Peak force and rate of force development during isometric and dynamic mid-thigh clean pulls performed at various intensities

Eight male collegiate weightlifters (age: 21.2 +/- 0.9 years; height: 177.6 +/- 2.3 cm; and body mass: 85.1 +/- 3.3 kg) participated in this study to compare isometric to dynamic force-time dependent variables. Subjects performed the isometric and dynamic mid-thigh clean pulls at 30-120% of their one repetition maximum (1RM) power clean (118.4 +/- 5.5 kg) on a 61 x 121.9-cm AMTI forceplate. Variables such as peak force (PF) and peak rate of force development (PRFD) were calculated and were compared between isometric and dynamic conditions. The relationships between force-time dependent variables and vertical jump performances also were examined. The data indicate that the isometric PF had no significant correlations with the dynamic PF against light loads. On the one hand, there was a general trend toward stronger relationships between the isometric and dynamic PF as the external load increased for dynamic muscle actions. On the other hand, the isometric and dynamic PRFD had no significant correlations regardless of the external load used for dynamic testing. In addition, the isometric PF and dynamic PRFD were shown to be strongly correlated with vertical jump performances, whereas the isometric PRFD and dynamic PF had no significant correlations with vertical jump performances. In conclusion, it appears that the isometric and dynamic measures of force-time curve characteristics represent relatively specific qualities, especially when dynamic testing involves small external loads. Additionally, the results suggest that athletes who possess greater isometric maximum strength and dynamic explosive strength tend to be able to jump higher.     

动态分子网络的构建与分析

分子网络研究是从全局角度揭示生物系统的结构和功能的重要手段,现有的网络分析大部分是基于静态网络.实际上,在不同的环境条件、组织类型和疾病状态以及生长和分化的过程中,分子网络时刻都在发生变化.经过研究人员的努力,人们已经提出了一些可用于分析分子网络动态的生物信息学方法,如节点的动态性分类、动态蛋白质复合物的预测、条件特异子网的构建以及网络动态行为的模拟等.本文综述了动态分子网络的构建与分析方法.可以预见,动态网络分析将成为未来网络研究的标准模式.     

Pedicle screw-based posterior dynamic stabilisation of the lumbar spine: in vitro cadaver investigation and a finite element study

Pedicle screw-based dynamic constructs either benefit from a dynamic (flexible) interconnecting rod or a dynamic (hinged) screw. Both types of systems have been reported in the literature. However, reports where the dynamic system is composed of two dynamic components, i.e. a dynamic (hinged) screw and a dynamic rod, are sparse. In this study, the biomechanical characteristics of a novel pedicle screw-based dynamic stabilisation system were investigated and compared with equivalent rigid and semi-rigid systems using in vitro testing and finite element modelling analysis. All stabilisation systems restored stability after decompression. A significant decrease in the range of motion was observed for the rigid system in all loadings. In the semi-rigid construct the range of motion was significantly less than the intact in extension, lateral bending and axial rotation loadings. There were no significant differences in motion between the intact spine and the spine treated with the dynamic system (P>0.05). The peak stress in screws was decreased when the stabilisation construct was equipped with dynamic rod and/or dynamic screws.     

The dynamic viscoelasticity and plasticizer leachability of tissue conditioners

doi: 10.1111/j.1741‐2358.2012.00639.x
The dynamic viscoelasticity and plasticizer leachability of tissue conditioners Objectives: Dynamic viscoelasticity is one of the most important characteristics of tissue conditioners. Leaching of plasticizer from tissue conditioners may cause changes in the dynamic viscoelasticity of these materials. The purpose of this study was to determine the dynamic viscoelasticity and plasticizer leachability of commercial tissue conditioners. Materials and methods: Five commercial tissue conditioners were used in this study: COE Comfort (CC), Fit Softer (FS), Hydro‐Cast (HC), Soft Conditioner (SC) and Visco‐Gel (VG). Five specimens of each material were stored in 37°C distilled water. The dynamic viscoelasticity and plasticizer leaching of each specimen were measured at 0, 1, 3, 7 and 14 days after immersion using a dynamic mechanical analyzer and high performance liquid chromatography. Data were analyzed using one‐way anova and Student–Newman–Keuls test (α = 0.05). Results: Significant differences in dynamic viscoelasticity and plasticizer leaching were found among the materials. The dynamic viscoelasticity of all materials increased or decreased significantly with time. Rapid changes in dynamic viscoelasticity were evident on day 1 after water immersion. The material CC recorded the highest level of plasticizer leaching. Conclusion: These results suggest that the dynamic viscoelasticity of commercial tissue conditioners is affected by plasticizer leaching. However, these effects are limited.     

