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1.
Tohno S Tohno Y Hayashi M Minami T Moriwake Y Azuma C Ohnishi Y 《Biological trace element research》2003,95(2):173-184
To examine whether the calcium accumulation in aged arteries is related to the way of walking, the mineral contents were determined
in the arteries of Japanese monkeys of quadrupedal walk by inductively coupled plasma-atomic emission spectrometry. Sixteen
Japanese monkeys consisting of 7 males and 9 females ranging in age from 2 to 33 yr were studied.
The accumulation of calcium, phosphorus, and magnesium occurred progressively in most, but not all, of the arteries with aging.
It was found that independent of the upper and lower limbs, a higher accumulation of calcium, phosphorus, and magnesium occurred
in the arteries of the proximal regions with aging, compared with the arteries of the distal regions.
In a comparison between the arteries of anatomically corresponding regions of the upper and lower limbs, the accumulation
of calcium and magnesium was 20–60% higher in the external iliac and femoral arteries of the lower limb than in the axillary
and brachial arteries of the upper limb. Regarding phosphorus, the accumulation was 20–120% higher in the external iliac and
femoral arteries than in the axillary and brachial arteries. It was known that in humans, the accumulation of calcium, phosphorus,
and magnesium was three to seven times higher in the arteries of the lower limb than in the arteries of the upper limb. It
is clear that there is a very significant difference in the accumulation of calcium and magnesium in the arteries of the lower
limbs between Japanese monkeys and humans. The present study suggests that the accumulation of calcium and magnesium in the
arteries of the lower limb with aging is affected by the way of walking. 相似文献
2.
Setsuko Tohno Yoshiyuki Tohno Motoharu Hayashi Yumi Moriwake Takeshi Minami Fumio Nishiwaki Tsutomu Araki 《Biological trace element research》2001,82(1-3):77-86
To examine whether the calcium accumulation in the arteries is related to the way of walk or not, the calcium contents were
determined in various arteries of Japanese monkeys of quadrupedal walk by inductively coupled plasma-atomic emission spectrometry.
Japanese monkeys consisted of five males and four females, ranging in age from 2 to 29 yr.
Age-related changes of the calcium content were examined in various monkey arteries. Significant relationships between age
and calcium content were found in the arteries, such as the axillary, brachial, radial, subclavian, common carotid, common
iliac, and femoral arteries, but not statistically in the thoracic and abdominal aortas, ulnar, external iliac, internal iliac,
popliteal, and tibial arteries.
The average contents of calcium were compared between the two groups of the monkeys below 14 yr and over 24 yr of age. Below
14 yr, the calcium content was a little higher in the arteries, such as the common, external and internal iliac, and femoral
arteries than that of the other ones. Over 24 yr, the calcium content increased remarkably in the arteries, such as the thoracic
aorta, common, internal and external iliac, common carotid, and subclavian arteries. The calcium contents of the thoracic
aorta, common, internal and external iliac, common carotid, and subclavian arteries increased by more than two times over
24 yr compared with those below 14 yr.
In a comparison between the calcium contents of the arteries in the anatomically corresponding regions of the upper and lower
limbs, no statistically significant differences were found in the subjects over 24 yr as well as the subjects 2–29 yr of age.
The calcium accumulation in the arteries of monkeys with aging was different from those in the arteries of humans, because
in the case of human, a very high accumulation of calcium occurred in the arteries of the lower limb with aging in comparison
with those in the upper limbs.
Therefore, it is likely that different ways of walk or different species are partly affected in the calcium accumulation in
the arteries with aging. 相似文献
3.
