共查询到20条相似文献,搜索用时 15 毫秒
1.
Chunmei Chen Jing Wang Hucheng Zhu Jianping Wang Yongbo Xue Guangzheng Wei Yi Guo Dongdong Tan Jinwen Zhang Chunping Yin Yonghui Zhang 《化学与生物多样性》2016,13(4):422-426
Two new azaphilone derivatives, chaephilones A ( 1 ) and B ( 2 ), were isolated from the fungus Chaetomium globosum, together with four structurally related analogs 3 – 6 . The structures of 1 and 2 were elucidated by comprehensive spectroscopic analyses including HR‐ESI‐MS and NMR. The known compounds were identified as chaetomugilin Q ( 3 ), chaetomugilin D ( 4 ), 11‐epichaetomugilin A ( 5 ), and chaetomugilin S ( 6 ) by comparing their NMR data and optical rotation values with those reported. Compound 2 represents the first example of azaphilone with an open furan ring. Compounds 1 and 2 were evaluated for cytotoxic activities against five human cancer cell lines (HL‐60, SMMC‐7721, A‐549, MCF‐7, and SW480) by the MTS method. 相似文献
2.
Meng Wang Bang‐Wei Yu Mei‐Hua Yu Li‐Xin Gao Jing‐Ya Li He‐Yao Wang Jia Li Ai‐Jun Hou 《化学与生物多样性》2015,12(6):937-945
Two new isoprenylated flavonoids, laevigasins A and B ( 1 and 2 , resp.), and one new isoprenylated 2‐arylbenzofuran, leavigasin C ( 3 ), together with eight known compounds, 4 – 11 , were isolated from the twigs of Morus laevigata. Their structures were elucidated by spectroscopic methods. Laevigasin A ( 1 ) showed significant inhibitory effect on α‐glucosidase in vitro. Notabilisin E ( 5 ), taxifolin ( 10 ), and hultenin ( 11 ) inhibited PTP1B phosphatase activity in vitro. 相似文献
3.
Two new protolimonoid compounds, namely, argentinin A (1) and B (2) along with five known triterpenoid compounds, dammar-24-en-3α-ol (3), 3-epi-cabraleahydroxy lactone (4), (E)-25-hydroperoxydammar-23-en-3β,20-diol (5), mixture of eichlerianic acid and shoreic acid (6a and 6b), and dammar-24-en-3α,20-diol (7), were isolated from the stem bark of Aglaia argentea. The structure of new compounds were elucidated by spectroscopic methods including one and two-dimensional NMR as well as high-resolution mass spectrometric analysis. All of the compounds were tested for their cytotoxic effects against P-388 murine leukemia cells in vitro. Among those isolated compounds, argentinin A (1) showed the strongest activity with an IC50 value of 1.27 μg/mL (3.05 μM). 相似文献
4.
Sheng‐Zhuo Huang Huai‐Rong Luo Qing‐Yun Ma Hua Peng Hao‐Fu Dai Jun Zhou You‐Xing Zhao 《化学与生物多样性》2014,11(9):1406-1416
Six new compounds, including two diterpenoids excocarinols F and G ( 1 and 2 , resp.), two carotane (daucane) sesquiterpenoids excoecafolinols A and B ( 3 and 4 , resp.), one lignanoid compound, excoecanol A ( 5 ), and one simple phenol, excoecanol B ( 6 ), together with 17 known compounds, were isolated from the BuOH extract of Excoecaria acerifolia Didr . stems. Their structures were elucidated through the analysis of the spectroscopic data. The AChE‐inhibitory activities of 17 compounds were evaluated and revealed that four of them possessed moderate inhibitory activities against AChE. 相似文献
5.
Two new oleanane-triterpenoid saponins, clinograsaponins A ( 1 ) and B ( 2 ), together with twelve known ones ( 3 – 14 ), were isolated from the whole herb of Clinopodium gracile (Bentham) Matsumura. Their structures were determined by spectroscopic analysis and chemical method. All the isolated compounds were evaluated for their activities against ATP-citrate lyase (ACLY) and nuclear factor kappa B (NF-κB). 相似文献
6.
Three new diterpenoids and one known diterpenoid have been isolated from a sea anemone of the order Actiniara, and the structures of the new compounds, actiniarins A-C (1-3) were established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation. Compound 1 has a six-membered ring hemiacetal ring, and the equilibrium of this ring is discussed. All the isolates were evaluated for their inhibition of Cdc25B and for cytotoxicity against the A2780 ovarian cancer cell line. 相似文献
7.
