共查询到20条相似文献,搜索用时 15 毫秒
1.
2.
3.
Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification 总被引:1,自引:0,他引:1
Nelson EA Walker SR Alvarez JV Frank DA 《The Journal of biological chemistry》2004,279(52):54724-54730
4.
5.
6.
7.
8.
9.
Rojas DA Moreira-Ramos S Zock-Emmenthal S Urbina F Contreras-Levicoy J Käufer NF Maldonado E 《The Journal of biological chemistry》2011,286(30):26480-26486
10.
Use of chromatin immunoprecipitation to clone novel E2F target promoters 总被引:20,自引:0,他引:20
下载免费PDF全文
![点击此处可从《Molecular and cellular biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Weinmann AS Bartley SM Zhang T Zhang MQ Farnham PJ 《Molecular and cellular biology》2001,21(20):6820-6832
11.
Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes 总被引:1,自引:0,他引:1
Magyar Z Horváth B Khan S Mohammed B Henriques R De Veylder L Bakó L Scheres B Bögre L 《The EMBO journal》2012,31(6):1480-1493
Post-embryonic growth in plants depends on the continuous supply of undifferentiated cells within meristems. Proliferating cells maintain their competence for division by active repression of differentiation and the associated endocycle entry. We show by upregulation and downregulation of E2FA that it is required for maintaining proliferation, as well as for endocycle entry. While E2FB-RBR1 (retinoblastoma-related protein 1) complexes are reduced after sucrose addition or at elevated CYCD3;1 levels, E2FA maintains a stable complex with RBR1 in proliferating cells. Chromatin immunoprecipitation shows that RBR1 binds in the proximity of E2F promoter elements in CCS52A1 and CSS52A2 genes, central regulators for the switch from proliferation to endocycles. Overexpression of a truncated E2FA mutant (E2FA(ΔRB)) lacking the RBR1-binding domain interferes with RBR1 recruitment to promoters through E2FA, leading to decreased meristem size in roots, premature cell expansion and hyperactivated endocycle in leaves. E2F target genes, including CCS52A1 and CCS52A2, are upregulated in E2FA(ΔRB) and e2fa knockout lines. These data suggest that E2FA in complex with RBR1 forms a repressor complex in proliferating cells to inhibit premature differentiation and endocycle entry. Thus, E2FA regulates organ growth via two distinct, sequentially operating pathways. 相似文献
12.
13.
14.
15.
Vandepoele K Vlieghe K Florquin K Hennig L Beemster GT Gruissem W Van de Peer Y Inzé D De Veylder L 《Plant physiology》2005,139(1):316-328
16.
17.
18.
19.
20.