TERATOLOGY IN TRILLIUM GRANDIFLORUM

Hall , Marion Trufant . (Butler U., Indianapolis, Ind.) Teratology in Trillium grandiflorum. Amer. Jour. Bot. 48(9): 803–811. Illus. 1961.—Attempts were made to determine the causes of persistent but seasonally variable abnormalities in both vegetative and floral organs of an assemblage of plants grouped under the name Trillium grandiflorum var. variegatum Smith. Comparative studies of vegetative and floral morphology between normal and abnormal plants are presented and illustrated. Normal shoots of the same rhizome vary but little from season to season. Abnormal shoots of the same rhizome vary markedly in some instances and very little in others from season to season. In the abnormal shoots, leaves and petals vary most, then stamens, ovaries, and sepals, in that order. In the populations observed, abnormal plants did not mature seed even though only a few specimens were seen which had no viable pollen. A comparative study of leaf and flower proteins of normal (var. grandiflorum) and abnormal (var. variegatum) plants was made. Electrophoretic analysis showed no virus but showed leaf protein abundant in the floral organs, particularly in the petals. It is suggested that the presence of these extra leaf proteins is sufficient to increase variability in the floral organs and in most cases to prevent the normal development of the sporophylls.     

蚤类畸形的研究

研究跳蚤分类的人,在观察大量标本时,往往遇到一些在形态结构上不正常或发育有缺陷的畸形个体。蚤类畸形问题早为学者们所注意,Иофф和Тифлоф(1940)、Holland(1943),Smit(1947,1949,1952,1955),Stark(1951,1953),Hopkins ＆ Rothschild(1956),Sharma ＆ Joshi(1961),和Rothschild(1961)都曾报告过一些例子。其中Smit提出的例子较丰富。但是总的说来,蚤类畸形的研究意义和方法尚待进一步阐明;对畸形的实例     

Protein-Protein Interactions: Principles,Techniques, and their Potential Role in New Drug Development

Abstract

A vast network of genes is inter-linked through protein-protein interactions and is critical component of almost every biological process under physiological conditions. Any disruption of the biologically essential network leads to pathological conditions resulting into related diseases. Therefore, proper understanding of biological functions warrants a comprehensive knowledge of protein-protein interactions and the molecular mechanisms that govern such processes. The importance of protein-protein interaction process is highlighted by the fact that a number of powerful techniques/methods have been developed to understand how such interactions take place under various physiological and pathological conditions. Many of the key protein-protein interactions are known to participate in disease-associated signaling pathways, and represent novel targets for therapeutic intervention. Thus, controlling protein-protein interactions offers a rich dividend for the discovery of new drug targets. Availability of various tools to study and the knowledge of human genome have put us in a unique position to understand highly complex biological network, and the mechanisms involved therein. In this review article, we have summarized protein-protein interaction networks, techniques/methods of their binding/kinetic parameters, and the role of these interactions in the development of potential tools for drug designing.     

Microdosimetry: Principles and applications

Aim

to present the most important aspects of Microdosimetry, a research field in radiation biophysics.

Background

microdosimetry is the branch of radiation biophysics that systematically studies the spatial, temporal and spectral aspects of the stochastic nature of the energy deposition processes in microscopic structures.

Materials and Methods

we briefly review its history, the people, the formalism and the theories and devices that allowed researchers to begin to understand the true nature of radiation action on living matter.

Results and Conclusions

we outline some of its applications, especially to Boron Neutron Capture Therapy, attempting to explain the biological effectiveness of the boron thermal neutron capture reaction.     

Ecological-Evolutionary Theory: Principles and Applications

Ecological-Evolutionary Theory: Principles and Applications. Gerhard Lenski. Boulder: Paradigm Publishers, 2005. 251 pp.     

MEDICAL PHARMACOLOGY: Principles and Concepts

Among 205 ovaries with cortical stromal hyperplasia or polycystic changes, 52 showed excessive luteinization. The clinical and pathologic parameters investigated were not statistically different in the group with extensive thecomatosis. Hyperthecosis is considered as the functional variant of ovarian stromal hyperplasia which reflects a predominance of pituitary luteinizing hormone.     

DNA芯片技术及应用

DNA芯片技术是随着人类基因组计划的实施发展起来的一项高新技术。本文介绍了DNA芯片的基本原理,并对近年来DNA芯片技术的应用进行了综述。