湖北郧西黄龙洞古人类遗址2006年发掘报告

2004—2005年,在湖北省郧西县境内的黄龙洞的两次发掘中,发现了5枚人类牙齿化石、20余件石制品及大量的动物化石。初步分析显示这是一处重要的更新世晚期的人类遗址。我们在2006年对该遗址进行了第三次发掘,又发现了2枚人类牙齿化石、11件古人类打制的石制品与6件骨制工具、1500余件动物化石以及其它古人类活动证据。野外工作期间我们还对黄龙洞洞穴堆积及山体地貌的考察,在此基础上对该洞穴发育及古人类在洞穴内的生活状况进行了初步推测。本文介绍了2006年的野外工作情况。     

江苏镇江莲花洞中、晚更新世人类化石地点的新材料

2001年对镇江莲花洞进行了第二次考古发掘,从洞内首次获7件石制品和一批哺乳动物化石。5件石核和2件刮削器分别用石英和火成岩制成,初步判断属于旧石器时代中期或稍早,文化面貌似与上世纪末在苏南地区发现的旧石器早、中期文化略有不同。根据对第2、3堆积层间的新生碳酸盐岩并参考动物化石的铀系年代测定,主要含化石的第2层年代应在～100-300ka之间,相当于中更新世晚期到晚更新世早期。由地层堆积、出土石制品和动物化石等埋藏情况分析,莲花洞不是人类的长期居址,很可能只是一处临时停留地。     

吉林榆树大桥屯发现的旧石器

在大桥屯地点发现17件石制品、两件骨制品和15种哺乳动物化石。石器以刮削器为主。打片技术都是采用锤击直接打法。修理工具的方式以向背面加工为主,反映了我国北方打击石器的传统修理方式。骨制品中一件系用猛犸象门齿残片制作的刮削器,属首次发现。     

吉林桦甸寿山仙人洞旧石器遗址试掘报告

本文记述了吉林烨甸寿山仙人洞遗址试掘所发现的４７件石制品及伴生动物化石１２种．依动物化石和石器特征分析,将其地质时代暂定为晚更新世后段,考古年代为旧石器时代晚期．１９９１年５—６月间．吉林大学考古学系在吉林地区进行旧石器野外考古调查时,在桦甸市榆木桥子镇发现了寿山仙人洞旧石器时代遗址,并进行了试掘,在距洞口７米处开了一个横向１×３米深沟,出土了较丰富的文化遗物：４７件石制品,少量的骨制品,以及大量的哺乳动物化石和一些鸟类化石．     

湖北郧西白龙洞古人类遗址初步研究

湖北省郧西县白龙洞遗址经过两次正式发掘,出土了古人类牙齿化石、石制品、骨制品等文化遗物和大量动物化石,是一处重要的古人类遗址.2007年4-5月,作者在该遗址周围进行了地质、地貌调查,并对以往发掘出土的部分动物化石和文化遗物进行了整理.同年9月,作者在白龙洞进行探察和小规模试掘,出土大量动物化石和少量石制品、骨制品等文化遗物.同时还发现可疑燃烧痕迹、动物骨骼表面痕迹以及特殊的动物化石埋藏现象等古人类活动证据.白龙洞发育于上新世沙坪组砾岩、泥晶灰岩和泥灰岩地层中,近水平状节理和裂隙为洞穴发育提供前提条件,垂直渗流为溶蚀的主要方式.白龙洞遗址属原地埋藏,动物群的组合显示中更新世早期的面貌,石英岩岩脉原料可能是导致石器工业组合显示北方石器工业面貌的原因.对遗址分布及埋藏现象的初步分析显示,白龙洞为一处多功能的古人类活动遗址.     

山西和顺当城旧石器时代洞穴遗址群初步研究

山西和顺当城旧石器时代洞穴遗址群出土了三千余件石制品,23种哺乳动物化石,两块人类顶骨。根据动物化石及^14C同位素年代测定;时代为晚更新世或旧石器时代晚期,该遗址群的发现,对于研究华北地区古人类及各旧石器文化间的关系,提供了新材料。     

