From Healing to Witchcraft: On Ritual Speech and Roboticization in the Hospital

Healthcare Information Technology (HIT), touted as a panacea by U.S. political actors ranging from Newt Gingrich to Barack Obama, is central to emerging forms of healthcare governance which Holmes et al.—in their critique of the institutionalization of magical thinking brought about by Orwellian techno-Newspeak—have provocatively labeled fascistic. Drawing from data collected over 3 years of working with and teaching continuing education (CE) courses for thousands of registered nurses as lead political educator for the California Nurses Association/National Nurses Organizing Committee (CNA/NNOC), I argue that HIT is an integral component of a broader technological restructuring of healthcare and thus society, both of which are part of a social discourse that is tied to a transformative system of ritual speech, with profound implications for healthcare work, patient health, and democracy.     

Ritual and Performance in Domestic Violence Healing: From Survivor to Thriver Through Rites of Passage

This article describes a group for domestic violence survivors to help them move past a “liminal” state in which their social identity is characterized by being “victim” or “survivor” to one of “incorporation” defined by “thriving” and joy. Through the creation and use of healing rituals, blessings, poetry, art and music, the women in the group establish “communitas” and support each other in the work of self-reclamation and healing. The group, “Rites of Passage” is intended for women who have completed shelter-based crisis interventions, and uses a structured curriculum that integrates theoretical and philosophical concepts from anthropology, post-modernism, humanistic psychology, social work, and existentialism. Through the Rites of Passage group, women identify and traverse a healing trajectory to construct an identity founded on strength and fulfillment. Patterned after non-western sex-segregated rites of transition, those who go through the group celebrate its conclusion with a defining ritual that publically marks their change in identity and status.     

The Anthropology of Development and Globalization: From Classical Political Economy to Contemporary Neoliberalism

The Anthropology of Development and Globalization: From Classical Political Economy to Contemporary Neoliberalism . Marc Edelman and Angelique Haugerud, eds. Oxford: Blackwell Publishers, 2005. 406 pp.     

Domesticating Revolution: From Socialist Reform to Ambivalent Transition in a Bulgarian Village

Domesticating Revolution: From Socialist Reform to Ambivalent Transition in. Bulgarian Village. Gerald W. Creed. University Park: Pennsylvania State University Press, 1998. 304 pp.     

The Oedipus Complex, Antigone, and Electra: The Woman as Hero and Victim

This paper reinterprets the structural interpretation of Greek mythology presented by Leach and Lévi-Strauss from a feminist perspective. The reinterpretation approaches the Oedipus myth and Freud's analysis of it from the perspective of Antigone, daughter of Oedipus and a hero of Sophoclean tragedy. Ancient Greek tragedy allowed a few mythic women the role of hero, although women in ancient Greek society were confined to the domestic sphere. The paper discusses Antigone, Electra, and other mythic women in their relations to family and the public domain. The interpretation of Greek mythology differs from previous ones but is not inconsistent with them, [mythology, gender roles, Oedipus complex, myth and social structure, structuralism]     

Individual and Collective Rationality in Pastoral Production: Evidence From Northern Kenya

This study explores the individual and collective rationality of livestock accumulation in pastoral production using data gathered in northern Kenya. Results suggest accumulating wealth in livestock even when facing the prospect of sudden dramatic loss makes sense at the household level, and that there is limited empirical support to the contention that herd accumulation at the household level imposes a cost on other households. I conclude by arguing the record of failure in pastoral development may be at least partially due to a faulty conceptual foundation, and suggest facilitating herd accumulation may offer more promise than discouraging it.     

From Moral Protest to Religious Politics: Ethical Demands and Beur Political Action in France

This paper traces the responses of Muslim youths ('Beurs') to their marginalisation in France. The Beur movement acquired national significance via the politicisation of moral protest in the early 1980s. In spite of early successes, the movement stumbled when the 'politics of austerity' adopted by the French state amplified a social crisis for which migrants became the scapegoats. The Beur movement, like other youth movements of the period, expressed a search for solidarity and a stress on ethical demands. Beurs' disenchantment when their civic elan ran out in the face of everyday difficulties led some to transfer their search for solidarity to the terrain of Islam. Islam, the paper argues, often appears to provide answers to the particular complex of politico-ethical demands for social justice and dignity that the Beur movement expressed. However, the Islamist re-conversion of some Beur militants is to be read as the result of a particular conjunction of multiple power relations which would integrate economic, social, cultural and gender dimensions. It is not necessarily indicative of a failure of the politics of moral protest to promote progressive transformational politics.     

From chromatin to splicing: RNA-processing as a total artwork

RNA plays a central role in the determination of the phenotype of the cell. The molecular mechanisms involved in primary RNA synthesis and subsequent post-processing are not completely understood, but there is increasing evidence that they are more tightly coupled than previously expected. The analyses by a number of groups of recently published genome wide maps of chromatin structure have further uncovered a role for primary chromatin structure in RNA processing. Indeed, these analyses have revealed that nucleosomes show a characteristic occupancy pattern in exonic regions of metazoan genomes. The pattern is strongly indicative of an implication of nucleosome positioning in exon recognition during pre-mRNA splicing. Characteristic exonic patterns have also been observed for a number of histone modifications, suggesting the possibility that chromatin state plays a direct role in the regulation of splicing.     

