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1.
Gross cystic breast disease (GCBD) is one of the most common breast diseases, and women with apocrine (type I) cysts are at
higher risk of developing breast cancer than women with flattened (type II) cysts. Type I cysts contain fluid with an electrolyte
composition similar to that of intracellular fluid (Na/K ratio <3), whereas type II cysts fluid’s content resembles that of
plasma (Na/K ratio >3). The electrolyte composition of breast cyst fluid (BCF) has been investigated intensively; however,
there have been only a few studies in literature reporting the content of trace elements in BCF. The aim of this study was
to compare the concentrations of Na, K, Ca, P, Zn, Cu, Fe, and Na/K and trace element ratios in breast cyst fluid in two subgroups
of breast cysts. Sixty-three BCF were obtained by needle aspiration from premenopausal women with GCBD diagnosed by clinical,
xheromammographic, and cytological studies. After separation of cells for cytological evaluation, the cyst fluid was centrifuged
and supernatant stored at −80°C until the analysis. Sodium, potassium, calcium, phosphorus, and iron were measured using Roche
Diagnostics commercial kits on Hitachi 747-200 autoanalyzer. Measurements of copper and zinc were performed by flame atomic
absorption spectrophotometer on Shimadzu AAS 680. We found statistically significant higher K, lower Na, higher phosphorus
concentrations, and lower Na/K ratios in type I cysts when compared with type II cysts’ values. Median values of Na/K ratio
in type I and in type II were 0.32 and 6.2, respectively. Higher Zn, Cu, and Fe concentrations with respect to median values
were noted in type I cysts; higher [Na.Cu/K.Zn], [Na.Cu/K.Fe], and [Na.Zn/K.Fe] ratios were found in type II cysts. A significant
negative correlation existed between Na/K and Cu, and a significant positive correlation between Na/K and Fe in type II cysts
(r = −0.660, p = 0.007; r = 0.615, p = 0.014, respectively). We can conclude that the trace elements content of BCF, in addition to electrolytes, could be useful
in classifying the breast cyst. Future studies in larger series are needed to confirm these data. 相似文献
2.
This study reports the effects of dietary iron (Fe) deficiency and recovery on bone mineral composition and strength in anemic
rats submitted to a hemoglobin (Hb) repletion assay. Weanling male Wistar rats were fed a low-Fe diet (12 mg/kg) for 15 days
followed by 2 weeks of Fe repletion with diets providing 35 mg Fe/kg as either ferrous sulfate (n = 8) or ferric pyrophosphate (FP; n = 12). At final day of each period (depletion and repletion), Fe-adequate animals were also euthanized. Iron status (blood
Hb, Hb Fe pool, Hb regeneration efficiency), tibia mineral concentrations (Ca, Mg, Fe, Cu, and Zn) and biomechanical properties
were evaluated. Iron-deficient rats had lower tibia Fe and Mg levels and bone strength when compared to controls. Yield load
and resilience were positively related to tibia Mg levels (r = 0.47, P = 0.02 and r = 0.56, P = 0.004, respectively). Iron repletion did not recover tibia Mg concentrations impaired by Fe deficiency. Moreover, bone
elastic properties were negatively affected by FP consumption. In conclusion, bone mineral composition and strength were affected
by Fe deficiency, whereas dietary Fe source influenced tibia Mg and resistance in the period during which rats were recovering
from anemia. 相似文献
3.
