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1.
Depression is an important cause of morbidity, and World Health Organization has predicted that it will be the second leading
contributor to the global burden of disease by 2020. Postgraduate students are at high risk for depression caused by the stress
of examinations, the academic environment, and relationship problems with peers, lecturers, and family members. Physical inactivity,
advancing age, unmarried status, and many other factors contribute to the development of depression in humans. Associations
between symptoms of depression and the intake of nutrients such as magnesium have been investigated; however, the relationship
between zinc intake and depression has not received as much attention. The purpose of the present study was to examine the
relationship between dietary intake of zinc and depression in postgraduate students. This study was conducted on 402 participants
with a mean age of 32.54 ± 6.22 years, including 173 (43%) women and 229 (57%) men. In this study, we found an inverse relationship
between dietary intake of zinc and depression. The results persisted even after we controlled for several potential confounding
variables related to depression symptoms, including age, sex, years of education, smoking status (current and past), and physical
activity. The results of this study show that long-term intake of zinc may modulate symptoms of depression. 相似文献
2.
Catherine A. Herbst Kavitha C. Menon Elaine L. Ferguson Christine D. Thomson Karl Bailey Andrew R. Gray Sanjay Zodpey Abhay Saraf Prabir Kumar Das Sheila A. Skeaff 《Biological trace element research》2014,161(1):38-47
Women in low-income settings, common in India, are at risk of inadequate zinc intake due to poor diet quality and low consumption of flesh foods rich in zinc. The aims of this study were to assess the prevalence of zinc status of non-pregnant rural and tribal women living in central India and to identify dietary and non-dietary factors associated with the biochemical zinc status of these women. Rural and tribal non-pregnant women 18–30 years of age were selected using proportion to population sampling near Nagpur, Maharashtra, India. Sociodemographic, biochemical (serum zinc), clinical, and dietary data (1-day interactive 24-h recall) were collected. The mean age of women (n?=?109; rural?=?52; tribal?=?56) was 23.2 years and mean BMI was 17.9 kg/m2. The majority of the participants identified as being non-vegetarian (72 %). The mean?±?SD serum zinc concentration was 10.8?±?1.6 μmol/L, and 52 % of participants had a low serum zinc concentration according to the International Zinc Nutrition Consultative Group (IZiNCG). The median (first and third quartile) energy, zinc intake, and phytate/zinc molar ratio was 5.4 (4.2, 6.7)?MJ/day, 5.3 (3.8, 7.0)?mg/day, and 26 (22, 28), respectively. Zinc intakes were well below IZiNCG recommendations for dietary zinc of 9 mg/day for non-pregnant women aged 14–18 years and 7 mg/day for non-pregnant women aged ≥19 years. Using linear regression analysis to identify non-dietary and dietary factors associated with serum zinc, a significant association was only found for current lactation (p?=?0.012) and energy intake (p?0.001). Diets low in energy with poor bioavailability of dietary zinc are likely to be the primary cause of the high proportion of Indian women with zinc deficiency. 相似文献
3.
Reza Amani Somaye Saeidi Zahra Nazari Sorour Nematpour 《Biological trace element research》2010,137(2):150-158
It has been suggested that mood disorders and depressive status may be accompanied by lowered zinc status in the body, and
adequate consumption of zinc increases a general perceived well-being. The main objective of this study was to assess the
correlation between serum zinc concentrations and dietary zinc intakes with depression scores in university female students.