Ongkana N Tohno S Mahakkanukrauh P Minami T Tohno Y 《Biological trace element research》2008,124(3):236-242
To elucidate compositional changes of the uterine artery with aging, the authors investigated age-related changes of elements in the uterine arteries of Thai. After ordinary dissection by medical students at Chiang Mai University was finished, the uterine arteries were resected from Thai subjects. Thai subjects ranged in age from 27 to 86 years (average age = 63.3 +/- 17.7 years). The element content of the uterine arteries was analyzed by inductively coupled plasma-atomic emission spectrometry. It was found that the Ca, P, and Na contents increased progressively in the uterine arteries of Thai with aging. A significant accumulation of Ca and P in the uterine arteries of Thai was found in the sixties patients, and the accumulation increased markedly in the seventies. Regarding the uterine arteries in subjects more than 60 years, the extent of accumulation of Ca and P in the uterine arteries of Thai was one half of that in the uterine arteries of Japanese. Regarding the relationships among elements, extremely significant direct correlations were found among the contents of Ca, P, Mg, Zn, and Na in the uterine arteries of Thai. As Ca increased in the uterine arteries of Thai, P, Mg, Zn, and Na increased simultaneously in the arteries. 相似文献
4.
Tohno Y Tohno S Laleva L Ongkana N Minami T Satoh H Oishi T Hayashi M Sinthubua A Suwannahoy P Mahakkanukrauh P 《Biological trace element research》2008,125(2):141-153
To elucidate compositional changes of the coronary artery with aging, the authors investigated age-related changes of elements
in the coronary arteries of rhesus and Japanese monkeys by direct chemical analysis in comparison with the coronary arteries
of Japanese and Thai. Used monkeys consisted of 38 rhesus monkeys and 23 Japanese monkeys, ranging in age from newborn to
33 years. After perfusion with a fixative, the hearts were resected from the monkeys, and the anterior interventricular branches
of the left coronary artery and the right coronary arteries were resected from the hearts. After ashing of the arteries, element
contents were determined by inductively coupled plasma-atomic emission spectrometry. It was found that the Ca and P contents
did not increase in both the left and right coronary arteries of rhesus and Japanese monkeys at old age. The average contents
of Ca and P decreased by 13% and 25% in the left coronary arteries more than 20 years of age in comparison with those below
20 years of age, whereas they decreased by 4% and 15% in the right coronary arteries more than 20 years of age in comparison
with those below 20 years of age. This finding indicated that atherosclerosis scarcely occurred in both the left and right
coronary arteries of rhesus and Japanese monkeys at old age. In contrast with monkeys, atherosclerosis occurred frequently
in the coronary arteries of Japanese and Thai at old age. 相似文献
5.
Mahakkanukrauh P Tohno S Tohno Y Azuma C Ongkana N Moriwake Y Minami T 《Biological trace element research》2005,106(3):219-229
To examine whether there were differences between reces in regard to age-related changes of elements and the relationships
among elements in the arteries, the authors investigated both the renal arteries of Thai and Japanese. The Thai subjects consisted
of 27 men and 11 women, ranging in age from 27 to 88 yr, whereas the Japanese subjects consisted of 19 men and 26 women, ranging
in age from 61 to 99 yr. After the ordinary dissections at Chiang Mai University and Nara Medical University were completed,
the bilateral renal arteries were resected and the element contents were determined by inductively coupled plasma-atomic emission
spectrometry. In the Thai, a slight accumulation of calcium and phosphorus occurred in the fifties, but thereafter headly
increased. In contrast, in the Japanese, an accumulation of calcium and phosphorus began to occur in the seventies and increased
markedly in the eighties. The result reveraled that a higher accumulation of calcium and phosphorus occurred in the renal
arteries of the Japanese in old age compared with those of the Thai. Regarding the relationships among elements, extremely
or very significant direct correlations were found among the contents of calcium, phosphorus, magnesium, and sodium in both
the renal arteries of the Thai and Japanese, except for magnesium and sodium contents in the renal arteries of the Thai. 相似文献
6.
