共查询到20条相似文献,搜索用时 15 毫秒
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The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase 总被引:13,自引:0,他引:13
Kirsh O Seeler JS Pichler A Gast A Müller S Miska E Mathieu M Harel-Bellan A Kouzarides T Melchior F Dejean A 《The EMBO journal》2002,21(11):2682-2691
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HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. 总被引:14,自引:0,他引:14
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Audrey H. Wang Nicholas R. Bertos Marko Vezmar Nadine Pelletier Milena Crosato Henry H. Heng John Thng Jiahuai Han Xiang-Jiao Yang 《Molecular and cellular biology》1999,19(11):7816-7827
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Differential localization of HDAC4 orchestrates muscle differentiation 总被引:11,自引:0,他引:11
Miska EA Langley E Wolf D Karlsson C Pines J Kouzarides T 《Nucleic acids research》2001,29(16):3439-3447
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Grégoire S Xiao L Nie J Zhang X Xu M Li J Wong J Seto E Yang XJ 《Molecular and cellular biology》2007,27(4):1280-1295
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Nucleocytoplasmic trafficking of histone deacetylase 4 (HDAC4) plays an important role in regulating its function, and binding of 14-3-3 proteins is necessary for its cytoplasmic retention. Here, we report the identification of nuclear import and export sequences of HDAC4. While its N-terminal 118 residues modulate the nuclear localization, residues 244 to 279 constitute an authentic, strong nuclear localization signal. Mutational analysis of this signal revealed that three arginine-lysine clusters are necessary for its nuclear import activity. As for nuclear export, leucine-rich sequences located in the middle part of HDAC4 do not function as nuclear export signals. By contrast, a hydrophobic motif (MXXLXVXV) located at the C-terminal end serves as a nuclear export signal that is necessary for cytoplasmic retention of HDAC4. This motif is required for CRM1-mediated nuclear export of HDAC4. Furthermore, binding of 14-3-3 proteins promotes cytoplasmic localization of HDAC4 by both inhibiting its nuclear import and stimulating its nuclear export. Unlike wild-type HDAC4, a point mutant with abrogated MEF2-binding ability remains cytoplasmic upon exogenous expression of MEF2C, supporting the notion that direct MEF2 binding targets HDAC4 to the nucleus. Therefore, HDAC4 possesses intrinsic nuclear import and export signals for its dynamic nucleocytoplasmic shuttling, and association with 14-3-3 and MEF2 proteins affects such shuttling and thus directs HDAC4 to the cytoplasm and the nucleus, respectively. 相似文献
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HDAC4 deacetylase associates with and represses the MEF2 transcription factor. 总被引:28,自引:0,他引:28
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E A Miska C Karlsson E Langley S J Nielsen J Pines T Kouzarides 《The EMBO journal》1999,18(18):5099-5107
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A dynamic role for HDAC7 in MEF2-mediated muscle differentiation 总被引:14,自引:0,他引:14
Dressel U Bailey PJ Wang SC Downes M Evans RM Muscat GE 《The Journal of biological chemistry》2001,276(20):17007-17013