David Ottoson (1918-2001)

View larger version (86K): [in this window] [in a new window]   David Ottoson. Photograph © IBRO.   A master in our field of sensory physiology has passed awayafter a short, but painful illness. He left his wife Inger anddaughter Gabrielle Ahlberg. David Ottoson was born and spent his childhood in Chalgan, China,where his parents were missionaries. David first studied odontology,then medicine, and started his scientific career in 1952 asa research assistant at the Department of Physiology at KarolinskaInstitutet, Stockholm. His thesis `Analysis of the electrical     

"Handbook of biomedical optics", edited by David A. Boas,Constantinos Pitris,and Nimmi Ramanujam

David A. Boas, Constantinos Pitris, and Nimmi Ramanujam, Eds.:     

"And This Is How You Shall Ask": Linguistics, Anthropology, and Education in the Work of David Smith

This article celebrates the life and work of David M. Smith, former Council on Anthropology and Education president and founder of the University of Pennsylania Ethnography in Education Research Forum, tracing his contributions to the fields of linguistics, anthropology, and education through the dual lens of his ten research principles and Walt Whitman's life advice. David Smith's pioneering efforts helped push disciplinary boundaries and generate innovations in sociolinguistics, pidgin and creole linguistics, ethnography and education, sociocultural studies of literacy, and Indigenous studies.     

David Sabatini--a lifelong fascination with organelles

As a pioneer molecular cell biologist, highly skilled in both morphological and biochemical approaches, David Sabatini was a key figure in laying the foundation for the field of intracellular protein trafficking with his seminal studies on cotranslational translocation of nascent polypeptides in the endoplasmic reticulum and the intracellular sorting of plasma membrane proteins in polarized epithelial cells.     

Plant Hunting Expeditions of David Fairchild to The Bahamas

The plant hunting expeditions made by David Fairchild on board the research boat Utowana represented some of the most important contributions in the history of plant exploration. These expeditions targeted all the continents except Australia and Antarctica and provided germplasm for the United States Department of Agriculture. As part of our current research to document the details and outputs of David Fairchild’s plant hunting expeditions, in this paper we present an account pertinent to the three trips that he made to The Bahamas. Two of these trips were on board the Utowana and were part of larger expeditions that David Fairchild undertook to the West Indies, Central America and the Guianas between December 1931 and April 1933. No plant material was collected on the third trip when David Fairchild and his wife flew to Nassau in April 1939. We believe that the main focus of this last trip was to meet with Anne Archbold to make arrangements for the Chêng Ho expedition to the East Indies. This Asian endeavor was the only major expedition undertaken by David Fairchild to collect plant material for Fairchild Tropical Botanic Garden (FTBG). During the Bahamian expedition eleven islands/cays were visited, 94 germplasm accessions (73 species) were collected, and 132 photographs were taken. Our research has been largely based on documents and photographs that belonged to David Fairchild and that are deposited at the Library and Archives of FTBG. “The more than ten years that I spent in the office that Fairchild founded for our Department of Agriculture made me a great admirer of Dr. Fairchild and to appreciate even more the work that he, Wilson Popenoe, and others in the Division had done for our country. Among their accomplishments was the encouragement or establishment as a crop or industry the date, fig, avocado, mango, pistachio, and other lesser known crops. These explorers were also concerned with introducing germ plasm, or breeding stock, for the improvement of traditional field crops, vegetables, and fruit plants, as well as the introduction and establishment of ornamental and other economic plants such as bamboos and Meyer’s Zoysia grass.” [Donovan Correll, from his unpublished autobiography “Notes from a Singing Plant Explorer," January 1983 (Korber et al., 2013)].     

David Roos. Interview by H. Craig Mak

Reflecting on the growth of bioinformatics over the past decade, the University of Pennsylvania's David Roos highlights the increasing diversity of large-scale data sets, changing paradigms for data release and the emergence of new career opportunities.     