In the first phase, Beck's depression questionnaire was applied in a random sampling of 308 selected 20–25-year-old female
students (one third of total students in Ahvaz Jondi-Shapour University of Medical Sciences Golestan dormitories) to assess
the major depressive disorder (MDD) scales. Then, in the second phase, 23 students who identified as having moderate and severe
depression were selected as the case group, and 23 healthy age matched were chosen as the controls. Each of them completed
a 12-item semiquantitative food frequency questionnaire containing the main food sources of zinc in the usual dietary patterns
and also a 24-h food recall questionnaire to assure the daily zinc intakes. Daily zinc intakes were obtained by multiplying
each portion size by its zinc content using food tables. A 5-ml blood sample was taken for further serum zinc status using
flame atomic absorption spectrophotometry technique. Pearson's r was used to show the correlation between quantitative variables. Both daily zinc intake and serum zinc concentrations of
MDD group were about two thirds of healthy index (p < 0.01). Depressed individuals used to eat lower servings of red meats and chicken as the main food sources of zinc in students'
usual diets (p < 0.001). Consumption of other foods as the sources of zinc was not significantly different in two groups. A linear significant
correlation between dietary zinc intakes and its serum levels was seen in samples (r = 0.62; p < 0.001) and MDD students (r = 0.55; p < 0.001). There was a linear inverse correlation between Beck questionnaire scores and serum zinc concentrations in all of
the investigated students(r = -0.65; p < 0.001) and MDD girls (r = −0.71; p < 0.001). Beck questionnaire scores and diatary zinc intakes were also inversly correlated (r = −0.58; p < 0.001). However, no statistical correlation was seen between these two variables in MDD cases. In depressed female students,
dietary zinc intake is correlated to its serum concentrations; however, the serum zinc levels are inversely correlated to
depression scales. Consumption of the main dietary sources of zinc such as red meats and chicken should be encouraged in young
depressed girls. 相似文献
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5.
Atakul Tolga Altinkaya S. Ozlem Abas Burcin Irem Yenisey Cigdem 《Biological trace element research》2020,195(1):46-54
Biological Trace Element Research - The aim of the present study was to evaluate serum concentrations of copper (Cu) and zinc (Zn), in relation with metabolic profile and clinicopathologic features... 相似文献
6.
Joanna Suliburska Paweł Bogdański Danuta Pupek-Musialik Zbigniew Krejpcio 《Biological trace element research》2011,139(2):137-150
Inadequate minerals intake, as well as disruption of some metabolic processes in which microelements are cofactors, are suggested
to lead to the development of hypertension. The role of minerals in the pathogenesis of hypertension still remains to be explained.
In the present study, we sought to determine associations between serum and hair mineral concentrations and serum lipids and
glucose levels. Forty obese hypertensive subjects with insulin resistance and 40 healthy volunteers were recruited in the
study. Blood pressure, BMI, and insulin resistance were recorded in all subjects. Levels of lipids, glucose, sodium and potassium,
iron, copper, zinc, magnesium, and calcium were assessed in serum. Iron, copper, zinc, magnesium, and calcium were assessed
in hair. Dietary intake of the analyzed minerals was estimated. We found distinctly higher concentrations of serum iron and
serum and hair calcium as well as markedly lower levels of hair zinc in the hypertensive subjects. The study group manifested
also significantly lower daily intake of calcium, magnesium, and iron. We observed a relationship between the concentrations
of iron, zinc, and copper in serum and hair and high and low range of cholesterol, triglycerides, and glucose serum levels
in the studied patients. Moreover, this study demonstrated significant correlation between serum and hair concentrations of
selected minerals and their dietary intake and levels of serum lipids and glucose and blood pressure in the study and the
control groups. The obtained results seem to indicate the association between lipid and glucose metabolism and iron, copper,
zinc, and calcium concentrations in blood and hair of hypertensive and obese patients with insulin resistance. 相似文献
7.
Jianguo Wang Xiaoyan Zhu Zhe Wang Xiaobing Li Baoyu Zhao Guowen Liu 《Biological trace element research》2014,159(1-3):135-139
The objective of this study was to determine the levels of serum copper and zinc in subclinically hypocalcemic peripartum dairy cows in comparison to healthy animals. Blood samples were taken from 219 multiparous Holstein cows near parturition (from 4 weeks prepartum to 4 weeks postpartum) and 51 cows with subclinical hypocalcemia. The results showed that the serum copper concentration increased gradually at 1 week prepartum and remained high for the first 4 weeks postpartum in the healthy periparturient dairy cows. The serum zinc concentration reached a nadir at 1 week postpartum and subsequently increased gradually to baseline. The serum zinc concentration was significantly decreased (P?<?0.01) in dairy cows with subclinical hypocalcemia compared with healthy cows. There was no significant difference in the serum copper concentration between cows with subclinical hypocalcemia and healthy cows. These data demonstrate that the concentrations of copper and zinc in serum change dramatically during the peripartum period in dairy cows, which is a tremendous challenge for the body and for the maintenance of dairy cow health. The present study further suggests that a decreased serum zinc concentration could be a cause of decreased productive performance and increased susceptibility to other diseases due to immunosuppression in dairy cows with subclinical hypocalcemia. Additionally, this decreased zinc concentration may be involved in the pathogenesis of subclinical hypocalcemia. 相似文献
8.
