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1.
O. P. Trachenko 《Journal of Evolutionary Biochemistry and Physiology》2003,39(1):40-50
This paper summarized experimental data on the role of the right and left brain hemispheres in performance of the verbal and thinking activity, which were obtained by Lev Yakovlevich Balonov and Vadim L'vovich Deglin and published in numerous articles and monographs. The interpretation of these results, the concepts of Balonov and Deglin on regularities underlying division of functions between two hemispheres and on mechanisms of the hemispheric interaction are presented. The original concept is exposed, which consists in that the functional brain asymmetry is based on different relation of the right and left hemispheres to the language sign, its different vision and perception by each hemisphere. The data of study on the functional brain asymmetry also helped the authors to find answers to the questions concerning general scientific and general human problems dealing with the conscious and the unconscious, speech development in child, evolution of psychic activity. The authors understood clearly that the answers to these questions ...by no means will be exhaustive... and that ...this is merely one of possible points of view. 相似文献
2.
T. N. Sollertinskaya 《Journal of Evolutionary Biochemistry and Physiology》2003,39(6):675-690
In a comparative row of mammals (hedgehogs, rabbits, monkeys), the role of the opioid neuropeptide Met-encephalin (ME) and the hypothalamic neurohormone vasopressin (VP) was studied in possibility of compensation of disturbed higher nervous functions in organic and functional pathologies of the higher nervous activity. Administration of ME and VP under conditions of destruction of neocortex in hedgehogs was found to restore predominantly congenital forms of the nervous activity. In rabbits, on administration of VP, a tendency is revealed for restoration of acquired forms of the nervous activity; however, it is of a limited character. On administration of ME and VP under conditions of functional pathology a similar regularity in restoration of disturbed higher nervous functions is observed. Injection of ME and VP to hedgehogs produced a more pronounced and longer effect on unconditioned reflexes. The effect of low doses of VP on HNA is of short-term, generally facilitating character. In rabbits, on the background of VP, the memory processes (trace conditioned responses) are briefly restored and are enhanced. In monkeys, the effect of ME and VP on acquired forms of the nervous activity and on various functional systems is of differential character. The VP compensatory effects are more pronounced after administration of low VP doses. The effects of ME and VP on congenital forms of the nervous activity are negligible. The established regularities are discussed and interpreted from the viewpoint of the concepts postulated by A.I. Karamyan about evolution of the compensatory brain activity, evolution of neocortex, and an increase of its neuroplasticity. 相似文献
3.
The evolution of the nervous system is one of the most fascinating, but also most nebulous fields of homology research. We do not know for example whether the last common ancestors of human, squid, and fly already possessed an elaborate brain and eyes, or rather had a simple, diffuse nervous system. Nevertheless, in the past decade molecular data has greatly advanced our understanding of bilaterian nervous system evolution. In this methodological review, I explain the four levels on which molecular genetic studies advance the quest for homologies between animal nervous systems. (I) Bioinformatic homology research elucidates the evolutionary history of gene families relevant for nervous system evolution such as the opsin superfamily. It tells us when and in what order genes and their functions have emerged. Based on this, we can (II) infer the organismal complexity of some remote ancestor from the functional diversity of its reconstructed proteome. (III) Most common in molecular homology research has been the comparison of expression patterns of developmental control genes. This approach matches and aligns embryonic regions along the body axes, between remote bilaterians. It does not tell us much, however, about the complexity of structures that developed from these regions in Urbilateria. (IV) This is overcome by a novel variant of molecular homology research, the comparison of cell types. Here, a similar “molecular fingerprint” of cells is taken as indication of cross-bilaterian homology. This approach makes it possible to reconstruct the cell-type repertoire of the urbilaterian nervous system. 相似文献
4.