Five brands of antidiabetic herbal formulations as tablets, Diabetex, Divya Madhu Nashini, Jambrushila, Diabeticin, and Madhumeh Nashini, from different pharmacies were analyzed for six minor (Na, K, Ca, Cl, Mg, and P) and 20 trace (As, Ba, Br, Ce, Co, Cr, Cs,
Cu, Fe, Hg, La, Mn, Rb, Sb, Sc, Se, Sm, Th, V, and Zn) elements by thermal neutron irradiation followed by high-resolution
gamma ray spectrometry. Further Ni, Cd, and Pb were determined by atomic absorption spectrophotometry. Most elements vary
in a narrow range by a factor of 2–4 while a few others vary in a wide range, e.g., Na (0.05–0.67 mg/g), Mn (26.7–250 μg/g),
and V (0.26–2.50 μg/g). All the five brands contain K, Cl, Mg, P, and Ca as minor constituents along with mean trace amounts
of Cr (2.11 ± 0.67 μg/g), Cu (15.7 ± 7.11 μg/g), Fe (459 ± 171 μg/g), Mn (143 ± 23 μg/g), Se (238 ± 112 ng/g), and V (0.99 ± 0.93 μg/g).
Jambrushila is enriched in Na, Ca, Mg, Cl, Fe, Cu, Se, and Zn, essential nutrients responsible for curing diabetes. Dietary intake of
Mn, Fe, and Cu are greater than 10% of the recommended dietary allowance, whereas that for Zn and Se is less than 2%. Mean
contents of toxic elements (As, Cd, Hg, and Pb) were found below permissible limits except in Jambrushila. Cr and Zn were inversely correlated with r = −0.81, whereas Rb and Cs exhibit linear correlation (r = 0.93) in five brands. C, H, N analysis showed C ∼ 55%, H ∼ 12%, and N ∼ 2% with a total of ∼70% organic matter. However,
thermal decomposition studies at 700°C suggest less than 5% nonvolatile metal oxides. Herbal formulations contain minor and
trace elements in bioavailable forms that favorably influence glucose tolerance and possibly increase the body’s ability to
ameliorate development of diabetes. 相似文献
4.
Tomza-Marciniak A Pilarczyk B Bąkowska M Pilarczyk R Wójcik J 《Biological trace element research》2011,143(2):863-870
Concentrations of cadmium, lead, iron, zinc, copper, chromium, nickel, aluminium and arsenium were analysed in blood serum
of cattle from organic (n = 20) and conventional (n = 21) farms. The elements were determined by inductively coupled plasma atomic emission spectrometry using an Optima 2000
DV instrument (Perkin Elmer Inc.). Animals from the organic farm were characterised by significantly lower (P < 0.01) serum concentrations of Pb, Zn, Fe, Cu, Cr, Ni, As and Al compared to animals from the conventional farm. The concentration
of Cd was similar in animals from both organic and conventional farms. The concentration of toxic elements in cattle from
organic and conventional farms studied was very low. The trace essential elements were generally within the adequate ranges
except Zn and Cu, which were deficient. In organically reared animals, also serum Fe content was below the critical level
for diagnosing iron deficiency. Pb was significantly correlated with Cd, Zn, Fe, Cu and Ni. A significant positive correlation
between the concentration of Cd and Zn, Cu and Ni concentrations was only observed in cows from the organic farm. The present
results suggest that organically raised animals are less exposed to harmful environmental influences such as the environmental
pollution with heavy metals. On the other hand, these animals are at a greater risk of mineral deficiency compared to animals
kept on conventional farms. 相似文献
5.
Jagmohan S. Negi Pramod Singh Geeta J. nee Pant Mohan S. Maniyari Rawat 《Biological trace element research》2010,136(3):364-371
Concentration level of nine elements viz. Zn, Cu, Mn, Fe, Co, Na, K, Ca, and Li were determined in leaves and roots of Asparagus curillus (Buch.-Ham.) ex Roxb. collected from four different altitudes in three seasons by atomic absorption spectroscopy. The overall
concentration of K was found to be highest, whereas the level of Cu was lowest. The maximum concentrations of Zn, Cu, Mn,
Fe, Co, Na, K, Ca, and Li were found to be 97.0 ± 1.5, 28.0 ± 7.0, 44.0 ± 7.3, 1138.0 ± 18.5, 91.0 ± 6.2, 381.0 ± 7.8, 9508.0 ± 7.8,
3076.0 ± 6.4, and 78.0 ± 4.6 mg/kg, respectively. 相似文献
6.