Shokrzadeh M Ghaemian A Salehifar E Aliakbari S Saravi SS Ebrahimi P 《Biological trace element research》2009,127(2):116-123
Changes in the copper (Cu) and zinc (Zn) concentrations have been reported previously in ischemic cardiomyopathy (ISCMP).
Due to controversial results, the aims of this study were to compare levels of Cu, Zn, and Zn/Cu ratio of ISCMP patients with
healthy volunteers and also to investigate the possible relationship between trace elements status in ISCMP patients with
the severity of clinical disease based on the New York Heart Association (NYHA) classification. The subjects of this study
consisted of 30 ISCMP and 27 healthy volunteers. ISCMP was diagnosed with a history of previous myocardial infarction and
also coronary artery disease was confirmed by coronary angiography. Exclusion criteria were renal or hepatic insufficiency,
alcohol usage, and intake of supplements containing Cu or Zn within 1 week. Cu and Zn levels have been assayed with atomic
absorption spectrophotometry. Statistical analysis was performed with the SPSS 10 software using independent sample t test for comparing the levels of Cu and Zn between ISCMP and normal subjects. The mean Cu level of the ISCMP group (1.54 ± 0.52 mg/L)
was significantly more than the Cu levels of the healthy volunteers (1.31 ± 0.24 mg/L; p = 0.048). The mean Zn levels of the ISCMP and healthy volunteers were 1.05 ± 0.28 and 1.12 ± 0.42, respectively, without
any significant difference between groups. There was a trend for higher Cu level, lower Zn level, and lower Zn/Cu ratio in
NYHA III patients in comparison with NYHA II group. Considering the results of this study, Cu may have a role in the development
of ISCMP. Interventions such as administration of Cu chelators to relieve the symptoms or to decrease the progression of ISCMP
is needed to be examined in large clinical trials. In this study, the Zn level of ISCMP patients was not significantly different
in comparison with the healthy volunteers. 相似文献
9.
Caterina Vacchi-Suzzi Kirsten T. Eriksen Keith Levine Jane McElroy Anne Tj?nneland Ole Raaschou-Nielsen James M. Harrington Jaymie R. Meliker 《PloS one》2015,10(9)
Background
Cadmium is a known carcinogen that can disrupt endocrine signalling. Cigarette smoking and food are the most common routes of non-occupational exposure to cadmium. Cadmium accumulates in the kidney and can be measured in urine, making urine cadmium (U-Cd) a biomarker of long-term exposure. However dietary-cadmium (D-Cd) intake estimates are often used as surrogate indicator of cadmium exposure in non-smoking subjects. It is therefore important to investigate the concordance between D-Cd estimates obtained with Food Frequency Questionnaires and U-Cd.Methods
U-Cd levels were compared with estimated dietary-cadmium (D-Cd) intake in 1764 post-menopausal women from the Danish Diet, Cancer and Health cohort. For each participant, a food frequency questionnaire, and measures of cadmium content in standard recipes were used to judge the daily intake of cadmium, normalized by daily caloric intake. Cadmium was measured by ICP-MS in spot urine sampled at baseline and normalized by urinary creatinine. Information on diet, socio-demographics and smoking were self-reported at baseline.Results
Linear regressions between U-Cd and D-Cd alone revealed minimal but significant positive correlation in never smokers (R2 = 0.0076, β = 1.5% increase per 1 ng Cd kcal-1, p = 0.0085, n = 782), and negative correlation in current smokers (R2 = 0.0184, β = 7.1% decrease per 1 ng Cd kcal-1 change, p = 0.0006, n = 584). In the full study population, most of the variability in U-Cd was explained by smoking status (R2 = 0.2450, n = 1764). A forward selection model revealed that the strongest predictors of U-Cd were age in never smokers (Δ R2 = 0.04), smoking duration in former smokers (Δ R2 = 0.06) and pack-years in current smokers (Δ R2 = 0.07). Food items that contributed to U-Cd were leafy vegetables and soy-based products, but explained very little of the variance in U-Cd.Conclusions
Dietary-Cd intake estimated from food frequency questionnaires correlates only minimally with U-Cd biomarker, and its use as a Cd exposure indicator may be of limited utility in epidemiologic studies. 相似文献10.