Skeletal muscle blood flow and flow heterogeneity during dynamic and isometric exercise in humans

The effects of dynamic and intermittent isometric knee extension exercises on skeletal muscle blood flow and flow heterogeneity were studied in seven healthy endurance-trained men. Regional muscle blood flow was measured using positron emission tomography (PET) and an [(15)O]H(2)O tracer, and electromyographic (EMG) activity was recorded in the quadriceps femoris (QF) muscle during submaximal intermittent isometric and dynamic exercises. QF blood flow was 61% (P = 0.002) higher during dynamic exercise. Interestingly, flow heterogeneity was 13% (P = 0.024) lower during dynamic compared with intermittent isometric exercise. EMG activity was significantly higher (P < 0.001) during dynamic exercise, and the change in EMG activity from isometric to dynamic exercise was tightly related to the change in blood flow in the vastus lateralis muscle (r = 0.98, P < 0.001) but not in the rectus femoris muscle (r = -0.09, P = 0.942). In conclusion, dynamic exercise causes higher and less heterogeneous blood flow than intermittent isometric exercise at the same exercise intensity. These responses are, at least partly, related to the increased EMG activity.     

Natural selection and social preferences

A large number of individuals are randomly matched into groups, where each group plays a finite symmetric game. Individuals breed true. The expected number of surviving offspring depends on own material payoff, but may also, due to cooperative breeding and/or reproductive competition, depend on the material payoffs to other group members. The induced population dynamic is equivalent with the replicator dynamic for a game with payoffs derived from those in the original game. We apply this selection dynamic to a number of examples, including prisoners' dilemma games with and without a punishment option, coordination games, and hawk-dove games. For each of these, we compare the outcomes with those obtained under the standard replicator dynamic. By way of a revealed-preference argument, our selection dynamic can explain certain "altruistic" and "spiteful" behaviors that are consistent with individuals having social preferences.     

Static and dynamic optimization solutions for gait are practically equivalent

The proposition that dynamic optimization provides better estimates of muscle forces during gait than static optimization is examined by comparing a dynamic solution with two static solutions. A 23-degree-of-freedom musculoskeletal model actuated by 54 Hill-type musculotendon units was used to simulate one cycle of normal gait. The dynamic problem was to find the muscle excitations which minimized metabolic energy per unit distance traveled, and which produced a repeatable gait cycle. In the dynamic problem, activation dynamics was described by a first-order differential equation. The joint moments predicted by the dynamic solution were used as input to the static problems. In each static problem, the problem was to find the muscle activations which minimized the sum of muscle activations squared, and which generated the joint moments input from the dynamic solution. In the first static problem, muscles were treated as ideal force generators; in the second, they were constrained by their force-length-velocity properties; and in both, activation dynamics was neglected. In terms of predicted muscle forces and joint contact forces, the dynamic and static solutions were remarkably similar. Also, activation dynamics and the force-length-velocity properties of muscle had little influence on the static solutions. Thus, for normal gait, if one can accurately solve the inverse dynamics problem and if one seeks only to estimate muscle forces, the use of dynamic optimization rather than static optimization is currently not justified. Scenarios in which the use of dynamic optimization is justified are suggested.     