Chih-Hung Guo Wang-Sheng Ko Pei-Chung Chen Guoo-Shyng W. Hsu Chia-Yeh Lin Chia-Liang Wang 《Biological trace element research》2009,131(1):13-24
The present study was conducted to compare the trace elements and oxidative status between uremic patients with and without
dementia. Chronic hemodialysis patients with dementia (n = 20) and without dementia (n = 25), and age-matched healthy volunteers (n = 20) were enrolled. The nutritional status, blood levels of trace elements aluminum (Al), zinc (Zn), copper (Cu), magnesium
(Mg) and iron (Fe), malondialdehyde (MDA), and protein carbonyl production, antioxidant enzymes glutathione peroxidase (GPx),
and glutathione reductase (GR) activities were measured. No significant difference in nutritional status or clinical characteristics
was observed between nondementia and dementia patients. However, uremic patients with dementia have significantly higher Al,
Cu, and Mg and lower Zn concentrations, as well as increased Cu/Zn ratio in comparison to nondementia patients. There were
statistically significant increased MDA and carbonyl production and decreased GPx and GR activities in dementia patients.
Furthermore, the significant associations of Al, Mg, and Cu/Zn ratio with oxidative status in patients with dementia were
noted. The dementia may initially worsen with abnormal metabolism of trace elements and oxidative stress occurrence. Our results
suggest that abnormalities in trace element levels are associated with oxidative stress and may be a major risk factor in
the dementia development of uremic patients. 相似文献
7.
Huang L Yu X Zhang J Liu X Zhang Y Jiao X Yu X 《Biological trace element research》2012,146(2):154-159
Wilson disease is an inherited autosomal recessive disorder causing copper accumulation and consequent toxicity. d-Penicillamine, a potent metal chelator, is an important therapy for Wilson disease. To investigate the changes of metal elements
under the treatment of d-penicillamine, we determined the levels of Cu, Zn, Mg, Ca, Fe, Se, Mn, Pb, Hg, Cd, As, Tl, and Al by ICP-MS in 24-h urine
of 115 Wilson disease patients who had received treatment with d-penicillamine for 1 month to 22 years at maintenance doses, as well as 115 age-matched, healthy controls. The levels of Cu,
Mg, Ca, Zn, Hg, Pb, Tl, Cd, and Mn in the 24-h urine of the cases were significantly higher than those of the controls (P < 0.05), and the observed increases in the levels of Mg, Ca, and Zn were directly correlated with the treatment duration
with Pearson Correlation Coefficient (R) of 0.356 (Mg), 0.329 (Ca), and 0.313 (Zn), respectively (P < 0.05). On the other hand, the levels of Al and As in the 24-h urine were lower than those of the controls (P < 0.05) and were negatively correlated with the treatment time with R of −0.337 (Al) and −0.398 (As), respectively, (P < 0.05). Thus, this study indicates that the levels of metal elements may be altered in patients with Wilson disease under
the treatment of d-penicillamine. 相似文献
8.
The present study was carried out to assess the impact of wastewater on parsley (Petroselinum crispum). The parameters determined for soil were pH, electrical conductivity (EC), soil organic matter (SOM), nutrient elements
(Ca, Mg, Na, K, Mn, Cu, Zn, and Fe), and heavy metals (Cd, Cr, Ni, and Pb), while the parameters determined for the plant
included pigment content, dry matter, nutrient element, and heavy metals. SOM, EC, and clay contents were higher, and pH was
slightly acidic in soil treated with wastewater compared to control soil. The enrichment factors (EF) of the nutrient elements
in contaminated soil are in the sequence of Na (2) > Ca (1.32) > Mn = Mg (1.17) > Cu (1.11) > Zn (1.08) > Fe (1.07) > K (0.93),
while EF in parsley are Na (6.63) > Ca (1.60) > Mg (1.34) > Zn (1.15) > Fe (0.95) > Cu = K (0.90) > Mn (0.85). Application
of wastewater significantly decreased dry matter, while photosynthetic pigment content increased in parsley. The enrichment
of the heavy metals is in the sequence: Cd (1.142) > Pb (1.131) > Ni (1.112) > Cr (1.095). P. crispum shows a high transfer factor (TF > 1) for Cd signifying a high mobility of Cd from soil to plant. Thus, although the wastewater
irrigation in parsley production aims to produce socioeconomic benefits, study results indicated that municipal wastewater
is not suitable for irrigation of parsley because it has negative effects on plant and causes heavy metal accumulation. 相似文献
9.