Sharing Individual Participant Data from Clinical Trials: An Opinion Survey Regarding the Establishment of a Central Repository

Background

Calls have been made for increased access to individual participant data (IPD) from clinical trials, to ensure that complete evidence is available. However, despite the obvious benefits, progress towards this is frustratingly slow. In the meantime, many systematic reviews have already collected IPD from clinical trials. We propose that a central repository for these IPD should be established to ensure that these datasets are safeguarded and made available for use by others, building on the strengths and advantages of the collaborative groups that have been brought together in developing the datasets.

Objective

Evaluate the level of support, and identify major issues, for establishing a central repository of IPD.

Design

On-line survey with email reminders.

Participants

71 reviewers affiliated with the Cochrane Collaboration''s IPD Meta-analysis Methods Group were invited to participate.

Results

30 (42%) invitees responded: 28 (93%) had been involved in an IPD review and 24 (80%) had been involved in a randomised trial. 25 (83%) agreed that a central repository was a good idea and 25 (83%) agreed that they would provide their IPD for central storage. Several benefits of a central repository were noted: safeguarding and standardisation of data, increased efficiency of IPD meta-analyses, knowledge advancement, and facilitating future clinical, and methodological research. The main concerns were gaining permission from trial data owners, uncertainty about the purpose of the repository, potential resource implications, and increased workload for IPD reviewers. Restricted access requiring approval, data security, anonymisation of data, and oversight committees were highlighted as issues under governance of the repository.

Conclusion

There is support in this community of IPD reviewers, many of whom are also involved in clinical trials, for storing IPD in a central repository. Results from this survey are informing further work on developing a repository of IPD which is currently underway by our group.     

From LOC to LIC: Using individual cells as experimentation platforms

There are many efforts today trying to mimic the properties of single cells in order to design chips that are as efficient as cells. However, cells are nature’s nanotechnology engineering at the scale of atoms and molecules. Therefore, it might be better to vision a microchip that utilizes a single cell as experimentation platform. A novel, so-called Lab-in-a-Cell (LIC) concept is described, where advantage is taken of micro/nanotechnological tools to enable precise control of the biochemical cellular environment and possibility to analyze the composition of single cells.     

From a Traditional Medicinal Plant to a Rational Drug: Understanding the Clinically Proven Wound Healing Efficacy of Birch Bark Extract

Background

Birch bark has a long lasting history as a traditional medicinal remedy to accelerate wound healing. Recently, the efficacy of birch bark preparations has also been proven clinically. As active principle pentacyclic triterpenes are generally accepted. Here, we report a comprehensive study on the underlying molecular mechanisms of the wound healing properties of a well-defined birch bark preparation named as TE (triterpene extract) as well as the isolated single triterpenes in human primary keratinocytes and porcine ex-vivo wound healing models.

Methodology/Principal Findings

We show positive wound healing effects of TE and betulin in scratch assay experiments with primary human keratinocytes and in a porcine ex-vivo wound healing model (WHM). Mechanistical studies elucidate that TE and betulin transiently upregulate pro-inflammatory cytokines, chemokines and cyclooxygenase-2 on gene and protein level. For COX-2 and IL-6 this increase of mRNA is due to an mRNA stabilizing effect of TE and betulin, a process in which p38 MAPK and HuR are involved. TE promotes keratinocyte migration, putatively by increasing the formation of actin filopodia, lamellipodia and stress fibers. Detailed analyses show that the TE components betulin, lupeol and erythrodiol exert this effect even in nanomolar concentrations. Targeting the actin cytoskeleton is dependent on the activation of Rho GTPases.

Conclusion/Significance

Our results provide insights to understand the molecular mechanism of the clinically proven wound healing effect of birch bark. TE and betulin address the inflammatory phase of wound healing by transient up-regulation of several pro-inflammatory mediators. Further, they enhance migration of keratinocytes, which is essential in the second phase of wound healing. Our results, together with the clinically proven efficacy, identify birch bark as the first medical plant with a high potential to improve wound healing, a field which urgently needs effective remedies.     

Biomimetics: From Bioinformatics to Rational Design of Dendrimers as Gene Carriers

Biomimetics, or the use of principles of Nature for developing new materials, is a paradigm that could help Nanomedicine tremendously. One of the current challenges in Nanomedicine is the rational design of new efficient and safer gene carriers. Poly(amidoamine) (PAMAM) dendrimers are a well-known class of nanoparticles, extensively used as non-viral nucleic acid carriers, due to their positively charged end-groups. Yet, there are still several aspects that can be improved for their successful application in in vitro and in vivo systems, including their affinity for nucleic acids as well as lowering their cytotoxicity. In the search of new functional groups that could be used as new dendrimer-reactive groups, we followed a biomimetic approach to determine the amino acids with highest prevalence in protein-DNA interactions. Then we introduced them individually as terminal groups of dendrimers, generating a new class of nanoparticles. Molecular dynamics studies of two systems: PAMAM-Arg and PAMAM-Lys were also performed in order to describe the formation of complexes with DNA. Results confirmed that the introduction of amino acids as terminal groups in a dendrimer increases their affinity for DNA and the interactions in the complexes were characterized at atomic level. We end up by briefly discussing additional modifications that can be made to PAMAM dendrimers to turned them into promising new gene carriers.