David Hubel and Torsten Wiesel

While attending medical school at McGill, David Hubel developed an interest in the nervous system during the summers he spent at the Montreal Neurological Institute. After heading to the United States in 1954 for a Neurology year at Johns Hopkins, he was drafted by the army and was assigned to the Neuropsychiatry Division at the Walter Reed Hospital, where he began his career in research and did his first recordings from the visual cortex of sleeping and awake cats. In 1958, he moved to the lab of Stephen Kuffler at Johns Hopkins, where he began a long and fruitful collaboration with Torsten Wiesel. Born in Sweden, Torsten Wiesel began his scientific career at the Karolinska Institute, where he received his medical degree in 1954. After spending a year in Carl Gustaf Bernhard's laboratory doing basic neurophysiological research, he moved to the United States to be a postdoctoral fellow with Stephen Kuffler. It was at Johns Hopkins where he met David Hubel in 1958, and they began working together on exploring the receptive field properties of neurons in the visual cortex. Their collaboration continued until the late seventies. Hubel and Wiesel's work provided fundamental insight into information processing in the visual system and laid the foundation for the field of visual neuroscience. They have had many achievements, including--but not limited to--the discovery of orientation selectivity in visual cortex neurons and the characterization of the columnar organization of visual cortex through their discovery of orientation columns and ocular-dominance columns. Their work earned them the Nobel Prize for Physiology or Medicine in 1981, which they shared with Roger Sperry.     

Large‐scale,long‐term ecosystem monitoring: Interview with David Lindenmayer

David Lindenmayer leads six large‐scale, long‐term research programmes in south‐eastern Australia to help conserve biodiversity in restored areas on farmland as well as conservation in reserves, national parks, wood production forests and plantations. What makes this award‐winning researcher tick and how is the research influencing biodiversity management and policy?     

Spinning with Dave: David Yphantis's contributions to ultracentrifugation

For nearly 50 years David Yphantis has helped advance analytical ultracentrifugation, promoted rigor in the thermodynamic analysis of biochemical data and encouraged students and colleagues to look for the deepest possible understanding of science. This article, written by five of Dave's students, presents some of the impressions he has made over the years.     

Dr. David Rimm is interviewed by Feras Akbik

Dr. David Rimm, MD PhD, is a professor of Pathology at the Yale University School of Medicine specializing in developing quantitative, diagnostic techniques. His lab recently engineered a fluorescence-based algorithm, Automated Quantitative Analysis (AQUA), to analyze tissue microarrays in the hope of moving toward personalized medicine and diagnoses.     

The Unwavering Eye: David McKnight's Ethnographic‐Historical Legacy

Book reviewed in this article: David McKnight . Going the Whiteman's Way: Kinship and Marriage among Australian Aborigines.     

Some Notes on David Nicholson's Contributions to Modelling Adsorption

Abstract

During his career David has built up a very large number of scientific contacts throughout the world. Many of these became friends and collaborators. Imperial College was, of course, a good place to start from: R.M. Barrer was from New Zealand and John Petropoulos from Greece. Subsequently, he collaborated with scientists from other European Union countries, especially from France and Germany as well as more researchers from Greece. He also made many contacts in the US. A very important example was the sabbatical he had with W.A. Steele at Penn State, where he made his first big incursion into intermolecular forces. He also had very useful exchanges of visits with K.E. Gubbins, which led to joint work. More recently he developed working relationships with scientists from Japan and from South Korea. The scientific value of these contacts may be gauged from the large number of his publications, which involve researchers from these countries as co-authors. However, I am sure the readiness with which overseas researchers participated was in part also due to the friendly and helpful manner with which David received them here.     

Moral Philosophers Are Moral Experts! A Reply to David Archard

In his article ‘Why Moral Philosophers Are Not and Should Not Be Moral Experts’ David Archard attempts to show that his argument from common‐sense morality is more convincing than other competing arguments in the debate. I examine his main line of argumentation and eventually refute his main argument in my reply.     