Xiao‐Pan Ma Wen‐Fang Zhang Ping Yi Jun‐Jie Lan Bin Xia Sai Jiang Hua‐Yong Lou Wei‐Dong Pan 《化学与生物多样性》2017,14(12)
Two new flavones, 6,7‐methylenedioxy‐4‐hydroxypeltogynan‐7′‐one ( 1 ), cochliophilin B ( 2 ), as well as two known ones, cochliophilin A ( 3 ) and 6‐methoxy‐7‐hydroxy flavone ( 4 ), were isolated from the ethanol extract of the root of Phytolacca acinosa Roxb . Compound 1 is a flavanol framework with one δ‐lactone unit, which is rather rare in nature. The structures of the new compounds were determined on the basis of extensive spectroscopic (IR, MS, 1D‐ and 2D‐NMR) analyses, the absolute configuration of 1 was established by comparing experimental and calculated electronic circular dichroism spectra. The structures of known compounds were fixed by comparison with literatures data. Compounds 2 and 4 showed modest inhibitory activities against BEL‐7402 cell line, with IC50 values of 28.22 and 39.16 μmol/L, respectively. 相似文献
8.
Peng Sun Juan Huo Tibor Kurtán Attila Mándi Sándor Antus Hua Tang Siegfried Draeger Barbara Schulz Hidayat Hussain Karsten Krohn Weihua Pan Yanghua Yi Wen Zhang 《Chirality》2013,25(2):141-148
Four known hydroxyanthraquinones ( 1–4 ) together with four new derivatives having a tetralone moiety, namely coniothyrinones A–D ( 5–8 ), were isolated from the culture of Coniothyrium sp., an endophytic fungus isolated from Salsola oppostifolia from Gomera in the Canary Islands. The structures of the new compounds were elucidated by detailed spectroscopic analysis and comparison with reported data. The absolute configurations of coniothyrinones A ( 5 ), B ( 6 ), and D ( 8 ) were determined by TDDFT calculations of CD spectra, allowing the determination of the absolute configuration of coniothyrinone C ( 7 ) as well. Coniothyrinones A ( 5 ), B ( 6 ), and D ( 8 ) could be used as ECD reference compounds in the determination of absolute configuration for related tetralone derivatives. This is the first report of anthraquinones and derivatives from an isolate of the genus Coniothyrium sp. These compounds showed inhibitory effects against the fungus Microbotryum violaceum, the alga Chlorella fusca, and the bacteria Escherichia coli and Bacillus megaterium. Chirality 25:141–148, 2013. © 2012 Wiley Periodicals, Inc. 相似文献
9.
Three new cadinane sesquiterpenes, trichodermaloids A ( 1 ), B ( 2 ), and C ( 5 ) were isolated from a symbiotic fungus Trichoderma sp. SM16 derived from the marine sponge Dysidea sp., together with three known ones, aspergilloid G ( 3 ), rhinomilisin E ( 4 ), and rhinomilisin G ( 6 ). The complete structures of three new compounds were determined by HR‐MS and NMR spectroscopic analyses coupled with ECD calculations. The absolute configurations of two known compounds ( 4 and 6 ) were determined for the first time. The six isolates were inactive as antibacterial agents. However, trichodermaloids A and B have shown cytotoxicity on human NCIH‐460 lung, NCIC‐H929 myeloma, and SW620 colorectal cancer cell lines with IC50 values at the range of 6.8–12.7 μm . 相似文献
10.
Two new 1,2,3,4-tetrahydroanthraquinones, auxarthrol A (compound 1) and auxarthrol B (2), along with three known pyrrolyloctatetraenyl--pyrone pigments, auxarconjugatin A (3), auxarconjugatin B (4) and rumbrin (5), were isolated from the fungus Auxarthron umbrinum. Structure elucidation of new compounds 1 and 2 was accomplished by spectroscopic data analysis while identification of the known pigments (3–5) was achieved by LC-MS-photodiode array detection. 相似文献
11.
Jirapast Sichaem Thammarat Aree Suttira Khumkratok Jonkolnee Jong-aramruang Santi Tip-pyang 《Phytochemistry letters》2012,5(3):665-667
A new apotirucallane, trichostemonate (1), was isolated from the roots of Walsura trichostemon. The complete structural assignment of this new compound was elucidated from spectroscopic methods and the stereochemistry of 1 was confirmed by X-ray crystallographic analysis. Moreover, this new compound was evaluated for its cytotoxicity (KB and HeLa cells), and showed significant cytotoxicity against both KB and HeLa cell lines with IC50 values of 3.28 and 0.93 μg/mL, respectively. 相似文献
12.