The objective of the present study is to explore the effects of acute swimming exercise on plasma levels of some elements
in rats, immediately after the exercise, and 24 and 48 h later. The study included 40 adult male rats of Spraque Dawley species,
which were equally allocated to four groups. Group 1: General Control Group; Group 2: Swimming Group, the group that was decapitated
immediately after 30-min acute swimming exercise; Group 3: Swimming Group, the group that was decapitated 24 h after 30-min
acute swimming exercise; Group 4: Swimming Group, the group that was decapitated 48 h after 30-min acute swimming exercise.
Plasma copper (Cu), iron (Fe), magnesium (Mg), phosphorus (P), selenium (Se), zinc (Zn) levels were determined according to
atomic emission method in the blood samples collected from the animals by decapitation method. Measurements conducted immediately
after acute swimming exercise (group 2) showed a significant decrease in Se and Zn levels (p < 0,01) and a significant increase in P levels (p < 0,01), when compared to group 1. Measurements carried out 24 h after the exercise (group 3) demonstrated a significant
increase in all parameters except for Mg, in comparison to groups 1 and 2 (p < 0,01). It was seen in the measurements made 48 h after the exercise (group 4) that all parameters were restored to control
values. The results of our study show that acute swimming exercise significantly changes plasma Cu, Fe, P, Se, and Zn levels. 相似文献
10.
Ersoy IH Koroglu BK Varol S Ersoy S Varol E Aylak F Tamer MN 《Biological trace element research》2011,143(2):619-624
Although there are many studies on effect of fluoride on trace elements in experimental animals, few studies exist on serum
trace elements levels in patients with endemic fluorosis. We aimed to determine the serum levels of trace elements including
serum copper (Cu), zinc (Zn), and serum levels of minerals including calcium (Ca), phosphorus (P), magnesium (Mg), sodium
(Na), potassium (K) in patients with endemic fluorosis. The study group consisted of 30 patients with endemic fluorosis (17
females, 13 males, mean age 33.53 ± 9.85 years). An age, gender, and body mass index matched 30 healthy volunteers comprised
control group (21 females, ten males with a mean age 33.93 ± 7.39 years). Urine fluoride levels of chronic fluorosis patients
were significantly higher than that of control subjects as expected (1.92 ± 0.10 mg/l vs. 0.41 ± 0.09 mg/l, respectively;
P < 0.001). Serum Cu levels (89.14 ± 16.77 μg/dL vs. 102.69 ± 25.04 μg/dL, respectively, P = 0.017), serum Zn levels (77.98 ± 20.58 μg/dL vs. 94.57 ± 35.87μg/dL, respectively, P = 0.032), and serum Mg levels (1.92 ± 0.18 mg/dL vs. 2.07 ± 0.31 mg/dL, respectively, p = 0.022) was significantly lower in chronic fluorosis patients than in controls. There were no statistically significant
differences between the fluorosis group and control group with respect to serum levels of Na, K, Ca, and P. We concluded that
chronic fluorosis is associated with reduced serum levels of Cu, Zn, and Mg. 相似文献
11.
