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The second-generation antiplatelet agents – the inhibitors of the ADP receptor – have proven important in the management of acute coronary syndromes with or without coronary intervention.  相似文献   

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May we talk about morphogenes as it is actually done about oncogenes? The author reviews some recent experimental discoveries which launch embryology on a new way: rethinking mitosis, studying cell movement and adhesion, neuronal migration, the role of gap-junctions, cell-death programmation. Embryology and genetics are today converging on identic aims, particularly in the fields of the homeotic genes and of transgenic animals.  相似文献   

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Robert Sibley 《CMAJ》2007,177(11):1464
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In search of lost introns   总被引:1,自引:0,他引:1  
Many fundamental questions concerning the emergence and subsequent evolution of eukaryotic exon-intron organization are still unsettled. Genome-scale comparative studies, which can shed light on crucial aspects of eukaryotic evolution, require adequate computational tools. We describe novel computational methods for studying spliceosomal intron evolution. Our goal is to give a reliable characterization of the dynamics of intron evolution. Our algorithmic innovations address the identification of orthologous introns, and the likelihood-based analysis of intron data. We discuss a compression method for the evaluation of the likelihood function, which is noteworthy for phylogenetic likelihood problems in general. We prove that after O(n l) preprocessing time, subsequent evaluations take O(n l/log l) time almost surely in the Yule-Harding random model of n-taxon phylogenies, where l is the input sequence length. We illustrate the practicality of our methods by compiling and analyzing a data set involving 18 eukaryotes, which is more than in any other study to date. The study yields the surprising result that ancestral eukaryotes were fairly intron-rich. For example, the bilaterian ancestor is estimated to have had more than 90% as many introns as vertebrates do now. AVAILABILITY: The Java implementations of the algorithms are publicly available from the corresponding author's site http://www.iro.umontreal.ca/~csuros/introns/. Data are available on request.  相似文献   

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