共查询到20条相似文献,搜索用时 46 毫秒
1.
Ralph Brandenberger Irina Khrebtukova R Scott Thies Takumi Miura Cai Jingli Raj Puri Tom Vasicek Jane Lebkowski Mahendra Rao 《BMC developmental biology》2004,4(1):10
Background
Pooled human embryonic stem cells (hESC) cell lines were profiled to obtain a comprehensive list of genes common to undifferentiated human embryonic stem cells. 相似文献2.
Philip Stegmaier Mathias Krull Nico Voss Alexander E Kel Edgar Wingender 《BMC systems biology》2010,4(1):124
Background
The study of relationships between human diseases provides new possibilities for biomedical research. Recent achievements on human genetic diseases have stimulated interest to derive methods to identify disease associations in order to gain further insight into the network of human diseases and to predict disease genes. 相似文献3.
James T Campanelli Robert W Sandrock Will Wheatley Haipeng Xue Jianhua Zheng Feng Liang Jonathan D Chesnut Ming Zhan Mahendra S Rao Ying Liu 《BMC developmental biology》2008,8(1):102
Background
We have generated gene expression databases for human glial precursors, neuronal precursors, astrocyte precursors and neural stem cells and focused on comparing the profile of glial precursors with that of other populations. 相似文献4.
Nicole Maca-Meyer Ana M González José M Larruga Carlos Flores Vicente M Cabrera 《BMC genetics》2001,2(1):13-8
Background
The phylogeographic distribution of human mitochondrial DNA variations allows a genetic approach to the study of modern Homo sapiens dispersals throughout the world from a female perspective. As a new contribution to this study we have phylogenetically analysed complete mitochondrial DNA(mtDNA) sequences from 42 human lineages, representing major clades with known geographic assignation. 相似文献5.
Background
Streptococcus pneumoniae can be carried asymptomatically in the nasopharynx of its human host but can also cause a wide range of infections. A role for pneumococcal phase variants in the different lifestyles of this bacterium has been suggested but no systematic survey of the colony phenotypes of isolates associated with human infections has been undertaken. 相似文献6.
Background
This study examines the use of a simple thermoregulatory model for the human body exposed to extended (45 minute) exposures to radiofrequency/microwave (RF/MW) energy at different frequencies (100, 450, 2450 MHz) and under different environmental conditions. The exposure levels were comparable to or above present limits for human exposure to RF energy. 相似文献7.
John Brannian Kathleen Eyster Breanne A Mueller Mandi G Bietz Keith Hansen 《Reproductive biology and endocrinology : RB&E》2010,8(1):25
Background
The study was designed to test the hypothesis that granulosa cell (GC) gene expression response differs between recombinant FSH and human menopausal gonadotropin (hMG) stimulation regimens. 相似文献8.
Leticia Labriola Maria G Peters Karin Krogh Iván Stigliano Letícia F Terra Cecilia Buchanan Marcel CC Machado Elisa Bal de Kier Joffé Lydia Puricelli Mari C Sogayar 《BMC cell biology》2009,10(1):49-16
Background
The in vitro culture of insulinomas provides an attractive tool to study cell proliferation and insulin synthesis and secretion. However, only a few human beta cell lines have been described, with long-term passage resulting in loss of insulin secretion. Therefore, we set out to establish and characterize human insulin-releasing cell lines. 相似文献9.
Thomas R Burkard Melanie Planyavsky Ines Kaupe Florian P Breitwieser Tilmann Bürckstümmer Keiryn L Bennett Giulio Superti-Furga Jacques Colinge 《BMC systems biology》2011,5(1):17
Background
On the basis of large proteomics datasets measured from seven human cell lines we consider their intersection as an approximation of the human central proteome, which is the set of proteins ubiquitously expressed in all human cells. Composition and properties of the central proteome are investigated through bioinformatics analyses. 相似文献10.
Karl Z Lukic Bruce Urch Michael Fila Marie E Faughnan Frances Silverman 《Biomedical engineering online》2006,5(1):54
Background
The objective was to determine the repeatability and stability of capnography interfaced with human exposure facility. 相似文献11.
DePrimo SE Diehn M Nelson JB Reiter RE Matese J Fero M Tibshirani R Brown PO Brooks JD 《Genome biology》2002,3(7):research00-12
Background
Androgens are required for both normal prostate development and prostate carcinogenesis. We used DNA microarrays, representing approximately 18,000 genes, to examine the temporal program of gene expression following treatment of the human prostate cancer cell line LNCaP with a synthetic androgen. 相似文献12.
Background
The ability of a gene to cause a disease is known to be associated with the topological position of its protein product in the molecular interaction network. Pleiotropy, in human genetic diseases, refers to the ability of different mutations within the same gene to cause different pathological effects. Here, we hypothesized that the ability of human disease genes to cause pleiotropic effects would be associated with their network properties. 相似文献13.
Roslyn Varki Ed Pequignot Mark C Leavitt Andres Ferber Walter K Kraft 《BMC clinical pharmacology》2009,9(1):2-8
Background
AVI-014 is an egg white-derived, recombinant, human granulocyte colony-stimulating factor (G-CSF). This healthy volunteer study is the first human investigation of AVI-014. 相似文献14.
Yumiko Abe Hiromitsu Sinozaki Takeshi Takagi Takashi Minegishi Koichi Kokame Kenji Kangawa Miki Uesaka Kaoru Miyamoto 《Reproductive biology and endocrinology : RB&E》2006,4(1):27-9
Background
Exposure to dioxins results in a broad range of pathophysiological disorders in human fetuses. In order to evaluate the effects of dioxins on the feto-placental tissues, we analyzed the gene expression in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treated primary cultures of human amniotic epithelial cells. 相似文献15.
Alexander Y Panchin Mikhail S Gelfand Vasily E Ramensky Irena I Artamonova 《Biology direct》2010,5(1):54
Background
Gene duplications are a source of new genes and protein functions. The innovative role of duplication events makes families of paralogous genes an interesting target for studies in evolutionary biology. Here we study global trends in the evolution of human genes that resulted from recent duplications. 相似文献16.
Autocrine regulation of human sperm motility by tachykinins 总被引:1,自引:0,他引:1
Francisco M Pinto Cristina G Ravina Nerea Subiran Antonio Cejudo-Román Manuel Fernández-Sánchez Jon Irazusta Nicolas Garrido Luz Candenas 《Reproductive biology and endocrinology : RB&E》2010,8(1):104
Background
We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa. 相似文献17.
Background
In this study, we have investigated the viscoelastic behaviour of individual human adult bone marrow-derived mesenchymal stem cells (hMSCs) and the role of F-actin filaments in maintaining these properties, using micropipette aspiration technique together with a standard linear viscoelastic solid model. 相似文献18.
19.
Background
In order to take full advantage of the newly available public human genome sequence data and associated annotations, biologists require visualization tools ("genome browsers") that can accommodate the high frequency of alternative splicing in human genes and other complexities. 相似文献20.