W F Bodmer 《BioEssays : news and reviews in molecular, cellular and developmental biology》1987,7(1):41-45
The 1986 Cold Spring Harbor Symposium was on the subject of human genetics; it was the first symposium at Cold Spring Harbor on this topic since 1964. In the opening remarks for the conference, Walter F. Bodmer first summarized the progress in this field since 1964. He then described what is presently known about the functional complexity of the human genome and discussed the case for a definitive characterization and sequencing of the human genome. The following is an abridged and slightly adapted version of this talk; it is reproduced courtesy of the Cold Spring Harbor Laboratory © 1987. 相似文献
5.
Comparative studies of hominids have long sought to identify mutational events that shaped the evolution of the human nervous system. However, functional genetic differences are outnumbered by millions of nearly neutral mutations, and the developmental mechanisms underlying human nervous system specializations are difficult to model and incompletely understood. Candidate-gene studies have attempted to map select human-specific genetic differences to neurodevelopmental functions, but it remains unclear how to contextualize the relative effects of genes that are investigated independently. Considering these limitations, we discuss scalable approaches for probing the functional contributions of human-specific genetic differences. We propose that a systems-level view will enable a more quantitative and integrative understanding of the genetic, molecular and cellular underpinnings of human nervous system evolution. 相似文献
6.
Medical education in the United States and Canada continues to evolve. However, many of the changes in pedagogy are being made without appropriate evaluation. Here, we attempt to evaluate the effectiveness of lecture capture technology as a learning tool in Podiatric medical education. In this pilot project, student performance in an inaugural lecture capture-supported biochemistry course was compared to that in the previous academic year. To examine the impact of online lecture podcasts on student performance a within-subjects design was implemented, a two way ANCOVA with repeated measures. The use of lecture capture-supported pedagogy resulted in significantly higher student test scores, than achieved historically using traditional pedagogy. The overall course performance using this lecture capture-supported pedagogy was almost 6% higher than in the previous year. Non-native English language speakers benefitted more significantly from the lecture capture-supported pedagogy than native English language speakers, since their performance improved by 10.0 points. Given that underrepresented minority (URM) students, whose native language is not English, makes up a growing proportion of medical school matriculates, these observations support the use of lecture capture technology in other courses. Furthermore, this technology may also be used as part of an academic enrichment plan to improve performance on the American Podiatric Medical Licensing Examination, reduce the attrition of URM students and potentially address the predicted minority physician shortage in 2020. 相似文献
7.
T N Sollertinskaia N N Korinkina 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》1999,49(2):234-244
The role of vasopressin (arginin-vasopressin) in the regulation of conditioned instrumental food-procuring reactions and different kinds of memory such as delayed reflexes, image, short-, and long-time memory was studied in monkeys. Motor and autonomic effects of vasopressin were assessed. It was found that in monkeys, vasopressin administration differently affected the simple conditioned food-procuring reactions and memory. During functional disorders of the higher nervous activity, vasopressin was more efficient in its action on memory and its restoration. Formation of two types of vasopressin effects on the higher nervous activity in evolution of mammals is discussed. 相似文献
8.
Krontiris-Litowitz J 《Advances in physiology education》2008,32(2):152-156
Functional Neuroanatomy is a course designed to help students learn the function and anatomy of the human nervous system. Historically, students have had difficulty with the spinal tract curricular unit and frequently resorted to memorization to "learn" the material. They performed poorly on exams and failed to demonstrate competence in the functional application of their knowledge. In an effort to improve learning and promote critical thinking in this course, the instructor revised the curriculum to include 1) shorter, less detailed lectures; 2) a set of practice problems that presented the spinal tracts in an applied context; and 3) a manipulative, which was composed of a magnetic bulletin board and a kit of magnets representing structures of the nervous system. Student learning, as assessed by summative exams, improved under the revised curriculum. Scores on knowledge, analytical, and synthesis questions were significantly higher than scores from previous classes using the traditional lecture curriculum (P < 0.05). This curricular protocol could potentially be applied to other topics where students resort to memorization and fail to comprehend concepts and processes. 相似文献
9.
