The medical profession and congenital malformations (1900-1979)

Physicians' interest in congenital malformations has varied greatly during the last two centuries. After an acme in the 19th century, teratology was of little inteerest to the medical profession during the first four decades of the 20th century. Since then a variety of events have again made birth defects important. An attempt is made to explain the waxing and waning of the physicians' attention to this age-old problem.     

Three thousand years of questioning sex determination

Of all the inborn differences that distinguish individual humans, as well as other animals, sex exerts the most far-reaching effects, and the question, what determines it, has been debated throughout history. A discriminating reading of Biblical and Ancient Greek sources reveals surprising insights that are relevant to present-day biology. The material basis of generation was inaccessible until, following the invention of the microscope and the discovery of "spermatic animalcules" in the 17th century, the 19th century witnessed the discovery of the mammalian egg, the nature of sperm, and the process of fertilization. Sex was thought to be determined by external conditions. The 20th century developed the genetics of sex determination. The search for the mammalian testis-determining gene during the last quarter century culminated in the discovery of SRY, soon to be accompanied by non-Y chromosome sex- determining genes. During the same period, data accumulated that testicular differentiation was accompanied by accelerated gonadal growth; subsequently, differences in growth were shown to distinguish early XX from early XY embryos. Other research showed that temperature-dependent sex determination was widely distributed among reptiles, thus illustrating that the mammalian system of sex determination is of recent evolutionary origin, adopted in response to homoiothermy and placentation. The recent discovery that Sry induces cell proliferation in the gonads of fetal mice suggests that the task for the 21st century will be to aim beyond simple genotype/phenotype correlations by unraveling the relationship between genes and epigenetic factors acting on cell growth during development and affecting the phenotype in later life.     

Water level fluctuations in Lake Baringo,Kenya, during the 19th and 20th centuries: Evidence from lake sediments

This article presents a fossil diatom-based, semi-quantitative reconstruction of water level fluctuations for Lake Baringo over the past 200 years as a consequence of climatic variations. A 285 cm long sediment core sample was collected using a Rod-Operated Single-drive Stationary Piston corer. Lake level was inferred using indices based on the proportion of planktonic to benthic diatom taxa (P/B ratio). The sediment archive presented distinct zones dominated by planktonic and benthic diatom flora. An initial transgression in the early 19th century was characterised as a shallow water environment dominated by planktonic Aulacoseira spp. This was a response to extreme drought during the late 18th to early 19th century. Mid-19th century was defined by a high lake stand. The late 19th to early 20th centuries experienced low water level following the widely documented aridity at the time. The mid-20th century was marked by a spectacular rise in water level that coincided with remarkably wet years during the early 1960s and late 1970s. The first decade of the 21st century witnessed widespread changes in water level. The proxy records show that lake ramping and drawdown over the years follow approximately 50-year climatic cycles.     

Vinegar: medicinal uses and antiglycemic effect

Vinegar folklore is as colorful as it is practical. Legend states that a courtier in Babylonia (c. 5000 BC) "discovered" wine, formed from unattended grape juice, leading to the eventual discovery of vinegar and its use as a food preservative. Hippocrates (c. 420 BC) used vinegar medicinally to manage wounds. Hannibal of Carthage (c. 200 BC), the great military leader and strategist, used vinegar to dissolve boulders that blocked his army's path. Cleopatra (c. 50 BC) dissolved precious pearls in vinegar and offered her love potion to Anthony. Sung Tse, the 10th century creator of forensic medicine, advocated hand washing with sulfur and vinegar to avoid infection during autopsies. Based on the writings of US medical practitioners dating to the late 18th century, many ailments, from dropsy to poison ivy, croup, and stomachache, were treated with vinegar, and, before the production and marketing of hypoglycemic agents, vinegar "teas" were commonly consumed by diabetics to help manage their chronic aliment. This review examines the scientific evidence for medicinal uses of vinegar, focusing particularly on the recent investigations supporting vinegar's role as an antiglycemic agent. Epidemiologic studies and clinical trials were identified by a MEDLINE title/abstract search with the following search terms: vinegar, glucose; vinegar, cancer; or vinegar, infection. All relevant randomized or case-control trials were included in this review.     