Abdel-Hasseb A. Fayed 《Biological trace element research》2010,134(1):64-67
Trace elements such as Zinc (Zn), copper (Cu), iron (Fe), and selenium (Se) are essential for male fertility. The fertilizing
capacity of most animals reduced with advancing age. The objective of the present work was to determine the serum and testicular
levels of Zn, Cu, and Se in young (10 months old) and old (30 months old) rabbits. Blood and testicular samples were obtained
from rabbits after their slaughter. All samples were digested by concentrated acids and analyzed for trace elements by flame
emission atomic absorption spectrophotometer. The results showed that serum Zn and Cu were lower in old rabbits than young
(P < 0.01). Serum Se was higher in old than young rabbits (P < 0.05). Testicular Cu and Se were significantly lower in old than young rabbits (P < 0.01). However, Zn level was higher in old compared to young rabbits (P < 0.01). The serum Zn and Se were higher than the testicular levels (P < 0.01). The testicular Cu in both ages was higher than the serum level (P < 0.01), which suggest a very important role for Cu in the process of spermatogenesis in rabbits. 相似文献
12.
Salehifar E Shokrzadeh M Ghaemian A Aliakbari S Saeedi Saravi SS 《Biological trace element research》2008,125(2):97-108
Changes in the cupper (Cu) and zinc (Zn) concentrations have been reported previously in idiopathic dilated cardiomyopathy
(IDCMP). As a result of controversial results, the aim of this study was to compare the Zn and Cu concentrations and Zn/Cu
ratio of IDCMP patients to healthy volunteers. In addition, the correlation of Cu and Zn levels with age has been evaluated.
The study population consisted of 18 IDCMP patients and 27 healthy volunteers. IDCMP patients had normal angiography with
echocardiography supporting cardiomyopathy without pericardial and valvular diseases. Exclusion criteria were renal or hepatic
insufficiency, alcohol usage, and intake of supplements containing Cu or Zn within 1 week ago. Cu and Zn levels have been
assayed with atomic absorption spectrophotometry. Statistical analysis was performed with SPSS 10 software with independent
sample t test for comparing the level of Cu and Zn of IDCMP patients with normal subjects and Pearson correlation to determine the
correlation between numeric data. P < 0.05 was considered as significant differences. There was a trend for a lower Zn level in IDCMP patients compared to healthy
volunteers. (0.97 ± 0.25 mg/l vs. 1.12 ± 0.42 mg/l, respectively). The mean Cu levels of IDCMP and normal subjects were 1.33 ± 0.20 mg/l
and 1.31 ± 0.23 mg/l, respectively. There was a significant difference in Zn/Cu ratio among patients based on the NYHA classification
of heart failure (P = 0.003). Age was negatively correlated with Zn levels in IDCMP group (P = 0.037) and positively with Cu levels in healthy volunteers (P = 0.012). A lower Zn level in IDCMP patients compared to healthy volunteers and specially a significant difference in Zn/Cu
ratio of patients based on their NYHA classification would suggest a critical role of zinc and Cu imbalance in development
of IDCMP. 相似文献
13.
During the 1994/1995 Antarctic summer 20 Antarctic cod (Notothenia coriiceps) of both sexes were collected at King George Island, South Shetland Islands, Antarctica, to determine the levels of Fe, Zn,
Mn and Cu in muscle, liver, gonad and kidney. Metal levels were assessed using the inductively coupled plasma-atomic emission
spectrometry (ICP-AES) technique. The levels of Fe, Zn, Mn and Cu observed in both sexes of N. coriiceps were significantly lower in muscle tissue than in liver, kidney and gonad; the livers of males and gonads of females had
the highest levels. The differences between the sexes were significant for Zn and Mn in gonads and for Cu in liver. Despite
the modest size-range of the specimens, the Cu levels in liver, muscle and kidney were significantly inversely correlated
with female mass (P < 0.05) as was gonad Cu level and male body length. Fe mainly presented the highest concentrations and Cu and Mn the lowest
ones. Mean muscle metal levels are similar to those of hake, cod, herring and mackerel; however, the level of Fe was slightly
higher. Accumulation may occur for Fe, Zn and Mn in liver, kidney and gonad, which have higher levels than those of most prey.