The science of storytelling: the David Attenborough style of scientific presentation

Many scientists approach speaking as they do writing a paper: an opportunity to present their data. But data without proper context is difficult to absorb. In this article, I describe a philosophy and set of heuristics for giving an engaging, narratively driven talk, inspired by the legendary documentaries of Sir David Attenborough.     

A Pioneer in the Study of Porous Materials: A Short Appreciation of the Work of David Nicholson

Abstract

David Nicholson's long-standing interest in the properties of porous materials appears to date back to his PhD work on the thermal decomposition of oxalates, which he undertook at Salford with the late David Dollimore. He evidently saw the opportunity to bring some mathematical rigour to bear on this rather messy area of research by making one of the first attempts to model the relationship between the development of surface area and the kinetics of thermal decomposition [1].     

Harnessing reforestation to achieve greater biodiversity gains: Interview with David Lamb

For some decades, David Lamb has been seeking ways to help communities around the world reforest landscapes to improve ecological functioning and enhance local people's livelihoods. Here he describes how there is increasing world‐wide interest in expanding reforestation to generate ecosystem services and outlines some of the issues this raises for restoration practitioners.     

David Hopwood and the emergence of Streptomyces genetics.

Streptomyces spp. are unusual among bacteria in growing as mycelial colonies with sporulating aerial hyphae. They are very important as the source of most of the major antibiotics. Pioneering work by David Hopwood in the 1950s and 1960s established Streptomyces coelicolor A3(2) as the model system for the genus. Since then he has led successive key phases of research on this organism. In the 1970s, plasmids were discovered and characterised, and used both to establish conditions for transformation and in the subsequent development of cloning vectors. Protoplasts were exploited in both transformation and highly efficient cell fusion. In the 1980s, the early cloning of resistance genes from antibiotic-producing strains was followed by the cloning of antibiotic biosynthetic gene clusters, and the development of general methods and probes for the cloning of such clusters from diverse species. Analysis of these gene sets led to wide-ranging inferences about the biosynthesis of the important polyketide class of antibiotics, and to the production of hybrid antibiotics, and then, in the last decade, to more sophisticated combinatorial biosynthesis of designer molecules. In parallel, David Hopwood's work has also provided a crucial platform for studies of the regulation of the morphological and physiological differentiation that is manifested by sporulating antibiotic-producing colonies. Most recently, his involvement in the physical mapping of the entire 8 Mb genome of S. coelicolor A3(2) has culminated in its complete DNA sequencing: a project that should be completed under his management during the year 2000.     

Charles Darwin's correspondence with David Moore of Glasnevin on insectivorous plants and potatoes

Recently discovered correspondence between Charles Darwin and David Moore shows the latter's role in providing fresh material of importance to Darwin's studies on insectivorous plants. One letter relates to Moore's experimental work on potatoes. This research, probably concerned with resistance of selected varieties of potato to blight, is apparently not supported by Glasnevin Botanic Garden (Dublin) records or contemporary literature.     

Developmental changes in DNA methylation of pollen mother cells of David lily during meiotic prophase I

Epigenetic marks in the form of DNA methylation are involved in the development of germ cells and are important in the maintenance of fertility. However, the controlling system of the on-off switch for DNA methylation largely remains unclear. In this study, the extent of cytosine methylation during the meiotic prophase I in David lily is assessed using high pressure liquid chromatography to evaluate the DNA methylation rates. Comparing the degree of DNA methylation before, during, and after synizesis, both de novo methylation and demethylation occurred. Mainly the methylation level decreased by 21.3% (from 54.8 to 33.5%) during synizesis in the pollen mother cells. The developmental timing of genome-wide DNA methylation acquisition during pollen mother cell development is clarified in this paper. The relative amounts of 5-methyl-deoxycytidine of global methylation in leaf DNA in David lily were also higher than in other species reported.