Yoshiyuki Tohno Patipath Suwanahoy Setsuko Tohno Apicha Sinthubua Cho Azuma Fumio Nishiwaki Yumi Moriwake Tsukasa Kumai Takeshi Minami Sikrai Laowatthanaphong Pasuk Mahakkanukrauh Takao Oishi Motoharu Hayashi 《Biological trace element research》2010,133(3):291-303
To elucidate compositional changes of the tendon of the peroneus longus muscle with aging, the authors investigated age-related changes of elements in the insertion of tendons of the peroneus longus muscle (peroneus longus tendons) in Thai, Japanese, and monkeys and the relationships among element contents by direct chemical analysis. After ordinary dissections at Chiang Mai University and Nara Medical University were finished, the peroneus longus tendons were resected from the subjects. The peroneus longus tendons were also resected from rhesus and Japanese monkeys bred in Primate Research Institute, Kyoto University. The wraparound regions of the insertion tendons of the peroneus longus muscle in contact with the cuboid bone were used as the peroneus longus tendon. After ashing with nitric acid and perchloric acid, element contents were determined with an inductively coupled plasma-atomic emission spectrometer. It was found that there were no significant correlations between age and the seven elements, such as Ca, P, S, Mg, Zn, Fe, and Na, in the peroneus longus tendons of Thai and Japanese. The Ca content higher than 10 mg/g was contained in seven cases out of 34 peroneus longus tendons of Thai (incidence?=?20.6%) and in one case out of 22 peroneus longus tendons of Japanese (incidence?=?4.5%), respectively. All of the peroneus longus tendons with the Ca content higher than 10 mg/g were found in Thai and Japanese men. In the peroneus longus tendons of monkeys, the Ca and P content increased suddenly at 2 years of age and reached to about 40 mg/g at 5 years of age. Thereafter, the Ca and P content did not increase in the peroneus longus tendons of monkeys at old age. Regarding the relationships among element contents, significant direct correlations were found among the contents of Ca, P, Mg, Zn, and Na in Thai and monkeys, whereas significant inverse correlations were found between S and element contents, such as Ca, P, Mg, Zn, and Na, in Thai and monkeys. 相似文献
7.
Tohno S Mahakkanukrauh P Tohno Y Vaidhayakarn P Minami T Somsarp V Moriwake Y Chomsung R Azuma C 《Biological trace element research》2002,87(1-3):69-82
To examine whether there were differences between races in regard to age-related changes of mineral contents and the relationships
among element contents in the arteries, the authors investigated the coronary arteries of Thai and Japanese. The Thai subjects
consisted of 13 men and 3 women, ranging in age from 39 to 84 yr, whereas the Japanese subjects consisted of 17 men and 9
women, ranging in age from 55 to 92 yr. After the ordinary dissections at Chiang Mai University and Nara Medical University
were finished, the coronary arteries were resected and the element contents were determined by inductively coupled plasma-atomic
emission spectrometry. In the Thai, an accumulation of calcium and phosphorus began to occur in the forties and increased
markedly in the fifties, whereas in the Japanese, an accumulation of calcium and phosphorus began to occur in the seventies
and increased markedly in the nineties. The result revealed that an accumulation of calcium and phosphorus occurred earlier
in the Thai than in the Japanese. Regarding the relationships among element contents, extremely significant correlations were
found between calcium and phosphorus contents, between calcium and magnesium contents, and between phosphorus and magnesium
contents in both the coronary arteries of the Thai and the Japanese. As far as the coronary arteries with a very high accumulation
of calcium and phosphorus, the mass ratios of magnesium to calcium and phosphorus were lower in the coronary arteries of the
Thai in comparison with the Japanese. 相似文献
8.
Tohno S Naganuma T Ongkana N Mahakkanukrauh P Tohno Y Azuma C Moriwake Y Minami T Maruyama H 《Biological trace element research》2007,116(2):111-118
To elucidate compositional changes of the uterine artery with aging, the authors investigated age-related changes of elements
in the uterine arteries. After ordinary dissection by medical students at Nara Medical University was finished, the uterine
arteries were resected from the subjects. The element content of the uterine arteries was analyzed by inductively coupled
plasma-atomic emission spectrometry. The subjects ranged in age from 58 to 99 yr (average age=82.7±10.1 yr). It was found
that the Ca, P, and Na contents increased progressively in the uterine arteries with aging. A significant accumulation of
Ca and P in the uterine arteries was found in the sixties and increased markedly in the eighties. It should be noted that
as far as the arteries in those over 70 yr of age, the extent of accumulation of Ca and P was the highest in the uterine arteries
within the limits of the arteries analyzed by us. Regarding the relationships among elements, significant direct correlations
were found among the contents of Ca, P, Mg, Zn, and Na. As Ca increased in the uterine arteries, P, Mg, Zn, and Na increased
simultaneously in the arteries. 相似文献
9.