The linking of polyp and medusa stages in Obelia and other coelenterates

Although medusa-release was first seen in Obelia in the mid-18th century (Baster, 1762b), the true nature of medusa-release in any coelenterate was not understood until Sars' (1829) observations on a scyphozoan scyphistoma. A flourish of work followed during which many coelenterate life-cycles were worked out, that of Obelia being among the first (by van Beneden, 1843). The impact on some areas of zoological thought of the mid-19th century was considerable. Around the 1880s Obelia became used in teaching to illustrate and introduce the concept of alternation of generations and, alongside Hydra , as a "type" example of the Hydrozoa and of the Coelenterata. It remained important as a teaching organism for many years.     

The Iron Age in the Mrągowo Lake District,Masuria, NE Poland: the Salęt settlement microregion as an example of long-lasting human impact on vegetation

Pollen, non-pollen palynomorphs, charcoal and geochemical analyses of sediments from Lake Sal?t (NE Poland) were used to reconstruct vegetation changes related to the activity of the West Balt tribes during the Iron Age, in the period between the second half of the 7th century bc and the beginning of the 10th century ad. We distinguished five phases of human impact on environment. Woodland clearing around the studied lake started at the end of the 7th century bc. The most characteristic feature of this area during the whole Iron Age was a very high representation of semi-natural Betula woodlands, which was probably linked to a shifting agriculture. This type of land use lasted for over 1,500 years, until the second half of the 9th century ad. The greatest reduction in Betula woodlands took place between cal. years 650 and 450 bc. Its regeneration took place after ca. ad 830 when human activity decreased.     

Evolution of evolutionary physiology

In 19th century and at the beginning 20th century, reports appeared in the field of comparative and ontogenetic physiology and the value of these methods for understanding of evolution of functions. The term "evolutionary physiology" was suggested by A. N. Severtsov in 1914. In the beginning of 30s, in the USSR, laboratories for researches in problems of evolutionary physiology were created, the results of these researches having been published. In 1956 in Leningrad, the Institute of Evolutionary Physiology was founded by L. A. Orbeli. He formulates the goals and methods of evolutionary physiology. In the following half a century, the evolutionary physiology was actively developed. The evolutionary physiology solves problems of evolution of function of functions evolution, often involving methods of adjacent sciences, including biochemistry, morphology, molecular biology.     

Man, vegetation and climate during the Holocene in the territory of Sagalassos, Western Taurus Mountains, SW Turkey

Past vegetation change and the influence of climate change and anthropogenic pressure during the Holocene is constructed from a series of palynological records sampled from three locations within the territory of the antique site of Sagalassos. The disappearance of the original deciduous oak woodlands and increases in anthropogenic indicator species around 5300 and 4300 b.c. correspond with an increase in settlements in the region. A period of drought following the deforestation may have hampered the recovery of deciduous oak. The timing of the onset of the Bey?ehir Occupation Phase (BO-Phase) in the territory differs between locations, estimates ranging from ca. 1000–800 b.c. to the start of the Hellenistic period (334 b.c.). The most intense period of arboriculture coincides with the Roman and late-Roman periods. Increases in human pressure on the landscape as reflected in the pollen record correspond with an increased rate of sedimentation and fire activity. The timing of the end of the BO-Phase again differs between locations. Estimates range from the 4th century a.d. to the mid 7th century a.d., when a region-wide shift to dry environmental conditions is observed. Numerical analyses show that post BO-Phase vegetation change is largely driven by climate and displays a succession of dry and wet periods that coincided with well-defined European climate shifts, including the Medieval Climate Anomaly and the Little Ice Age. Current agricultural activities in the region are of a very recent (20th century) origin.     

Influences of infrequent fire, elevation and pre-fire vegetation on the persistence of quaking aspen (Populus tremuloides Michx.) in the Flat Tops area, Colorado, USA

Aim  The recent concern that quaking aspen ( Populus tremuloides Michx.) has been declining in parts of western North America due to fire suppression is largely based on trends during the latter part of the 20th century. The aim of the current study was to compare the extent of aspen in the modern landscape with its extent in the late 19th century prior to fire suppression, and to assess the effects of elevation, late-19th century fires, and pre-fire forest composition on the successional status of aspen.
Location  North-west Colorado, USA.
Methods  We used a georeferenced 1898 map and modern maps to examine trends in aspen dominance since the late 19th century in a 348,586 ha area of White River and Routt National Forests in north-western Colorado. Stand age and structure were sampled in 30 stands.
Results  We found no evidence of overall aspen decline over this period. In fact, aspen distribution has increased in parts of the study area following severe fires in the late 19th century in forests that were previously dominated by conifers. Aspen persistence and increase was especially pronounced at elevations below 3000 m a.s.l. Most 120-year-old post-fire stands that are presently being successionally replaced by conifers were dominated by conifers prior to the last severe fire.
Main conclusions  Human perceptions of ecosystems are often on time scales that are shorter than the cycles of natural variation within those ecosystems. This disparity may lead to an underestimation of the range of natural variability of ecosystem patterns and processes. The appropriate temporal scale of inquiry is necessary for the correct understanding of natural variation in ecosystems.     

