共查询到20条相似文献,搜索用时 15 毫秒
1.
The prediction of patient-specific proximal femur mechanical response to various load conditions is of major clinical importance in orthopaedics. This paper presents a novel, empirically validated high-order finite element method (FEM) for simulating the bone response to loads. A model of the bone geometry was constructed from a quantitative computerized tomography (QCT) scan using smooth surfaces for both the cortical and trabecular regions. Inhomogeneous isotropic elastic properties were assigned to the finite element model using distinct continuous spatial fields for each region. The Young's modulus was represented as a continuous function computed by a least mean squares method. p-FEMs were used to bound the simulation numerical error and to quantify the modeling assumptions. We validated the FE results with in-vitro experiments on a fresh-frozen femur loaded by a quasi-static force of up to 1500 N at four different angles. We measured the vertical displacement and strains at various locations and investigated the sensitivity of the simulation. Good agreement was found for the displacements, and a fair agreement found in the measured strain in some of the locations. The presented study is a first step toward a reliable p-FEM simulation of human femurs based on QCT data for clinical computer aided decision making. 相似文献
2.
A simple and efficient numerical method for predicting the remodelling of adaptive materials and structures under applied loading was presented and implemented within a finite element framework. The model uses the trajectorial architecture theory of optimisation to predict the remodelling of material microstructure and structural organisation under mechanical loading. We used the proposed model to calculate the density distribution of proximal femur in the frontal plane. The loading considered was the hip joint contact forces and muscular forces at the attachment sites of the muscles to the bone. These forces were estimated from a separate finite element calculation using a heterogeneous three-dimensional model of the proximal femur. The density distributions obtained by this procedure has a qualitative similarity with in vivo observations. Solutions displayed the characteristic high-density channels that are evident in the Dual X-ray Absorptiometry scan. There is also evidence of the intramedullary canal, as well as low-density regions in the femoral neck. Several parametric studies were carried out to highlight the advantages of the proposed method, which includes fast convergence and low-computational cost. The potential applications of the proposed method in predicting bone structural remodelling in cancer are also briefly discussed. 相似文献
3.
Three-dimensional finite element stress analysis of bone is a key to understanding bone remodelling, assessing fracture risk, and designing prostheses; however, the cost and complexity of predicting the stress field in bone with accuracy has precluded the routine use of this method. A new, automated method of generating patient-specific three-dimensional finite element models of bone is presented — it uses digital computed tomographic (CT) scan data to derive the geometry of the bone and to estimate its inhomogeneous material properties. Cubic elements of a user-specified size are automatically defined and then individually assigned the CT scan-derived material properties. The method is demonstrated by predicting the stress, strain, and strain energy in a human proximal femur in vivo. Three-dimensional loading conditions corresponding to the stance phase of gait were taken from the literature and applied to the model. Maximum principal compressive stresses of 8–23 MPa were computed for the medial femoral neck. Automated generation of additional finite element models with larger numbers of elements was used to verify convergence in strain energy. 相似文献
4.
Modeling of cancellous bone has important applications in the detection and treatment of fatigue fractures and diseases like osteoporosis. In this paper, we present a fully coupled multiscale approach considering mechanical, electric and magnetic effects by using the multiscale finite element method and a two-phase material model on the microscale. We show numerical results for both scales, including calculations for a femur bone, comparing a healthy bone to ones affected by different stages of osteoporosis. Here, the magnetic field strength resulting from a small mechanical impact decreases drastically for later stages of the disease, confirming experimental research. 相似文献
5.
Patient-specific finite element (PSFE) models based on quantitative computer tomography (qCT) are generally used to "predict" the biomechanical response of human bones with the future goal to be applied in clinical decision-making. However, clinical applications require a well validated tool that is free of numerical errors and furthermore match closely experimental findings. In previous studies, not all measurable data (strains and displacements) were considered for validation. Furthermore, the same research group performed both the experiments and PSFE analyses; thus, the validation may have been biased. The aim of the present study was therefore to validate PSFE models with biomechanical experiments, and to address the above-mentioned issues of measurable data and validation bias. A PSFE model (p-method) of each cadaver femur (n = 12) was generated based on qCT scans of the specimens. The models were validated by biomechanical in-vitro experiments, which determined strains and local displacements on the bone surface and the axial stiffness of the specimens. The validation was performed in a double-blinded manner by two different research institutes to avoid any bias. Inspecting all measurements (155 values), the numerical results correlated well with the experimental results (R(2) = 0.93, slope 1.0093, mean of absolute deviations 22%). In conclusion, a method to generate PSFE models from qCT scans was used in this study on a sample size not yet considered in the past, and compared to experiments in a douple-blinded manner. The results demonstrate that the presented method is in an advanced stage, and can be used in clinical computer-aided decision-making. 相似文献
6.