Mahakkanukrauh P Tohno S Tohno Y Chomsung R Azuma C Moriwake Y Minami T 《Biological trace element research》2004,100(3):205-214
To examine whether there were differences between races in regard to the relationships among element contents in the arteries,
the authors investigated the relationships among the average contents of calcium, phosphorus, sulfur, and magnesium in the
18 kinds of the Thai artery. After ordinary dissection by medical students at Chiang Mai University was finished, the thoracic
and abdominal aortas, ramifying site of the abdominal aorta into the common iliac arteries, coronary, common carotid, internal
thoracic, subclavian, axillary, brachial, radial, superior and inferior mesenteric, renal, common iliac, internal iliac, and
external iliac arteries were resected from the subjects who consisted of 12 men and 3 women, ranging in age from 39 to 84
yr. The femoral and posterior tibial arteries were resected from the subjects, consisting of 15 men and 5 women, ranging in
age from 25 to 88 yr. The element content of the arteries was analyzed by inductively coupled plasma-atomic emission spectrometry.
It was found that there were extremely significant direct correlations among the average contents of calcium, phosphorus,
and magnesium in the 18 kinds of the Thai artery, but no significant correlations were found between the average contents
of sulfur and elements, such as calcium, phosphorus, and magnesium. These results were in agreement with those of the Japanese
arteries. Therefore, it was suggested that there was no significant difference between the arteries of the Thai and the Japanese
in the relationships among calcium, phosphorus, sulfur, and magnesium. 相似文献
10.
To examine whether an accumulation of elements in the arteries with aging differs between human and animal, the authors investigated
the relationships among element contents in the arteries of the Japanese monkeys. The Japanese monkeys consisted of five males
and four females, ranging in age from 2 to 29 yr. The aorta, common and external iliac, femoral, common carotid, subclavian,
and axillary arteries were resected from the monkeys and element contents were determined by inductively coupled plasma-atomic
emission spectrometry. It was found that there were very high correlations between calcium and phosphorus contents, between
calcium and magnesium contents, and between phosphorus and magnesium contents in all of the monkey arteries. In addition,
significant correlations were found among the other element contents in some, but not all of the arteries. These results were
consistent with the foregoing findings of the human arteries. It is likely that magnesium forms compounds with phosphorus
or calcium in the monkey arteries. 相似文献
11.
Ohnishi Y Tohno S Mahakkanukrauh P Tohno Y Vaidhayakarn P Azuma C Satoh H Moriwake Y Chomsung R Minami T 《Biological trace element research》2003,96(1-3):71-92
To elucidate whether the extent of element accumulation in the arteries and cardiac valves with aging was different between
different races, the authors investigated the accumulation of elements in the arteries and cardiac valves of the Thai with
aging and the relationships among elements in the cardiac valves. After ordinary dissection at Chiang Mai University was finished,
16 arteries and 4 cardiac valves were resected and element contents were determined by inductively coupled plasma-atomic emission
spectrometry.
In the 16 arteries, the average content of calcium was the highest in the site of the abdominal aorta ramifying into the common
iliac arteries, and it decreased in the order internal iliac, coronary, abdominal aorta, common iliac, external iliac, superior
mesenteric, inferior mesenteric, thoracic aorta, brachial, radial, common carotid, subclavian, ulnar, axillary, renal, and
internal thoracic arteries. The average contents of phosphorus and magnesium in respective arteries were parallel with the
average contents of calcium, except for the coronary artery. In comparison with the arteries of the Japanese, the trend of
calcium accumulation in the arteries of the Thai was almost similar to that in the arteries of the Japanese, except for the
coronary artery and thoracic aorta. The calcium accumulation in the coronary artery was much higher in the Thai than in the
Japanese, whereas that in the thoracic aorta was lower in the Thai than in the Japanese.