Re-evaluating the Silk Road's Qinghai Route using dendrochronology

The opening of the Silk Road vigorously promoted economic and cultural exchanges between Central Asia, Europe, northern India and China. The easternmost section of the ancient trade route was established during the Qin-Han period (221 BC to 220 AD). Previous research has shown that there were three routes: the first is known as the “Hexi Route”, the second is known as the “Juyan Route” or “Prairie Route”, and the third is known as the “Qinghai Route”. The Qinghai Route has long been viewed as merely an auxiliary line of the Hexi Route which was used when the main Hexi Route was blocked by warfare. Others believe that the Qinghai Route was used during the 5th to 6th century when it was controlled by Tuyuhun Kingdom. Yet, by the 7th to 8th century, after the Tibetan occupation of the region, it was no longer a main trade route. Dendrochronology, the study of tree-rings, is a precise dating method that can be accurate to the year. In this study, wood remains excavated from tombs along the ancient Qinghai Route were studied by the means of dendrochronology in order to determine the date and better understand when Qinghai Route was used. In the tombs a lot of commercial goods such as silk products, pottery, lacquer carpentry were found. The date of the tombs determined by dendrochronology when viewed together with other archaeological data, showed that from the early Tang Dynasty to the High Tang Dynasty (early 7th century to late 8th century), the Qinghai Route was one of the routes of communication between the West and China. This disproves the hypothesis that this route was only used during the 5th to 6th century.     

Low twinning rate and seasonal effects on twinning in a fertile population,the Hutterites

This paper analyzes from the mid 18th century to 1987 the birth records of the Dariusleut, one of the three subgroups of the Hutterite population. The aim of this study is to describe several aspects of the twinning rate in a fertile population. The overall rate of twinning was 0.90%:103 twins among all 11492 maternities. The rate peaked at the 7th birth order and at the maternal age of 40 years and over. Until the mid 19th century when the Hutterites lived in Russia, the twinning rate was higher (1.5%), and it decreased during the migration period in the second half of the 19th century (0.7%). After the group had settled in the USA and Canada, the population maintained a twinning rate of 1.0% until 1965. After 1965 the rate decreased to 0.7%, partly due to a decline in fertility among women aged 30 years and over. There was a significant seasonal variation: the twinning rate decreased to 0.5% in May–July compared to 1.2% for the other three seasons during the years up to 1965 (P<0.01), while more recent mothers did not show such a seasonal variation. The incidence of twin births in this population seems to have been influenced by environmental factors, which would change their effect seasonally and secularly.     

High throughput, multiplexed pathogen detection authenticates plague waves in medieval Venice, Italy

Background

Historical records suggest that multiple burial sites from the 14th–16^th centuries in Venice, Italy, were used during the Black Death and subsequent plague epidemics.

Methodology/Principal Findings

High throughput, multiplexed real-time PCR detected DNA of seven highly transmissible pathogens in 173 dental pulp specimens collected from 46 graves. Bartonella quintana DNA was identified in five (2.9%) samples, including three from the 16th century and two from the 15th century, and Yersinia pestis DNA was detected in three (1.7%) samples, including two from the 14th century and one from the 16th century. Partial glpD gene sequencing indicated that the detected Y. pestis was the Orientalis biotype.

Conclusions

These data document for the first time successive plague epidemics in the medieval European city where quarantine was first instituted in the 14th century.     

On the natural polymorphism of pollen grains of Acer tataricum L.

To study natural polymorphism, pollen grains should be collected from ecologically clean sites. Taking the ecological conditions at the end of the 19th century and at the beginning of the 20th century as more favorable than the modern state, herbarium material (LE) was examined. In addition to typical (normally developed) pollen grains, we found two more morphological types within the range of natural polymorphism of pollen grains of Acer tataricum L. that were produced at the end of the 19th century and at the beginning of the 20th century.     