A. N. Knyazev 《Entomological Review》2010,90(2):149-162
This paper is based on the author’s lecture presented at the conference Theoretical and Applied Entomology: Past, Present and Future, dedicated to the 150th anniversary of the Russian Entomological Society, which took place on April 2, 2009 in St. Petersburg.
The lecture suggested a definition of the concept “experimental entomology” and listed the most popular research objects.
A brief historical review of the origin and development of some trends in experimental entomology in the XX and XXI centuries
in Russia was given. Special attention was paid to the contribution of Acad. L.A. Orbeli and his ideas concerning evolution
of functions and functional evolution as well as to the importance of ideas of his collaborators and followers, G.V. Gershuni,
L.G. Leibson and A.L. Polenov, in developing a number of present directions of experimental entomology. These classic and
ultramodern directions include comparative genetics of behavior (M.E. Lobashev, A.K. Voskresenskaya, N.G. Lopatina, I.A. Nikitina,
V.B. Savvateev, V.V. Ponomarenko, N.G. Kamyshev), genetics of higher nervous activity (N.G. Lopatina), neurogenetics (E.V.
Savvateeva-Popova), biorhythmology (ecological concept of photoperiodism—A.S. Danilevsky, investigation of the physiological
mechanisms of photoperiodic adaptations—V.P. Tyshchenko), immunology (S.I. Chernysh), neuroendocrinology and mechanisms of
stress (I.Yu. Raushenbach, S.I. Chernysh, G.V. Ben’kovskaya), psychoneuroendocrinology (the hypothesis of “dynamic neuroendocrine
integration”—A.N. Knyazev), etc. A special place in the lecture was assigned to sensory physiology of insects and, first of
all, to the series of monographs by F.G. Gribakin, Yu.A. Elizarov, G.A. Mazokhin-Porshnyakov, R.D. Zhantiev, A.V. Popov, V.L.
Svidersky, A.V. Skirkyavichus, L.I. Frantsevich awarded the USSR State Prize in 1987. The origin of a novel field, cognitive
ethology (Zh.I. Reznikova) that emerged at the intersection of ethology, ecology, theory of evolution, and comparative psychology
is noted in the final part of the lecture. 相似文献
10.
E. Sharpey-Schafer 《The Journal of general physiology》1927,8(6):645-651
1. In the higher animals control of the functions of the body is dual, being partly neural and partly humoral. 2. When the control of any function is single and not dual, it is entirely neural. Exceptions to this statement appear to occur in connexion with the secretion of urine and milk, since these functions have not hitherto been shown to be under direct neural control. The mamma, and perhaps the kidney also, is, however, influenced by certain internal secretions which are themselves subJect both to neural and to humoral control. 3. The functions which are controlled both neurally and humorally are initiated by direct nervous influence: the humoral influence succeeds this. 4. In the lowest organisms possessed of a nervous system there is no evidence of humoral control, and no probability that this could be exercised, since there is no circulatory fluid, and the fluid which bathes the tissue has a composition appreciably the same as that of the environment. 5. It is, therefore, inferred that in all cases in which a dual control exists the neural, which is more rapid in its action, is primary, and the humoral secondary; and that the object of the humoral influence is to continue and prolong the effect of the neural influence, and thus to effect an economy of nervous energy. 相似文献
11.
Iriki A Taoka M 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》2012,367(1585):10-23
Hominin evolution has involved a continuous process of addition of new kinds of cognitive capacity, including those relating to manufacture and use of tools and to the establishment of linguistic faculties. The dramatic expansion of the brain that accompanied additions of new functional areas would have supported such continuous evolution. Extended brain functions would have driven rapid and drastic changes in the hominin ecological niche, which in turn demanded further brain resources to adapt to it. In this way, humans have constructed a novel niche in each of the ecological, cognitive and neural domains, whose interactions accelerated their individual evolution through a process of triadic niche construction. Human higher cognitive activity can therefore be viewed holistically as one component in a terrestrial ecosystem. The brain's functional characteristics seem to play a key role in this triadic interaction. We advance a speculative argument about the origins of its neurobiological mechanisms, as an extension (with wider scope) of the evolutionary principles of adaptive function in the animal nervous system. The brain mechanisms that subserve tool use may bridge the gap between gesture and language--the site of such integration seems to be the parietal and extending opercular cortices. 相似文献
12.