Generality versus specificity: a comparison of dynamic and isometric measures of strength and speed-strength

Considerable debate exists as to whether the qualities of muscle function exist as general or specific physiological capacities. If there is a generality of muscle function then strong relationships would exist between various measures of function for the same muscle(s), independent of the test contraction, mode or velocity. The purpose of this study was to examine the relationship between isometric and dynamic measures of muscle function to determine the existence of generality or specificity. A group of 22 men, experienced in weight training, were tested for lower and upper body dynamic and isometric measures of strength and speed-strength. The changes in these measures consequent to a resistance training programme were also investigated. The results of this study indicated that whilst isometric and dynamic measures of strength did significantly correlate (r=0.57-0.61), the relationship was below that required to denote statistical generality. More important, the changes in isometric and dynamic strength consequent to a dynamic heavy resistance training programme were unrelated (r=0.12-0.15). Thus the mechanisms that contribute to enhanced dynamic strength appearred unrelated to the mechanisms that contribute to enhanced isometric strength. Measures of dynamic and isometric speed-strength were unrelated, as were the changes in these measures resulting from training. The results of this study demonstrated that a generality of muscle function did not exist and that modality specific results were observed. Consequently this study calls into question the validity of isometric tests to monitor dynamically induced training adaptations.     

Breeding biology and the evolution of dynamic sexual dichromatism in frogs

Dynamic sexual dichromatism is a temporary colour change between the sexes and has evolved independently in a wide range of anurans, many of which are explosive breeders wherein males physically compete for access to females. Behavioural studies in a few species indicate that dynamic dichromatism functions as a visual signal in large breeding aggregations; however, the prevalence of this trait and the social and environmental factors underlying its expression are poorly understood. We compiled a database of 178 anurans with dynamic dichromatism that include representatives from 15 families and subfamilies. Dynamic dichromatism is common in two of the three subfamilies of hylid treefrogs. Phylogenetic comparative analyses of 355 hylid species (of which 95 display dynamic dichromatism) reveal high transition rates between dynamic dichromatism, ontogenetic (permanent) dichromatism and monochromatism reflecting the high evolutionary lability of this trait. Correlated evolution in hylids between dynamic dichromatism and forming large breeding aggregations indicates that the evolution of large breeding aggregations precedes the evolution of dynamic dichromatism. Multivariate phylogenetic logistic regression recovers the interaction between biogeographic distribution and forming breeding aggregations as a significant predictor of dynamic dichromatism in hylids. Accounting for macroecological differences between temperate and tropical regions, such as seasonality and the availability of breeding sites, may improve our understanding of ecological contexts in which dynamic dichromatism is likely to arise in tropical lineages and why it is retained in some temperate species and lost in others.     

动态MPCA在发酵过程监测与故障诊断中的应用

针对发酵过程非线性和时变特点,提出了一种具有实时性的动态MPCA方法,采用多模型非线性结构代替传统MPCA单模型线性化结构,克服了后者不能处理非线性过程和实时性的问题,并避免了MPCA在线应用时预报未来测量值带来的误差,提高了发酵过程性能监测和故障诊断的准确性。对头孢菌素C发酵过程的拟在线仿真研究,验证了基于动态MPCA的统计过程监测的有效性。     

Relationship between measures of balance and strength in middle-aged adults

The purpose of this study was to investigate the relationship between variables of static and dynamic postural control as well as between isometric and dynamic muscle strength. A single-group design was used. Thirty-two middle-aged healthy adults (mean age: 56 ± 4 years) performed measurements of static (unperturbed)/dynamic (perturbed) balance and of isometric (i.e., maximal isometric torque [MIT]; rate of torque development [RTD] of the plantar flexor)/dynamic (i.e., countermovement jump [CMJ] height and power) lower extremity muscle strength. No significant associations were observed between variables of static and dynamic postural control (r = +0.128-0.341, p > 0.05) and between measures of balance and strength (r = -0.189 to +0.316, p > 0.05). Significant positive correlations were detected between variables of isometric and dynamic strength ranging from r = +0.361 to +0.501 (p < 0.05). Further, simple regression analyses revealed that a 10% increase in the mean CMJ height (3.1 cm) was associated with 44.4 N·m and 118.4 N·m·s better MIT and RTD, respectively. The nonsignificant correlations between static and dynamic balance measures and between balance and strength variables imply that static and dynamic postural control and balance and strength are independent of each other and may have to be tested and trained complementarily.     

