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Successive expression and activation of NFAT family members during thymocyte differentiation 总被引:5,自引:0,他引:5
Adachi S Amasaki Y Miyatake S Arai N Iwata M 《The Journal of biological chemistry》2000,275(19):14708-14716
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Ping Wang Wenying Li Yumeng Yang Na Cheng Yuchen Zhang Nan Zhang Yanxia Yin Li Tong Zhimei Li Jing Luo 《Journal of enzyme inhibition and medicinal chemistry》2022,37(1):202
Calcineurin (CN) controls the immune response by regulating nuclear factor of activated T cells (NFAT). Inhibition of CN function is an effective treatment for immune diseases. The PVIVIT peptide is an artificial peptide based on the NFAT-PxIxIT motif, which exhibits stronger binding to CN. A bioactive peptide (named pep4) that inhibits the CN/NFAT interaction was designed. Pep4 contains a segment of A238L as the linker and the LxVP motif and PVIVIT motif as CN binding sites. Pep4 has strong binding capacity to CN and inhibits CN activity competitively. 11-arginine-modified pep4 (11 R-pep4) inhibits the nuclear translocation of NFAT and reduces the expression of IL-2. 11 R-pep4 improves the pathological characteristics of asthmatic mice to a certain extent. The above results indicated that pep4 is a high-affinity CN inhibitor. These findings will contribute to the discovery of new CN inhibitors and promising immunosuppressive drugs. 相似文献
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Fürstenau U Schwaninger M Blume R Jendrusch EM Knepel W 《The Journal of biological chemistry》1999,274(9):5851-5860
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