Dorus S Vallender EJ Evans PD Anderson JR Gilbert SL Mahowald M Wyckoff GJ Malcom CM Lahn BT 《Cell》2004,119(7):1027-1040
Human evolution is characterized by a dramatic increase in brain size and complexity. To probe its genetic basis, we examined the evolution of genes involved in diverse aspects of nervous system biology. We found that these genes display significantly higher rates of protein evolution in primates than in rodents. Importantly, this trend is most pronounced for the subset of genes implicated in nervous system development. Moreover, within primates, the acceleration of protein evolution is most prominent in the lineage leading from ancestral primates to humans. Thus, the remarkable phenotypic evolution of the human nervous system has a salient molecular correlate, i.e., accelerated evolution of the underlying genes, particularly those linked to nervous system development. In addition to uncovering broad evolutionary trends, our study also identified many candidate genes--most of which are implicated in regulating brain size and behavior--that might have played important roles in the evolution of the human brain. 相似文献
13.
Yu. V. Natochin 《Journal of Evolutionary Biochemistry and Physiology》2017,53(2):156-170
The tasks, methods and principles of the evolution of functions are overviewed at various levels of organization of physiological systems with the focus on the central problem of physiological evolution—the origin of life and formation of protocellular functions. This stage of evolution is associated with the emergence of the plasma membrane and ion asymmetry of the cell relative to the extracellular environment. For a long time, evolution proceeded in the sea, where extracellular sodium ions in tandem with the intracellular potassium dominance created conditions for the emergence of electrogenesis, polar cells and epithelia, as well as for the formation of the extracellular body fluid system, making up the internal environment of multicellular organisms. The features of the evolution of organs and functional systems are analyzed. During evolution, hormones, autakoids and incretins began to be involved in the regulation of functions alongside with the nervous system. Sodium-dependent processes in the plasma membrane stimulated the development of absorptive, digestive, excretory, respiratory and homeostatic functions. The substance and patterns of functional evolution are discussed. 相似文献
14.
杨蓉 《中国生物化学与分子生物学报》2017,33(5):441-447
长链非编码RNA(long non-coding RNA,lncRNA)是一类转录本长度在200至数千个核苷酸序列,且不具有蛋白质编码潜能的非编码RNA。相较于研究较多的微小RNA(microRNA,miRNA)和干扰小RNA(small interfering,siRNA)等非编码小RNA,lncRNA的许多功能仍尚不清楚。但越来越多的研究发现,lncRNA可通过多种方式调控中枢神经系统发育,包括表观遗传组蛋白甲基化、转录辅因子调控、可变剪接调控等途经。而以上途经的异常均与多种人类重大疾病的发生密切相关,例如,阿尔兹海默症(Alzheimer’s disease,AD)、自闭症(autism spectrum disorder,ASD)、精神分裂症(schizophrenia,SZ)等。本文就lncRNA在表观遗传水平、转录水平、转录后水平和翻译水平上调控神经系统发育以及其在人类神经性疾病中的作用进行综述。 相似文献
15.
Iu V Natochin 《Zhurnal evoliutsionno? biokhimii i fiziologii》1987,23(3):372-389
In the article the history of comparative and evolutionary physiology since the early XIX is given. The most substantial methods of evolutionary physiology are described. In the mid-50ies Orbely put forward the suggestion concerning two tasks facing evolutionary physiology, namely the study of evolution of functions and functional evolution. In the present work attention is given to the principles underlying evolution of functions on different levels of physiological systems. The main aspects of functional evolution are discussed. 相似文献
16.
17.