A comparison of the effects of mixed static and dynamic work with mainly dynamic work in hot conditions

Current physiological criteria for limiting work in hot conditions are frequently based on responses to mainly dynamic work (eg treadmill walking). Their applicability to industrial situations containing mixed static and dynamic work is questioned, since the physiological responses to static work are different from those of dynamic work. Each of eight subjects attempted a one hour uphill treadmill walk (mainly dynamic work), and an uphill treadmill walk whilst intermittently carrying a 20 kg weight in the arms (mixed static and dynamic work). The external work rates in the two conditions were equal, effected by lowering the treadmill gradient in the loaded condition. Experiments were conducted in a hot climate (33 degrees C dry bulb, 25 degrees C wet bulb). Oxygen consumption, minute ventilation, sweat rate and rated perceived exertion were all significantly higher (p less than 0.001) for the mixed static and dynamic work than for the dynamic work. This was also the case for heart rate and forearm skin temperature (p less than 0.01), and for auditory canal temperature (p less than 0.05). There was no significant difference between the two types of work for mean skin temperature, calf skin temperature and chest skin temperature. These results show that for the same external work, physiological strain and perceived exertion are greater for mixed static and dynamic work (carrying a load in the arms) than for mainly dynamic work (walking on a treadmill). They suggest that it is not appropriate to make direct comparisons of laboratory studies based on dynamic work, with practical situations containing mixed static and dynamic work in the heat.     

Laplacian Estrada and Normalized Laplacian Estrada Indices of Evolving Graphs

Large-scale time-evolving networks have been generated by many natural and technological applications, posing challenges for computation and modeling. Thus, it is of theoretical and practical significance to probe mathematical tools tailored for evolving networks. In this paper, on top of the dynamic Estrada index, we study the dynamic Laplacian Estrada index and the dynamic normalized Laplacian Estrada index of evolving graphs. Using linear algebra techniques, we established general upper and lower bounds for these graph-spectrum-based invariants through a couple of intuitive graph-theoretic measures, including the number of vertices or edges. Synthetic random evolving small-world networks are employed to show the relevance of the proposed dynamic Estrada indices. It is found that neither the static snapshot graphs nor the aggregated graph can approximate the evolving graph itself, indicating the fundamental difference between the static and dynamic Estrada indices.     

Innovation cascades: artefacts,organization and attributions

Innovation cascades inextricably link the introduction of new artefacts, transformations in social organization, and the emergence of new functionalities and new needs. This paper describes a positive feedback dynamic, exaptive bootstrapping, through which these cascades proceed, and the characteristics of the relationships in which the new attributions that drive this dynamic are generated. It concludes by arguing that the exaptive bootstrapping dynamic is the principal driver of our current Innovation Society.     

Static and Dynamic Facial Images Cue Similar Attractiveness Judgements

Approaches to the study of human mate preferences commonly involve judgements of facial photographs and assume that these judgements provide a reasonable reflection of how individuals would be perceived in real encounters. However, three recent studies have each reported non‐significant correlations between judgements using photos (static images) and those using videos (dynamic images). These results have led previous authors to conclude that static and dynamic faces are judged according to different evaluative standards and that this may call into question the validity of findings from experiments using static images. However, the extent of the discrepancy in judgements between image formats remains unknown, and may be influenced by different experimental designs. Here, we tested the effects of several experimental design factors on the strength of correlations between image presentation formats. Using both male and female targets, we compared observed static–dynamic judgement correlations when (1) judgements were made by the same or different raters, or (2) by raters of the same‐ or opposite‐sex to the targets, and (3) when dynamic stimuli were collected under different contextual scenarios. For (1) and (2), we also measured correlations when order of presentation of static and dynamic stimuli was alternated. Our results suggest that each design feature has independent effects on the strength of static–dynamic correlations. Correlations were stronger when static and dynamic stimuli were rated by the same raters. They were weakest for judgements of males by females, when based on seeing photos before videos. This interaction with sex is consistent with previous studies, indicating that females are especially responsive to male dynamic cues. However, in contrast to previous findings and in all cases, static–dynamic correlations were strongly and significantly positive, indicating that judgments based on static images provide an accurate representation of someone’s attractiveness during prolonged encounters.     