Regarding elements in the cardiac valves, the calcium content increased remarkably in the seventies in the aortic valve and
in the nineties in the pulmonary valve, but it hardly increased in both the mitral and tricuspid valves with aging. The average
content of calcium was the highest in the aortic valve, and it decreased in the order pulmonary, tricuspid, and mitral valves.
Regarding the relationship among elements in the aortic valves, it was found that there were extremely significant direct
correlations among the contents of calcium, phosphorus, and magnesium, whereas there were significant direct correlations
between zinc and either calcium or phosphorus contents. Although significant correlations were found between sulfur and the
other element contents in the aortic valves of the Japanese, no significant correlations were found between them in the aortic
valves of the Thai. In the mitral valves, extremely or very significant direct correlations were found among the contents
of calcium, phosphorus, magnesium, and sulfur, with some exceptions that there were no significant correlations between phosphorus
and either magnesium or sulfur contents.
In addition, no significant correlation was found in the calcium content between the aortic valve and coronary artery in the
same individuals. 相似文献
12.
Tohno S Kobayashi M Shimizu H Tohno Y Suwannahoy P Azuma C Minami T Sinthubua A Mahakkanukrauh P 《Biological trace element research》2009,127(3):211-227
To elucidate compositional changes of the prostate with aging, the authors investigated age-related changes of elements in
the prostates and the relationships among their elements using Japanese and Thai. After ordinary dissections by students at
Nara Medical University and Chiang Mai University were finished, the prostates were resected from the subjects. Fifty-seven
Japanese subjects ranged in age from 65 to 101 years (average age = 82.5 ± 7.8 years), whereas 13 Thai subjects ranged in
age from 43 to 86 years (average age = 67.9 ± 11.9 years). After ashing with nitric acid and perchloric acid, element contents
were determined by inductively coupled plasma–atomic emission spectrometry. It was found that although there were no significant
correlations between age and seven element contents, such as Ca, P, S, Mg, Zn, Fe, and Na, in the prostates of Japanese, high
contents of Ca (>5 mg/g) and P (>4 mg/g) were contained in one fourth of the prostates of Japanese over 70 years of age. In
the prostates of Thai, a significant direct correlation was found between age and Ca content, but it was not found between
age and the other element contents, such as P, S, Mg, Zn, Fe, and Na. Regarding the relationships among their elements, extremely
significant direct correlations were found among the contents of Ca, P, Mg, Zn, and Na in the prostates of Japanese. In the
prostates of Thai, significant direct correlations were found among the contents of Ca, Mg, and Zn, but no significant correlations
were found between Ca and P contents and between P and Mg contents. Regarding the relationships among their elements, there
were differences between the prostates of Japanese and Thai. To examine whether element contents changed in prostatic hypertrophy,
the transverse width of the Japanese prostates was measured. No significant correlations were found between the transverse
width and element contents, such as Ca, P, S, Mg, Zn, Fe, and Na, in the Japanese prostates. Therefore, it is unlikely that
the increase of elements results in prostatic hypertrophy. 相似文献
13.
