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Judith L. Rapoport 《World psychiatry》2013,12(2):118-123
This paper provides a selective overview of the past, present and future of pediatric psychopharmacology. The acceptance of medication use in child psychiatry was based on the results of double‐blind, placebo‐controlled trials documenting the efficacy of drug treatments for attention‐deficit/hyperactivity disorder, enuresis, depression, anxiety disorders, obsessive‐compulsive disorder and psychoses. This period of success was followed by a series of challenges, including a growing awareness of the long‐term adverse effects of medications and of the inadequacy of long‐term drug surveillance. There is great concern today that children are being overtreated with medication, especially in the US. Further advances in pediatric psychopharmacology may come from examination of large medical data sets including both pharmacological and psychiatric information, which could lead to drug repurposing, as well as from preclinical translational studies such as those using human induced pluripotent stem cells. 相似文献
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Metabolome diversity: too few genes,too many metabolites? 总被引:12,自引:0,他引:12
Schwab W 《Phytochemistry》2003,62(6):837-849
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Rassaf T Bryan NS Maloney RE Specian V Kelm M Kalyanaraman B Rodriguez J Feelisch M 《Nature medicine》2003,9(5):481-2; author reply 482-3
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Stoute JA 《Trends in parasitology》2005,21(5):218-223
Data from several laboratories suggest that erythrocyte complement-regulatory proteins, in particular complement receptor 1 (CR1), are important in the pathogenesis of severe malaria. Additional studies suggest that the levels of expression of CR1 and the complement regulator CD55 on erythrocytes vary with age, being low in young children and increasing with age. It is proposed that the interplay between the rate at which immunity develops during malaria exposure and the changes in levels of erythrocyte complement-regulatory proteins that occur with age might contribute to the differences in epidemiology of severe malaria-associated anaemia and cerebral malaria. 相似文献
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Not too excited? Thank your endocannabinoids 总被引:2,自引:0,他引:2
Endocannabinoids can mediate neuroprotection, but it is not known how. In this issue of Neuron, Monory et al. use mutant mice and localized viral targeting to produce conditional knockouts of the cannabinoid CB1 receptor. They show that protection against kainic acid-induced seizures and cell death is conferred by CB1Rs on hippocampal glutamatergic nerve terminals. 相似文献
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Adding to the concept that Mediator acts as an "integrative hub,"Ding et al. (2008) report in this issue of Molecular Cell that, by facilitating the recruitment of the G9a methyl transferase, Mediator can also promote epigenetic silencing of selected genes. 相似文献
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Alberts BM 《Trends in cell biology》1999,9(12):214-M75
As we enter the 21st century, we face a world that will be increasingly dominated by science and technology. More and more jobs will require many of the analytical and thinking skills of a scientist. Citizens everywhere must also become better able to evaluate and understand the judgements of scientific and technical experts when making personal and community decisions. To spread the values and knowledge of science much more widely throughout our societies, we must also spread scientists. Therefore, advanced training in science and the acquisition of important skills through an extensive exposure to research are valuable tools for a wide variety of occupations. 相似文献
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