Received: 21 October 1997 / Accepted: 1 February 1998 相似文献
14.
The effects of FeCl3 and Fe–EDTA on the development of psoriasis were studied in the mouse model of vaginal epithelium and tail epidermis. The
mitoses of vaginal epithelial cell in female mice of their estrogenic stage and the formation of granular cell layers in male
mouse tail scale were observed. Mice were randomly divided into eight groups and treated with normal saline, methotrexate,
and different doses of two iron forms, FeCl3 and Fe–EDTA, respectively, for 10 days. To explore the influence of FeCl3 and Fe–EDTA on the excretion of Cu, Fe, Zn, Ca, Mg, Mn, and Se, the concentration of those elements in liver and kidney was
analyzed by atomic absorption spectrometry. The different doses of FeCl3 or Fe–EDTA could obviously inhibit the mitoses of vaginal epithelial cell (p< 0.05) and promote the formation of granular cell layers in mice tail scale (p < 0.05). No statistically significant results were found between the groups of FeCl3 and Fe–EDTA, and between experimental groups and methotrexate group acted as the positive control (p>0.05). Compared with the negative group, the concentrations of Cu, Fe, Zn, Ca, Mg, Mn, and Se in liver and kidney of experimental
groups and positive control group were not significantly changed (p > 0.05). FeCl3 and Fe–EDTA are as effective as methotrexate on inhibiting hyperplasia of epidermal cells and increasing the formation of
granular cell layers, and the concentrations of Cu, Fe, Zn, Ca, Mg, Mn, and Se in liver and kidney of experimental groups
and positive control group were not significantly changed compared with the negative group, possibly retarding the development
of psoriasis. 相似文献
15.
U. Carpentieri J. Myers C. W. Daeschner M. E. Haggard 《Biological trace element research》1988,16(2):165-176
The effects of simultaneous changes of calcium, magnesium, iron, copper, and zinc concentrations were evaluated in normal
human T and B lymphocytes, cultured in cation-depleted media. Optimal concentrations for thymidine incorporation (TI) in both
cell populations were Fe and Zn 15 μM and Cu 5 μM; for t cells Ca 2 mM and Mg 4 mM; for B cells Ca 4 mM and Mg 6 mM. TI decreased with increasing molarity of cations and the decrease was particularly apparent with Cu. Minimal amounts of
Ca and Mg (0.5 mM) were necessary for growth, even in presence of optimal concentrations of Fe, Cu, and Zn. Fe and Cu showed synergistic stimulatory
effects at low concentrations and synergistic inhibitory effects at high concentrations. Antagonism between Fe and Zn, Cu
and Zn, and Ca and Zn was also demonstrated. CD4/CD8 increased with PHA stimulation in presence of Zn, and decreased with
ConA stimulation in presence of Zn or Fe. The results demonstrate: (1) the relationship and interdependence of Fe, Cu, and
Zn concentrations in modulating the growth of normal lymphocytes; (2) the stimulatory effects of Fe on B cells and Zn on CD8
positive cells; (3) the inhibitory effect of Cu at concentrations lower than those of Fe and Zn; (4) the requirement of Ca
and Mg in certain concentration and ratio for the action of the other cations; and (5) the Ca and Mg requirement for the growth
of B cells higher than T cells. 相似文献
16.
