Gene finding in novel genomes

Background  

Computational gene prediction continues to be an important problem, especially for genomes with little experimental data.     

Intermediate filament-co-localized molecules with myosin heavy chain epitopes define distinct cellular domains in hair follicles and epidermis

Background  

Proteins linking intermediate filaments to other cytoskeletal components have important functions in maintaining tissue integrity and cell shape.     

Preferred analysis methods for Affymetrix GeneChips revealed by a wholly defined control dataset

Background  

As more methods are developed to analyze RNA-profiling data, assessing their performance using control datasets becomes increasingly important.     

Discovery of protein-protein interactions using a combination of linguistic,statistical and graphical information

Background  

The rapid publication of important research in the biomedical literature makes it increasingly difficult for researchers to keep current with significant work in their area of interest.     

MochiView: versatile software for genome browsing and DNA motif analysis

Background  

As high-throughput technologies rapidly generate genome-scale data, it becomes increasingly important to visually integrate these data so that specific hypotheses can be formulated and tested.     

Use of historic metabolic biotransformation data as a means of anticipating metabolic sites using MetaPrint2D and Bioclipse

Background  

Predicting metabolic sites is important in the drug discovery process to aid in rapid compound optimisation. No interactive tool exists and most of the useful tools are quite expensive.     

Dynamics of a disabled population in Morocco

Background  

The disabled population constitutes a class of people needing special care and necessitating important economic and social effort.     

Simplifying gene trees for easier comprehension

Background  

In the genomic age, gene trees may contain large amounts of data making them hard to read and understand. Therefore, an automated simplification is important.     

Propagation velocity profile in a cross-section of a cardiac muscle bundle from PSpice simulation

Background  

The effect of depth on propagation velocity within a bundle of cardiac muscle fibers is likely to be an important factor in the genesis of some heart arrhythmias.     

Identification of metabolic system parameters using global optimization methods

Background  

The problem of estimating the parameters of dynamic models of complex biological systems from time series data is becoming increasingly important.     

Bridging the phenotypic gap: Real-time assessment of mitochondrial function and metabolism of the nematode <Emphasis Type="Italic">Caenorhabditis elegans</Emphasis>

Background  

The ATP levels of an organism are an important physiological parameter that is affected by genetic make up, ageing, stress and disease.     

Biochemical responses and oxidative stress in <Emphasis Type="Italic">Francisella tularensis</Emphasis> infection: a European brown hare model

Background  

The aim of the present study was to investigate biochemical and oxidative stress responses to experimental F. tularensis infection in European brown hares, an important source of human tularemia infections.     

Comparison of estrogens and estrogen metabolites in human breast tissue and urine

Background  

An important aspect of the link between estrogen and breast cancer is whether urinary estrogen levels are representative of the intra-tissue levels of bioavailable estrogens.     

New statistical potential for quality assessment of protein models and a survey of energy functions

Background  

Scoring functions, such as molecular mechanic forcefields and statistical potentials are fundamentally important tools in protein structure modeling and quality assessment.     

Exercise-induced up-regulation of MMP-1 and IL-8 genes in endurance horses

Background  

The stress response is a critical factor in the training of equine athletes; it is important for performance and for protection of the animal against physio-pathological disorders.     

LOSITAN: A workbench to detect molecular adaptation based on a <Emphasis Type="Italic">F</Emphasis><Subscript><Emphasis Type="Italic">st</Emphasis></Subscript>-outlier method

Background  

Testing for selection is becoming one of the most important steps in the analysis of multilocus population genetics data sets. Existing applications are difficult to use, leaving many non-trivial, error-prone tasks to the user.     

Regions important for the adhesin activity of <Emphasis Type="Italic">Moraxella catarrhalis</Emphasis> Hag

Background  

The Moraxella catarrhalis Hag protein, an Oca autotransporter adhesin, has previously been shown to be important for adherence of this respiratory tract pathogen to human middle ear and A549 lung cells.     

Automatic noninvasive measurement of systolic blood pressure using photoplethysmography

Background  

Automatic measurement of arterial blood pressure is important, but the available commercial automatic blood pressure meters, mostly based on oscillometry, are of low accuracy.     

Identification of biomolecule mass transport and binding rate parameters in living cells by inverse modeling

Background  

Quantification of in-vivo biomolecule mass transport and reaction rate parameters from experimental data obtained by Fluorescence Recovery after Photobleaching (FRAP) is becoming more important.