共查询到20条相似文献,搜索用时 15 毫秒
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BRUCE W. HALSTEAD PAUL C. ENGEN ANTHONY T. TU 《Zoological Journal of the Linnean Society》1978,63(4):371-396
The venom apparatus of Lapemis hardwicki , consisting of two functional fangs, their venom glands, and associated musculature, are described. The yield of venom per snake ranged from 2.4-5.2 mg. The LD50 of the crude venom varied from 0.7-1.4 mg/kg intravenously in mice. The toxicological, chemical and immunological properties of the venom are discussed. 相似文献
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Beata Halassy Lidija Habjanec Maja Lang Balija Tihana Kurtović Marija Brgles Igor Križaj 《Comparative biochemistry and physiology. Toxicology & pharmacology : CBP》2010,151(4):455-460
Venoms are complex mixtures of proteins, peptides and other compounds whose biochemical and biological variability has been clearly demonstrated. These molecules have been used as antigens for immunization of anti-venom-producing animals (horses or sheep). Ammodytoxins (Atx) are potently neurotoxic compounds, and the most toxic compounds isolated so far from the Vipera ammodytes ammodytes (Vaa) venom. Recently we have shown that the level of antibodies specific to Vaa venom's most toxic component, ammodytoxin A (AtxA), (anti-AtxA IgG) in Vaa venom immunized rabbit sera highly correlated to the venom toxicity–neutralization potential of these sera. Here we investigated whether Atx content of Vaa venom could influence the outcome of immunization procedure. The novel ELISA was developed for precise determination of Atx content and Atx was quantified in venom samples used for immunization of rabbits. We clearly showed that animals immunized with the venom containing lower amount of Atx produced sera with significantly lower venom toxicity–neutralizing power and, vice versa, animals immunized with venoms containing higher amount of Atx produced sera with higher venom toxicity–neutralizing ability. Thus, the content of Atx in Vaa venom is a relevant parameter of its suitability in the production of highly protective Vaa anti-venom. 相似文献
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Phospholipase A from bee venom 总被引:3,自引:0,他引:3
R A Shipolini G L Callewaert R C Cottrell S Doonan C A Vernon B E Banks 《European journal of biochemistry》1971,20(4):459-468
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SPINK WW 《The Yale journal of biology and medicine》1958,30(5):355-367
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Spider venom, a factor that has played a decisive role in the evolution of one of the most successful groups of living organisms,
is reviewed. Unique molecular diversity of venom components including substances of variable structure (from simple low molecular
weight compounds to large multidomain proteins) with different functions is considered. Special attention is given to the
structure, properties, and biosynthesis of toxins of polypeptide nature. 相似文献
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CERMAK 《Polski tygodnik lekarski (Warsaw, Poland : 1960)》1956,11(32):1401-1405
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A A Abidov L G Lisochenko S M Zaidova 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》1978,(2):115-118
Avidity of antivenom sera used for the treatment of snake bites was studied. Sera against the venom of Vipera libetina obtained from producers immunized with crude venoms were more avid than analogous sera obtained to anavenoms. In studying the avidity of polyvalent serum neutralizing the Vipera libetina, echis and cobra venoms showed the serum obtained in immunization with the mixture of crude venoms to be highly avid to all the venoms composing the antigen; besides, it bound the venoms of Vipera libetina and echis more rapidly and more stably than the corresponding monovalent sera. 相似文献
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Saibil HR 《Nature structural biology》2000,7(1):3-4
The structure of a tetrameric form of the spider neurotoxin, alpha-latrotoxin, has been determined by single particle cryo-electron microscopy. It reveals a pore complex with extended arms that could bind receptors involved in synaptic vesicle exocytosis. 相似文献
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Duan ZG Yan XJ He XZ Zhou H Chen P Cao R Xiong JX Hu WJ Wang XC Liang SP 《Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology》2006,145(3-4):350-357
Black widow spiders (genus Latrodectus) have attracted increasing attention due to frequently reported human injuries caused by them and the potential applications of biologically active components in their venoms. Although a number of studies have described the biological properties and structures of several venomous proteins such as latrotoxins, a comprehensive analysis of protein component of the venom from the spider is not available. We used combinative proteomic strategies to assess the protein components of the crude venom collected from Latrodectus tredecimguttatus by extracting the dissected venom glands. The experiments demonstrated that the crude venom of L. tredecimguttatus has a high abundance of acidic proteins with molecular masses greater than 15 kDa, and the content of proteins and peptides of below 15 kDa is low. 86 unique proteins were identified, part of which were contaminations of cellular components during the extraction, determined in comparison with venom obtained by electrostimulation. Except for members of latrotoxin family that were commonly considered as the primary toxic components of the venom, several other special enzymes and proteins were detected such as protease, phosphatase, lysozyme, inhibitory protein, and so on. These protein components, particularly the proteases, were speculated to play important roles in the action of L. tredecimguttatus venom. 相似文献