Amerindian cannibalism: practice and discursive strategy

This paper examines certain colonial and contemporary texts for their representations of Amerindian cannibalism during the Columbian period. Colonial texts from this period describe cannibalism as one of the Amerindians’ major “offences” against humanity. Some contemporary studies criticize this depiction of Amerindian cannibalism as a “myth” perpetrated by colonizers and their apologists to justify the enslavement and genocide of Amerindians. On the one hand colonial texts fall prey to an ethnocentric view of cannibalism; on the other hand contemporary texts explain away this amply documented cultural phenomenon. While the two positions appear to be at variance with each other, it is suggested that what they hold in common is a schema of analyzing culture that does not easily admit the existence of a phenomenon that is “Other” without explaining it as a totalized alterity or without explaining it away. Both positions thus help reinscribe the Wild Savage-Noble Savage stereotypes. ...each man calls barbarism, whatever is not his own practice ... Michel De Montaigne     

Epigenetic inheritance in Arabidopsis: selective silence

Eukaryotic organisms have the remarkable ability to inherit states of gene activity without altering the underlying DNA sequence. This epigenetic inheritance can persist over thousands of years, providing an alternative to genetic mutations as a substrate for natural selection. Epigenetic inheritance might be propagated by differences in DNA methylation, post-translational histone modifications, and deposition of histone variants. Mounting evidence also indicates that small interfering RNA (siRNA)-mediated mechanisms play central roles in setting up and maintaining states of gene activity. Much of the epigenetic machinery of many organisms, including Arabidopsis, appears to be directed at silencing viruses and transposable elements, with epigenetic regulation of endogenous genes being mostly derived from such processes.     

Migrant deportability: Israel and Ireland as case studies

This article critiques policies of deportation and deportability – a technology emanating from three seemingly conflicting rationalities: states' obligations under international human rights regimes, capitalism's need to facilitate the movement of labour, and the need to reaffirm state sovereignty. After outlining the concept of deportability, we argue that although justified by state actors as an integral part of asylum and immigration policies, deportability epitomizes the paradox of immigration regimes at a point of crisis. We use Israel and Ireland as case studies to illustrate that migrant deportability circumvents human rights and domestic legislation that hinder the power of the state to deport unwanted migrants. Paradoxically, in both, policies that engender the deportability of asylum seekers are a response to their undeportability. Despite their differences, Israel and Ireland are unusual immigration destinations and quintessential diaspora nations, whose histories of dispersal configure Jewishness and Irishness in ethno-racially rigid yet spatially fluid terms, as illustrated by their citizenship regimes.     

Debates in xenotransplantation: on the consequences of contradiction

Abstract

This paper addresses disputes in the transplantation of tissues from transgenic animals to humans (XTP) between a number of biotech firms and several UK-based animal advocacy groups. Debates centre on the management of human and non-human identity, the indeterminacies of therapeutic efficacy and the risks of trans- species disease. Both constituencies make use of moral/cultural and scientific repertoires to advance their arguments.

Science and Technology Studies treatments of the dynamics between scientific institutions and pressure group Non-governmental organizations tend to emphasize the epistemological privileges of the former over the latter. However, the XTP case highlights a strategic flexibility enabling animal advocacy groups to deploy social and scientific arguments that are fundamentally contradictory. Such contradictions are much more difficult for scientific institutions to maintain, given the rigidities of the material and symbolic resources from which they derive their expertise in the first place.     

Sounds of silence: synonymous nucleotides as a key to biological regulation and complexity

Messenger RNA is a key component of an intricate regulatory network of its own. It accommodates numerous nucleotide signals that overlap protein coding sequences and are responsible for multiple levels of regulation and generation of biological complexity. A wealth of structural and regulatory information, which mRNA carries in addition to the encoded amino acid sequence, raises the question of how these signals and overlapping codes are delineated along non-synonymous and synonymous positions in protein coding regions, especially in eukaryotes. Silent or synonymous codon positions, which do not determine amino acid sequences of the encoded proteins, define mRNA secondary structure and stability and affect the rate of translation, folding and post-translational modifications of nascent polypeptides. The RNA level selection is acting on synonymous sites in both prokaryotes and eukaryotes and is more common than previously thought. Selection pressure on the coding gene regions follows three-nucleotide periodic pattern of nucleotide base-pairing in mRNA, which is imposed by the genetic code. Synonymous positions of the coding regions have a higher level of hybridization potential relative to non-synonymous positions, and are multifunctional in their regulatory and structural roles. Recent experimental evidence and analysis of mRNA structure and interspecies conservation suggest that there is an evolutionary tradeoff between selective pressure acting at the RNA and protein levels. Here we provide a comprehensive overview of the studies that define the role of silent positions in regulating RNA structure and processing that exert downstream effects on proteins and their functions.     

Cystic fibrosis as a cause of infertility

Cystic fibrosis (CF) is one of the autosomal recessive diseases, caused by mutations in a gene known as cystic fibrosis transmembrane regulator (CFTR). The majority of adult males with CF (99%) is characterized by congenital bilateral absence of vas deferens (CBAVD). CBAVD is encountered in 1-2% of infertile males without CF. Females with CF are found to be less fertile than normal healthy women. In females with CF, delayed puberty and amenorrhoea are common due to malnutrition. CFTR mutations are also associated with congenital absence of the uterus and vagina (CAUV). The National Institutes of Health recommend genetic counseling for any couple seeking assisted reproductive techniques with a CF male or obstructive azoospermia which is positive for a CF mutation.     

Antisense RNA in imprinting: spreading silence through Air

In some animals, including mammals, a number of genes are expressed differently according to whether they have been inherited from the mother or from the father, through a process known as genomic imprinting. Noncoding RNAs have increasingly been found associated with imprinted genes, but their role, if any, has remained enigmatic. A recent study provides the first evidence that, at least in one case, a noncoding RNA has a direct role in regulating imprinted gene expression in cis.     

Suffering in silence: the tolerance of DNA damage

When cells that are actively replicating DNA encounter sites of base damage or strand breaks, replication might stall or arrest. In this situation, cells rely on DNA-damage-tolerance mechanisms to bypass the damage effectively. One of these mechanisms, known as translesion DNA synthesis, is supported by specialized DNA polymerases that are able to catalyse nucleotide incorporation opposite lesions that cannot be negotiated by high-fidelity replicative polymerases. A second category of tolerance mechanism involves alternative replication strategies that obviate the need to replicate directly across sites of template-strand damage.