Evolutionary physiology as independent direction of physiology was formed in the XX century and was rapidly developing in its second half. To evaluate some tendencies of this process, we analyzed publications in Journal of Evolutionary Biochemistry and Physiology, one of the leading specialized periodicals on this problem. Analysis of works published for 4 decades has shown that the majority of papers deals with study of evolution of function of the nervous system (40–60 papers per year), less papers concern study of functions of sensory and visceral systems (20–30 per year). Among the used method, the most widely spread is the comparative-physiological method. By the end of the 1990s the number of works with use of methods of embryophysiology decreased. In the performed studies, predominant are physiological methods. Use of biochemical methods decreased, while of methods of molecular biology increased. The most often used objects of studies were mammals. By the end of the XX—beginning of the XXI century, in the greater number of papers the object of study has become human, while the number of publications in which experiments were performed on amphibians, reptiles, and birds decreased. More than a half of all works were carried out in St. Petersburg (Leningrad); the number of papers submitted from Moscow institutions gradually decreased, but the number of works from regions of Russia rose. Most studies were performed at institutes of the Russian Academy of Sciences and universities, while the number of papers from institutes of the Russian Academy of Medical Sciences decreased. For the last few years, several generalizations on evolution of functions and functional evolution have been formulated; handbooks and monographs on problems of evolutional physiology have been published. 相似文献
18.
We have evaluated the molecular evolution of the chemokine receptor CCR5 in primates. The chemokine receptor CCR5 serves as a major co-receptor for human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) infection. Knowledge of evolution of the CCR5 molecule and selection on the CCR5 gene may shed light on its functional role. The comparison of differences between intraspecific polymorphisms and interspecific fixed substitutions provides useful information regarding modes of selection during the course of evolution. There is marked polymorphism in the CCR5 gene sequence within different primate species, whereas sequence divergence between different species is small. By using contingency tests, we compared synonymous (SS) and nonsynonymous (NS) CCR5 mutations occurring within and between a broad range of primates. Our results demonstrate that CCR5 evolution did not follow expectations of strict neutrality at the level of the whole gene. The proportion of NS to SS at the intraspecific level was significantly higher than that observed at the interspecific level. These results suggest that most CCR5 NS polymorphisms are slightly deleterious. However, at domains more closely correlated with its known biological functions, there was no obvious evidence to support deviation from neutrality. 相似文献
19.
Min Guo 《FEBS letters》2010,584(2):434-227
Known as an essential component of the translational apparatus, the aminoacyl-tRNA synthetase family catalyzes the first step reaction in protein synthesis, that is, to specifically attach each amino acid to its cognate tRNA. While preserving this essential role, tRNA synthetases developed other roles during evolution. Human tRNA synthetases, in particular, have diverse functions in different pathways involving angiogenesis, inflammation and apoptosis. The functional diversity is further illustrated in the association with various diseases through genetic mutations that do not affect aminoacylation or protein synthesis. Here we review the accumulated knowledge on how human tRNA synthetases used structural inventions to achieve functional expansions. 相似文献
20.
V. J. A. Novák 《Human Evolution》1991,6(2):153-157
The results of anthropological research into human evolution have been discussed. Only two research places in CSSR have been
engaged with the human evolution: the Department Anthropos in the Moravian Museum in Brno and the Laboratory of Evolutionary
Biology of the Czechoslovak Academy of Sciences in Praha. The first of them has been mainly concerned with the paleontological
and archeological research reported elsewhere. In the second, the following main questions of human evolution have been discussed:
the evolution of bipedal locomotion, the morphological aspects, both qualitative and quantitative ones, the locomotion in
other primates and various aspects of their behaviour have been studied. In this connection also various questions of the
evolution the of human mind and social consciousness were studied. Special attention has been paid to role of neoteny in the
evolution of man and to the import of synergism of the main evolutionary factors. As one of the main results is the principle
of sociogenesis viewed and its various aspects. Its top product is human consciousness integrating the most important results
of human thinking. Much attention has been paid to its evolution on the basis of the principle of reflection. Also the philosophical
and ideological consequences of the sociogenesis as the main trend in the evolution of organisms have been elaborated in detail. 相似文献