Toward a Typology of Dynamic and Hazardous Work Environments

The most hazardous work environments share one feature in common: constant change. Many different, but constantly changing hazards are found in agriculture, construction, mining, and transport. This dynamic feature of workplace hazards varies by: (1) degree of control, (2) predictability, (3) visibility, (4) movement, and (5) degree of speed and force. In some cases the actions of the dynamic hazards are required for production to take place, and in many cases, several different hazards may overlap and interact. Finally, whether intentional or unintentional, some dynamic hazards are human generated. These are some of the features that distinguish dynamic and hazardous work environments across a variety of industries. The authors propose a preliminary typology of dynamic and hazardous work environments, along with a schema to systematically observe the dynamic characteristics of these hazards. The implications of this typology are considered with respect to worker training, hazard awareness, and safe work practices. For example, the implementation of the Hierarchy of Control is shown to require active worker involvement at every level in the hierarchy, except where an environmental hazard has been completely eliminated.     

Dynamic response of immature bovine articular cartilage in tension and compression, and nonlinear viscoelastic modeling of the tensile response

Very limited information is currently available on the constitutive modeling of the tensile response of articular cartilage and its dynamic modulus at various loading frequencies. The objectives of this study were to (1) formulate and experimentally validate a constitutive model for the intrinsic viscoelasticity of cartilage in tension, (2) confirm the hypothesis that energy dissipation in tension is less than in compression at various loading frequencies, and (3) test the hypothesis that the dynamic modulus of cartilage in unconfined compression is dependent upon the dynamic tensile modulus. Experiment 1: Immature bovine articular cartilage samples were tested in tensile stress relaxation and cyclical loading. A proposed reduced relaxation function was fitted to the stress-relaxation response and the resulting material coefficients were used to predict the response to cyclical loading. Adjoining tissue samples were tested in unconfined compression stress relaxation and cyclical loading. Experiment 2: Tensile stress relaxation experiments were performed at varying strains to explore the strain-dependence of the viscoelastic response. The proposed relaxation function successfully fit the experimental tensile stress-relaxation response, with R2 = 0.970+/-0.019 at 1% strain and R2 = 0.992+/-0.007 at 2% strain. The predicted cyclical response agreed well with experimental measurements, particularly for the dynamic modulus at various frequencies. The relaxation function, measured from 2% to 10% strain, was found to be strain dependent, indicating that cartilage is nonlinearly viscoelastic in tension. Under dynamic loading, the tensile modulus at 10 Hz was approximately 2.3 times the value of the equilibrium modulus. In contrast, the dynamic stiffening ratio in unconfined compression was approximately 24. The energy dissipation in tension was found to be significantly smaller than in compression (dynamic phase angle of 16.7+/-7.4 deg versus 53.5+/-12.8 deg at 10(-3) Hz). A very strong linear correlation was observed between the dynamic tensile and dynamic compressive moduli at various frequencies (R2 = 0.908+/-0.100). The tensile response of cartilage is nonlinearly viscoelastic, with the relaxation response varying with strain. A proposed constitutive relation for the tensile response was successfully validated. The frequency response of the tensile modulus of cartilage was reported for the first time. Results emphasize that fluid-flow dependent viscoelasticity dominates the compressive response of cartilage, whereas intrinsic solid matrix viscoelasticity dominates the tensile response. Yet the dynamic compressive modulus of cartilage is critically dependent upon elevated values of the dynamic tensile modulus.     