Jie Chen Hongquan Peng Kun Zhang Long Xiao Zhimin Yuan Jianping Chen Zhiyu Wang Jingfeng Wang Hui Huang 《PloS one》2013,8(6)
The relations between dietary micronutrient, nutritional status and inflammation in hemodialysis patients are still unclear. A cross-sectional study was performed in hemodialysis population. 75 hemodialysis patients from South China participated in the dietary and nutritional assessment. Clinical and dietary data were collected. Nutritional status was assessed by Malnutrition-Inflammation Score (MIS) in addition to related anthropometric measurements. And according to the MIS score, the whole hemodialysis patients were divided into normal nutrition group and malnutrition group. The results showed that mid arm circumference (MAC) negatively correlated with MIS (r = −0.425; P = 0.002). The area under the ROC curve (AUC) for MAC was 0.737 (0.614–0.859). Comparing with the normal nutritional group, lower dietary selenium (Se), copper (Cu), iodine (I) and manganese (Mn) intake were observed among patients with malnutrition (P<0.05). While no significant differences of diverse vitamins were found. In conclusion, MAC was effective indicator for assessing nutritional and inflammatory status (P<0.05). The reduction of dietary Se, Cu, I and Mn intake level may be alarming markers for malnutrition and inflammatory status in hemodialysis patients. 相似文献
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Myrte Merkestein James S. McTaggart Sheena Lee Holger B. Kramer Fiona McMurray Mathilde Lafond Lily Boutens Roger Cox Frances M. Ashcroft 《PloS one》2014,9(5)
Single nucleotide polymorphisms in the first intron of the fat-mass-and-obesity-related gene FTO are associated with increased body weight and adiposity. Increased expression of FTO is likely underlying this obesity phenotype, as mice with two additional copies of Fto (FTO-4 mice) exhibit increased adiposity and are hyperphagic. FTO is a demethylase of single stranded DNA and RNA, and one of its targets is the m6A modification in RNA, which might play a role in the regulation of gene expression. In this study, we aimed to examine the changes in gene expression that occur in FTO-4 mice in order to gain more insight into the underlying mechanisms by which FTO influences body weight and adiposity. Our results indicate an upregulation of anabolic pathways and a downregulation of catabolic pathways in FTO-4 mice. Interestingly, although genes involved in methylation were differentially regulated in skeletal muscle of FTO-4 mice, no effect of FTO overexpression on m6A methylation of total mRNA was detected. 相似文献
14.
Shu-Jun Zhao Yan Ye Fu-Jun Sun En-Jiang Tian Zu-Pei Chen 《Biological trace element research》2011,142(3):581-588
The present study has been designed to investigate the impact of dietary iodine intake on lipid metabolism in mice, including
iodine deficiency and iodine excess. Different amounts of iodine mixed in the drinking water were continuously administered
to mice. The body weights and the levels of urinary iodine were measured 8 months after the treatment. Thyroid hormones in
the serum were detected by chemiluminescence immunoassay. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein
cholesterol and low-density lipoprotein cholesterol (LDL-C) were determined enzymatically by automatic analyzer. Results showed
that the urine iodine concentrations paralleled the amounts of iodine intakes. No statistical differences of body weights
among different groups were found. The levels of thyroid hormones were dramatically decreased in iodine deficiency while no
significant differences were found between iodine excess groups and normal iodine group. In iodine deficiency groups, the
levels of TG, TC, and LDL were increased at varying degrees. In iodine excess groups, the levels of TG in the male mice and
the levels of TC in the female mice were much lower than normal iodine group. In conclusion, dietary iodine intake may affect
the metabolism of serum lipids. Hypothyroid function induced by iodine deficiency may be responsible for the changes of lipids.
