共查询到20条相似文献,搜索用时 31 毫秒
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Mechanisms of hypoxic gene regulation of angiogenesis factor Cyr61 in melanoma cells 总被引:8,自引:0,他引:8
Kunz M Moeller S Koczan D Lorenz P Wenger RH Glocker MO Thiesen HJ Gross G Ibrahim SM 《The Journal of biological chemistry》2003,278(46):45651-45660
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Hypoxia-inducible factors, stem cells, and cancer 总被引:14,自引:0,他引:14
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I Guccini D Serio I Cond�� A Rufini B Tomassini A Mangiola G Maira C Anile D Fina F Pallone M P Mongiardi A Levi N Ventura R Testi F Malisan 《Cell death & disease》2011,2(2):e123
Defective expression of frataxin is responsible for the degenerative disease Friedreich''s ataxia. Frataxin is a protein required for cell survival since complete knockout is lethal. Frataxin protects tumor cells against oxidative stress and apoptosis but also acts as a tumor suppressor. The molecular bases of this apparent paradox are missing. We therefore sought to investigate the pathways through which frataxin enhances stress resistance in tumor cells. We found that frataxin expression is upregulated in several tumor cell lines in response to hypoxic stress, a condition often associated with tumor progression. Moreover, frataxin upregulation in response to hypoxia is dependent on hypoxia-inducible factors expression and modulates the activation of the tumor-suppressor p53. Importantly, we show for the first time that frataxin is in fact increased in human tumors in vivo. These results show that frataxin participates to the hypoxia-induced stress response in tumors, thus implying that modulation of its expression could have a critical role in tumor cell survival and/or progression. 相似文献
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