Tohno Y Tohno S Mahakkanukrauh P Minami T Sinthubua A Suwannahoy P Ongkana N Laowatthanaphong S Azuma C 《Biological trace element research》2011,144(1-3):17-26
To examine whether there were gender differences in compositional changes of the coronary artery with aging, the authors investigated the gender difference in age-related changes of elements in the left coronary arteries of Thais by direct chemical analysis. After ordinary dissections by students at Chiang Mai University were finished, the left coronary arteries were resected from Thai subjects. The Thai subjects consisted of 69 men and 34 women. The ages of the male subjects ranged from 25 to 87?years (average age?=?62.6?±?11.4?years) and of the female subjects from 24 to 86?years (average age?=?59.4?±?14.6?years). After incinerating the arteries with nitric acid and perchloric acid, the element content was determined by inductively coupled plasma-atomic emission spectrometry. The Ca and P contents tended to increase in the left coronary arteries of men with age, but the increases were not statistically significant. In the left coronary arteries of women, the Ca and P contents increased significantly and progressively with aging. In addition, the Na content increased significantly in the left coronary arteries of both men and women with aging. The differences in the average contents of Ca and P by age group were observed between the left coronary arteries of men and women. With Student's t test, significant gender differences in the average contents of Ca and P were found in both the 40s and the 70s. The Ca and P contents of the left coronary arteries in the 40s were significantly higher in men than in women. In contrast, the Ca and P contents in the 70s were significantly higher in women than in men. These results indicated that the accumulation of Ca and P in the left coronary arteries of Thais occurred at least 10?years earlier in men than in women, but a higher accumulation of Ca and P in old age occurred in the left coronary arteries of women compared with those of men. The present study revealed that there were significant gender differences in the left coronary arteries with regard to the accumulation of Ca and P with aging. It is reasonable to presume that taking clinical findings into consideration, the gender differences in the left coronary arteries may result from hormonal and/or genetic factors rather than lifestyle factors. 相似文献
14.
Tohno Y Tohno S Mahakkanukrauh P Azuma C Moriwake Y Ongkana N Kumai T Minami T Maruyama H 《Biological trace element research》2006,112(1):31-42
To explore reasons for a high accumulation of Ca and P occurring in the coronary artery of Thai with aging, the authors investigated
age-related changes of elements in the coronary artery, ascending aorta near the heart, and cardiac valves in single individuals,
and the relationships in the elements between the coronary artery and either the ascending aorta or cardiac valves. After
an ordinary dissection by medical students at Chiang Mai University was finished, the anterior descending arteries of the
left coronary artery, ascending aortas, mitral valves, and aortic valves were resected from the subjects. The subjects consisted
of 17 men and 9 women, ranging in age from 46 to 76 yr. The element content was analyzed by inductively coupled plasma-atomic
emission spectrometry. The average content of Ca and P was the highest in the coronary artery and decreased in the order aortic
valve, ascending aorta, and mitral valve. The Ca, P, and Mg content increased in the coronary artery in the fifties and in
the ascending aorta, aortic valve, and mitral valve in the sixties. It should be noted that the accumulation of Ca, P, and
Mg occurred earlier in the coronary artery than in the ascending aorta, aortic valve, and mitral valve. It was found that
with respect to the Ca, P, Mg, and Na contents, the coronary artery correlated well with both the aortic valve and ascending
aorta, especially with the aortic valve, but it did not correlate with the mitral valves. This finding suggests that the accumulation
of Ca, P, Mg, and Na occurs in the coronary artery together with the aortic valve and ascending aorta, but not together with
the mitral valve. Because regarding the accumulation of Ca, P, and Mg, the ascending aorta and aortic valve are preceded by
the coronary artery, it is unlikely that the accumulation of Ca, P, and Mg spreads from the ascending aorta or aortic valve
to the coronary artery. 相似文献
15.
Tohno S Tohno Y Azuma C Moriwake Y Satoh H Minami T Mahakkanukrauh P Ohishi T Hayashi M 《Biological trace element research》2006,110(3):233-249
To elucidate compositional changes of the cardiac walls with development and aging, the authors investigated changes of elements
in the atrial and ventricular walls of monkeys. The left and right atrial walls, left and right ventricular walls, and interatrial
and interventricular septa were resected from the subjects. The subjects consisted of 17 rhesus and 13 Japanese monkeys, ranging
in age from 10 d to 33 yr. The element content of the cardiac walls was analyzed by inductively coupled plasma-atomic emission
spectrometry. The Ca and P contents decreased in all of the left and right atrial and ventricular walls, interatrial septa,
and interventricular septa with development, whereas the S and Mg contents decreased in the left and right ventricular walls
with development. Regarding the relationships among elements, significant direct correlations were found among Ca, P, Mg,
and Zn in all of the left and right atrial walls, left and right ventricular walls, and interatrial and interventricular septa,
with some exceptions. As Ca decresed in the cardic walls, P, Mg, and Zn decreased simultaneously in the cardiac walls. The
mass ratio of Ca/P decreased gradually with Ca decrease in both the atrial and ventricular walls, but it was not constant. 相似文献
16.