Finite element analysis is a common tool that has been used for the past few decades to predict the mechanical behavior of bone. However, to our knowledge, there are no round-robin finite element analyses of long human bones with more than two participating biomechanics laboratories published yet, where the results of the experimental tests were not known in advance. We prepared a fresh-frozen human femur for a compression test in a universal testing machine measuring the strains at 10 bone locations as well as the deformation of the bone in terms of the displacement of the loading point at a load of 2?kN. The computed tomography data of the bone with a calibration phantom as well as the orientation of the bone in the testing machine with the according boundary conditions were delivered to seven participating laboratories. These were asked to perform a finite element analysis simulating the experimental setup and deliver their results to the coordinator without knowing the experimental results. Resultantly, four laboratories had deviations from the experimentally measured strains of less than 40%, and three laboratories had deviations of their numerically determined values compared to the experimental data of more than 120%. These deviations are thought to be based on different material laws and material data, as well as different material mapping methods. Investigations will be conducted to clarify and assess the reasons for the large deviations in the numerical data. It was shown that the precision of finite element models of the human femur is not yet as developed as desired by the biomechanics community. 相似文献
7.
A non-linear fracture mechanics approach was used to predict the failure response of complex cement-bone constructs. A series of eight mechanical tests with a combination of tensile and shear loading along the cement-bone interface was performed. Each experiment was modeled using the finite element method with non-linear constitutive models at the cement-bone interface. Interface constitutive parameters were assigned based on the quantity of bone interdigitated with the cement. There was a strong correlation (r2 = 0.80) between experimentally measured and finite element predicted ultimate loads. The average error in predicted ultimate load was 23.9 percent. In comparison to the ultimate load predictions, correlations and errors for total energy to failure (r2 = 0.24, avg. error = 38.2 percent) and displacement at 50 percent of the ultimate load (r2 = 0.27, avg. error = 52.2 percent) were poor The results indicate that the non-linear constitutive laws could be useful in predicting the initiation and progression of interface failure of cemented bone-implant systems. However improvements in the estimation of post-yield interface properties from the quantity of bone interdigitated with cement are needed to enhance predictions of the overall failure response. 相似文献
8.
Background Bone adapts to mechanical strain by rearranging the trabecular geometry and bone density. The common finite element methods
used to simulate this adaptation have inconsistencies regarding material properties at each node and are computationally demanding.
Here, a volume-based, non-continuum formulation is proposed as an alternative. Adaptive processes corresponding to various
external mechanical loading conditions are simulated for the femur. 相似文献
9.
To assess the performance of femoral orthopedic implants, they are often attached to cadaveric femurs, and biomechanical testing is performed. To identify areas of high stress, stress shielding, and to facilitate implant redesign, these tests are often accompanied by finite element (FE) models of the bone/implant system. However, cadaveric bone suffers from wide specimen to specimen variability both in terms of bone geometry and mechanical properties, making it virtually impossible for experimental results to be reproduced. An alternative approach is to utilize synthetic femurs of standardized geometry, having material behavior approximating that of human bone, but with very small specimen to specimen variability. This approach allows for repeatable experimental results and a standard geometry for use in accompanying FE models. While the synthetic bones appear to be of appropriate geometry to simulate bone mechanical behavior, it has not, however, been established what bone quality they most resemble, i.e., osteoporotic or osteopenic versus healthy bone. Furthermore, it is also of interest to determine whether FE models of synthetic bones, with appropriate adjustments in input material properties or geometric size, could be used to simulate the mechanical behavior of a wider range of bone quality and size. To shed light on these questions, the axial and torsional stiffness of cadaveric femurs were compared to those measured on synthetic femurs. A FE model, previously validated by the authors to represent the geometry of a synthetic femur, was then used with a range of input material properties and change in geometric size, to establish whether cadaveric results could be simulated. Axial and torsional stiffnesses and rigidities were measured for 25 human cadaveric femurs (simulating poor bone stock) and three synthetic "third generation composite" femurs (3GCF) (simulating normal healthy bone stock) in the midstance orientation. The measured results were compared, under identical loading conditions, to those predicted by a previously validated three-dimensional finite element model of the 3GCF at a variety of Young's modulus values. A smaller FE model of the 3GCF was also created to examine the effects of a simple change in bone size. The 3GCF was found to be significantly stiffer (2.3 times in torsional loading, 1.7 times in axial loading) than the presently utilized cadaveric samples. Nevertheless, the FE model was able to successfully simulate both the behavior of the 3GCF, and a wide range of cadaveric bone data scatter by an appropriate adjustment of Young's modulus or geometric size. The synthetic femur had a significantly higher stiffness than the cadaveric bone samples. The finite element model provided a good estimate of upper and lower bounds for the axial and torsional stiffness of human femurs because it was effective at reproducing the geometric properties of a femur. Cadaveric bone experiments can be used to calibrate FE models' input material properties so that bones of varying quality can be simulated. 相似文献
10.
