共查询到20条相似文献,搜索用时 46 毫秒
1.
2.
光遗传学是近十年来神经科学领域最受关注的一种神经调控技术.本文首先简要介绍了光遗传技术的工作原理,归纳了该技术在神经调控上的优势,并列出了一些可能的应用方向.随后指出,将光遗传技术与非人灵长类结合是推动该技术转化到临床治疗等领域的必要环节.本文系统回顾了光遗传技术在非人灵长类动物上取得的研究进展,并重点介绍了Dai等的工作.在总结这些工作的基础上,还分析了光遗传技术应用到灵长类研究所面临的一些挑战.最后,本文对筹划中的"中国脑计划"提出一些关于光遗传技术,尤其是在非人灵长类的立项建议. 相似文献
3.
《生物化学与生物物理进展》2016,(4)
光遗传学是近十年来神经科学领域最受关注的一种神经调控技术.本文首先简要介绍了光遗传技术的工作原理,归纳了该技术在神经调控上的优势,并列出了一些可能的应用方向.随后指出,将光遗传技术与非人灵长类结合是推动该技术转化到临床治疗等领域的必要环节.本文系统回顾了光遗传技术在非人灵长类动物上取得的研究进展,并重点介绍了Dai等的工作.在总结这些工作的基础上,还分析了光遗传技术应用到灵长类研究所面临的一些挑战.最后,本文对筹划中的"中国脑计划"提出一些关于光遗传技术,尤其是在非人灵长类的立项建议. 相似文献
4.
微生物原生质体融合技术经过十多年的实际应用,证明确是一项有用的育种技术。该技术的基本实验方法已发展得比较成熟,近年来虽也有一些新的进展,却无重大突破,但在实际应用和实验设计思路方面确实取得了一些可喜的结果。 相似文献
5.
由于犬具有一些独特的生殖生理特点,使犬的繁殖调控技术的发展一直面临着一些困难。目前犬繁殖调控技术的研究远远落后于其他哺乳动物。本文综述了犬诱导发情、精液保存、人工受精、胚胎移植及克隆等犬的繁殖调控技术国内外研究进展。 相似文献
6.
应用蛋白质组技术已对正常人胎盘和大鼠肝线粒体蛋白质进行分离与鉴定,补充了线粒体蛋白质组数据库,并且通过比较蛋白质组学研究技术寻找病理条件下线粒体差异表达的蛋白质,为疾病的诊断和治疗提供作用靶标。随着蛋白质组技术的发展和完善,一些新方法也被应用于线粒体蛋白质的研究,推动了线粒体研究的发展。线粒体蛋白质组研究虽然已取得了一些成果,但线粒体蛋白质组数据库中的数据仍较匮乏,并且还有一些问题亟待解决和改善。 相似文献
7.
8.
9.
10.
11.
12.
13.
14.
15.
In experiments on Black Sea skates (Raja clavata), the potential of the receptor epithelium of the ampullae of Lorenzini and spike activity of single nerve fibers connected to them were investigated during electrical and temperature stimulation. Usually the potential within the canal was between 0 and –2 mV, and the input resistance of the ampulla 250–400 k. Heating of the region of the receptor epithelium was accompanied by a negative wave of potential, an increase in input resistance, and inhibition of spike activity. With worsening of the animal's condition the transepithelial potential became positive (up to +10 mV) but the input resistance of the ampulla during stimulation with a positive current was nonlinear in some cases: a regenerative spike of positive polarity appeared in the channel. During heating, the spike response was sometimes reversed in sign. It is suggested that fluctuations of the transepithelial potential and spike responses to temperature stimulation reflect changes in the potential difference on the basal membrane of the receptor cells, which is described by a relationship of the Nernst's or Goldman's equation type.I. P. Pavlov Institute of Physiology, Academy of Sciences of the USSR, Leningrad. I. M. Sechenov, Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences of the USSR, Leningrad. Pacific Institute of Oceanology, Far Eastern Scientific Center, Academy of Sciences of the USSR, Vladivostok. Translated from Neirofiziologiya, Vol. 12, No. 1, pp. 67–74, January–February, 1980. 相似文献
16.
17.
N. P. Vesselkin Yu. V. Natochin 《Journal of Evolutionary Biochemistry and Physiology》2010,46(6):592-603
Evolution of living organisms is closely connected with evolution of structure of the system of regulations and its mechanisms.
The functional ground of regulations is chemical signalization. As early as in unicellular organisms there is a set of signal
mechanisms providing their life activity and orientation in space and time. Subsequent evolution of ways of chemical signalization
followed the way of development of delivery pathways of chemical signal and development of mechanisms of its regulation. The
mechanism of chemical regulation of the signal interaction is discussed by the example of the specialized system of transduction
of signal from neuron to neuron, of effect of hormone on the epithelial cell and modulation of this effect. These mechanisms
are considered as the most important ways of the fine and precise adaptation of chemical signalization underlying functioning
of physiological systems and organs of the living organism 相似文献
18.
19.