Awang K Chan G Litaudon M Ismail NH Martin MT Gueritte F 《Bioorganic & medicinal chemistry》2010,18(22):7873-7877
A significant acetylcholinesterase (AChE) inhibitory activity was observed for the hexane extract from the bark of Mesua elegans (Clusiaceae). Thus, the hexane extract was subjected to chemical investigation, which led to the isolation of nine 4-phenylcoumarins, in which three are new; mesuagenin A (1), mesuagenin C (3), mesuagenin D (4) and one new natural product; mesuagenin B (2). The structures of the isolated compounds were characterized by spectroscopic data interpretation, especially 1D and 2D NMR. Four compounds showed significant AChE inhibitory activity, with mesuagenin B (2) being the most potent (IC(50)=0.7μM). 相似文献
13.
Nwet Nwet Win May Mon Kyaw Prema Hla Ngwe Takuya Ito Yoshinori Asakawa Yasuko Okamoto Masami Tanaka Ikuro Abe Hiroyuki Morita 《化学与生物多样性》2019,16(4)
A new dinorcassane diterpenoid, seikphoochinal A ( 1 ), and four known compounds, pinostrobin ( 2 ), 4′,7‐dimethylkaempferol ( 3 ), and galanals A ( 4 ) and B ( 5 ), were isolated from the chloroform‐soluble crude extract of wild type Boesenbergia rotunda rhizomes collected in Lower Myanmar. The chemical structures of these compounds were identified, using a combination of spectroscopic methods. The presence of the diterpenoids 1 , 4 , and 5 demonstrated the structural diversity of wild type B. rotunda. Among the isolates, compounds 4 and 5 exhibited significant antiproliferative activities against a small panel of human cancer cell lines, including lung (LK‐2, A549), stomach (ECC4), breast (MCF7), cervix (HeLa), and prostate (DU145). 相似文献
14.
Wei‐Guang Wang Zhao‐Yuan Wu Rui Chen Hai‐Zhou Li Hong‐Mei Li Yuan‐Dan Li Rong‐Tao Li Huai‐Rong Luo 《化学与生物多样性》2013,10(6):1061-1071
Four highly acylated diterpenoids, designated as pierisformotoxins A–D ( 1 – 4 , resp.), along with 26 known compounds, were isolated from the flowers of Pieris formosa. Among them, pierisformotoxins A and B ( 1 and 2 , resp.) were new highly acylated grayanane diterpenoids, of which the five‐membered ring A has undergone an oxidative cleavage between C(3) and C(4), followed by lactonization, to give rise to a five‐membered lactone ring between C(3) and C(5), differing from the previously reported grayanane diterpenoids with a 5/7/6/5 ring system. Results of the cAMP‐regulation‐activity assay showed that pierisformotoxin C ( 3 ) at 10 μM (inhibitory ratio (IR): 10.1%) or 2 μM (9.8%), and pierisformotoxin B ( 2 ) at 50 μM (13.9%) significantly decreased the cAMP level in N1E‐115 neuroblastoma cells (p<0.05). 相似文献
15.
Hidayat Hussain Natalia Root Farah Jabeen Ahmed Al‐Harrasi Manzoor Ahmad Fazal Mabood Zahid Hassan Afzal Shah Ivan R. Green Barbara Schulz Karsten Krohn 《化学与生物多样性》2015,12(2):289-294
A new polychlorinated triphenyl diether named microsphaerol ( 1 ), has been isolated from the endophtic fungus Microsphaeropsis sp. An intensive phytochemical investigation of the endophytic fungus Seimatosporium sp., led to the isolation of a new naphthalene derivative named seimatorone ( 2 ) and eight known compounds, i.e., 1‐(2,6‐dihydroxyphenyl)‐3‐hydroxybutan‐1‐one ( 3 ), 1‐(2,6‐dihydroxyphenyl)butan‐1‐one ( 4 ), 1‐(2‐hydroxy‐6‐methoxyphenyl)butan‐1‐one ( 5 ), 5‐hydroxy‐2‐methyl‐4H‐chromen‐4‐one ( 6 ), 2,3‐dihydro‐5‐hydroxy‐2‐methyl‐4H‐chromen‐4‐one ( 7 ), 8‐methoxynaphthalen‐1‐ol ( 8 ), nodulisporins A and B ( 9 and 10 , resp.), and daldinol ( 11 ). The structures of 1 and 2 were elucidated by detailed spectroscopic analysis including 1H‐ and 13C‐NMR, COSY, HMQC, HMBC, and HR‐EI‐MS, while the structures of the known compounds were deduced from comparison of their spectral data with those in the literature. Preliminary studies revealed that microsphaerol ( 1 ) showed good antibacterial activities against B. Megaterium and E. coli, and good antilagal and antifungal activities against C. fusca, M. violaceum, respectively. On the other hand, seimatorone ( 2 ) exhibited moderate antibacterial, antialgal, and antifungal activities. 相似文献
16.