The mechanical properties of cancellous bone and the biological response of the tissue to mechanical loading are related to deformation and strain in the trabeculae during function. Due to the small size of trabeculae, their motion is difficult to measure. To avoid the need to measure trabecular motions during loading the finite element method has been used to estimate trabecular level mechanical deformation. This analytical approach has been empirically successful in that the analytical models are solvable and their results correlate with the macroscopically measured stiffness and strength of bones. The present work is a direct comparison of finite element predictions to measurements of the deformation and strain at near trabecular level. Using the method of digital volume correlation, we measured the deformation and calculated the strain at a resolution approaching the trabecular level for cancellous bone specimens loaded in uniaxial compression. Smoothed results from linearly elastic finite element models of the same mechanical tests were correlated to the empirical three-dimensional (3D) deformation in the direction of loading with a coefficient of determination as high as 97% and a slope of the prediction near one. However, real deformations in the directions perpendicular to the loading direction were not as well predicted by the analytical models. Our results show, that the finite element modeling of the internal deformation and strain in cancellous bone can be accurate in one direction but that this does not ensure accuracy for all deformations and strains. 相似文献
11.
The underlying mechanisms by which bone cells respond to mechanical stimuli or how mechanical loads act on osteocytes housed
in lacunae in bone are not well understood. In this study, a multilevel finite element (FE) approach is applied to predict
local cell deformations in bone tissue. The local structure of the matrix dictates the local mechanical environment of an
osteocyte. Cell deformations are predicted from detailed linear FE analysis of the microstructure, consisting of an arrangement
of cells embedded in bone matrix material. This work has related the loads applied to a whole femur during the stance phase
of the gait cycle to the strain of a single lacuna and of canaliculi. The predicted bone matrix strains around osteocyte lacunae
and canaliculi were nonuniform and differed significantly from the macroscopically measured strains. Peak stresses and strains
in the walls of the lacuna were up to six times those in the bulk extracellular matrix. Significant strain concentrations
were observed at sites where the process meets the cell body. 相似文献
12.
The ability to incorporate detailed geometry into finite element models has allowed researchers to investigate the influence of morphology on performance aspects of skeletal components. This advance has also allowed researchers to explore the effect of different material models, ranging from simple (e.g., isotropic) to complex (e.g., orthotropic), on the response of bone. However, bone's complicated geometry makes it difficult to incorporate complex material models into finite element models of bone. This difficulty is due to variation in the spatial orientation of material properties throughout bone. Our analysis addresses this problem by taking full advantage of a finite element program's ability to solve thermal-structural problems. Using a linear relationship between temperature and modulus, we seeded specific nodes of the finite element model with temperatures. We then used thermal diffusion to propagate the modulus throughout the finite element model. Finally, we solved for the mechanical response of the finite element model to the applied loads and constraints. We found that using the thermal diffusion analogy to control the modulus of bone throughout its structure provides a simple and effective method of spatially varying modulus. Results compare favorably against both experimental data and results from an FE model that incorporated a complex (orthotropic) material model. This method presented will allow researchers the ability to easily incorporate more material property data into their finite element models in an effort to improve the model's accuracy. 相似文献
13.
Investigations are reported in the literature, by means of experimental, analytical and numerical methods, concerning the biomechanical properties of bone. However, the evolutionary phenomena of bone fracture healing does not have a large reference literature. This work investigates and describes the behaviour of inclined human femur fractures with external fixation up to complete healing. A numerical formulation based on the finite element method has been adopted. Geometric configuration is defined using data from a magnetic resonance process applied to a femur in vivo. A three dimensional model has been developed by adopting an orthotropic material law for cortical bone and an isotropic law for the fracture gap zone. Stress and strain reponses of the bone and fixation device are investigated with reference to the evolutionary behaviour of the healing tissue. 相似文献
14.
