.
Jussi P?ivinen Alessandro Grapputo Veijo Kaitala Atte Komonen Janne S Kotiaho Kimmo Saarinen Niklas Wahlberg 《BMC biology》2005,3(1):5
Background
Because "laws of nature" do not exist in ecology, much of the foundations of community ecology rely on broad statistical generalisations. One of the strongest generalisations is the positive relationship between density and distribution within a given taxonomic assemblage; that is, locally abundant species are more widespread than locally sparse species. Several mechanisms have been proposed to create this positive relationship, and the testing of these mechanisms is attracting increasing attention. 相似文献17.
Background
Epitope vaccines have been suggested as a strategy to counteract viral escape and development of drug resistance. Multiple studies have shown that Cytotoxic T-Lymphocyte (CTL) and T-Helper (Th) epitopes can generate strong immune responses in Human Immunodeficiency Virus (HIV-1). However, not much is known about the relationship among different types of HIV epitopes, particularly those epitopes that can be considered potential candidates for inclusion in the multi-epitope vaccines. 相似文献18.
Background
Patients with Alzheimer's disease experience a progressive loss of cognitive function, and the ability to independently perform activities of daily life. Sometimes a dependent stage is reached quite early in the disease, when caregivers decide that the patients can no longer be left alone safely. This is an important aspect of Alzheimer's for patients, their families, and also health care providers. Understanding the relationship between a patient's current cognitive status and their need for care may assist clinicians when recommending an appropriate management plan. In this study, we investigated the relationship of cognitive function to dependence on caregivers before the patients reach a severe stage of the disease. 相似文献19.