Essential hypertension (EH) is a major public health problem world over and in India. Recent data on EH in the population
of Chandigarh (Union Territory and capital of Punjab and Haryana States of India) revealed that the prevalence of EH has become
double in the last 30 years in the residents of Chandigarh (26.9 to 45.80% in the year 1968 and 2002). Zinc (Zn), copper (Cu),
magnesium (Mg), and manganese (Mn) in the serum are considered important in maintaining the human hypertension. The high Zn
intake was considered to increase the blood pressure (BP) and to affect the other mineral status in the body. Recent survey
on the trace metal status of different vegetables in the State of Punjab around Chandigarh (India) revealed that Zn level
is significantly higher (40 mg/kg or more in above ground vegetables and 120 mg/kg or above in underground vegetables) in
underground water-irrigated vegetables, but the levels of Cu and Mg are within prescribed limit. The present study was conducted
on Chandigarh population to evaluate the levels of Zn, Cu, Mg, and Mn in the blood and urine of normotensive (NT) control
and hypertensive (HT) subjects matched with number, age and sex. Atomic absorption spectrophotometer studies revaluated that
the levels of serum Zn, Mg, and Mn were significantly higher (p < 0.001), but the level of Cu was low in the HT subjects (BP = 160/93) compared to NT control (BP = 140/83). Higher levels
of urinary Zn, Cu, Mg, and Mn were observed in the HT subject vs NT control (p < 0.001). Positive correlations were evaluated between the levels of serum Zn, Mg, and Mn vs systolic and diastolic pressures
(DP and SP), respectively (r = 0.928, 0.863, 0.876, 0.808, 0.404, 0.326, p < 0.01), but negative and positive nonsignificant correlations between the serum Cu with SP and DP were recorded (r = −0.032, r = 0.024). Positive correlations were also evaluated between urinary levels of Zn, Cu, Mg, and Mn vs SP and DP (r = 0.718, 0.657, 0.750, 0.681, 0.630, 0.578, 0.516, 0.461, p < 0.01). Prevalence of essential hypertension may be due to higher Zn level in the food chain that makes the individuals vulnerable
to other diseases over the time related to essential hypertension. 相似文献
17.
Dietary Zinc Glycine Chelate on Growth Performance,Tissue Mineral Concentrations,and Serum Enzyme Activity in Weanling Piglets 总被引:2,自引:0,他引:2
One hundred twenty crossbred piglets (Duroc × Landrace × Yorkshire) were used to determine the effects of dietary zinc glycine
chelate on growth performance, tissue mineral concentrations, and serum enzyme activity. All pigs were allotted to four treatments
and fed with basal diets supplemented with 0, 50, and 100 mg/kg Zn as zinc glycine chelate or 3,000 mg/kg Zn as zinc oxide
(ZnO). After the 35-day feeding trial, results of the study showed that, compared to the control, average daily gain was improved
(P < 0.05) for pigs fed 100 mg/kg Zn from zinc glycine chelate or 3,000 mg/kg Zn from ZnO and Zn concentrations in serum and
M. longissimus dorsi were significantly enhanced by 100 mg/kg dietary zinc glycine chelate and 3,000 mg/kg ZnO. In addition, supplementation of
100 mg/kg zinc glycine chelate decreased (P < 0.05) the liver Fe level, liver Zn level, spleen Cu level, and kidney Cu level compared to that of the 3,000-mg/kg ZnO
group. For feces mineral excretion, 3,000 mg/kg Zn from ZnO greatly increased the concentration of fecal Zn (P < 0.01) and Mn (P < 0.05) compared to that of the control or the 100-mg/kg zinc glycine chelate group. Moreover, alkaline phosphatase and Cu/Zn
superoxide dismutase activities of pigs in 100 mg/kg zinc glycine chelate and ZnO treatments were greatly higher than that
of the control. The results of present study showed that supplementation with zinc glycine chelate could improve growth and
serum enzyme activities and could also decrease zinc excretion in feces in weanling pig compared to high dietary ZnO. 相似文献
18.
