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A 53 kDa protein binds to the negative regulatory region of JC virus early promoter. 总被引:2,自引:0,他引:2
Using gel retardation and photocrosslinking experiments, we have identified proteins of about 53 kDa in size in both rat glioma (C6) and cervical carcinoma (HeLa) cell extracts which bind to the negative regulatory region of JV virus (JCV) early promoter. The glial cell protein binds to its cognate promoter element with lesser affinity when compared to the protein present in HeLa cells. Further, these proteins interacted differentially to an oligonucleotide, containing the neighboring cis-acting domain, which is recognized by nuclear factor 1 (NF1). These findings suggest that the interactions of the 53 kDa HeLa protein may contribute to the negative regulation of JCV early promoter in HeLA cells. 相似文献
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Perrais M Pigny P Copin MC Aubert JP Van Seuningen I 《The Journal of biological chemistry》2002,277(35):32258-32267
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Schweppe RE Melton AA Brodsky KS Aveline LD Resing KA Ahn NG Gutierrez-Hartmann A 《The Journal of biological chemistry》2003,278(19):16863-16872
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Harris VK Coticchia CM Kagan BL Ahmad S Wellstein A Riegel AT 《The Journal of biological chemistry》2000,275(15):10802-10811