Higher iodine intake might benefit lipid metabolism. 相似文献
15.
Farrell Cahill Mariam Shahidi Jennifer Shea Danny Wadden Wayne Gulliver Edward Randell Sudesh Vasdev Guang Sun 《PloS one》2013,8(3)
Background
Magnesium plays a role in glucose and insulin homeostasis and evidence suggests that magnesium intake is associated with insulin resistance (IR). However, data is inconsistent and most studies have not adequately controlled for critical confounding factors.Objective
The study investigated the association between magnesium intake and IR in normal-weight (NW), overweight (OW) and obese (OB) along with pre- and post- menopausal women.Design
A total of 2295 subjects (590 men and 1705 women) were recruited from the CODING study. Dietary magnesium intake was computed from the Willett Food Frequency Questionnaire (FFQ). Adiposity (NW, OW and OB) was classified by body fat percentage (%BF) measured by Dual-energy X-ray absorptiometry according to the Bray criteria. Multiple regression analyses were used to test adiposity-specific associations of dietary magnesium intake on insulin resistance adjusting for caloric intake, physical activity, medication use and menopausal status.Results
Subjects with the highest intakes of dietary magnesium had the lowest levels of circulating insulin, HOMA-IR, and HOMA-ß and subjects with the lowest intake of dietary magnesium had the highest levels of these measures, suggesting a dose effect. Multiple regression analysis revealed a strong inverse association between dietary magnesium with IR. In addition, adiposity and menopausal status were found to be critical factors revealing that the association between dietary magnesium and IR was stronger in OW and OB along with Pre-menopausal women.Conclusion
The results of this study indicate that higher dietary magnesium intake is strongly associated with the attenuation of insulin resistance and is more beneficial for overweight and obese individuals in the general population and pre-menopausal women. Moreover, the inverse correlation between insulin resistance and dietary magnesium intake is stronger when adjusting for %BF than BMI. 相似文献16.
Ronan Thibault Anne-Marie Makhlouf Michel P. Kossovsky Jimison Iavindrasana Marinette Chikhi Rodolphe Meyer Didier Pittet Walter Zingg Claude Pichard 《PloS one》2015,10(4)
Background
Indicators to predict healthcare-associated infections (HCAI) are scarce. Malnutrition is known to be associated with adverse outcomes in healthcare but its identification is time-consuming and rarely done in daily practice. This cross-sectional study assessed the association between dietary intake, nutritional risk, and the prevalence of HCAI, in a general hospital population.Methods and findings
Dietary intake was assessed by dedicated dieticians on one day for all hospitalized patients receiving three meals per day. Nutritional risk was assessed using Nutritional Risk Screening (NRS)-2002, and defined as a NRS score ≥ 3. Energy needs were calculated using 110% of Harris-Benedict formula. HCAIs were diagnosed based on the Center for Disease Control criteria and their association with nutritional risk and measured energy intake was done using a multivariate logistic regression analysis. From 1689 hospitalised patients, 1024 and 1091 were eligible for the measurement of energy intake and nutritional risk, respectively. The prevalence of HCAI was 6.8%, and 30.1% of patients were at nutritional risk. Patients with HCAI were more likely identified with decreased energy intake (i.e. ≤ 70% of predicted energy needs) (30.3% vs. 14.5%, P = 0.002). The proportion of patients at nutritional risk was not significantly different between patients with and without HCAI (35.6% vs.29.7%, P = 0.28), respectively. Measured energy intake ≤ 70% of predicted energy needs (odds ratio: 2.26; 95% CI: 1.24 to 4.11, P = 0.008) and moderate severity of the disease (odds ratio: 3.38; 95% CI: 1.49 to 7.68, P = 0.004) were associated with HCAI in the multivariate analysis.Conclusion
Measured energy intake ≤ 70% of predicted energy needs is associated with HCAI in hospitalised patients. This suggests that insufficient dietary intake could be a risk factor of HCAI, without excluding reverse causality. Randomized trials are needed to assess whether improving energy intake in patients identified with decreased dietary intake could be a novel strategy for HCAI prevention. 相似文献17.