Background: The mechanical response of patient-specific bone to various load conditions is of major clinical importance in orthopedics. Herein we enhance the methods presented in Yosibash et al. [2007. A CT-based high-order finite element analysis of the human proximal femur compared to in-vitro experiments. ASME Journal of Biomechanical Engineering 129(3), 297–309.] for the reliable simulations of the human proximal femur by high-order finite elements (FEs) and validate the simulations by experimental observations. Method of approach: A fresh-frozen human femur was scanned by quantitative computed tomography (QCT) and thereafter loaded (in vitro experiments) by a quasi-static force of up to 1250 N. QCT scans were manipulated to generate a high-order FE bone model with distinct cortical and trabecular regions having inhomogeneous isotropic elastic properties with Young's modulus represented by continuous spatial functions. Sensitivity analyses were performed to quantify parameters that mostly influence the mechanical response. FE results were compared to displacements and strains measured in the experiments. Results: Young moduli correlated to QCT Hounsfield Units by relations in Keyak and Falkinstein [2003. Comparison of in situ and in vitro CT scan-based finite element model predictions of proximal femoral fracture load. Medical Engineering and Physics 25, 781–787.] were found to provide predictions that match the experimental results closely. Excellent agreement was found for both the displacements and strains. The presented study demonstrates that reliable and validated high-order patient-specific FE simulations of human femurs based on QCT data are achievable for clinical computer-aided decision making. 相似文献
15.
Bone remodeling simulation is an effective tool for the prediction of long-term effect of implant on the bone tissue, as well as the selection of an appropriate implant in terms of architecture and material. In this paper, a finite element model of proximal femur was developed to simulate the structures of internal trabecular and cortical bones by incorporating quantitative bone functional adaptation theory with finite element analysis. Cementless stems made of titanium, two types of Functionally Graded Material (FGM) and flexible ‘iso-elastic’ material as comparison were implanted in the structure of proximal femur respectively to simulate the bone remodeling behaviors of host bone. The distributions of bone density, von Mises stress, and interface shear stress were obtained. All the prosthetic stems had effects on the bone remodeling behaviors of proximal femur, but the degrees of stress shielding were different. The amount of bone loss caused by titanium implant was in agreement with the clinical observation. The FGM stems caused less bone loss than that of the titanium stem, in which FGM I stem (titanium richer at the top to more HAP/Col towards the bottom) could relieve stress shielding effectively, and the interface shear stresses were more evenly distributed in the model with FGM I stem in comparison with those in the models with FGM II (titanium and bioglass) and titanium stems. The numerical simulations in the present study provided theoretical basis for FGM as an appropriate material of femoral implant from a biomechanical point of view. The next steps are to fabricate FGM stem and to conduct animal experiments to investigate the effects of FGM stem on the remodeling behaviors using animal model. 相似文献
16.
Functional adaptation of the femur has been investigated in several studies by embedding bone remodelling algorithms in finite element (FE) models, with simplifications often made to the representation of bone’s material symmetry and mechanical environment. An orthotropic strain-driven adaptation algorithm is proposed in order to predict the femur’s volumetric material property distribution and directionality of its internal structures within a continuum. The algorithm was applied to a FE model of the femur, with muscles, ligaments and joints included explicitly. Multiple load cases representing distinct frames of two activities of daily living (walking and stair climbing) were considered. It is hypothesised that low shear moduli occur in areas of bone that are simply loaded and high shear moduli in areas subjected to complex loading conditions. In addition, it is investigated whether material properties of different femoral regions are stimulated by different activities. The loading and boundary conditions were considered to provide a physiological mechanical environment. The resulting volumetric material property distribution and directionalities agreed with ex vivo imaging data for the whole femur. Regions where non-orthogonal trabecular crossing has been documented coincided with higher values of predicted shear moduli. The topological influence of the different activities modelled was analysed. The influence of stair climbing on the properties of the femoral neck region is highlighted. It is recommended that multiple load cases should be considered when modelling bone adaptation. The orthotropic model of the complete femur is released with this study. 相似文献
17.
