共查询到20条相似文献,搜索用时 31 毫秒
1.
Gianluca Tamagno Yahya Celik Rafael Simó Marcel Dihné Kazumi Kimura Giorgio Gelosa Byung I Lee Caroline Hommet Giovanni Murialdo 《BMC neurology》2010,10(1):27
Background
The encephalopathy associated with autoimmune thyroid disease (EAATD) is characterized by neurological/psychiatric symptoms, high levels of anti-thyroid antibodies, increased cerebrospinal fluid protein concentration, non-specific electroencephalogram abnormalities, and responsiveness to the corticosteroid treatment in patients with an autoimmune thyroid disease. Almost all EAATD patients are affected by Hashimoto's thyroiditis (HT), although fourteen EAATD patients with Graves' disease (GD) have been also reported. 相似文献2.
Ghazi Chabchoub Elif Uz Abdellatif Maalej Chigdem A Mustafa Ahmed Rebai Mouna Mnif Zouheir Bahloul Nadir R Farid Tayfun Ozcelik Hammadi Ayadi 《Arthritis research & therapy》2009,11(4):R106-8
Introduction
The majority of autoimmune diseases such as rheumatoid arthritis (RA) and autoimmune thyroid diseases (AITDs) are characterized by a striking female predominance superimposed on a predisposing genetic background. The role of extremely skewed X-chromosome inactivation (XCI) has been questioned in the pathogenesis of several autoimmune diseases. 相似文献3.
Ying J Nie Mo Y Mok Godfrey CF Chan Albert W Chan Ou Jin Sushma Kavikondala Albert KW Lie Chak S Lau 《Arthritis research & therapy》2010,12(3):R91
Introduction
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoreactive T and B cells, which are believed to be secondary to deficient dendritic cells (DCs). However, whether DC abnormalities occur during their development in the bone marrow (BM) or in the periphery is not known. 相似文献4.
Evgeny A Semchenko Christopher J Day Jennifer C Wilson I Darren Grice Anthony P Moran Victoria Korolik 《BMC microbiology》2010,10(1):305
Background
Campylobacter jejuni is a major bacterial cause of food-borne enteritis, and its lipooligosaccharide (LOS) plays an initiating role in the development of the autoimmune neuropathy, Guillain-Barré syndrome, by induction of anti-neural cross-reactive antibodies through ganglioside molecular mimicry. 相似文献5.
Naheed Anjum Philip N Baker Nicola J Robinson John D Aplin 《Reproductive biology and endocrinology : RB&E》2009,7(1):16-7
Background
Celiac disease (CD) occurs in as many as 1 in 80 pregnant women and is associated with poor pregnancy outcome, but it is not known if this is an effect on maternal nutrient absorption or, alternatively, if the placenta is an autoimmune target. The major autoantigen, tissue transglutaminase (tTG), has previously been shown to be present in the maternal-facing syncytiotrophoblast plasma membrane of the placenta. 相似文献6.
Introduction
Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organ systems. Previous studies have suggested that interferon-lambda 1 (IFN-λ1), a type III interferon, plays an immunomodulatory role. In this study we investigated its role in SLE, including its correlation with disease activity, organ disorder and production of chemokines. 相似文献7.
Feng Y Shen J Streaker ED Lockwood M Zhu Z Low PS Dimitrov DS 《Arthritis research & therapy》2011,13(2):R59
Introduction
Folate receptor beta (FRβ) is only detectable in placenta and limited to some hematopoietic cells of myeloid lineage in healthy people. Studies have indicated that FRβ is over-expressed in activated macrophages in autoimmune diseases and some cancer cells. In this study we aimed to develop an FRβ-specific human monoclonal antibody (mAb) that could be used as a therapeutic agent to treat rheumatoid arthritis and other autoimmune diseases, as well as FRβ positive cancers. 相似文献8.
Introduction
Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by various systemic symptoms and multiple organ damage. We clarify biological and functional abnormalities in SLE by comparing the gene expression profiles of SLE patients with those of healthy individuals. 相似文献9.
Lisa GM van Baarsen Carla A Wijbrandts François Rustenburg Tineke Cantaert Tineke CTM van der Pouw Kraan Dominique L Baeten Ben AC Dijkmans Paul P Tak Cornelis L Verweij 《Arthritis research & therapy》2010,12(1):R11
Introduction
Cross-regulation between TNF and type I IFN has been postulated to play an important role in autoimmune diseases. Therefore, we determined the effect of TNF blockade in rheumatoid arthritis (RA) on the type I IFN response gene activity in relation to clinical response. 相似文献10.
Chun-Chou Tsai Bor-Show Tzang Szu-Yi Chiang Gwo-Jong Hsu Tsai-Ching Hsu 《Journal of biomedical science》2009,16(1):14-9
Background
Human parvovirus B19 infection has been postulated to the anti-phospholipid syndrome (APS) in autoimmunity. However, the influence of anti-B19-VP1u antibody in autoimmune diseases is still obscure. 相似文献11.