Time Horizon and Dominance in Dynamic Life Cycle Assessment

Temporal aspects have traditionally not been recognized adequately in life cycle assessment (LCA). The dynamic LCA model recently proposed offers a significant step forward in the dynamic assessment of global warming impacts. The results obtained with dynamic LCA are highly sensitive to the choice of a time horizon. Therefore, decision making between alternative systems can be critical because conclusions are dependent on the specific time horizon. In this article, we develop a decision‐making methodology based on the concept of time dominance. We introduce instantaneous and cumulative time dominance criteria to the dynamic LCA context and argue why the dominance of an alternative should also imply preference. Our approach allows for the rejection of certain alternatives without the determination of a specific time horizon. The number of decision‐relevant alternatives can thereby be reduced and the decision problem facilitated. We demonstrate our methodology by means of a case study of end‐of‐life alternatives for a wooden chair derived from the original authors of dynamic LCA and discuss the implications and limitations of the approach. The methodology based on time dominance criteria is supplementary to the dynamic LCA model, but does not substitute it. The overall value of this article stretches beyond LCA onto more general assessments of global warming, for example, in policy where the choice of a time horizon is equally significant.     

Chondrocyte intracellular calcium, cytoskeletal organization, and gene expression responses to dynamic osmotic loading

While chondrocytes in articular cartilage experience dynamic stimuli from joint loading activities, few studies have examined the effects of dynamic osmotic loading on their signaling and biosynthetic activities. We hypothesize that dynamic osmotic loading modulates chondrocyte signaling and gene expression differently than static osmotic loading. With the use of a novel microfluidic device developed in our laboratory, dynamic hypotonic loading (–200 mosM) was applied up to 0.1 Hz and chondrocyte calcium signaling, cytoskeleton organization, and gene expression responses were examined. Chondrocytes exhibited decreasing volume and calcium responses with increasing loading frequency. Phalloidin staining showed osmotic loading-induced changes to the actin cytoskeleton in chondrocytes. Real-time PCR analysis revealed a stimulatory effect of dynamic osmotic loading compared with static osmotic loading. These studies illustrate the utility of the microfluidic device in cell signaling investigations, and their potential role in helping to elucidate mechanisms that mediate chondrocyte mechanotransduction to dynamic stimuli. cartilage; calcium signaling; actin cytoskeleton; aggrecan     

Dynamic Range of Vertebrate Retina Ganglion Cells: Importance of Active Dendrites and Coupling by Electrical Synapses

The vertebrate retina has a very high dynamic range. This is due to the concerted action of its diverse cell types. Ganglion cells, which are the output cells of the retina, have to preserve this high dynamic range to convey it to higher brain areas. Experimental evidence shows that the firing response of ganglion cells is strongly correlated with their total dendritic area and only weakly correlated with their dendritic branching complexity. On the other hand, theoretical studies with simple neuron models claim that active and large dendritic trees enhance the dynamic range of single neurons. Theoretical models also claim that electrical coupling between ganglion cells via gap junctions enhances their collective dynamic range. In this work we use morphologically reconstructed multi-compartmental ganglion cell models to perform two studies. In the first study we investigate the relationship between single ganglion cell dynamic range and number of dendritic branches/total dendritic area for both active and passive dendrites. Our results support the claim that large and active dendrites enhance the dynamic range of a single ganglion cell and show that total dendritic area has stronger correlation with dynamic range than with number of dendritic branches. In the second study we investigate the dynamic range of a square array of ganglion cells with passive or active dendritic trees coupled with each other via dendrodendritic gap junctions. Our results suggest that electrical coupling between active dendritic trees enhances the dynamic range of the ganglion cell array in comparison with both the uncoupled case and the coupled case with cells with passive dendrites. The results from our detailed computational modeling studies suggest that the key properties of the ganglion cells that endow them with a large dynamic range are large and active dendritic trees and electrical coupling via gap junctions.