A test for heterozygocity of 21-hydroxylase deficiency

Summary The urinary excretion of steroids was studied in 8 parents of children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency of the simple virilizing and of the salt-losing type. Eight parents of normal children served as controls. 24-hour urines before and after the injection of 40 IU of ACTH were fractionated using gas liquid chromatography on glass capillary columns.Before stimulation no excretion of pregnanetriolone was detected in heterozygous and in normal parents. Following ACTH only heterozygotes showed an excretion of pregnanetriolone in the urine. This averaged 289 g per 24 h.Employing gas liquid chromatography on glass capillary columns heterozygous carriers of congenital adrenal hyperplasia due to 21-hydroxylase deficiency may reliably be detected by their increased urinary excretion of pregnanetriolone following ACTH.Supported by Deutsche Forschungsgemeinschaft, SFB 87, Project C₃.Presented in part at the Annual Meeting of the European Society for Paediatric Research, Budapest, August 21st–24th, 1975.     

Recent environmental change in North African wetland lakes: diatom and other stratigraphic evidence from nine sites in the CASSARINA Project

All nine wetland lakes in the CASSARINA North African suite of sample sites have been disturbed strongly by human activity during the 20th century. Dated lake sediment core were used to provide evidence of the extent of recent environmental change at each site. Sedimentary diatoms at seven sites were useful for inferring salinity change trends during the last century. At two sites preservation problems severely degraded the sedimentary diatom record. Sediment core integrity was otherwise established.Lithostratigraphic measurements indicated some site specific changes in soil erosion and sediment composition but, for the Egyptian Delta lakes, no physical signal synchronous with Aswan High Dam construction was found. Sedimentary diatom assemblages were generally site characteristic and halophilous taxa were common. At two sites planktonic diatoms indicated some recent eutrophication but generally the assemblages were more indicative of salinity changes. Diatom-inferred salinity trends for the seven sites typically indicated that reductions in water salinity occurred sometime during the early or mid 20th century.Rather than climate, hydrological modification of water resources is implicated as the primary driver of salinity changes during most of the 20th century. In the western North African region these modifications were mainly local land drainage and water diversion programmes to alleviate winter flooding and/or promote summer water availability. In the Delta region, the Nile has been intensively exploited since antiquity and intensively so from the late 19th century to release more fresh water for agriculture. Here, diatom records indicate that freshening began well before the Aswan High Dam but salinity fluctuations have tended to diminish during the latter part of the 20th century. A small reversal in the water freshening trend in the 1980/90s was possibly a response to land subsidence/sea-level change or to reduced freshwater supply.Freshwater supply to the sites is generally diminishing as former freshwater surpluses switch to deficit. One site (Merja Bokka, Morocco) became completely dry in 1998 as agriculture encroached and Megene Chitane, the only acid lake in Tunisia, is currently affected by excessive inflow abstraction. At the beginning of the 21st century, eight of the nine CASSARINA sites persist as viable but modified aquatic ecosystems. They nevertheless continue to support valuable aquatic biodiversity, especially in the Delta sites and in Chitane. The modern diatom communities are clearly tolerant of considerable environmental change but the remaining sites are increasingly threatened by major hydrological disturbance. Base-line floristic data for the late 20th century are given but continuous biomonitoring combined with effective management is needed urgently to help conserve North Africa's diminishing natural wetland lake resources.     

Hindcasting of nutrient loadings from its catchment on a highly valuable coastal lagoon: the example of the Fleet, Dorset, UK, 1866–2004

Background

Nutrient loadings from its catchment upon The Fleet, a highly valuable coastal lagoon in Southern England, were hindcast for the period AD 1866–2004, using a catchment model, export coefficients, and historical data on land use changes, livestock numbers, and human population. Agriculture was the main nutrient source throughout, other inputs representing minor contributions. Permanent pasture was historically the main land use, with temporary grassland and cereals increasing during the mid-20th century. Sheep, the main 19th century livestock, were replaced by cattle during the 1930s.