Ewa Rębacz Irena Baranowska-Bosiacka Dariusz Chlubek 《Biological trace element research》2010,137(3):262-279
Research works that would determine the content of chemical elements in black population organisms on the basis of hair analysis
are not numerous. There are no studies referring to black populations living in indigenous environment, like the Mafinga region,
Iringa District in Tanzania examined by us. The aim of the study performed was to analyse the content of chemical elements
Fe, Ca, Mg, Zn and Cu in easily available biological media like hair. The material was collected in October 2005 and March
2006 during anthropological examination, which came from young males (n = 91), students of a secondary school. Large Ca concentration range was found for the total number of subjects (680.20 to
2,089.70 μg/g d.m.). Mean Fe content in hair for the total number of subjects was 11.19 ± 3.70 μg/g d.m., while that of Mg
6.84 ± 2.02 μg/g d.m. Mean Zn concentration for the total number of subjects was 91.06 ± 39.22 μg/g d.m., being significantly
higher in younger group than in older one (p = 0.039). Mean Cu concentration in hair for the total number of subjects was 7.50 ± 2.90 μg/g d.m Body mass index (BMI = kg/m2) was calculated for the subjects showing that out of 91 men participating in the study 15.4% was characterised by mediocre
nutrition. No statistically significant correlations were found between BMI and the analysed chemical elements. The analysis
of the content of trace elements in the hair of the examined young males showed deficiencies in Zn, Cu, Fe and significantly
in Mg. 相似文献
19.
Objective Study the effects of acute and chronic restraint stress on the whole blood concentrations of iron (Fe), zinc (Zn), calcium
(Ca), and magnesium (Mg) in mice.
Materials and methods Single or repeat restraints were applied to mice to induce acute or chronic stress. The levels of elements in whole blood
were determined by flame atomic absorption spectrometry.
Results The levels of Fe, Zn, Ca, and Mg in blood in the acute-stress group were 351, 5.05, 60, and 44 μg/ml, respectively, and those
in the corresponding control group were 391, 5.90, 59, and 45 μg/ml, respectively. The levels of blood Fe, Zn, Ca, and Mg
in the chronic-tress group were 291, 3.62, 59, and 40 μg/ml, respectively, and those in the corresponding control group were
393, 4.82, 48, and 43 μg/ml, respectively. The levels of Fe and Zn in the blood of both the acute-stress and the chronic-stress
groups were significantly lower (P < 0.05) than that in the control groups. The Ca level in whole blood was significantly (P < 0.05) higher in the chronic-stress group than that in the control group.
Conclusion Acute and chronic restraint stress can cause changes in blood levels of Fe and Zn in mice. 相似文献
20.
Khaled M. Al-Qudah Ahmad A. Gharaibeh Maysa’a M. Al-Shyyab 《Biological trace element research》2010,136(1):40-47
The aim of this study was to determine the levels of trace minerals Zn, Cu, and Se, the effect of dermatophytosis on the level
of thiobarbituric acid reactive substances (TBARS) as an indicator of lipid peroxidation, the status of enzymatic and nonenzymatic
antioxidants, and the relationship between the mentioned trace minerals and antioxidant defense system in calves with dermatophytosis.
A total of 21 Holstein calves with clinically established diagnosis of dermatophytosis and an equal number of healthy ones
were included in this study. Results showed that 81% of mycotic isolates were Trichophyton verrucosum, while 19% were Trichophyton mentagrophytes. The level of Zn, Cu, Se, and glutathione (GSH) and the activity of the antioxidant enzymes, glutathione peroxidase (GSH-Px),
and superoxide dismutase (SOD) were significantly (P ≤ 0.05) lower. The plasma level of TBARS was significantly (P ≤ 0.05) higher in dermatophytic calves compared to healthy controls. SOD activity was fairly correlated with serum Cu and
positively correlated with serum Zn in healthy control (r = 0.68, P ≤ 0.05; r = 0.58, P ≤ 0.05) and in calves affected with dermatophytosis (r = 0.73, P ≤ 0.05; r = 0.55, P ≤ 0.05), respectively. GSH-Px activity was highly correlated with whole blood selenium (r = 0.78, P ≤ 0.05) in healthy control and dermatophytic subjects (r = 0.76, P ≤ 0.05). Our results demonstrated that in dermatophytosis, the alteration in the antioxidant enzyme activities might be secondary
to changes in their cofactor concentrations. 相似文献