共查询到20条相似文献,搜索用时 15 毫秒
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p53-dependent down-regulation of telomerase is mediated by p21waf1 总被引:13,自引:0,他引:13
Shats I Milyavsky M Tang X Stambolsky P Erez N Brosh R Kogan I Braunstein I Tzukerman M Ginsberg D Rotter V 《The Journal of biological chemistry》2004,279(49):50976-50985
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CTCF binds the proximal exonic region of hTERT and inhibits its transcription 总被引:1,自引:0,他引:1
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Renaud S Loukinov D Bosman FT Lobanenkov V Benhattar J 《Nucleic acids research》2005,33(21):6850-6860
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Sang Hyeok Woo Sungkwan An Hyung-Chahn Lee Hyeon-Ok Jin Sung-Keum Seo Doo-Hyun Yoo Kee-Ho Lee Chang Hun Rhee Eui-Ju Choi Seok-Il Hong In-Chul Park 《The Journal of biological chemistry》2009,284(45):30871-30880
The Hsp90-associated protein p23 modulates Hsp90 activity during the final stages of the chaperone pathway to facilitate maturation of client proteins. Previous reports indicate that p23 cleavage induced by caspases during cell death triggers destabilization of client proteins. However, the specific role of truncated p23 (Δp23) in this process and the underlying mechanisms remain to be determined. One such client protein, hTERT, is a telomerase catalytic subunit regulated by several chaperone proteins, including Hsp90 and p23. In the present study, we examined the effects of p23 cleavage on hTERT stability and telomerase activity. Our data showed that overexpression of Δp23 resulted in a decrease in hTERT levels, and a down-regulation in telomerase activity. Serine phosphorylation of Hsp90 was significantly reduced in cells expressing high levels of Δp23 compared with those expressing full-length p23. Mutation analyses revealed that two serine residues (Ser-231 and Ser-263) in Hsp90 are important for activation of telomerase, and down-regulation of telomerase activity by Δp23 was associated with inhibition of cell growth and sensitization of cells to cisplatin. Our data aid in determining the mechanism underlying the regulation of telomerase activity by the chaperone complex during caspase-dependent cell death. 相似文献
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Histone deacetylation is directly involved in desilencing the expression of the catalytic subunit of telomerase in normal lung fibroblast 总被引:2,自引:0,他引:2
Mukhopadhyay NK Gordon GJ Maulik G Doerre G Liu BC Bueno R Sugarbaker DJ Jaklitsch MT 《Journal of cellular and molecular medicine》2005,9(3):662-669
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The EBNA2-related resistance towards alpha interferon (IFN-alpha) in Burkitt''s lymphoma cells effects induction of IFN-induced genes but not the activation of transcription factor ISGF-3.
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K Kanda T Decker P Aman M Wahlstr?m A von Gabain B Kallin 《Molecular and cellular biology》1992,12(11):4930-4936
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