Influence of phosphorohydrazone derivatives of benzopyrones on polymerization and viscosity of fibrin

The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity.     

寡聚脱氧核苷酸的结构与抗降解特性的研究

合成了４段具有不同高级结构或不同修饰的寡聚脱氧核苷酸,检查它们在２０％血清中的稳定性．发现：（１）寡核苷酸主要被血清中的３′外切核酸酶降解,未经修饰的线性寡核苷酸降解严重;（２）末端部分硫代修饰的寡核苷酸稳定性明显提高;（３）自身互补形成的配对结构可有效保护３′末端．具有４个以上（含４个）ＧＣ对的３′端发夹结构寡核苷酸,其抗核酸酶的能力几乎与硫代修饰的寡核苷酸相当．