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Phosphorylation of cellular proteins regulates their binding to the cAMP response element 总被引:7,自引:0,他引:7
A Merino L Buckbinder F H Mermelstein D Reinberg 《The Journal of biological chemistry》1989,264(35):21266-21276
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1. The data herein reveal the existence of cAMP-responsive element (CRE)-binding factors (CRF) in the nuclear extracts from cAMP-treated rat liver. 2. DNAase I and DMS footprinting analysis showed that the CRFs protected the CRE (-77 to -92) in the phosphoenolpyruvate carboxykinase (PEPCK) promoter and the TGACGTCA motif in a consensus oligodeoxynucleotide based on the sequence of the CRE's of 6 cAMP-regulated genes (C32mer). 3. Competition assays indicate that the CRF(s) is a CGTCA-specific, ATF/CREB-like factor(s). 4. Southwestern (SW) blot analysis detected 2 apparent CRFs which have molecular weights of about 30 and 32 kDa, respectively. 5. Based on the comparison of the size and binding specificity of the CRFs with the CREBs reported to date, the CRFs appear to be novel CRE-binding nuclear factors. 相似文献
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A CRE/ATF-like site in the upstream regulatory sequence of the human interleukin 1 beta gene is necessary for induction in U937 and THP-1 monocytic cell lines. 下载免费PDF全文
J G Gray G Chandra W C Clay S W Stinnett S A Haneline J J Lorenz I R Patel G B Wisely P J Furdon J D Taylor et al. 《Molecular and cellular biology》1993,13(11):6678-6689