Tohno Y Tohno S Mahakkanukrauh P Azuma C Vaidhayakarn P Moriwake Y Ohnishi Y Minami T 《Biological trace element research》2003,91(3):217-230
To elucidate quantitative changes of Ca, P, and Mg in the arteries with aging, the authors investigated changes of the mass
ratios of Mg to Ca and P in the arteries of Japanese and Thai by inductively coupled plasma-atomic emission spectrometry.
The arteries of Japanese that were used were the thoracic and abdominal aortas, coronary, common iliac, internal iliac, external
iliac, and femoral arteries, in which very high accumulations of Ca and P occurred in old age. The arteries of Thai that were
used were the abdominal aorta, ramifying site of the abdominal aorta, coronary, common iliac, internal iliac, and external
iliac arteries.
It was found that there were extremely significant correlations both between Ca and Mg contents and between P and Mg contents
in all of the arteries of the Japanese and the Thai. With regard to the mass ratio, the mass ratios of Mg to Ca ranged from
1.5% to 2.1% in the six arteries of the Japanese, except for the thoracic aorta at 3.1%, at an advanced stage of atherosclerosis,
being similar to each other. In the arteries of the Thai, the mass ratios of Mg to Ca ranged from 1.9% to 3.0%, except for
the coronary artery at 0.5%, at an advanced stage of atherosclerosis.
The mass ratios of Mg to P ranged from 2.5% to 2.7% in the six arteries of the Japanese, except for the coronary artery at
1.8%, at an advanced stage of atherosclerosis. With regard to the arteries of the Thai, the mass ratios of Mg to P ranged
from 1.9% to 3.3%, except for the coronary artery at 0.7%, at an advanced stage of atherosclerosis. These results revealed
that both the mass ratios of Mg to Ca and Mg to P were almost similar among the arteries of Japanese and Thai, except for
the coronary arteries. Therefore, these results suggested that the inorganic deposits in the coronary arteries of Japanese
and Thai were similar to those in the intimal tunica of the thoracic aorta, whereas in the other arteries, they were similar
to those in the middle tunica of the thoracic aorta. 相似文献
17.
Ongkana N Tohno S Payo IM Azuma C Moriwake Y Minami T Tohno Y 《Biological trace element research》2007,117(1-3):23-38
To elucidate whether the accumulation of elements occurred simultaneously in the various arteries with aging, the authors
investigated age-related changes of elements in the eight arteries, such as the thoracic and abdominal aortas and the coronary,
common carotid, pulmonary, splenic, common iliac, and uterine arteries, and the relationships in the element contents among
their arteries. After ordinary dissection by medical students was finished, the thoracic and abdominal aortas and the coronary,
common carotid, pulmonary, splenic, common iliac, and uterine arteries were resected from the subjects, who ranged in age
from 58 to 94 yr. The element contents were analyzed by inductively coupled plasma-atomic emission spectrometry. It was found
that the accumulation of Ca was the highest in the common iliac artery and decreased in the order of the uterine artery, abdominal
aorta, coronary artery, thoracic aorta, splenic artery, common carotid artery, and pulmonary artery. Regarding the relationships
in the element contents among the eight arteries, it was found that there were significant direct correlations in the contents
of Ca, P, Mg, Zn, Fe, and Na between the coronary and splenic arteries, and there were significant correlations in the contents
of Ca, P, and Mg between the abdominal aorta and pulmonary artery. 相似文献
18.