Characterising the mechanisms causing viscoelastic mechanical properties of human cortical bone, as well as understanding sources of variation, is important in predicting response of the bone to creep and fatigue loads. Any better understanding, when incorporated into simulations including finite element analysis, would assist bioengineers, clinicians and biomedical scientists. In this study, we used an empirically verified model of creep strain accumulation, in a simulation of 10 non-homogeneous samples, which were created from micro-CT scans of human cortical bone of the femur midshaft obtained from a 74-year-old female cadaver. These non-homogeneous samples incorporate the presence of Haversian canals and resorption cavities. The influence of inhomogeneity on the response and variation in the samples in both creep and stress relaxation tests are examined. The relationship between steady-state creep rate, applied loads (stress relaxation and creep tests) and microstructure, that is bone apparent porosity, is obtained. These relations may provide insight into damage accumulation of whole human bones and be relevant to studies on osteoporosis. 相似文献
18.
The determination of the mechanical stresses induced in human bones is of great importance in both research and clinical practice. Since the stresses in bones cannot be measured non-invasively in vivo, the only way to estimate them is through subject-specific finite element modelling. Several methods exist for the automatic generation of these models from CT data, but before bringing them in the clinical practice it is necessary to assess their accuracy in the predictions of the bone stresses. Particular attention should be paid to those regions, like the epiphyseal and metaphyseal parts of long bones, where the automatic methods are typically less accurate. Aim of the present study was to implement a general procedure to automatically generate subject-specific finite element models of bones from CT data and estimate the accuracy of this general procedure by applying it to one real femur. This femur was tested in vitro under five different loading scenarios and the results of these tests were used to verify how the adoption of a simplified two-material homogeneous model would change the accuracy with respect to the density-based inhomogeneous one, with special attention paid to the epiphyseal and metaphyseal proximal regions of the bone. The results showed that the density-based inhomogeneous model predicts with a very good accuracy the measured stresses (R(2)=0.91, RMSE=8.6%, peak error=27%), while the two-material model was less accurate (R(2)=0.89, RMSE=9.6%, peak error=35%). The results showed that it is possible to automatically generate accurate finite element models of bones from CT data and that the strategy of material properties mapping has a significant influence on its accuracy. 相似文献
19.
Trabecular bone is composed of organized mineralized collagen fibrils, which results in heterogeneous and anisotropic mechanical properties at the tissue level. Recently, biomechanical models computing stresses and strains in trabecular bone have indicated a significant effect of tissue heterogeneity on predicted stresses and strains. However, the effect of the tissue-level mechanical anisotropy on the trabecular bone biomechanical response is unknown. Here, a computational method was established to automatically impose physiologically relevant orientation inherent in trabecular bone tissue on a trabecular bone microscale finite element model. Spatially varying tissue-level anisotropic elastic properties were then applied according to the bone mineral density and the local tissue orientation. The model was used to test the hypothesis that anisotropy in both homogeneous and heterogeneous models alters the predicted distribution of stress invariants. Linear elastic finite element computations were performed on a 3 mm cube model isolated from a microcomputed tomography scan of human trabecular bone from the distal femur. Hydrostatic stress and von Mises equivalent stress were recorded at every element, and the distributions of these values were analyzed. Anisotropy reduced the range of hydrostatic stress in both tension and compression more strongly than the associated increase in von Mises equivalent stress. The effect of anisotropy was independent of the spatial redistribution high compressive stresses due to tissue elastic heterogeneity. Tissue anisotropy and heterogeneity are likely important mechanisms to protect bone from failure and should be included for stress analyses in trabecular bone. 相似文献
20.
Characterising the mechanisms causing viscoelastic mechanical properties of human cortical bone, as well as understanding sources of variation, is important in predicting response of the bone to creep and fatigue loads. Any better understanding, when incorporated into simulations including finite element analysis, would assist bioengineers, clinicians and biomedical scientists. In this study, we used an empirically verified model of creep strain accumulation, in a simulation of 10 non-homogeneous samples, which were created from micro-CT scans of human cortical bone of the femur midshaft obtained from a 74-year-old female cadaver. These non-homogeneous samples incorporate the presence of Haversian canals and resorption cavities. The influence of inhomogeneity on the response and variation in the samples in both creep and stress relaxation tests are examined. The relationship between steady-state creep rate, applied loads (stress relaxation and creep tests) and microstructure, that is bone apparent porosity, is obtained. These relations may provide insight into damage accumulation of whole human bones and be relevant to studies on osteoporosis. 相似文献
|