安徽芜湖金盆洞旧石器地点2002年发掘报告

2001年春季,在安徽芜湖石硊镇发现了,一处富含脊椎动物化石的称为金盆洞的洞穴堆积。翌年秋季,对金盆洞化石点进行了为期1个月的野外地质调查和化石发掘,发现人工石制品和哺乳动物化石共伴,收集到10余件人工制品和3千余件哺乳动物化石,初步搞清了这一地点的地层、化石种类分布及其时代。经初步研究,金盆洞出土的动物化石可以归入8个目18个科23个属27个种哺乳动物;该动物群与和县龙潭洞的动物群最接近,其次为南京汤山葫芦洞的动物群较接近,其生存时代很可能是中更新世晚期。金盆洞旧石器地点的发现进一步证明了长江下游石灰岩地区的洞穴和裂隙堆积中具有发现史前人类活动遗迹的潜力。     

河南新郑黄帝口遗址2009年发掘简报

河南新郑观音寺镇黄帝口是一处旧石器时代晚期遗址。2006年调查发现后经过当年和2009年两次发掘。2009年发掘出土了76件石制品及75件动物化石,分别出自第3、4、5层,其中以第5层的发现居多。石制品原料以石英为主,个体较小, 砸击法与锤击法并用,类型包括石核、石片、石器及断块等。其中石器3件, 分别为刮削器和尖状器。石制品面貌属北方小石器工业传统。动物化石以鹿类、食肉类和啮齿类居多, 其中少数具有人工痕迹。遗物和堆积状况表明, 黄帝口遗址为一处人类的短暂活动场所。     

“长阳人”的“老邻居”

自1956年在湖北省长阳县下钟家湾龙洞中发现长阳人化石以来,考古工作者无时不在关心长阳人的来龙去脉,寻找长阳人的文化遗物,探究长阳人的文化面貌。他们爬山梁,涉江汉,攀悬崖,钻洞穴,努力在江汉流域寻找新线索和新的材料,然而收效甚微。好象长阳人有意开玩笑一样,在下钟家湾留下了泥鸿指爪之后便悄然隐逝,使我们今天无处追寻其踪迹。过了十五年,1971年冬,在大冶石龙头发现一处裂隙,从残存的堆积物中发现石制品近百件,哺乳动物化石共八种。此处没有发现人类化石材料,地点离长阳又比较远,使我们很难与长阳人联系起来研究。又过了十年,1980年初,在长阳果酒岩发现一批人类化石,可惜的是都很破碎,又缺乏有时代意义的动物化石和文化遗物,也难以和长阳人进行比较研究。整整过去三十年了,终于有了新的发现,使我们     

广东韶关马坝发现的早期古人类型人类化石

1958年6月,广东韶关(原曲江县)马坝农民挖掘当地狮子山石灰岩洞穴中的堆积作肥料时,发现了一个人类头骨化石和许多动物化石,发现经过和对人类化石以及动物化石的初步观察,广东省博物馆和梁钊韬、李见賢已先后有文章发表。狮子山位于韶关市马坝乡西南约1.5公厘处,为由石炭纪石灰岩的两个孤峯(狮头峯     

Crystal structure, detonation performance, and thermal stability of a new polynitro cage compound: 2, 4, 6, 8, 10, 12, 13, 14, 15-nonanitro-2, 4, 6, 8, 10, 12, 13, 14, 15-nonaazaheptacyclo [5.5.1.13, 11. 15, 9] pentadecane

A new polynitro cage compound 2, 4, 6, 8, 10, 12, 13, 14, 15-nonanitro-2, 4, 6, 8, 10, 12, 13, 14, 15-nonaazaheptcyclo [5.5.1.1(3,11).1(5,9)] pentadecane (NNNAHP) was designed in the present work. Its molecular structure was optimized at the B3LYP/6-31 G(d,p) level of density functional theory (DFT) and crystal structure was predicted using the Compass and Dreiding force fields and refined by DFT GGA-RPBE method. The obtained crystal structure of NNNAHP belongs to the P-1 space group and the lattice parameters are a = 9.99 ?, b = 10.78 ?, c = 9.99 ?, α = 90.01°, β = 120.01°, γ = 90.00°, and Z = 2, respectively. Based on the optimized crystal structure, the band gap, density of state, thermodynamic properties, infrared spectrum, strain energy, detonation characteristics, and thermal stability were predicted. Calculation results show that NNNAHP has detonation properties close to those of CL-20 and is a high energy density compound with moderate stability.     