Mahakkanukrauh P Tohno S Sinthubau A Tohno Y Azuma C Minami T 《Biological trace element research》2006,112(1):43-56
To elucidate compositional changes of the cerebral arteries with aging, the authors investigated age-related changes of elements
in the cerebral arteries by inductively coupled plasma-atomic emission spectrometry (ICP-AES). After an ordinary dissection
by medical students at Chiang Mai University was finished, the anterior, middle, and posterior cerebral arteries and the anterior
and posterior communicating arteries were resected from the subjects. The subjects consisted of six men and seven women, ranging
in age from 34 to 86 yr. The element content was determined by ICP-AES. It was found that the Mg content increased progressively
with aging in all of the anterior, middle, and posterior cerebral arteries, but the Ca and P content did not increase significantly
with aging in the anterior, middle, and posterior cerebral arteries, with the one exception being that the P content increased
significantly in the posterior cerebral arteries with aging. The average content of Ca was higher in the order of the anterior
communicating, anterior cerebral, posterior communicating, posterior cerebral, and middle cerebral arteries. 相似文献
19.
Azuma C Tohno S Mahakkanukrauh P Tohno Y Satoh H Chomsung R Minami T Moriwake Y Utsumi M Vaidhayakarn P 《Biological trace element research》2003,95(3):211-218
To analyze the accumulation of elements in the rami of the coronary arteries, the authors determined element contents in both
the coronary arteries and their rami of the Thai by inductively coupled plasma-atomic emission spectrometry. The subjects
consisted of 13 men and 6 women, ranging in age from 34 to 83 yr. It was found that a higher accumulation of calcium and phosphorus
occurred in the proximal sites of coronary arteries such as the anterior descending, right coronary, left coronary, and circumflex
arteries than the distal sites such as the diagonal, lateral, conus, acute marginal, and posterior descending arteries. The
accumulation of calcium and phosphorus in the anterior descending and right coronary arteries of the Thai increased remarkably
in the fifties, thereafter decreased, and increased again in the eighties. It should be noted that a very high accumulation
of calcium and phosphorus in the coronary arteries occurred in the fifties. In regard to relationships among the average contents
of elements in the coronary arteries and their rami, it was found that there were very significant direct correlations between
calcium and phosphorus contents, between calcium and magnesium contents, and between phosphorus and magnesium contents. These
results suggested that as calcium and phosphorus increased in the coronary arteries and their rami, magnesium increased simultaneously
in all of the coronary arteries and their rami. 相似文献
20.
Tohno Y Tohno S Mahakkanukrauh P Minami T Sinthubua A Suwannahoy P Khanpetch P Azuma C 《Biological trace element research》2012,145(3):275-282
To clarify the manner of accumulation of Ca and P in the coronary arteries, the authors divided the coronary arteries into
many segments based on arterial ramification and investigated the element contents of the segments by direct chemical analysis.
After ordinary dissection at Chiang Mai University was finished, the left coronary (LC) and the right coronary (RC) arteries
were removed successively from the hearts of Thai subjects. The Thai subjects consisted of seven men and five women, ranging
in age from 42 to 87 years (average age = 73.9 ± 13.5 years). The LC and the RC arteries were divided into 19 segments based
on arterial ramification. After incineration with nitric acid and perchloric acid, element contents of the segments were analyzed
by inductively coupled plasma–atomic emission spectrometry. In two cases, a significant content of Ca and P was contained
only in the left anterior descending (LAD) artery (type I). In four cases, a significant content of Ca and P was contained
in both the LAD and the RC arteries (type II). In five cases, a significant content of Ca and P was contained in all the LAD,
the RC, and the circumflex (CF) arteries (type III). In the other one case, no significant content of Ca and P was contained
in the coronary arteries. The manner of accumulation of Ca and P in the coronary arteries was classified into the three types,
I, II, and III. Regarding the average content of elements in 12 cases, the average content of Ca was the highest in the segment
of the LAD artery ramifying the first left diagonal artery and was higher in the proximal and distal adjacent segments of
the LAD artery ramifying the first left diagonal artery, the proximal segment of the RC artery, and the proximal segment of
the CF artery. To examine an effect of arterial ramification on accumulation of Ca and P, the differences in the Ca and P
content between artery-ramifying and non-ramified proximal or distal segments of the coronary arteries were analyzed with
Student’s t test. It was found that there were no significant differences in the Ca and P content between the artery-ramifying and non-ramified
proximal or distal segments of the coronary arteries. 相似文献