Diterpenes from the Roots of Oryza sativa L. and Their Inhibition Activity on NO Production in LPS‐Stimulated RAW264.7 Macrophages
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Jin‐Gyeong Cho Byeong‐Ju Cha Sang Min Lee Sabina Shrestha Rak‐Hun Jeong Dong Sung Lee Youn‐Chul Kim Dong‐Geol Lee Hee‐Cheol Kang Jiyoung Kim Nam‐In Baek 《化学与生物多样性》2015,12(9):1356-1364
Two new pimarane diterpenoids, momilactone D ( 3 ) and momilactone E ( 5 ), along with three known diterpenoids, momilactone A ( 1 ), sandaracopimaradien‐3‐one ( 2 ), and oryzalexin A ( 4 ) were isolated from Oryza sativa roots. The chemical structures of the compounds were determined by spectroscopic data analysis. The isolated diterpenoids were evaluated for their ability to inhibit NO production and iNOS mRNA and protein expression in LPS‐stimulated RAW264.7 macrophages. Compound 4 showed strong inhibition activity on NO production, and compounds 1 and 4 decreased the expression of iNOS mRNA and protein levels. 相似文献
17.
Five eremophilane sesquiterpenes including three new ones, named paraconions A–C ( 1 – 3 ), were isolated from an endophytic fungus, Paraconiothyrium sp. from Artemisia selengensis. The structures of these new compounds were established based on spectroscopic methods, including nuclear magnetic resonance (NMR), ultraviolet (UV), and infrared (IR) spectroscopy, as well as high resolution electrospray ionization mass spectrometry (HR-ESI-MS). An anti-inflammatory assay indicated that paraconion B ( 2 ) inhibited lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 cells, with an IC50 value of 51.7 μM. The compounds discovered in this study will enrich the structural types of secondary metabolites of the endophytic fungus Paraconiothyrium sp. 相似文献
18.
Qing‐Yun Ma Yi‐Chun Chen Sheng‐Zhuo Huang Fan‐Dong Kong Li‐Man Zhou Hao‐Fu Dai Yan Hua You‐Xing Zhao 《化学与生物多样性》2016,13(11):1469-1474
Two new compounds, one flavanol dimer dapholosericol A ( 1 ) and one tigliane diterpene dapholosericin A ( 2 ), together with ten known ones, were isolated from the AcOEt extract of Daphne holosericea (Diels ) Hamaya . Their structures were elucidated by their spectroscopic data analysis. Compounds 1 and 2 showed moderate activities against acetylcholinesterase with inhibition ratio of 36% and 29% at a concentration of 100 μmol/l, respectively. 相似文献
19.
Na Liu Dong‐Xiao Guo Shu‐Qi Wang Yan‐Yan Wang Li Zhang Gang Li Hong‐Xiang Lou 《化学与生物多样性》2012,9(10):2254-2261
One undescribed 6,7‐secofusicoccane‐type diterpene, albifolione ( 1 ), and one new aromadendrane‐type sesquiterpenoid ketone, methyl 2‐oxoaromadendra‐1(10),3‐dien‐12‐oate ( 2 ), along with four known compounds, δ‐cuparenol ( 3 ), fusicoauritone ( 4 ), chiloscyphenols A and B ( 5 and 6 , resp.), were isolated from the liverwort Bazzania albifolia Horik. The structures and relative configurations of 1 and 2 were established unequivocally on the basis of spectroscopic data analysis. Preliminary bioassay revealed that compound 5 showed quite strong cytotoxicity against the human tumor cell line MCF‐7, with an IC50 value of 5.6 μM . 相似文献
20.
A new nor-oleanane triterpene 24-nor-4(23)-12-oleanadien-2α,3α,28-triol (1) and two new sesterterpenes salvidominicolide A (2), salvidominicolide B (3) together with fifteen known compounds were isolated from Salvia dominica L. growing wild in Jordan. The known compounds comprised six flavones, three triterpenes, one diterpene, one sesterterpene, two oxygenated monoterpenes, one sterol glucoside and one flavone glucoside. The isolated compounds were elucidated by extensive spectroscopic methods including NMR (1D and 2D), UV, IR and MS (HRMS). 相似文献