共查询到20条相似文献,搜索用时 31 毫秒
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Ting Gong Jianhua Xuan Li Chen Rebecca B Riggins Huai Li Eric P Hoffman Robert Clarke Yue Wang 《BMC bioinformatics》2011,12(1):82
Background
Genes work coordinately as gene modules or gene networks. Various computational approaches have been proposed to find gene modules based on gene expression data; for example, gene clustering is a popular method for grouping genes with similar gene expression patterns. However, traditional gene clustering often yields unsatisfactory results for regulatory module identification because the resulting gene clusters are co-expressed but not necessarily co-regulated. 相似文献5.
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Areejit Samal Shalini Singh Varun Giri Sandeep Krishna Nandula Raghuram Sanjay Jain 《BMC bioinformatics》2006,7(1):118
Background
Recently there has been a lot of interest in identifying modules at the level of genetic and metabolic networks of organisms, as well as in identifying single genes and reactions that are essential for the organism. A goal of computational and systems biology is to go beyond identification towards an explanation of specific modules and essential genes and reactions in terms of specific structural or evolutionary constraints. 相似文献9.
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Reza Mobini Bengt A Andersson Jonas Erjefält Mirjana Hahn-Zoric Michael A Langston Andy D Perkins Lars Olaf Cardell Mikael Benson 《BMC systems biology》2009,3(1):19-11
Background
The identification of novel genes by high-throughput studies of complex diseases is complicated by the large number of potential genes. However, since disease-associated genes tend to interact, one solution is to arrange them in modules based on co-expression data and known gene interactions. The hypothesis of this study was that such a module could be a) found and validated in allergic disease and b) used to find and validate one ore more novel disease-associated genes. 相似文献13.
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Background
Cis-regulatory modules (CRMs) are short stretches of DNA that help regulate gene expression in higher eukaryotes. They have been found up to 1 megabase away from the genes they regulate and can be located upstream, downstream, and even within their target genes. Due to the difficulty of finding CRMs using biological and computational techniques, even well-studied regulatory systems may contain CRMs that have not yet been discovered. 相似文献18.
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The discovery of cis-regulatory modules in metazoan genomes is crucial for understanding the connection between genes and organism diversity. It is important to quantify how comparative genomics can improve computational detection of such modules. 相似文献19.
Detection of evolutionarily stable fragments of cellular pathways by hierarchical clustering of phyletic patterns 总被引:2,自引:0,他引:2
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