胞质钙信号

胞质钙作为信使对细胞各种生理活动具有广泛调控作用。早期的研究揭示,钙在肌肉收缩,激素、消化酶类和神经递质的释放中起重要作用;近期的研究发现,钙参与更广泛的生理过程,如生物膜通透性及细胞兴奋性的控制、细胞代谢、细胞形态的维持、细胞周期的调控以及生殖细胞...     

GA信号转导

文章概述了赤霉素（GA）调节植物生长和发育的信号转导研究进展。     

血管内皮生长因子受体的信号转导通路

血管内皮生长因子受体(VEGFR)是VEGF的特异性受体,由于在刺激血管内皮细胞增殖、迁移、管腔形成,促进肿瘤生长和转移过程中起着重要的作用,而成为抗肿瘤新生血管生成的热点。该主要围绕VEGF及其不同受体的信号转导通路作一综述。     

The Genome-Packaging Signal of the Influenza A Virus Genome Comprises a Genome Incorporation Signal and a Genome-Bundling Signal

The influenza A virus genome comprises eight single-stranded negative-sense RNA segments (vRNAs). All eight vRNAs are selectively packaged into each progeny virion via so-called segment-specific genome-packaging signal sequences that are located in the noncoding and terminal coding regions of both the 3′ and the 5′ ends of the vRNAs. However, it remains unclear how these signals ensure that eight different vRNAs are packaged. Here, by using a reverse genetics system, we demonstrated that, in the absence of the other seven vRNAs, a recombinant NP vRNA bearing only a reporter gene flanked by the noncoding NP regions was incorporated into virus-like particles (VLPs) as efficiently as a recombinant NP vRNA bearing the reporter gene flanked by the complete NP packaging signals (i.e., the noncoding sequences and the terminal coding regions). Viruses that comprised a recombinant NP vRNA whose packaging signal was disrupted, and the remaining seven authentic vRNAs, did not undergo multiple cycles of replication; however, a recombinant NP vRNA with only the noncoding regions was readily incorporated into VLPs, suggesting that the packaging signal as currently defined is not necessarily essential for the packaging of the vRNA in which it resides; rather, it is required for the packaging of the full set of vRNAs. We propose that the 3′ and 5′ noncoding regions of each vRNA bear a virion incorporation signal for that vRNA and that the terminal coding regions serve as a bundling signal that ensures the incorporation of the complete set of eight vRNAs into the virion.     

Signal transduction-related bioinformatics services

Signal transduction pathways are crucial for the regulation of a very wide variety of cellular functions ranging, for example, from translation to intercellular communication, and from metabolism to apoptosis. Protein kinases and phosphatases, together with their binding partners, are key players in these cascades. They also form a substantial part of the genes in genomes and proteins in proteomes in all animals. Signalling can be studied in many different levels and ways. This has resulted in large body of publications and Internet services. This paper describes open-access databases and software aiming at presenting the kind of data available and how to perform bioinformatics analyses.     

GPI微域与信号转导

许多真核细胞膜表面蛋白 (例如ＣＤ1 4、ＣＤ1 6ｂ、ＣＤ2 4、ＣＤ48、ＣＤ5 2、ＣＤ5 9、ＣＤ5 5 /ＤＡＦ、ＣＤ5 8 /ＬＦＡ 3、ＣＤ6 6、ＣＤ6 7、ＣＤ73、ＣＤ87、ＣＤ90 /Ｔｈｙ 1、ＣＤ1 5 7、Ｌｙ 6等 )通过糖基磷脂酰肌醇(ｇｌｙｃｏｓｙｌｐｈｏｓｐｈａｔｉｄｙｌｉｎｏｓｉｔｏｌ,ＧＰＩ)锚着于细胞膜上 ,称为ＧＰＩ锚定蛋白 (ＧＰＩ ａｎｃｈｏｒｅｄｐｒｏｔｅｉｎｓ,ＧＰＩ ＡＰ) ,它们没有跨膜区和胞内部分 ,不能直接与胞内发生联系。但用特异性抗体结合这些结构上不同的膜蛋白或膜糖鞘脂 (ｇｌｙｃｏｓｐｈｉｎｇｏｌｉｐｉ…