共查询到7条相似文献,搜索用时 0 毫秒
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Petra Patakova Jan Kolek Karel Sedlar Pavlina Koscova Barbora Branska Kristyna Kupkova Leona Paulova Ivo Provaznik 《Biotechnology advances》2018,36(3):721-738
2016, was the 100 years anniversary from launching of the first industrial acetone-butanol-ethanol (ABE) microbial production process. Despite this long period and also revival of scientific interest in this fermentative process over the last 20 years, solventogenic clostridia, mainly Clostridium acetobutylicum, Clostridium beijerinckii, Clostridium saccharoperbutylacetonicum and Clostridium pasteurianum, still have most of their secrets. One such poorly understood mechanism is butanol tolerance, which seems to be one of the most significant bottlenecks obstructing industrial exploitation of the process because the maximum achievable butanol concentration is only about 21 g/L. This review describes all the known cellular responses elicited by butanol, such as modifications of cell membrane and cell wall, formation of stress proteins, extrusion of butanol by efflux pumps, response of regulatory pathways, and also maps both random and targeted mutations resulting in high butanol production phenotypes. As progress in the field is inseparably associated with emerging methods, enabling a deeper understanding of butanol tolerance and production, progress in these methods, including genome mining, RNA sequencing and constructing of genome scale models are also reviewed. In conclusion, a comparative analysis of both phenomena is presented and a theoretical relationship is described between butanol tolerance/high production and common features including efflux pump formation/activity, stress protein production, membrane modifications and biofilm growth. 相似文献
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Genome‐scale metabolic modeling and in silico analysis of lipid accumulating yeast Candida tropicalis for dicarboxylic acid production
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Pranjul Mishra Gyu‐Yeon Park Meiyappan Lakshmanan Hee‐Seok Lee Hongweon Lee Matthew Wook Chang Chi Bun Ching Jungoh Ahn Dong‐Yup Lee 《Biotechnology and bioengineering》2016,113(9):1993-2004
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Ectopic expression of NnPER1, a Nelumbo nucifera 1‐cysteine peroxiredoxin antioxidant,enhances seed longevity and stress tolerance in Arabidopsis
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Hu‐hui Chen Pu Chu Yu‐liang Zhou Yu Ding Yin Li Jun Liu Li‐wen Jiang Shang‐zhi Huang 《The Plant journal : for cell and molecular biology》2016,88(4):608-619
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Heterotrimeric G‐proteins consisting of Gα, Gβ and Gγ subunits play an integral role in mediating multiple signalling pathways in plants. A novel, recently identified plant‐specific Gγ protein, AGG3, has been proposed to be an important regulator of organ size and mediator of stress responses in Arabidopsis, whereas its potential homologs in rice are major quantitative trait loci for seed size and panicle branching. To evaluate the role of AGG3 towards seed and oil yield improvement, the gene was overexpressed in Camelina sativa, an oilseed crop of the Brassicaceae family. Analysis of multiple homozygous T4 transgenic Camelina lines showed that constitutive overexpression of AGG3 resulted in faster vegetative as well as reproductive growth accompanied by an increase in photosynthetic efficiency. Moreover, when expressed constitutively or specifically in seed tissue, AGG3 was found to increase seed size, seed mass and seed number per plant by 15%–40%, effectively resulting in significantly higher oil yield per plant. AGG3 overexpressing Camelina plants also exhibited improved stress tolerance. These observations draw a strong link between the roles of AGG3 in regulating two critical yield parameters, seed traits and plant stress responses, and reveal an effective biotechnological tool to dramatically increase yield in agricultural crops. 相似文献
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Protective effects of microRNA‐330 on amyloid β‐protein production,oxidative stress,and mitochondrial dysfunction in Alzheimer's disease by targeting VAV1 via the MAPK signaling pathway
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Ying Zhou Zhou‐Fan Wang Wei Li Hui Hong Juan Chen Yi Tian Zhao‐Yun Liu 《Journal of cellular biochemistry》2018,119(7):5437-5448
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Yoshiji Ohta Koji Yashiro Shingo Kaida Yoichiro Imai Koji Ohashi Akira Kitagawa 《Cell biochemistry and function》2013,31(3):254-262
We examined whether water‐immersion restraint stress (WIRS) disrupts nonenzymatic antioxidant defense systems through ascorbic acid depletion in the adrenal gland of rats. Rats were exposed to WIRS for 0.5, 1.5, 3 or 6 h. WIRS increased serum adrenocorticotropic hormone, corticosterone and glucose concentrations and adrenal corticosterone content at each time point. WIRS increased adrenal lipid peroxide content at 3 and 6 h, and the increase was twofold higher than the unstressed level at 6 h. WIRS decreased adrenal ascorbic acid content at each time point, and the decrease reached one‐third of the unstressed level at 6 h. WIRS increased adrenal reduced glutathione content at 0.5 and 6 h but reduced that content to half of the unstressed level at 6 h. WIRS increased adrenal α‐tocopherol content at 1.5 h but returned that content to the unstressed level thereafter. When rats with 6 h of WIRS was orally preadministered with l ‐ascorbic acid (250 mg/kg), WIRS‐induced changes in adrenal lipid peroxide, ascorbic acid and reduced glutathione contents were attenuated without any change in stress response. These results indicate that WIRS disrupts nonenzymatic antioxidant defense systems through rapid and continuous ascorbic acid depletion in the adrenal gland of rats. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献