García S Forteza J López-Otin C Gómez-Reino JJ González A Conde C 《Arthritis research & therapy》2010,12(6):R224
Introduction
Rheumatoid arthritis is an autoimmune disease in which joint inflammation leads to progressive cartilage and bone erosion. Matrix metalloproteinases (MMPs) implicated in homeostasis of the extracellular matrix play a central role in cartilage degradation. However, the role of specific MMPs in arthritis pathogenesis is largely unknown. The aim of the present study was to investigate the role of Mmp-8 (collagenase-2) in an arthritis model. 相似文献12.
Rizwanul Haque Fengyang Lei Xiaofang Xiong Yuzhang Wu Jianxun Song 《Arthritis research & therapy》2010,12(2):R66
Introduction
Forkhead box p3 (FoxP3)-expressing regulatory T cells (Tregs) have been clearly implicated in the control of autoimmune disease in murine models. In addition, ectopic expression of FoxP3 conveys a Treg phenotype to CD4+ T cells, lending itself to therapeutic use in the prevention of rheumatoid arthritis (RA). In this study, we generated therapeutically active Tregs with an increased life span and hence greater therapeutic potential. 相似文献13.
Bor-Show Tzang Der-Yuan Chen Chun-Chou Tsai Szu-Yi Chiang Tsung-Ming Lin Tsai-Ching Hsu 《Journal of biomedical science》2010,17(1):40
Background
Human parvovirus B19 (B19) is known to induce apoptosis that has been associated with a variety of autoimmune disorders. Although we have previously reported that B19 non-structural protein (NS1) induces mitochondrial-dependent apoptosis in COS-7 cells, the precise mechanism of B19-NS1 in developing autoimmunity is still obscure. 相似文献14.
Dolff S Abdulahad WH Westra J Doornbos-van der Meer B Limburg PC Kallenberg CG Bijl M 《Arthritis research & therapy》2011,13(5):R157
Introduction
Systemic lupus erythematosus (SLE) is an autoimmune disease accompanied by a disturbed T-cell balance skewed towards effector T-cells, in particular Th17-cells. The novel cytokine interleukin-21 (IL-21) is suggested to be crucial for triggering T-cell responses towards IL-17 producing cells. Thus, we aimed to investigate the ability of T-cells to produce IL-21 and IL-17 in SLE patients. 相似文献15.
Yu-Huei Liu Cheng-Hsu Chen Shih-Yin Chen Ying-Ju Lin Wen-Ling Liao Chang-Hai Tsai Lei Wan Fuu-Jen Tsai 《Journal of biomedical science》2010,17(1):81
Background
Idiopathic membranous nephropathy (IMN) is one of the most common forms of autoimmune nephritic syndrome in adults. The purpose of this study is to evaluate whether polymorphisms of PLA2R1 affect the development of IMN. 相似文献16.
Bäcklund A Holmdahl M Mattsson R Håkansson K Lindström V Nandakumar KS Grubb A Holmdahl R 《Arthritis research & therapy》2011,13(2):R54
Introduction
Collagen-induced arthritis (CIA) is a mouse model for rheumatoid arthritis (RA) and is induced after immunization with type II collagen (CII). CIA, like RA, is an autoimmune disease leading to destruction of cartilage and joints, and both the priming and inflammatory phases have been suggested to be dependent on proteases. In particular, the cysteine proteases have been proposed to be detrimental to the arthritic process and even immunomodulatory. A natural inhibitor of cysteine proteases is cystatin C. 相似文献17.
Introduction
Autoimmune inflammation is a characteristic feature of rheumatoid arthritis (RA) and other autoimmune diseases. In the natural course of human autoimmune diseases, it is rather difficult to pinpoint the precise timing of the initial event that triggers the cascade of pathogenic events that later culminate into clinically overt disease. Therefore, it is a challenge to examine the early preclinical events in these disorders. Animal models are an invaluable resource in this regard. Furthermore, considering the complex nature of the pathogenic immune events in arthritis, microarray analysis offers a versatile tool to define the dynamic patterns of gene expression during the disease course. 相似文献18.
Background
Multiple sclerosis (MS) is considered an autoimmune disease of the central nervous system and therapeutic inhibition of leukocyte migration with natalizumab, an anti-alpha4 integrin antibody, is highly effective in patients with MS. Recent studies performed in experimental animal models with relevance to human disease suggested a key role for blood-brain barrier damage and leukocyte trafficking mechanisms also in the pathogenesis of epilepsy. In addition, vascular alterations and increased leukocyte accumulation into the brain were recently documented in patients with refractory epilepsy independently on the disease etiology. 相似文献19.
Chun-Ling Xu Lei Liu Wei-Qin Zhao Ji-Mei Li Rui-Jin Wang Shu-Hui Wang De-Xin Wang Mei-Yun Liu Shan-Shan Qiao Jia-Wei Wang 《BMC neurology》2011,11(1):149
Background
Anti-N-methyl-D-aspartate receptor encephalitis is an increasingly common autoimmune disorder mediated by antibodies to certain subunit of the N-methyl-D-aspartate receptor. Recent literatures have described anti-thyroid and infectious serology in this encephalitis but without follow-up. 相似文献20.
Adrienn Angyal Colt Egelston Tamás Kobezda Katalin Olasz Anna László Tibor T Glant Katalin Mikecz 《Arthritis research & therapy》2010,12(2):R44