Results

Total nitrogen loadings rose from ca 41 t yr-1 during the late 19th century to 49–54 t yr-1 for the mid-20th, increasing to 98 t yr-1 by 1986. Current values are ca 77 t yr-1. Total phosphorus loads increased from ca 0.75 t yr-1 for the late 19th century to ca 1.6 t yr-1 for the mid-20th, reached ca 2.2 t yr-1 in 1986, and are now ca 1.5 t yr-1. Loadings rose most rapidly between 1946 and 1988, owing to increased use of inorganic fertilisers, and rising sheep and cattle numbers. Livestock were the main nutrient source throughout, but inputs from inorganic fertilisers increased after 1946, peaking in 1986. Sewage treatment works and other sources contribute little nitrogen, but ca 35% of total phosphorus. Abbotsbury Swannery, an ancient Mute Swan community, provides ca 0.5% of total nitrogen, and ca 5% of total phosphorus inputs.

Conclusion

The Fleet has been grossly overloaded with nitrogen since 1866, climaxing during the 1980s. Total phosphorus inputs lay below 'permissible' limits until the 1980s, exceeding them in inner, less tidal parts of the lagoon, during the 1940s. Loadings on Abbotsbury Bay exceeded 'permissible' limits by the 1860s, becoming 'dangerous' during the mid-20th century. Phosphorus stripping at point sources will not significantly reduce loadings to all parts of the lagoon. Installation of 5 m buffer strips throughout the catchment and shoreline will marginally affect nitrogen loadings, but will reduce phosphorus inputs to the West Fleet below 'permissible' limits. Only a combination of measures will significantly affect Abbotsbury Bay, where, without effluent diversion, loadings will remain beyond 'permissible'.     

历史上向"天朝"上贡对滇南犀牛灭绝和亚洲象濒危过程的影响

根据有关历史资料的统计分析,在元朝以后,滇南各土司向天朝上贡的犀角估算有79～123支,并在清朝于18世纪末19世纪初犀牛就成为濒于灭绝的物种,而最后的一头犀牛是在1957年在滇南被捕杀。滇南各土司在元朝以后向天朝上贡的大象估算有1140～1339头、象牙38～76支,加上大象和犀牛被用于频繁的战争,它在17世纪中期就处于濒危的状态。因而,向天朝上贡这一特殊的人文因素是大象和犀牛在滇南濒危和灭绝的重要原因之一。虽然犀牛已在滇南灭绝,但从现代的生态环境来说,实现再引种是可能的。     

The environmental and cultural contexts of the late Iron Age and medieval settlement in the Mazurian Lake District,NE Poland: combined palaeobotanical and archaeological data

Pollen analysis of sediments from three lakes and analysis of plant macroremains including charcoal from archaeological sites in the Mazurian Lake District provide new data for the reconstruction of vegetation changes related to human activity between the 1st and 13th century ad. At that time settlements of the Bogaczewo culture (from the turn of the 1st century ad to the first part of the 5th century ad), the Olsztyn Group (second part of the 5th century ad to the 7th or beginning of the 8th century ad), and the Prussian Galinditae tribes (8th/9th–13th century ad) developed. The most intensive woodland clearing occurred between the 1st and 6th/7th century ad. Presence of Cerealia-type, Secale cereale and Cannabis-type pollen, as well as macroremains of Hordeum vulgare, S. cereale, Triticum spelta, T. cf. monococcum, T. cf. dicoccum, Avena sp. and Panicum miliaceum documented local agriculture. High Betula representation synchronous with microcharcoal occurrence suggests shifting agriculture. After forest regeneration between c. ad 650 and 1100, the area was strongly deforested due to the early medieval occupation by Prussian tribes. The archaeobotanical examination of samples taken in a cemetery and a large settlement of the Roman Iron Age revealed strong differences in the taxonomic composition of the fossil plant remains. An absolute dominance of birch charcoal in the samples from the cemetery indicates its selective use for funeral pyre construction. There is a difference between cereals found in both contexts: numerous grains of Triticum have been found in the cemetery, while in the settlement crops were represented mostly by Secale and Hordeum. Grass tubers, belonging probably to Phleum pratense, are among the particularly interesting plant remains found in the cemetery.     

Mirko Drazen Grmek: the genesis of scientific fact and archaeology of disease

Professor Mirko Drazen Grmek (Krapina 1924--Paris 2000) was one of the most prominent Croatian scientists. Work in history of science directed him to the crossroads of various fields placing his approach in anthropological perspective. Two models will serve as illustrations of his main theories. The historical reconstruction of scientific discovery (mostly on examples of 17th century) will be presented as well as Grmek's ideas on a concept of disease. The introduction of the term "memoricide" within his activities during aggression on Croatia is mentioned.