Distribution of N,P, K,Ca, Mg,S, Zn,Fe, Mn and Cu in groundnut

Summary Concentration of N, P, K, Ca, Mg and S in summer groundnut crop was higher than in kharif while Zn, Fe, Mn and Cu contents were higher in summer crop. Kernel's N, P and Zn; Leaflet's Ca and Mn; Stem's K and Fe; Root's S and Cu and Petiole's Mg contents were highest. Shell's N, P, K, Mg, S, Zn and Cu; Kernel's Ca, Fe and Mn contents were the least. N, P, K, S, Zn and Cu concentrations decreased linearly as the crop grew. Ca, Mg, Fe and Mn concentrations did not display any distinct pattern. Ca concentration was positively correlated with pod yield in both the seasons.     

Simultaneous measurement of the trace elements Al, As, B, Be, Cd, Co, Cu, Fe, Li, Mn, Mo, Ni, Rb, Se, Sr, and Zn in human serum and their reference ranges by ICP-MS

The goal of this article was to establish reference ranges of the concentration of trace elements in human serum and to compare these results with those reported by other authors. We describe the sample preparation and measurement conditions that allow the rapid, precise, and accurate determination of Al, As, B, Be, Cd, Co, Cu, Fe, Li, Mn, Mo, Ni, Rb, Se, Sr, and Zn in human serum samples (n=110) by inductively coupled plasma-mass spectrometry (ICP-MS). Accuracy and precision were determined by analyzing three reconstituted reference serum samples by comparison with other methods and by the standard addition procedure. The advantages of the ICP-MS method include short time of analysis of the elements mentioned, low detection limit, high precision, and high accuracy. Disadventages include a high risk of contamination due to the presence of some of the elements of interest in the environment, the relatively delicate sample handling, and the high cost of the equipment.     

Reference values for the concentrations of As,Cd, Co,Cr, Cu,Fe, I,Hg, Mn,Mo, Ni,Pb, Se,and Zn in selected human tissues and body fluids

This report attempts to formulate reference ranges of elemental concentrations for 15 trace elements in selected human tissues and body fluids. A set of samples consisting of whole blood, blood serum, urine, milk, liver, and hair were chosen and considered for 15 elements of biological significance: As, Cd, Co, Cr, Cu, F, Fe, I, Hg, Mn, Mo, Ni, Pb, Se, and Zn. The results represent wholly or partially data received from 40 countries of the global regions of Africa, Asia, Europe, North, South, and Central America, Australia, and New Zealand. This survey, even if qualitative, has been useful in demonstrating certain trends of trace-element scenarios around the world. It is of course recognized that both diet and environment exert a strong influence on the distribution pattern of several elements, such as As, Cd, Mn, Pb, Se, and Zn. A limited comparison of the available information on soil status of different countries reflected some interesting associations for elements, such as Mn and Zn. Importantly, this study revealed that only a few countries were in a position to identify a reasonable amount of data on samples requested for this project. Regretably, for a number of countries, any dependable data for even such essential elements as Cu, Fe, and Zn were not available. In view of the nutritional importance of many elements, the time is ripe for concerted efforts by intergovernmental agencies to initiate investigations or commission task forces/projects to generate reliable reference data for selected global regions, which sadly lack data of any kind at present.     

Relations of the Al,B, Ba,Br, Ca,Cl, Cu,Fe, K,Li, Mg,Mn, Na,P, S,Si, Sr,and Zn mass fractions to morphometric parameters in pediatric and nonhyperplastic young adult prostate glands

