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Differential binding of zinc fingers from Xenopus TFIIIA and p43 to 5S RNA and the 5S RNA gene.
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Zinc fingers are usually associated with proteins that interact with DNA. Yet in two oocyte-specific Xenopus proteins, TFIIA and p43, zinc fingers are used to bind 5S RNA. One of these, TFIIIA, also binds the 5S RNA gene. Both proteins have nine zinc fingers that are nearly identical with respect to size and spacing. We have determined the relative affinities of groups of zinc fingers from TFIIIA for both 5S RNA and the 5S RNA gene. We have also determined the relative affinities of groups of zinc fingers from p43 for 5S RNA. The primary protein regions for RNA and DNA interaction in TFIIIA are located at opposite ends of the molecule. All zinc fingers from TFIIIA participate in binding 5S RNA, but zinc fingers from the C terminus have the highest affinity. N-terminal zinc fingers are essential for binding the 5S RNA gene. In contrast, zinc fingers at the amino terminus of p43 are essential for binding 5S RNA. 相似文献
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Characterization of the equilibrium binding of Xenopus transcription factor IIIA to the 5 S RNA gene 总被引:3,自引:0,他引:3
P J Romaniuk 《The Journal of biological chemistry》1990,265(29):17593-17600
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Transcription fraction TFIIIC can regulate differential Xenopus 5S RNA gene transcription in vitro 总被引:30,自引:4,他引:26
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A P Wolffe 《The EMBO journal》1988,7(4):1071-1079
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Xenopus transcription factor IIIA-dependent DNA renaturation 总被引:1,自引:0,他引:1