18.
Dingxiu He Yun Zhang Biao Zhang Wei Jian Xiaojian Deng Yi Yang Tao Xiao Hanyang Yu Shuyin Wen Kaisen Huang 《Cellular and molecular neurobiology》2018,38(3):727-733
Procalcitonin (PCT) has emerged as a new prognostic inflammatory marker in a variety of diseases. This study aimed to evaluate whether PCT is associated with increased risk of unfavorable outcome in intracerebral hemorrhage (ICH) patients. During January 2015–December 2016, we conducted a prospective cohort investigation involved 251 primary ICH patients who were admitted within 24 h after the onset of symptoms. We assessed serum PCT levels for all patients at admission. The functional outcome after 3 months was evaluated by modified Rankin Scale (mRS) and dichotomized as favorable (mRS 0–2) and unfavorable (mRS 3–6). The independent risk factors for unfavorable outcome and mortality after 3 months were examined by binary logistic regression. Of 251 ICH patients, the median PCT concentration was 0.053 µg/L (interquartile range 0.035–0.078 µg/L). Unfavorable outcome and mortality at 3 months were observed in 161 (64.1%) and 51 (20.3%) patients, respectively. After adjusting for potential confounders, patients with PCT levels in the top quartile (>0.078 ug/L), compared with the lowest quartile (<0.035 μg/L) were more likely to have a higher risk of poor functional outcome [odds ratio (OR) 7.341; 95% confidence interval (CI) 2.770–21.114; P = 0.001] and mortality (OR 7.483; 95% CI 1.871–24.458, P = 0.006). Furthermore, the area under the receiver operating characteristic curve of PCT showed 0.701 (95% CI 0.635–0.767) for worse functional prognosis, and 0.652 (95% CI 0.569–0.735) for mortality. This study demonstrated that elevated PCT levels at admission were independently associated with unfavorable clinical outcome in ICH patients. 相似文献
19.
Ersoy IH Koroglu BK Varol S Ersoy S Varol E Aylak F Tamer MN 《Biological trace element research》2011,143(2):619-624
Although there are many studies on effect of fluoride on trace elements in experimental animals, few studies exist on serum
trace elements levels in patients with endemic fluorosis. We aimed to determine the serum levels of trace elements including
serum copper (Cu), zinc (Zn), and serum levels of minerals including calcium (Ca), phosphorus (P), magnesium (Mg), sodium
(Na), potassium (K) in patients with endemic fluorosis. The study group consisted of 30 patients with endemic fluorosis (17
females, 13 males, mean age 33.53 ± 9.85 years). An age, gender, and body mass index matched 30 healthy volunteers comprised
control group (21 females, ten males with a mean age 33.93 ± 7.39 years). Urine fluoride levels of chronic fluorosis patients
were significantly higher than that of control subjects as expected (1.92 ± 0.10 mg/l vs. 0.41 ± 0.09 mg/l, respectively;
P < 0.001). Serum Cu levels (89.14 ± 16.77 μg/dL vs. 102.69 ± 25.04 μg/dL, respectively, P = 0.017), serum Zn levels (77.98 ± 20.58 μg/dL vs. 94.57 ± 35.87μg/dL, respectively, P = 0.032), and serum Mg levels (1.92 ± 0.18 mg/dL vs. 2.07 ± 0.31 mg/dL, respectively, p = 0.022) was significantly lower in chronic fluorosis patients than in controls. There were no statistically significant
differences between the fluorosis group and control group with respect to serum levels of Na, K, Ca, and P. We concluded that
chronic fluorosis is associated with reduced serum levels of Cu, Zn, and Mg. 相似文献