The variation with age of the 18 trace element mass fractions and some histological characteristics of intact prostate glands of 50 subjects aged 0–30 years was investigated by instrumental neutron activation analysis, inductively coupled plasma atomic emission spectrometry, and a quantitative morphometric analysis. Mean values ± standard error of the mean (M ± SΕΜ) for the mass fractions (in milligrams per kilogram wet tissue) of these trace elements in pre-puberty were: Al 28.5 ± 9.0, B 0.40 ± 0.11, Ba 1.48 ± 0.44, Br 10.5 ± 1.5, Ca 241 ± 30, Cl 3,203 ± 278, Cu 3.51 ± 0.89, Fe 33.7 ± 4.1, K 2,364 ± 145, Li 0.020 ± 0.004, Mg 153 ± 23, Mn 0.46 ± 0.06, Na 2,286 ± 130, P 1,391 ± 100, S 1,698 ± 132, Si 62 ± 11, Sr 0.38 ± 0.08, and Zn 27.6 ± 2.3. During puberty and postpuberty, when there is a significant increase in circulating androgens, the mean values were: Al 7.2 ± 1.4, B 0.21 ± 0.05, Ba 0.25 ± 0.06, Br 5.8 ± 1.0, Ca 433 ± 81, Cl 2,314 ± 201, Cu 1.77 ± 0.13, Fe 20.9 ± 1.6, K 2,585 ± 118, Li 0.0088 ± 0.0014, Mg 232 ± 27, Mn 0.34 ± 0.04, Na 1,875 ± 107, P 1,403 ± 98, S 1,673 ± 73, Si 22.2 ± 3.1, Sr 0.22 ± 0.03, and Zn 93.3 ± 8.9. Mean values (M ± SΕΜ) of percent volumes (%) of the stroma, epithelium and lumen in the prostate before puberty were 73.4 ± 2.6, 20.4 ± 1.7, and 4.45 ± 0.94, respectively, versus 46.5 ± 2.5, 38.5 ± 1.9, and 14.9 ± 1.2 during puberty and postpuberty. This work’s results confirm that the Zn mass fraction in prostate tissue is an androgen-dependent parameter. For the first time it has been demonstrated that the glandular lumen is a main pool of Ca, Mg, and Zn accumulation and that the stroma is a main pool of Al, B, Ba, Br, Cl, Cu, Fe, Mn, Na, and Si accumulation in the normal human prostate, for the age range 0–30 years. It was concluded that the Ca, Mg, and Zn binds tightly within the prostatic fluid, because the volume of glandular lumen reflects the volume of prostatic fluid.     

The Effect of Age and Gender on Al, B, Ba, Ca, Cu, Fe, K, Li, Mg, Mn, Na, P, S, Sr, V, and Zn Contents in Rib Bone of Healthy Humans

The effect of age and gender on major, minor, and trace element contents in the intact rib bone of 80 relatively healthy 15–55-year-old women and men was investigated. Contents or upper limit of contents of 16 chemical elements in the rib bone were determined by inductively coupled plasma atomic emission spectrometry (ICP-AES). Mean values (M?±?SΕΜ) for the mass fraction of Ba, Ca, Cu, Fe, K, Li, Mg, Na, P, S, Sr, and Zn (milligram per kilogram of dry bone) were as follows: 2.54?±?0.16, 171,400?±?4,050, 1.35?±?0.22, 140?±?11, 1,874?±?71, 0.049?±?0.011, 2,139?±?38, 5,378?±?88, 75,140?±?1,660, 1,881?±?51, 291?±?20, and 92.8?±?1.5, respectively. The upper limits of contents of Al, B, Mn, and V were <7.20, <0.65, <0.36, and <0.03, respectively. Statistically significant tendency for the Ca, Mg, and P content to decrease with age was found in the human rib bone, regardless of gender. The mass fraction of Fe in the male rib bone increases with age. It was shown that higher Ca, Mg, Na, P, and Sr mass fractions as well as lower Fe content were typical of female ribs as compared to those in male ribs.     

Potential Compounds for Oral Cancer Treatment: Resveratrol,Nimbolide, Lovastatin,Bortezomib, Vorinostat,Berberine, Pterostilbene,Deguelin, Andrographolide,and Colchicine

Oral cancer is one of the main causes of cancer-related deaths in South-Asian countries. There are very limited treatment options available for oral cancer. Research endeavors focused on discovery and development of novel therapies for oral cancer, is necessary to control the ever rising oral cancer related mortalities. We mined the large pool of compounds from the publicly available compound databases, to identify potential therapeutic compounds for oral cancer. Over 84 million compounds were screened for the possible anti-cancer activity by custom build SVM classifier. The molecular targets of the predicted anti-cancer compounds were mined from reliable sources like experimental bioassays studies associated with the compound, and from protein-compound interaction databases. Therapeutic compounds from DrugBank, and a list of natural anti-cancer compounds derived from literature mining of published studies, were used for building partial least squares regression model. The regression model thus built, was used for the estimation of oral cancer specific weights based on the molecular targets. These weights were used to compute scores for screening the predicted anti-cancer compounds for their potential to treat oral cancer. The list of potential compounds was annotated with corresponding physicochemical properties, cancer specific bioactivity evidences, and literature evidences. In all, 288 compounds with the potential to treat oral cancer were identified in the current study. The majority of the compounds in this list are natural products, which are well-tolerated and have minimal side-effects compared to the synthetic counterparts. Some of the potential therapeutic compounds identified in the current study are resveratrol, nimbolide, lovastatin, bortezomib, vorinostat, berberine, pterostilbene, deguelin, andrographolide, and colchicine.